15 items (Kryptolebias marmoratus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	snw1	SNW domain containing 1. (537 aa)
	LOC108248076	Checkpoint kinase 2. (534 aa)
	LOC108250440	E1A binding protein p300 a. (2399 aa)
	brca2	BRCA2 DNA repair associated. (2641 aa)
	sirt1	Sirtuin 1. (693 aa)
	LOC108231464	Uncharacterized protein. (252 aa)
	LOC108231528	Uncharacterized protein. (279 aa)
	msh2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	tp73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (719 aa)
	tp63	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (665 aa)
	ep300	E1A binding protein p300 b. (2785 aa)
	cdip1	Cell death-inducing p53 target 1. (195 aa)
	ENSKMAP00000027531	Pleckstrin homology-like domain, family A, member 3. (138 aa)
	atad5	ATPase family AAA domain containing 5a. (1804 aa)
	bag6	BCL2 associated athanogene 6. (1215 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC108231464	LOC108231528	ENSKMAP00000015240	ENSKMAP00000015264	Uncharacterized protein.	Uncharacterized protein.	0.907
LOC108231528	LOC108231464	ENSKMAP00000015264	ENSKMAP00000015240	Uncharacterized protein.	Uncharacterized protein.	0.907
LOC108248076	atad5	ENSKMAP00000007793	ENSKMAP00000028595	Checkpoint kinase 2.	ATPase family AAA domain containing 5a.	0.557
LOC108248076	brca2	ENSKMAP00000007793	ENSKMAP00000010397	Checkpoint kinase 2.	BRCA2 DNA repair associated.	0.739
LOC108248076	msh2	ENSKMAP00000007793	ENSKMAP00000015699	Checkpoint kinase 2.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.715
LOC108248076	sirt1	ENSKMAP00000007793	ENSKMAP00000011175	Checkpoint kinase 2.	Sirtuin 1.	0.466
LOC108248076	tp63	ENSKMAP00000007793	ENSKMAP00000020318	Checkpoint kinase 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.759
LOC108248076	tp73	ENSKMAP00000007793	ENSKMAP00000018389	Checkpoint kinase 2.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.759
LOC108250440	sirt1	ENSKMAP00000008734	ENSKMAP00000011175	E1A binding protein p300 a.	Sirtuin 1.	0.596
LOC108250440	snw1	ENSKMAP00000008734	ENSKMAP00000004331	E1A binding protein p300 a.	SNW domain containing 1.	0.668
LOC108250440	tp63	ENSKMAP00000008734	ENSKMAP00000020318	E1A binding protein p300 a.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.561
LOC108250440	tp73	ENSKMAP00000008734	ENSKMAP00000018389	E1A binding protein p300 a.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.561
atad5	LOC108248076	ENSKMAP00000028595	ENSKMAP00000007793	ATPase family AAA domain containing 5a.	Checkpoint kinase 2.	0.557
atad5	brca2	ENSKMAP00000028595	ENSKMAP00000010397	ATPase family AAA domain containing 5a.	BRCA2 DNA repair associated.	0.692
atad5	msh2	ENSKMAP00000028595	ENSKMAP00000015699	ATPase family AAA domain containing 5a.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.466
brca2	LOC108248076	ENSKMAP00000010397	ENSKMAP00000007793	BRCA2 DNA repair associated.	Checkpoint kinase 2.	0.739
brca2	atad5	ENSKMAP00000010397	ENSKMAP00000028595	BRCA2 DNA repair associated.	ATPase family AAA domain containing 5a.	0.692
brca2	msh2	ENSKMAP00000010397	ENSKMAP00000015699	BRCA2 DNA repair associated.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.739
brca2	tp63	ENSKMAP00000010397	ENSKMAP00000020318	BRCA2 DNA repair associated.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.563
brca2	tp73	ENSKMAP00000010397	ENSKMAP00000018389	BRCA2 DNA repair associated.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.563