node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPA1 | pola1 | ENSKMAP00000000242 | ENSKMAP00000020098 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | DNA polymerase. | 0.797 |
RPA1 | pola2 | ENSKMAP00000000242 | ENSKMAP00000024565 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. | 0.650 |
RPA1 | pold1 | ENSKMAP00000000242 | ENSKMAP00000013397 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | DNA polymerase. | 0.842 |
RPA1 | pold2 | ENSKMAP00000000242 | ENSKMAP00000003731 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | Polymerase (DNA directed), delta 2, regulatory subunit. | 0.642 |
RPA1 | pold3 | ENSKMAP00000000242 | ENSKMAP00000022542 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | Polymerase (DNA-directed), delta 3, accessory subunit. | 0.549 |
RPA1 | prim1 | ENSKMAP00000000242 | ENSKMAP00000016298 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | 0.755 |
RPA1 | prim2 | ENSKMAP00000000242 | ENSKMAP00000024620 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. | 0.780 |
RPA1 | prpf19 | ENSKMAP00000000242 | ENSKMAP00000013702 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | Pre-mRNA processing factor 19. | 0.539 |
RPA1 | rpa1 | ENSKMAP00000000242 | ENSKMAP00000007505 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.901 |
RPA1 | rpa3 | ENSKMAP00000000242 | ENSKMAP00000019992 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | Replication protein A 14kDa subunit. | 0.997 |
pola1 | RPA1 | ENSKMAP00000020098 | ENSKMAP00000000242 | DNA polymerase. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.797 |
pola1 | pola2 | ENSKMAP00000020098 | ENSKMAP00000024565 | DNA polymerase. | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. | 0.999 |
pola1 | pold1 | ENSKMAP00000020098 | ENSKMAP00000013397 | DNA polymerase. | DNA polymerase. | 0.978 |
pola1 | pold2 | ENSKMAP00000020098 | ENSKMAP00000003731 | DNA polymerase. | Polymerase (DNA directed), delta 2, regulatory subunit. | 0.984 |
pola1 | pold3 | ENSKMAP00000020098 | ENSKMAP00000022542 | DNA polymerase. | Polymerase (DNA-directed), delta 3, accessory subunit. | 0.776 |
pola1 | pold4 | ENSKMAP00000020098 | ENSKMAP00000010277 | DNA polymerase. | Uncharacterized protein. | 0.813 |
pola1 | prim1 | ENSKMAP00000020098 | ENSKMAP00000016298 | DNA polymerase. | DNA primase; Belongs to the eukaryotic-type primase small subunit family. | 0.999 |
pola1 | prim2 | ENSKMAP00000020098 | ENSKMAP00000024620 | DNA polymerase. | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. | 0.999 |
pola1 | rpa1 | ENSKMAP00000020098 | ENSKMAP00000007505 | DNA polymerase. | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. | 0.797 |
pola1 | rpa3 | ENSKMAP00000020098 | ENSKMAP00000019992 | DNA polymerase. | Replication protein A 14kDa subunit. | 0.715 |