(51 nodes) Oligodendrocyte differentiation network (Kryptolebias marmoratus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	Cdkn2c	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (159 aa)
	LOC108247340	Protein tyrosine phosphatase receptor type Z1a. (1262 aa)
	ENSKMAP00000000483	Protein tyrosine phosphatase receptor type Z1b. (790 aa)
	ENSKMAP00000000575	Alpha-carbonic anhydrase domain-containing protein. (221 aa)
	LOC108232961	Aspartoacylase (aminocyclase) 3, tandem duplicate 2. (307 aa)
	ACY3	Aminoacylase 3. (331 aa)
	leo1	LEO1 homolog, Paf1/RNA polymerase II complex component. (600 aa)
	prdm8	PR domain containing 8b. (568 aa)
	cdk5	Cyclin-dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (253 aa)
	LOC108238902	Vitronectin b. (439 aa)
	fa2h	Fatty acid 2-hydroxylase; Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters i [...] (378 aa)
	LOC108242275	Zinc finger protein 16 like. (539 aa)
	LOC108228916	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	wasf3	WASP family member 3b. (490 aa)
	ENSKMAP00000012493	Uncharacterized protein. (294 aa)
	LOC108241363	SRY-box transcription factor 9b. (475 aa)
	eif2b3	Eukaryotic translation initiation factor 2B, subunit 3 gamma. (454 aa)
	LOC108244723	HMG box domain-containing protein. (494 aa)
	LOC108233894	Si:dkey-175m17.7. (883 aa)
	LOC108247610	Proteolipid protein 1b. (257 aa)
	aspa	Aspartoacylase. (275 aa)
	shh	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (413 aa)
	LOC108246483	Zgc:109889. (552 aa)
	fgf3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (242 aa)
	nkx2-2	NK2 homeobox 2a. (311 aa)
	eif2b4	Eukaryotic translation initiation factor 2B, subunit 4 delta; Belongs to the eIF-2B alpha/beta/delta subunits family. (546 aa)
	nf1	Neurofibromin 1b. (2727 aa)
	TPPP	Tubulin polymerization promoting protein. (237 aa)
	eif2b2	Eukaryotic translation initiation factor 2B, subunit 2 beta; Belongs to the eIF-2B alpha/beta/delta subunits family. (360 aa)
	sox10	SRY-box transcription factor 10. (457 aa)
	gpr17	G protein-coupled receptor 17. (403 aa)
	ENSKMAP00000020764	HH_signal domain-containing protein. (101 aa)
	LOC108231483	Tetraspanin. (218 aa)
	nkx6-2	NK6 homeobox 2. (281 aa)
	LOC108246043	Vitronectin a. (525 aa)
	nkx6-1	NK6 homeobox 1. (528 aa)
	cntn2	Contactin 2. (713 aa)
	LOC108239148	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
	NCSTN	Nicastrin. (701 aa)
	LOC108236917	WH2 domain-containing protein. (469 aa)
	dusp10	Dual specificity phosphatase 10. (472 aa)
	SOX10	SRY-box transcription factor 10. (501 aa)
	LOC108242072	Proteolipid protein 1a. (245 aa)
	eif2b5	Eukaryotic translation initiation factor 2B, subunit 5 epsilon. (709 aa)
	LOC108235148	Tetraspanin. (214 aa)
	CNP	2',3'-cyclic nucleotide 3' phosphodiesterase. (641 aa)
	LOC108240386	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (434 aa)
	LOC108234043	PR domain containing 8. (510 aa)
	ercc2	Excision repair cross-complementation group 2. (760 aa)
	eif2b1	Eukaryotic translation initiation factor 2B, subunit 1 alpha; Belongs to the eIF-2B alpha/beta/delta subunits family. (328 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNP	LOC108242072	ENSKMAP00000027259	ENSKMAP00000026898	2',3'-cyclic nucleotide 3' phosphodiesterase.	Proteolipid protein 1a.	0.424
CNP	LOC108247610	ENSKMAP00000027259	ENSKMAP00000015940	2',3'-cyclic nucleotide 3' phosphodiesterase.	Proteolipid protein 1b.	0.424
ENSKMAP00000000483	ENSKMAP00000000575	ENSKMAP00000000483	ENSKMAP00000000575	Protein tyrosine phosphatase receptor type Z1b.	Alpha-carbonic anhydrase domain-containing protein.	0.899
ENSKMAP00000000575	ENSKMAP00000000483	ENSKMAP00000000575	ENSKMAP00000000483	Alpha-carbonic anhydrase domain-containing protein.	Protein tyrosine phosphatase receptor type Z1b.	0.899
ENSKMAP00000012493	cntn2	ENSKMAP00000012493	ENSKMAP00000022586	Uncharacterized protein.	Contactin 2.	0.764
LOC108228916	LOC108239148	ENSKMAP00000011171	ENSKMAP00000023606	Transforming growth factor beta; Belongs to the TGF-beta family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.491
LOC108228916	fgf3	ENSKMAP00000011171	ENSKMAP00000017192	Transforming growth factor beta; Belongs to the TGF-beta family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.491
LOC108231483	LOC108242072	ENSKMAP00000020848	ENSKMAP00000026898	Tetraspanin.	Proteolipid protein 1a.	0.545
LOC108236917	LOC108246483	ENSKMAP00000024383	ENSKMAP00000016959	WH2 domain-containing protein.	Zgc:109889.	0.901
LOC108236917	wasf3	ENSKMAP00000024383	ENSKMAP00000012131	WH2 domain-containing protein.	WASP family member 3b.	0.902
LOC108238902	LOC108246043	ENSKMAP00000009448	ENSKMAP00000021852	Vitronectin b.	Vitronectin a.	0.906
LOC108239148	LOC108228916	ENSKMAP00000023606	ENSKMAP00000011171	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.491
LOC108239148	fgf16	ENSKMAP00000023606	ENSKMAP00000008679	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.412
LOC108239148	fgf3	ENSKMAP00000023606	ENSKMAP00000017192	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.814
LOC108239148	shh	ENSKMAP00000023606	ENSKMAP00000016956	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.635
LOC108239148	sox10	ENSKMAP00000023606	ENSKMAP00000019119	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	SRY-box transcription factor 10.	0.487
LOC108242072	CNP	ENSKMAP00000026898	ENSKMAP00000027259	Proteolipid protein 1a.	2',3'-cyclic nucleotide 3' phosphodiesterase.	0.424
LOC108242072	LOC108231483	ENSKMAP00000026898	ENSKMAP00000020848	Proteolipid protein 1a.	Tetraspanin.	0.545
LOC108242072	sox10	ENSKMAP00000026898	ENSKMAP00000019119	Proteolipid protein 1a.	SRY-box transcription factor 10.	0.480
LOC108246043	LOC108238902	ENSKMAP00000021852	ENSKMAP00000009448	Vitronectin a.	Vitronectin b.	0.906