(38 nodes) Negative regulation of axon extension involved in axon guidance network (Kryptolebias marmoratus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108243308	Uncharacterized protein; Belongs to the semaphorin family. (623 aa)
	sema4c	Uncharacterized protein; Belongs to the semaphorin family. (871 aa)
	sema3b	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B; Belongs to the semaphorin family. (809 aa)
	sema3g	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3bl; Belongs to the semaphorin family. (782 aa)
	sema3c	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C; Belongs to the semaphorin family. (769 aa)
	LOC108244167	Sema domain-containing protein. (1098 aa)
	sema3e	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; Belongs to the semaphorin family. (796 aa)
	LOC108230078	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab; Belongs to the semaphorin family. (799 aa)
	sema3d	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Belongs to the semaphorin family. (807 aa)
	LOC108239522	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba; Belongs to the semaphorin family. (901 aa)
	LOC108239517	Semaphorin 4e; Belongs to the semaphorin family. (764 aa)
	sema4g	Uncharacterized protein; Belongs to the semaphorin family. (709 aa)
	LOC108243287	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6E; Belongs to the semaphorin family. (1060 aa)
	LOC108244468	Sema domain-containing protein; Belongs to the semaphorin family. (812 aa)
	sema6a	Semaphorin 6A; Belongs to the semaphorin family. (1012 aa)
	LOC108235111	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Aa; Belongs to the semaphorin family. (864 aa)
	sema6b	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Bb; Belongs to the semaphorin family. (867 aa)
	LOC108243445	Uncharacterized protein; Belongs to the semaphorin family. (880 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	sema5b	Sema domain-containing protein. (1103 aa)
	LOC108249203	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	LOC108230473	Sema domain-containing protein. (1078 aa)
	LOC108230818	Si:ch211-129c21.1; Belongs to the semaphorin family. (799 aa)
	LOC108231368	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fa; Belongs to the semaphorin family. (790 aa)
	SEMA4F	Ssemaphorin 4F; Belongs to the semaphorin family. (797 aa)
	sema6d	Sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D, like; Belongs to the semaphorin family. (1110 aa)
	ENSKMAP00000019942	Uncharacterized protein. (147 aa)
	SEMA4D	Semaphorin 4D; Belongs to the semaphorin family. (906 aa)
	ryk	Receptor like tyrosine kinase. (628 aa)
	LOC108241743	Sema domain-containing protein; Belongs to the semaphorin family. (682 aa)
	ENSKMAP00000029554	Sema domain-containing protein; Belongs to the semaphorin family. (355 aa)
	LOC108244397	Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Fb; Belongs to the semaphorin family. (804 aa)
	LOC108251309	Uncharacterized protein; Belongs to the semaphorin family. (683 aa)
	sema7a	Semaphorin 7A; Belongs to the semaphorin family. (662 aa)
	LOC108250076	Si:dkey-49n23.1; Belongs to the semaphorin family. (780 aa)
	LOC108230190	Sema domain-containing protein; Belongs to the semaphorin family. (835 aa)
	LOC108243248	Si:ch211-113g11.6; Belongs to the semaphorin family. (643 aa)
	LOC108237396	Sema domain-containing protein; Belongs to the semaphorin family. (825 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000019942	SEMA4D	ENSKMAP00000019942	ENSKMAP00000020066	Uncharacterized protein.	Semaphorin 4D; Belongs to the semaphorin family.	0.476
LOC108249203	ryk	ENSKMAP00000007256	ENSKMAP00000020943	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Receptor like tyrosine kinase.	0.750
SEMA4D	ENSKMAP00000019942	ENSKMAP00000020066	ENSKMAP00000019942	Semaphorin 4D; Belongs to the semaphorin family.	Uncharacterized protein.	0.476
ryk	LOC108249203	ENSKMAP00000020943	ENSKMAP00000007256	Receptor like tyrosine kinase.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.750
ryk	wnt3a	ENSKMAP00000020943	ENSKMAP00000005684	Receptor like tyrosine kinase.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.750
wnt3a	ryk	ENSKMAP00000005684	ENSKMAP00000020943	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Receptor like tyrosine kinase.	0.750