(59 nodes) Kidney morphogenesis network (Kryptolebias marmoratus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pax5	Paired box 5. (386 aa)
	lzts3	Leucine zipper, putative tumor suppressor family member 3b. (607 aa)
	GREM1	Gremlin; Belongs to the DAN family. (172 aa)
	LOC108238717	Iroquois homeobox 1b. (443 aa)
	LOC108236879	Uncharacterized protein. (452 aa)
	ENSKMAP00000002093	Polycystic kidney disease 1b. (2655 aa)
	hs2st1	Heparan sulfate 2-O-sulfotransferase 1a. (358 aa)
	pkd2	Polycystic kidney disease 2. (911 aa)
	tmem59l	Transmembrane protein 59-like. (463 aa)
	lhx1	LIM homeobox 1a. (407 aa)
	fras1	Fraser extracellular matrix complex subunit 1. (2750 aa)
	cfap298	Cilia and flagella associated protein 298. (290 aa)
	invs	Inversin. (667 aa)
	klhl2	Kelch-like family member 2. (605 aa)
	commd5	COMM domain containing 5. (211 aa)
	LOC108240579	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (158 aa)
	gdnf	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (246 aa)
	LOC108248798	Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (680 aa)
	ENSKMAP00000010032	Heparan sulfate 2-O-sulfotransferase 1b. (132 aa)
	LOC108246890	WT1 transcription factor a. (444 aa)
	zmpste24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (467 aa)
	ENSKMAP00000011965	Uncharacterized protein. (107 aa)
	ILK	Integrin linked kinase. (452 aa)
	pax8	Paired box 8. (508 aa)
	LOC108247541	Mothers against decapentaplegic homolog. (503 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (168 aa)
	ENSKMAP00000013680	Uncharacterized protein. (507 aa)
	efhc2	EF-hand domain (C-terminal) containing 2. (734 aa)
	LOC108228999	Mothers against decapentaplegic homolog. (553 aa)
	klhl3	Kelch-like family member 3. (604 aa)
	wt1	WT1 transcription factor b. (425 aa)
	epcam	Epithelial cell adhesion molecule. (277 aa)
	ENSKMAP00000015205	Paired domain-containing protein. (150 aa)
	bmp4	Bone morphogenetic protein 4. (403 aa)
	tcf21	Transcription factor 21. (179 aa)
	prkx	Protein kinase X-linked; Belongs to the protein kinase superfamily. (347 aa)
	ahi1	Abelson helper integration site 1. (1195 aa)
	LOC108249631	Paired box 2b. (391 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2550 aa)
	ttc26	Tetratricopeptide repeat domain 26. (274 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (818 aa)
	bbs5	Bardet-Biedl syndrome 5 protein homolog; Required for ciliogenesis; Belongs to the BBS5 family. (342 aa)
	Ctnnbip1	Catenin, beta interacting protein 1. (76 aa)
	LOC108248927	T-box transcription factor Ta. (422 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	irx3	Iroquois homeobox 3a. (432 aa)
	LOC108242789	Paired box 2a. (417 aa)
	ENSKMAP00000024145	Glucosaminyl (N-acetyl) transferase 3, mucin type. (421 aa)
	LOC108229947	Glucosaminyl (N-acetyl) transferase 3, mucin type. (407 aa)
	ENSKMAP00000024214	Glucosaminyl (N-acetyl) transferase 3, mucin type. (417 aa)
	ENSKMAP00000024250	Glucosaminyl (N-acetyl) transferase 3, mucin type. (402 aa)
	pkd1	Polycystic kidney disease 1a. (4448 aa)
	greb1	Growth regulating estrogen receptor binding 1. (1781 aa)
	nek8	NIMA-related kinase 8. (703 aa)
	LOC108234507	Uncharacterized protein. (430 aa)
	LOC108232200	Iroquois homeobox 1a. (490 aa)
	LOC108234497	Uncharacterized protein. (420 aa)
	SMAD4	Mothers against decapentaplegic homolog. (457 aa)
	LOC108240827	Bone morphogenetic protein 16. (416 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000002093	pkd2	ENSKMAP00000002093	ENSKMAP00000003620	Polycystic kidney disease 1b.	Polycystic kidney disease 2.	0.828
ENSKMAP00000010032	hs2st1	ENSKMAP00000010032	ENSKMAP00000003570	Heparan sulfate 2-O-sulfotransferase 1b.	Heparan sulfate 2-O-sulfotransferase 1a.	0.901
ENSKMAP00000011965	zmpste24	ENSKMAP00000011965	ENSKMAP00000011944	Uncharacterized protein.	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family.	0.900
ENSKMAP00000024145	ENSKMAP00000024250	ENSKMAP00000024145	ENSKMAP00000024250	Glucosaminyl (N-acetyl) transferase 3, mucin type.	Glucosaminyl (N-acetyl) transferase 3, mucin type.	0.901
ENSKMAP00000024145	LOC108229947	ENSKMAP00000024145	ENSKMAP00000024180	Glucosaminyl (N-acetyl) transferase 3, mucin type.	Glucosaminyl (N-acetyl) transferase 3, mucin type.	0.901
ENSKMAP00000024250	ENSKMAP00000024145	ENSKMAP00000024250	ENSKMAP00000024145	Glucosaminyl (N-acetyl) transferase 3, mucin type.	Glucosaminyl (N-acetyl) transferase 3, mucin type.	0.901
ENSKMAP00000024250	LOC108229947	ENSKMAP00000024250	ENSKMAP00000024180	Glucosaminyl (N-acetyl) transferase 3, mucin type.	Glucosaminyl (N-acetyl) transferase 3, mucin type.	0.900
GREM1	bmp4	ENSKMAP00000000656	ENSKMAP00000015505	Gremlin; Belongs to the DAN family.	Bone morphogenetic protein 4.	0.709
ILK	LOC108236879	ENSKMAP00000012250	ENSKMAP00000001989	Integrin linked kinase.	Uncharacterized protein.	0.900
LOC108228999	LOC108240827	ENSKMAP00000014115	ENSKMAP00000028769	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 16.	0.666
LOC108228999	bmp4	ENSKMAP00000014115	ENSKMAP00000015505	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 4.	0.666
LOC108229947	ENSKMAP00000024145	ENSKMAP00000024180	ENSKMAP00000024145	Glucosaminyl (N-acetyl) transferase 3, mucin type.	Glucosaminyl (N-acetyl) transferase 3, mucin type.	0.901
LOC108229947	ENSKMAP00000024250	ENSKMAP00000024180	ENSKMAP00000024250	Glucosaminyl (N-acetyl) transferase 3, mucin type.	Glucosaminyl (N-acetyl) transferase 3, mucin type.	0.900
LOC108236879	ILK	ENSKMAP00000001989	ENSKMAP00000012250	Uncharacterized protein.	Integrin linked kinase.	0.900
LOC108240827	LOC108228999	ENSKMAP00000028769	ENSKMAP00000014115	Bone morphogenetic protein 16.	Mothers against decapentaplegic homolog.	0.666
LOC108240827	LOC108247541	ENSKMAP00000028769	ENSKMAP00000013171	Bone morphogenetic protein 16.	Mothers against decapentaplegic homolog.	0.666
LOC108240827	LOC108248927	ENSKMAP00000028769	ENSKMAP00000022585	Bone morphogenetic protein 16.	T-box transcription factor Ta.	0.431
LOC108240827	SMAD4	ENSKMAP00000028769	ENSKMAP00000028560	Bone morphogenetic protein 16.	Mothers against decapentaplegic homolog.	0.666
LOC108246890	tcf21	ENSKMAP00000010138	ENSKMAP00000016466	WT1 transcription factor a.	Transcription factor 21.	0.439
LOC108247541	LOC108240827	ENSKMAP00000013171	ENSKMAP00000028769	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 16.	0.666