(101 nodes) Regulation of leukocyte proliferation network (Kryptolebias marmoratus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108230245	Uncharacterized protein. (275 aa)
	dhps	Deoxyhypusine synthase. (362 aa)
	ENSKMAP00000000467	TAN domain-containing protein. (123 aa)
	Atm	Uncharacterized protein. (130 aa)
	GREM1	Gremlin; Belongs to the DAN family. (172 aa)
	sash3	SAM and SH3 domain containing 3. (395 aa)
	ENSKMAP00000001054	Galectin. (344 aa)
	nck2	Cytoplasmic protein. (396 aa)
	LOC108236974	Solute carrier family 7 member 1a. (650 aa)
	tnfrsf13b	TNFR-Cys domain-containing protein. (263 aa)
	igf2	Insulin-like growth factor 2b. (215 aa)
	LOC108231281	CD40 ligand; Belongs to the tumor necrosis factor family. (267 aa)
	LOC108229350	TNFR-Cys domain-containing protein. (258 aa)
	glmn	Glomulin, FKBP associated protein a. (600 aa)
	tirap	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. (241 aa)
	ENSKMAP00000003041	IGv domain-containing protein. (214 aa)
	nfatc2	Nuclear factor of activated T cells 2a. (888 aa)
	LOC108242738	Interleukin-1. (244 aa)
	LOC108237606	TNFR-Cys domain-containing protein. (301 aa)
	LOC108244547	C-C motif chemokine. (109 aa)
	ripk2	Receptor-interacting serine-threonine kinase 2. (581 aa)
	LOC108248610	Receptor-interacting serine-threonine kinase 3; Belongs to the protein kinase superfamily. (493 aa)
	ptprc	Protein tyrosine phosphatase receptor type C. (1165 aa)
	Il20rb	Uncharacterized protein. (177 aa)
	SDC4	Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (182 aa)
	SLC7A1	Solute carrier family 7 member 1. (644 aa)
	LOC108245177	Signal transducer and activator of transcription. (788 aa)
	LOC108244589	Signal transducer and activator of transcription. (774 aa)
	Pth	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. (99 aa)
	LOC108233117	E3 ubiquitin-protein ligase. (897 aa)
	LOC108250452	Son of sevenless homolog 1 (Drosophila). (941 aa)
	il34	Uncharacterized protein. (201 aa)
	LOC108232104	Tumor necrosis factor receptor superfamily, member 9a. (289 aa)
	marchf7	Membrane associated ring-CH-type finger 7. (769 aa)
	LOC108250490	Neuromedin B receptor. (244 aa)
	LOC108228916	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	LOC108228918	Uncharacterized protein. (262 aa)
	LOC108249257	Arginase. (340 aa)
	vsir	V-set immunoregulatory receptor. (282 aa)
	LOC108231575	Uncharacterized protein. (494 aa)
	mad1l1	Mitotic arrest deficient 1 like 1. (722 aa)
	ENSKMAP00000013387	Histone domain-containing protein. (135 aa)
	LOC108249875	ZP domain-containing protein. (495 aa)
	rc3h1	Ring finger and CCCH-type domains 1b. (1122 aa)
	ENSKMAP00000014207	TNFR-Cys domain-containing protein. (326 aa)
	LOC108232633	Uncharacterized protein. (457 aa)
	ENSKMAP00000014415	MPL proto-oncogene, thrombopoietin receptor. (514 aa)
	ENSKMAP00000014556	Tumor necrosis factor receptor superfamily, member 21. (607 aa)
	nck1	Cytoplasmic protein. (393 aa)
	syk	Spleen tyrosine kinase. (648 aa)
	pawr	PRKC, apoptosis, WT1, regulator. (322 aa)
	LOC108229992	ZP domain-containing protein. (427 aa)
	LOC108243584	Leucine rich repeat containing 32. (652 aa)
	fadd	Uncharacterized protein. (187 aa)
	TGFBR2	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (555 aa)
	LOC108229097	Galectin. (309 aa)
	LOC108230000	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (353 aa)
	sh3rf1	SH3 domain containing ring finger 1. (845 aa)
	nf1	Neurofibromin 1b. (2727 aa)
	LOC108238465	Tyrosine-protein kinase. (616 aa)
	ENSKMAP00000019033	Ig-like domain-containing protein. (256 aa)
	ENSKMAP00000019063	Uncharacterized protein. (337 aa)
	LOC108231686	E3 ubiquitin-protein ligase. (868 aa)
	ENSKMAP00000019182	Uncharacterized protein. (378 aa)
	rassf5	Ras association domain family member 5. (476 aa)
	il10	Interleukin 10. (184 aa)
	inpp5d	Inositol polyphosphate-5-phosphatase D. (1070 aa)
	LOC108251256	Uncharacterized protein. (384 aa)
	LOC108251257	Uncharacterized protein. (394 aa)
	ENSKMAP00000020400	Uncharacterized protein. (289 aa)
	LOC108251259	Uncharacterized protein. (353 aa)
	ENSKMAP00000020467	Uncharacterized protein. (1211 aa)
	il18	Uncharacterized protein. (202 aa)
	il6st	Uncharacterized protein. (890 aa)
	VTCN1	V-set domain containing T cell activation inhibitor 1. (272 aa)
	crtam	Ig-like domain-containing protein. (439 aa)
	arg2	Arginase. (349 aa)
	card11	Caspase recruitment domain family, member 11. (1044 aa)
	LOC108236108	Uncharacterized protein. (702 aa)
	LOC108231931	Uncharacterized protein. (272 aa)
	AIF1	Allograft inflammatory factor 1. (152 aa)
	LOC108236841	Galectin. (376 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (1318 aa)
	ENSKMAP00000023212	Uncharacterized protein. (93 aa)
	Tyrobp	Uncharacterized protein. (166 aa)
	gpam	Glycerol-3-phosphate acyltransferase 1, mitochondrial. (827 aa)
	LOC108247742	TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (586 aa)
	LOC108240241	CD276 molecule. (299 aa)
	LOC108230372	Uncharacterized protein. (206 aa)
	tmem147	Transmembrane protein 147. (225 aa)
	ENSKMAP00000024546	Osteoclast stimulatory transmembrane protein. (383 aa)
	LOC108231107	Galectin. (276 aa)
	ENSKMAP00000024975	HERV-H LTR-associating 2a, tandem duplicate 2. (465 aa)
	dlg5	Discs, large homolog 5a (Drosophila); Belongs to the MAGUK family. (2043 aa)
	LOC112449723	Uncharacterized protein. (653 aa)
	gpnmb	Glycoprotein (transmembrane) nmb. (624 aa)
	LOC108246714	ZP domain-containing protein. (467 aa)
	LOC108243804	Signal transducer and activator of transcription. (791 aa)
	LOC108238035	Interferon regulatory factor 1b. (353 aa)
	atad5	ATPase family AAA domain containing 5a. (1804 aa)
	tnfsf13b	TNF superfamily member 13b; Belongs to the tumor necrosis factor family. (264 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AIF1	ENSKMAP00000023212	ENSKMAP00000022559	ENSKMAP00000023212	Allograft inflammatory factor 1.	Uncharacterized protein.	0.755
AIF1	LOC108242738	ENSKMAP00000022559	ENSKMAP00000003272	Allograft inflammatory factor 1.	Interleukin-1.	0.600
AIF1	Tyrobp	ENSKMAP00000022559	ENSKMAP00000023236	Allograft inflammatory factor 1.	Uncharacterized protein.	0.755
AIF1	il10	ENSKMAP00000022559	ENSKMAP00000019970	Allograft inflammatory factor 1.	Interleukin 10.	0.426
AIF1	ptprc	ENSKMAP00000022559	ENSKMAP00000005592	Allograft inflammatory factor 1.	Protein tyrosine phosphatase receptor type C.	0.472
Atm	ENSKMAP00000000467	ENSKMAP00000000507	ENSKMAP00000000467	Uncharacterized protein.	TAN domain-containing protein.	0.926
Atm	atad5	ENSKMAP00000000507	ENSKMAP00000028595	Uncharacterized protein.	ATPase family AAA domain containing 5a.	0.579
Atm	nf1	ENSKMAP00000000507	ENSKMAP00000018458	Uncharacterized protein.	Neurofibromin 1b.	0.412
ENSKMAP00000000467	Atm	ENSKMAP00000000467	ENSKMAP00000000507	TAN domain-containing protein.	Uncharacterized protein.	0.926
ENSKMAP00000000467	atad5	ENSKMAP00000000467	ENSKMAP00000028595	TAN domain-containing protein.	ATPase family AAA domain containing 5a.	0.579
ENSKMAP00000000467	nf1	ENSKMAP00000000467	ENSKMAP00000018458	TAN domain-containing protein.	Neurofibromin 1b.	0.412
ENSKMAP00000001054	LOC108229097	ENSKMAP00000001054	ENSKMAP00000017545	Galectin.	Galectin.	0.447
ENSKMAP00000001054	ptprc	ENSKMAP00000001054	ENSKMAP00000005592	Galectin.	Protein tyrosine phosphatase receptor type C.	0.421
ENSKMAP00000003041	LOC108231281	ENSKMAP00000003041	ENSKMAP00000002051	IGv domain-containing protein.	CD40 ligand; Belongs to the tumor necrosis factor family.	0.690
ENSKMAP00000003041	LOC108237606	ENSKMAP00000003041	ENSKMAP00000003560	IGv domain-containing protein.	TNFR-Cys domain-containing protein.	0.662
ENSKMAP00000003041	LOC108240241	ENSKMAP00000003041	ENSKMAP00000024165	IGv domain-containing protein.	CD276 molecule.	0.601
ENSKMAP00000003041	ptprc	ENSKMAP00000003041	ENSKMAP00000005592	IGv domain-containing protein.	Protein tyrosine phosphatase receptor type C.	0.426
ENSKMAP00000013387	nck1	ENSKMAP00000013387	ENSKMAP00000015469	Histone domain-containing protein.	Cytoplasmic protein.	0.601
ENSKMAP00000013387	nck2	ENSKMAP00000013387	ENSKMAP00000001099	Histone domain-containing protein.	Cytoplasmic protein.	0.601
ENSKMAP00000013387	nf1	ENSKMAP00000013387	ENSKMAP00000018458	Histone domain-containing protein.	Neurofibromin 1b.	0.433