(66 nodes) Nephron epithelium development network (Kryptolebias marmoratus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	irx3	Iroquois homeobox 3a. (432 aa)
	LOC108239726	Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family. (423 aa)
	nphs1	NPHS1 adhesion molecule, nephrin. (1134 aa)
	kank2	KN motif and ankyrin repeat domains 2. (1027 aa)
	pkd1	Polycystic kidney disease 1a. (4448 aa)
	greb1	Growth regulating estrogen receptor binding 1. (1781 aa)
	LOC108232200	Iroquois homeobox 1a. (490 aa)
	LOC108247334	Coenzyme Q8B. (642 aa)
	SMAD4	Mothers against decapentaplegic homolog. (457 aa)
	LOC108240827	Bone morphogenetic protein 16. (416 aa)
	prkci	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (598 aa)
	hs2st1	Heparan sulfate 2-O-sulfotransferase 1a. (358 aa)
	podxl	Uncharacterized protein. (441 aa)
	pkd2	Polycystic kidney disease 2. (911 aa)
	LOC108245037	Odd-skipped related transcription factor 1. (268 aa)
	tmem59l	Transmembrane protein 59-like. (463 aa)
	TBX2	T-box transcription factor 2. (682 aa)
	etv4	Ets variant 4. (509 aa)
	lhx1	LIM homeobox 1a. (407 aa)
	LOC108234774	Uncharacterized protein. (755 aa)
	LOC108241711	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (256 aa)
	LOC108241647	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (261 aa)
	ednra	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family. (426 aa)
	LOC108249163	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family. (469 aa)
	LOC108234309	NPHS2 stomatin family member, podocin. (354 aa)
	klhl2	Kelch-like family member 2. (605 aa)
	lzts3	Leucine zipper, putative tumor suppressor family member 3b. (607 aa)
	GREM1	Gremlin; Belongs to the DAN family. (172 aa)
	ENSKMAP00000000874	Thrombospondin, type I, domain containing 7Aa. (1197 aa)
	LOC108238717	Iroquois homeobox 1b. (443 aa)
	basp1	Brain abundant, membrane attached signal protein 1. (176 aa)
	LOC108236879	Uncharacterized protein. (452 aa)
	ENSKMAP00000002093	Polycystic kidney disease 1b. (2655 aa)
	LOC108239949	Membrane associated guanylate kinase, WW and PDZ domain containing 2b. (1340 aa)
	commd5	COMM domain containing 5. (211 aa)
	LOC108240579	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (158 aa)
	gdnf	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (246 aa)
	LOC108248798	Leucine zipper putative tumor suppressor 2 homolog; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Belongs to the LZTS2 family. (680 aa)
	ENSKMAP00000010032	Heparan sulfate 2-O-sulfotransferase 1b. (132 aa)
	LOC108246890	WT1 transcription factor a. (444 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC108238201	Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family. (421 aa)
	ENSKMAP00000011299	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes. (265 aa)
	LOC108242931	Platelet/endothelial cell adhesion molecule 1. (778 aa)
	ILK	Integrin linked kinase. (452 aa)
	LOC108247541	Mothers against decapentaplegic homolog. (503 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (168 aa)
	ENSKMAP00000013680	Uncharacterized protein. (507 aa)
	LOC108233821	T-box transcription factor 2a. (643 aa)
	efhc2	EF-hand domain (C-terminal) containing 2. (734 aa)
	LOC108228999	Mothers against decapentaplegic homolog. (553 aa)
	klhl3	Kelch-like family member 3. (604 aa)
	wt1	WT1 transcription factor b. (425 aa)
	magi2	Membrane associated guanylate kinase, WW and PDZ domain containing 2a. (1427 aa)
	epcam	Epithelial cell adhesion molecule. (277 aa)
	bmp4	Bone morphogenetic protein 4. (403 aa)
	LOC108248220	Si:dkey-237i9.8. (703 aa)
	tcf21	Transcription factor 21. (179 aa)
	ahi1	Abelson helper integration site 1. (1195 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (818 aa)
	LOC108238010	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (412 aa)
	kmo	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (471 aa)
	Ctnnbip1	Catenin, beta interacting protein 1. (76 aa)
	LOC108246069	Empty spiracles homeobox 1. (233 aa)
	LOC108233353	Uncharacterized protein. (761 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000002093	pkd2	ENSKMAP00000002093	ENSKMAP00000003620	Polycystic kidney disease 1b.	Polycystic kidney disease 2.	0.828
ENSKMAP00000010032	hs2st1	ENSKMAP00000010032	ENSKMAP00000003570	Heparan sulfate 2-O-sulfotransferase 1b.	Heparan sulfate 2-O-sulfotransferase 1a.	0.901
ENSKMAP00000011299	LOC108241647	ENSKMAP00000011299	ENSKMAP00000005282	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	Aquaporin 1a (Colton blood group), tandem duplicate 1; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.552
ENSKMAP00000011299	LOC108241711	ENSKMAP00000011299	ENSKMAP00000005260	Aquaporin; Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.552
GREM1	bmp4	ENSKMAP00000000656	ENSKMAP00000015505	Gremlin; Belongs to the DAN family.	Bone morphogenetic protein 4.	0.709
ILK	LOC108236879	ENSKMAP00000012250	ENSKMAP00000001989	Integrin linked kinase.	Uncharacterized protein.	0.900
LOC108228999	LOC108240827	ENSKMAP00000014115	ENSKMAP00000028769	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 16.	0.666
LOC108228999	bmp4	ENSKMAP00000014115	ENSKMAP00000015505	Mothers against decapentaplegic homolog.	Bone morphogenetic protein 4.	0.666
LOC108234309	LOC108246890	ENSKMAP00000005909	ENSKMAP00000010138	NPHS2 stomatin family member, podocin.	WT1 transcription factor a.	0.498
LOC108234309	nphs1	ENSKMAP00000005909	ENSKMAP00000023581	NPHS2 stomatin family member, podocin.	NPHS1 adhesion molecule, nephrin.	0.707
LOC108234309	podxl	ENSKMAP00000005909	ENSKMAP00000003590	NPHS2 stomatin family member, podocin.	Uncharacterized protein.	0.586
LOC108234309	wt1	ENSKMAP00000005909	ENSKMAP00000014839	NPHS2 stomatin family member, podocin.	WT1 transcription factor b.	0.498
LOC108234774	lhx1	ENSKMAP00000005173	ENSKMAP00000004159	Uncharacterized protein.	LIM homeobox 1a.	0.667
LOC108236879	ILK	ENSKMAP00000001989	ENSKMAP00000012250	Uncharacterized protein.	Integrin linked kinase.	0.900
LOC108238010	LOC108238201	ENSKMAP00000020554	ENSKMAP00000011089	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family.	0.901
LOC108238010	LOC108239726	ENSKMAP00000020554	ENSKMAP00000023225	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family.	0.902
LOC108238010	LOC108249163	ENSKMAP00000020554	ENSKMAP00000005893	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type Ab; Belongs to the G-protein coupled receptor 1 family.	0.540
LOC108238010	ednra	ENSKMAP00000020554	ENSKMAP00000005460	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type Aa; Belongs to the G-protein coupled receptor 1 family.	0.540
LOC108238201	LOC108238010	ENSKMAP00000011089	ENSKMAP00000020554	Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family.	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family.	0.901
LOC108238201	LOC108239726	ENSKMAP00000011089	ENSKMAP00000023225	Endothelin receptor Ba; Belongs to the G-protein coupled receptor 1 family.	Endothelin receptor type Bb; Belongs to the G-protein coupled receptor 1 family.	0.902