(68 nodes) Positive regulation of canonical Wnt signaling pathway network (Kryptolebias marmoratus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108235881	Casein kinase 1, epsilon; Belongs to the protein kinase superfamily. (440 aa)
	LOC108240954	Protein phosphatase, Mg2+/Mn2+ dependent, 1Na (putative). (435 aa)
	RNF146	Ring finger protein 146. (320 aa)
	ENSKMAP00000028219	Glypican 5c; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (576 aa)
	rnf220	Ring finger protein 220a. (680 aa)
	FAM53B	Family with sequence similarity 53 member B. (451 aa)
	LOC108235698	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (166 aa)
	LOC108240444	Transmembrane protein 198a. (390 aa)
	eda	Ectodysplasin A; Belongs to the tumor necrosis factor family. (248 aa)
	rspo1	R-spondin 1. (281 aa)
	gprc5b	G protein-coupled receptor, class C, group 5, member Ba. (399 aa)
	LOC108239707	Transducin beta like 1 X-linked. (513 aa)
	LOC108235174	GID complex subunit 8 homolog b (S. cerevisiae). (228 aa)
	xiap	X-linked inhibitor of apoptosis. (462 aa)
	LOC108235745	DUF4203 domain-containing protein. (342 aa)
	usp8	Ubiquitin specific peptidase 8; Belongs to the peptidase C19 family. (1078 aa)
	LOC108228374	FZ domain-containing protein. (285 aa)
	bambi	BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (255 aa)
	LOC108232008	WNK lysine deficient protein kinase 2. (1925 aa)
	ttc21b	Tetratricopeptide repeat domain 21B. (1318 aa)
	lrrk2	Leucine-rich repeat kinase 2. (2550 aa)
	LOC108237267	PH domain-containing protein. (1307 aa)
	gpc3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (524 aa)
	csnk1e	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (417 aa)
	csnk1g2	Casein kinase 1 gamma 2; Belongs to the protein kinase superfamily. (444 aa)
	LOC108232644	Poly [ADP-ribose] polymerase. (1288 aa)
	csnk1d	Casein kinase 1, delta b; Belongs to the protein kinase superfamily. (405 aa)
	fam53b	Family with sequence similarity 53 member B. (409 aa)
	LOC108248884	Protein phosphatase, Mg2+/Mn2+ dependent, 1Bb. (451 aa)
	LOC108248208	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (180 aa)
	LOC108234987	Poly [ADP-ribose] polymerase. (1267 aa)
	PRDM15	PR/SET domain 15. (1108 aa)
	LOC108238433	Uncharacterized protein; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (644 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
	LOC108245806	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
	LOC108245811	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
	LOC108229763	Uncharacterized protein. (432 aa)
	ILK	Integrin linked kinase. (452 aa)
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	LOC108229729	Transmembrane protein 198b. (362 aa)
	reck	Reversion-inducing-cysteine-rich protein with kazal motifs. (954 aa)
	LOC108250476	G_PROTEIN_RECEP_F1_2 domain-containing protein. (859 aa)
	ENSKMAP00000010095	Dickkopf_N domain-containing protein. (228 aa)
	sfrp2	Secreted frizzled-related protein 2. (308 aa)
	LOC108237621	DUF4203 domain-containing protein. (334 aa)
	usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1363 aa)
	ppm1a	Protein phosphatase, Mg2+/Mn2+ dependent, 1Aa. (382 aa)
	LOC108231957	GID complex subunit 8 homolog. (229 aa)
	adgra2	Adhesion G protein-coupled receptor A2; Belongs to the G-protein coupled receptor 2 family. (1384 aa)
	USP34	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family. (3503 aa)
	LOC108247443	APC membrane recruitment protein 1. (954 aa)
	LOC108238308	Transducin (beta)-like 1 X-linked receptor 1b. (512 aa)
	ppm1b	Protein phosphatase, Mg2+/Mn2+ dependent, 1Ba. (398 aa)
	LOC108247392	WNK lysine deficient protein kinase 2. (2148 aa)
	scel	LIM zinc-binding domain-containing protein. (523 aa)
	atp6ap2	ATPase H+ transporting accessory protein 2. (362 aa)
	lgr4	Leucine-rich repeat containing G protein-coupled receptor 4. (975 aa)
	wls	Wnt ligand secretion mediator. (546 aa)
	csnk1g1	Casein kinase 1, gamma 1; Belongs to the protein kinase superfamily. (468 aa)
	dkk2	Dickkopf WNT signaling pathway inhibitor 2. (242 aa)
	ubr5	Ubiquitin protein ligase E3 component n-recognin 5. (2742 aa)
	LOC108236879	Uncharacterized protein. (452 aa)
	LOC108247939	G protein-coupled receptor, class C, group 5, member Bb. (423 aa)
	nle1	Notchless homolog 1 (Drosophila). (478 aa)
	gpc5	Glypican 5a; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (566 aa)
	ENSKMAP00000024612	Ring finger protein 146. (305 aa)
	ENSKMAP00000029942	Ring finger protein 220b. (284 aa)
	LOC108230646	RING-type domain-containing protein. (259 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000024612	LOC108232644	ENSKMAP00000024612	ENSKMAP00000019104	Ring finger protein 146.	Poly [ADP-ribose] polymerase.	0.908
ENSKMAP00000024612	LOC108234987	ENSKMAP00000024612	ENSKMAP00000014253	Ring finger protein 146.	Poly [ADP-ribose] polymerase.	0.848
ENSKMAP00000024612	USP34	ENSKMAP00000024612	ENSKMAP00000006787	Ring finger protein 146.	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family.	0.510
ENSKMAP00000029942	LOC108230646	ENSKMAP00000029942	ENSKMAP00000029940	Ring finger protein 220b.	RING-type domain-containing protein.	0.881
ILK	LOC108236879	ENSKMAP00000012250	ENSKMAP00000001989	Integrin linked kinase.	Uncharacterized protein.	0.900
LOC108228374	LOC108245806	ENSKMAP00000020020	ENSKMAP00000013109	FZ domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.404
LOC108228374	LOC108245811	ENSKMAP00000020020	ENSKMAP00000013022	FZ domain-containing protein.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.520
LOC108229729	xiap	ENSKMAP00000011581	ENSKMAP00000022309	Transmembrane protein 198b.	X-linked inhibitor of apoptosis.	0.450
LOC108229763	LOC108250476	ENSKMAP00000012549	ENSKMAP00000010433	Uncharacterized protein.	G_PROTEIN_RECEP_F1_2 domain-containing protein.	0.411
LOC108230646	ENSKMAP00000029942	ENSKMAP00000029940	ENSKMAP00000029942	RING-type domain-containing protein.	Ring finger protein 220b.	0.881
LOC108232644	ENSKMAP00000024612	ENSKMAP00000019104	ENSKMAP00000024612	Poly [ADP-ribose] polymerase.	Ring finger protein 146.	0.908
LOC108232644	RNF146	ENSKMAP00000019104	ENSKMAP00000028543	Poly [ADP-ribose] polymerase.	Ring finger protein 146.	0.931
LOC108232644	USP34	ENSKMAP00000019104	ENSKMAP00000006787	Poly [ADP-ribose] polymerase.	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family.	0.541
LOC108234987	ENSKMAP00000024612	ENSKMAP00000014253	ENSKMAP00000024612	Poly [ADP-ribose] polymerase.	Ring finger protein 146.	0.848
LOC108234987	RNF146	ENSKMAP00000014253	ENSKMAP00000028543	Poly [ADP-ribose] polymerase.	Ring finger protein 146.	0.886
LOC108234987	USP34	ENSKMAP00000014253	ENSKMAP00000006787	Poly [ADP-ribose] polymerase.	Ubiquitin specific peptidase 34; Belongs to the peptidase C19 family.	0.541
LOC108235745	xiap	ENSKMAP00000022278	ENSKMAP00000022309	DUF4203 domain-containing protein.	X-linked inhibitor of apoptosis.	0.450
LOC108235881	csnk1e	ENSKMAP00000029646	ENSKMAP00000019363	Casein kinase 1, epsilon; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.900
LOC108236879	ILK	ENSKMAP00000001989	ENSKMAP00000012250	Uncharacterized protein.	Integrin linked kinase.	0.900
LOC108237621	xiap	ENSKMAP00000008489	ENSKMAP00000022309	DUF4203 domain-containing protein.	X-linked inhibitor of apoptosis.	0.450