(54 nodes) Cellular response to alcohol network (Kryptolebias marmoratus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108249570	Golgi phosphoprotein 3. (294 aa)
	brca1	Uncharacterized protein. (1354 aa)
	glra2	Glycine receptor, alpha 2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (455 aa)
	adcy3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
	podn	Podocan. (586 aa)
	LOC108248366	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1125 aa)
	blm	BLM RecQ like helicase. (1384 aa)
	LOC108247157	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (621 aa)
	smo	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (818 aa)
	LOC108247680	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1055 aa)
	LOC108239683	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1180 aa)
	LOC108228327	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (445 aa)
	LOC108229092	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (814 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (334 aa)
	LOC108231104	Si:dkey-27b3.2. (294 aa)
	LOC108249375	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (516 aa)
	adcy6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
	LOC108233300	Uncharacterized protein. (354 aa)
	gramd1c	GRAM domain containing 1c. (652 aa)
	LOC108233892	Glycine receptor, alpha 4b; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (485 aa)
	aifm1	Apoptosis inducing factor mitochondrion associated 1. (650 aa)
	LOC108230868	Prostaglandin E receptor 4 (subtype EP4) b. (456 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (573 aa)
	recql5	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (996 aa)
	P2RY6	Pyrimidinergic receptor P2Y6. (352 aa)
	ENSKMAP00000009679	Uncharacterized protein. (70 aa)
	ache	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (622 aa)
	LOC108242279	Si:dkey-6n21.13; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	LOC108244602	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1182 aa)
	adcy5	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1202 aa)
	LOC108239985	Uncharacterized protein. (354 aa)
	LOC108232083	DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (1476 aa)
	SPIDR	Scaffold protein involved in DNA repair. (938 aa)
	cftr	Cystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1303 aa)
	LOC108232166	Orthodenticle homeobox 2b. (290 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (557 aa)
	ENSKMAP00000004266	GRAM domain-containing protein. (233 aa)
	glra1	Glycine receptor, alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (451 aa)
	P2RY4	Pyrimidinergic receptor P2Y4; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	gramd1b	GRAM domain containing 1Bb. (924 aa)
	ptgfr	Prostaglandin F receptor (FP). (368 aa)
	LOC108244492	Prostaglandin E receptor 4 (subtype EP4) c; Belongs to the G-protein coupled receptor 1 family. (488 aa)
	adcy8	Adenylate cyclase 8 (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1269 aa)
	ptger2	Prostaglandin E receptor 2a (subtype EP2). (376 aa)
	LOC108233591	Prostaglandin E receptor 4 (subtype EP4) a; Belongs to the G-protein coupled receptor 1 family. (446 aa)
	ENSKMAP00000000220	Cytochrome P450, family 1, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (525 aa)
	ENSKMAP00000000213	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (524 aa)
	LOC108231762	Homeobox domain-containing protein. (295 aa)
	mlc1	Modulator of VRAC current 1. (400 aa)
	xrn1	5'-3' exoribonuclease 1. (1630 aa)
	ENSKMAP00000027305	PWWP domain-containing protein. (61 aa)
	tp53inp1	Tumor protein p53 inducible nuclear protein 1. (284 aa)
	LOC108236365	Junction plakoglobin a. (725 aa)
	LOC108231179	Glycine receptor, alpha 4a; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (492 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC108229092	LOC108233300	ENSKMAP00000017125	ENSKMAP00000015252	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.794
LOC108229092	LOC108239683	ENSKMAP00000017125	ENSKMAP00000019657	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.474
LOC108229092	LOC108239985	ENSKMAP00000017125	ENSKMAP00000007502	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Uncharacterized protein.	0.794
LOC108229092	LOC108244602	ENSKMAP00000017125	ENSKMAP00000008135	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.436
LOC108229092	LOC108247680	ENSKMAP00000017125	ENSKMAP00000020343	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.520
LOC108229092	LOC108248366	ENSKMAP00000017125	ENSKMAP00000023425	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.477
LOC108229092	adcy3	ENSKMAP00000017125	ENSKMAP00000023876	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.508
LOC108229092	adcy5	ENSKMAP00000017125	ENSKMAP00000007503	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.427
LOC108229092	adcy6	ENSKMAP00000017125	ENSKMAP00000015966	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.433
LOC108230868	ptger2	ENSKMAP00000012377	ENSKMAP00000001214	Prostaglandin E receptor 4 (subtype EP4) b.	Prostaglandin E receptor 2a (subtype EP2).	0.514
LOC108233300	LOC108229092	ENSKMAP00000015252	ENSKMAP00000017125	Uncharacterized protein.	Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.794
LOC108233300	LOC108239683	ENSKMAP00000015252	ENSKMAP00000019657	Uncharacterized protein.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.794
LOC108233300	LOC108244602	ENSKMAP00000015252	ENSKMAP00000008135	Uncharacterized protein.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.776
LOC108233300	LOC108247680	ENSKMAP00000015252	ENSKMAP00000020343	Uncharacterized protein.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.435
LOC108233300	LOC108248366	ENSKMAP00000015252	ENSKMAP00000023425	Uncharacterized protein.	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.794
LOC108233300	adcy3	ENSKMAP00000015252	ENSKMAP00000023876	Uncharacterized protein.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.794
LOC108233300	adcy5	ENSKMAP00000015252	ENSKMAP00000007503	Uncharacterized protein.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.776
LOC108233300	adcy6	ENSKMAP00000015252	ENSKMAP00000015966	Uncharacterized protein.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.776
LOC108233300	adcy8	ENSKMAP00000015252	ENSKMAP00000001432	Uncharacterized protein.	Adenylate cyclase 8 (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.	0.794
LOC108233300	smo	ENSKMAP00000015252	ENSKMAP00000020439	Uncharacterized protein.	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family.	0.490