(93 nodes) Cystine-knot cytokine network (Kryptolebias marmoratus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108232032	Platelet-derived growth factor beta polypeptide a; Belongs to the PDGF/VEGF growth factor family. (569 aa)
	LOC108249887	Bone morphogenetic protein 8a. (445 aa)
	LOC108237947	Platelet-derived growth factor alpha polypeptide a; Belongs to the PDGF/VEGF growth factor family. (199 aa)
	ndp	Norrin cystine knot growth factor NDP. (143 aa)
	pdgfc	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family. (345 aa)
	LOC108247539	Bone morphogenetic protein 10, like. (456 aa)
	gdnf	Glial cell line-derived neurotrophic factor; Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high- affinity dopamine uptake. (246 aa)
	LOC108228885	TGF_BETA_2 domain-containing protein. (371 aa)
	LOC108242884	Si:dkey-23i12.9. (139 aa)
	gpha2	Glycoprotein hormone subunit alpha 2. (142 aa)
	LOC108237705	NGF domain-containing protein; Belongs to the NGF-beta family. (458 aa)
	pdgfd	Platelet derived growth factor d. (333 aa)
	LOC108228916	Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
	ENSKMAP00000011206	Bone morphogenetic protein 10. (489 aa)
	cga	Glycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (151 aa)
	ENSKMAP00000011440	Uncharacterized protein. (190 aa)
	LOC108251122	Uncharacterized protein. (182 aa)
	LOC108232637	Nodal-related 1. (368 aa)
	LOC108242427	Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
	LOC108237136	Noggin; Belongs to the noggin family. (209 aa)
	LOC108250685	Uncharacterized protein. (196 aa)
	bmp7	Bone morphogenetic protein 7b. (428 aa)
	LOC108230958	TGF_BETA_2 domain-containing protein. (208 aa)
	INHBC	Inhibin subunit beta C. (380 aa)
	ENSKMAP00000029413	Noggin; Belongs to the noggin family. (227 aa)
	NBL1	NBL1, DAN family BMP antagonist. (194 aa)
	LOC108232862	Anti-dorsalizing morphogenic protein. (374 aa)
	ntf3	Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (350 aa)
	LOC108232825	Neurturin. (229 aa)
	LOC108240827	Bone morphogenetic protein 16. (416 aa)
	ENSKMAP00000028656	CTCK domain-containing protein. (99 aa)
	GDF10	Growth differentiation factor 10. (506 aa)
	LOC108234523	Glial cell derived neurotrophic factor b. (256 aa)
	sostdc1	Sclerostin domain containing 1a. (208 aa)
	LOC108233514	Gremlin 1a, DAN family BMP antagonist. (173 aa)
	ENSKMAP00000027218	Nerve growth factor a (beta polypeptide); Belongs to the NGF-beta family. (208 aa)
	TSHB	Thyroid stimulating hormone subunit beta. (122 aa)
	LOC108246724	Inhibin subunit beta B. (396 aa)
	bmp5	Bone morphogenetic protein 5. (457 aa)
	LOC108245471	Interleukin 17a/f3. (154 aa)
	LOC108228553	Inhibin subunit beta Aa. (134 aa)
	LOC108244339	DAN domain family, member 5. (255 aa)
	LOC108234526	Southpaw. (422 aa)
	LOC108250814	Glycoprotein hormone subunit beta 5. (140 aa)
	LOC108236096	Platelet-derived growth factor beta polypeptide b; Belongs to the PDGF/VEGF growth factor family. (506 aa)
	LOC108250775	TGF_BETA_2 domain-containing protein. (275 aa)
	gdf11	Growth differentiation factor 11. (397 aa)
	LOC108244838	TGF_BETA_2 domain-containing protein. (381 aa)
	LOC108231487	Nerve growth factor b (beta polypeptide); Belongs to the NGF-beta family. (195 aa)
	LOC108231646	Thyroid stimulating hormone subunit beta a. (148 aa)
	LOC108247721	Nodal-related 2. (387 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	pdgfa	Platelet-derived growth factor alpha polypeptide b; Belongs to the PDGF/VEGF growth factor family. (227 aa)
	il17d	Interleukin 17d. (205 aa)
	ENSKMAP00000028508	CTCK domain-containing protein. (117 aa)
	LOC108231808	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (170 aa)
	GREM1	Gremlin; Belongs to the DAN family. (172 aa)
	LOC108245003	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (410 aa)
	grem2	Gremlin 2, DAN family BMP antagonist a. (192 aa)
	bmp2	Bone morphogenetic protein 2b. (418 aa)
	mstn	Myostatin b. (396 aa)
	LOC108244491	TGF_BETA_2 domain-containing protein. (318 aa)
	bdnf	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family. (307 aa)
	ENSKMAP00000002910	Uncharacterized protein. (152 aa)
	ENSKMAP00000002913	Growth differentiation factor 5. (393 aa)
	ENSKMAP00000003084	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (169 aa)
	tgfb3	Transforming growth factor beta; Belongs to the TGF-beta family. (405 aa)
	LOC108234775	Follicle stimulating hormone beta subunit. (120 aa)
	inha	Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (332 aa)
	amh	TGF_BETA_2 domain-containing protein. (519 aa)
	gdf6	Growth differentiation factor 6a. (408 aa)
	LOC108248589	Sclerostin domain containing 1b. (211 aa)
	INHBB	Inhibin subunit beta B. (392 aa)
	bmp3	Bone morphogenetic protein 3; Belongs to the TGF-beta family. (460 aa)
	vegfb	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (253 aa)
	pgf	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (136 aa)
	LOC108231423	Transforming growth factor beta; Belongs to the TGF-beta family. (419 aa)
	LOC108250950	Bone morphogenetic protein 15. (455 aa)
	gdf3	Growth differentiation factor 3. (343 aa)
	LOC108231812	Left-right determination factor. (359 aa)
	LOC108244027	Bone morphogenetic protein 6. (422 aa)
	LOC108249193	Growth differentiation factor 2. (393 aa)
	sost	Sclerostin. (217 aa)
	LOC108245161	Luteinizing hormone, beta polypeptide. (164 aa)
	LOC108241192	Bone morphogenetic protein 7a. (425 aa)
	LOC108240536	Growth differentiation factor 9. (420 aa)
	Nog	Noggin; Belongs to the noggin family. (211 aa)
	PSPN	Persephin. (140 aa)
	inhba	Inhibin subunit beta Ab. (397 aa)
	bmp4	Bone morphogenetic protein 4. (403 aa)
	vegfc	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family. (417 aa)
	ENSKMAP00000014728	Interleukin 17a/f1. (170 aa)
	ENSKMAP00000014683	Uncharacterized protein. (140 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000002910	ENSKMAP00000014683	ENSKMAP00000002910	ENSKMAP00000014683	Uncharacterized protein.	Uncharacterized protein.	0.636
ENSKMAP00000002910	ENSKMAP00000014728	ENSKMAP00000002910	ENSKMAP00000014728	Uncharacterized protein.	Interleukin 17a/f1.	0.627
ENSKMAP00000002910	LOC108245471	ENSKMAP00000002910	ENSKMAP00000026512	Uncharacterized protein.	Interleukin 17a/f3.	0.507
ENSKMAP00000002910	LOC108251122	ENSKMAP00000002910	ENSKMAP00000013028	Uncharacterized protein.	Uncharacterized protein.	0.657
ENSKMAP00000002913	ENSKMAP00000011440	ENSKMAP00000002913	ENSKMAP00000011440	Growth differentiation factor 5.	Uncharacterized protein.	0.491
ENSKMAP00000002913	Nog	ENSKMAP00000002913	ENSKMAP00000008856	Growth differentiation factor 5.	Noggin; Belongs to the noggin family.	0.491
ENSKMAP00000003084	pdgfc	ENSKMAP00000003084	ENSKMAP00000013152	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	Platelet derived growth factor c; Belongs to the PDGF/VEGF growth factor family.	0.511
ENSKMAP00000003084	pgf	ENSKMAP00000003084	ENSKMAP00000004889	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.443
ENSKMAP00000003084	vegfb	ENSKMAP00000003084	ENSKMAP00000004876	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family.	0.666
ENSKMAP00000003084	vegfc	ENSKMAP00000003084	ENSKMAP00000014812	Vascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family.	Vascular endothelial growth factor c; Belongs to the PDGF/VEGF growth factor family.	0.814
ENSKMAP00000011206	LOC108244838	ENSKMAP00000011206	ENSKMAP00000021479	Bone morphogenetic protein 10.	TGF_BETA_2 domain-containing protein.	0.403
ENSKMAP00000011206	LOC108247539	ENSKMAP00000011206	ENSKMAP00000013116	Bone morphogenetic protein 10.	Bone morphogenetic protein 10, like.	0.908
ENSKMAP00000011440	ENSKMAP00000002913	ENSKMAP00000011440	ENSKMAP00000002913	Uncharacterized protein.	Growth differentiation factor 5.	0.491
ENSKMAP00000011440	LOC108240827	ENSKMAP00000011440	ENSKMAP00000028769	Uncharacterized protein.	Bone morphogenetic protein 16.	0.777
ENSKMAP00000011440	LOC108241192	ENSKMAP00000011440	ENSKMAP00000007971	Uncharacterized protein.	Bone morphogenetic protein 7a.	0.593
ENSKMAP00000011440	LOC108244027	ENSKMAP00000011440	ENSKMAP00000005950	Uncharacterized protein.	Bone morphogenetic protein 6.	0.639
ENSKMAP00000011440	bdnf	ENSKMAP00000011440	ENSKMAP00000002366	Uncharacterized protein.	Brain-derived neurotrophic factor; Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it; Belongs to the NGF-beta family.	0.479
ENSKMAP00000011440	bmp2	ENSKMAP00000011440	ENSKMAP00000001494	Uncharacterized protein.	Bone morphogenetic protein 2b.	0.777
ENSKMAP00000011440	bmp4	ENSKMAP00000011440	ENSKMAP00000015505	Uncharacterized protein.	Bone morphogenetic protein 4.	0.802
ENSKMAP00000011440	bmp5	ENSKMAP00000011440	ENSKMAP00000026520	Uncharacterized protein.	Bone morphogenetic protein 5.	0.639