STRINGSTRING
pold1 pold1 apex1 apex1 parp3 parp3 parp2 parp2 LOC108245173 LOC108245173 lig1 lig1 pold3 pold3 LOC108245390 LOC108245390 ENSKMAP00000020750 ENSKMAP00000020750 Pole Pole rpa3 rpa3 LOC108245935 LOC108245935 rpa2 rpa2 parp1 parp1 rfc4 rfc4 LOC108244139 LOC108244139 pole2 pole2 rfc1 rfc1 RPA1 RPA1 rfc5 rfc5 RCBTB1 RCBTB1 pold2 pold2 pcna pcna LOC108244487 LOC108244487 polb polb rcbtb2 rcbtb2 fen1 fen1 vwa5b2 vwa5b2 rpa1 rpa1 rfc3 rfc3 ENSKMAP00000009313 ENSKMAP00000009313 apex2 apex2 LOC108248126 LOC108248126 pold4 pold4 rfc2 rfc2 adprhl2 adprhl2 pole3 pole3 pole4 pole4 atad5 atad5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pold1DNA polymerase. (1105 aa)
apex1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (310 aa)
parp3Poly [ADP-ribose] polymerase. (530 aa)
parp2Poly [ADP-ribose] polymerase. (655 aa)
LOC108245173Poly (ADP-ribose) glycohydrolase a. (755 aa)
lig1DNA ligase. (1010 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (440 aa)
LOC108245390Poly (ADP-ribose) glycohydrolase, like. (593 aa)
ENSKMAP00000020750DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (314 aa)
PoleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (298 aa)
rpa3Replication protein A 14kDa subunit. (122 aa)
LOC108245935Uncharacterized protein. (643 aa)
rpa2RPA_C domain-containing protein. (274 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
rfc4Replication factor C (activator 1) 4. (388 aa)
LOC108244139Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
rfc1Replication factor C subunit 1. (1180 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
rfc5Replication factor C (activator 1) 5. (339 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
LOC108244487Zgc:110269. (346 aa)
polbDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (336 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
vwa5b2Von Willebrand factor A domain containing 5B2. (1143 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
ENSKMAP00000009313Methionine sulfoxide reductase B1b. (467 aa)
apex2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (553 aa)
LOC108248126RPA_C domain-containing protein. (199 aa)
pold4Uncharacterized protein. (110 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
adprhl2ADP-ribosylhydrolase like 2. (406 aa)
pole3CBFD_NFYB_HMF domain-containing protein. (153 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (130 aa)
atad5ATPase family AAA domain containing 5a. (1804 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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