STRINGSTRING
cdc7 cdc7 RPA1 RPA1 ENSKMAP00000001053 ENSKMAP00000001053 rfc5 rfc5 RCBTB1 RCBTB1 cdc45 cdc45 cdc6 cdc6 dbf4 dbf4 orc4 orc4 rcbtb2 rcbtb2 mcm4 mcm4 mcm8 mcm8 rpa1 rpa1 rfc3 rfc3 orc1 orc1 Rad9b Rad9b LOC108248126 LOC108248126 orc3 orc3 rfc2 rfc2 mcm6 mcm6 mcm10 mcm10 hus1 hus1 orc5 orc5 LOC108244139 LOC108244139 rfc4 rfc4 rad9a rad9a mcm5 mcm5 rpa2 rpa2 mcm2 mcm2 rad1 rad1 rpa3 rpa3 cdk2 cdk2 LOC108246065 LOC108246065 rad17 rad17 CLSPN CLSPN mcm7 mcm7 orc2 orc2 mcm3 mcm3 atrip atrip chek1 chek1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdc7Cell division cycle 7 homolog (S. cerevisiae). (547 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
ENSKMAP00000001053Uncharacterized protein. (109 aa)
rfc5Replication factor C (activator 1) 5. (339 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (572 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (575 aa)
dbf4DBF4 zinc finger. (606 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
mcm4DNA helicase; Belongs to the MCM family. (861 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (781 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (695 aa)
Rad9bRAD9 checkpoint clamp component B. (194 aa)
LOC108248126RPA_C domain-containing protein. (199 aa)
orc3Origin recognition complex, subunit 3. (718 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
mcm6DNA helicase; Belongs to the MCM family. (823 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (848 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
orc5Origin recognition complex, subunit 5. (445 aa)
LOC108244139Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
rfc4Replication factor C (activator 1) 4. (388 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (387 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
rpa2RPA_C domain-containing protein. (274 aa)
mcm2DNA helicase; Belongs to the MCM family. (890 aa)
rad1RAD1 homolog (S. pombe). (280 aa)
rpa3Replication protein A 14kDa subunit. (122 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
LOC108246065Cell division cycle 25B. (528 aa)
rad17RAD17 checkpoint clamp loader component. (528 aa)
CLSPNClaspin. (1213 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
orc2Origin recognition complex, subunit 2. (585 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
atripUncharacterized protein. (776 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (455 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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