STRINGSTRING
LOC108239041 LOC108239041 ankrd28 ankrd28 pola1 pola1 rpa3 rpa3 ruvbl2 ruvbl2 rpa2 rpa2 prim1 prim1 LOC108245905 LOC108245905 rfc4 rfc4 ten1 ten1 LOC108244139 LOC108244139 gar1 gar1 ENSKMAP00000013709 ENSKMAP00000013709 terf2ip terf2ip pold1 pold1 recql4 recql4 ccna2 ccna2 rfc2 rfc2 PPP6C PPP6C dkc1 dkc1 pold4 pold4 LOC108248126 LOC108248126 chtf18 chtf18 terf1 terf1 ENSKMAP00000009313 ENSKMAP00000009313 pot1 pot1 trub1 trub1 ENSKMAP00000008045 ENSKMAP00000008045 rfc3 rfc3 rpa1 rpa1 ccna1 ccna1 wrap53 wrap53 ctc1 ctc1 fen1 fen1 rcbtb2 rcbtb2 LOC108240440 LOC108240440 RPA1 RPA1 nop10 nop10 shq1 shq1 lig1 lig1 LOC108228507 LOC108228507 dscc1 dscc1 pola2 pola2 prim2 prim2 terf2 terf2 DNA2 DNA2 stn1 stn1 tert tert ankrd44 ankrd44 chtf8 chtf8 LOC108244487 LOC108244487 pcna pcna pold2 pold2 rtel1 rtel1 RCBTB1 RCBTB1 rfc1 rfc1 pif1 pif1 rfc5 rfc5 exd2 exd2 pold3 pold3 blm blm cdk2 cdk2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108239041Ankyrin repeat domain 66. (158 aa)
ankrd28Ankyrin repeat domain 28b. (1052 aa)
pola1DNA polymerase. (1476 aa)
rpa3Replication protein A 14kDa subunit. (122 aa)
ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (459 aa)
rpa2RPA_C domain-containing protein. (274 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (427 aa)
LOC108245905TERF1 (TRF1)-interacting nuclear factor 2. (570 aa)
rfc4Replication factor C (activator 1) 4. (388 aa)
ten1TEN1 subunit of CST complex. (135 aa)
LOC108244139Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (211 aa)
ENSKMAP00000013709Uncharacterized protein. (437 aa)
terf2ipUncharacterized protein. (682 aa)
pold1DNA polymerase. (1105 aa)
recql4RecQ helicase-like 4. (1281 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
dkc1Dyskeratosis congenita 1, dyskerin. (497 aa)
pold4Uncharacterized protein. (110 aa)
LOC108248126RPA_C domain-containing protein. (199 aa)
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae). (775 aa)
terf1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (366 aa)
ENSKMAP00000009313Methionine sulfoxide reductase B1b. (467 aa)
pot1Protection of telomeres 1 homolog. (770 aa)
trub1TruB pseudouridine (psi) synthase family member 1. (278 aa)
ENSKMAP00000008045Uncharacterized protein. (79 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (335 aa)
wrap53WD repeat containing, antisense to TP53. (547 aa)
ctc1Uncharacterized protein. (993 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
LOC108240440ANK_REP_REGION domain-containing protein. (1101 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
nop10NOP10 ribonucleoprotein homolog (yeast). (64 aa)
shq1SHQ1, H/ACA ribonucleoprotein assembly factor. (587 aa)
lig1DNA ligase. (1010 aa)
LOC108228507ATP-dependent DNA helicase; Belongs to the helicase family. (1236 aa)
dscc1DNA replication and sister chromatid cohesion 1. (390 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (516 aa)
terf2HTH myb-type domain-containing protein. (603 aa)
DNA2DNA replication helicase/nuclease 2. (1388 aa)
stn1STN1 subunit of CST complex. (315 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1104 aa)
ankrd44Ankyrin repeat domain 44. (981 aa)
chtf8CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (136 aa)
LOC108244487Zgc:110269. (346 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1179 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
rfc1Replication factor C subunit 1. (1180 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (626 aa)
rfc5Replication factor C (activator 1) 5. (339 aa)
exd2Exonuclease 3'-5' domain containing 2. (639 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (440 aa)
blmBLM RecQ like helicase. (1384 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.