18 items (Kryptolebias marmoratus) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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gene neighborhood

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Your Input:
	ets1	V-ets avian erythroblastosis virus E26 oncogene homolog 1. (488 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	CDKN2A	Cyclin dependent kinase inhibitor 2A. (124 aa)
	cdk6	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
	id2	Inhibitor of DNA binding 2a. (139 aa)
	LOC108242980	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (408 aa)
	LOC108249856	Ets variant 2. (322 aa)
	LOC108235397	Ets2 repressor factor like 3. (731 aa)
	erfl	Ets2 repressor factor like 1. (470 aa)
	ubb	Uncharacterized protein. (270 aa)
	mdm4	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (490 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (372 aa)
	cdk4	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (317 aa)
	LOC108233962	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (206 aa)
	cdkn2d	Cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
	LOC108244375	Inhibitor of DNA binding 1, HLH protein. (129 aa)
	Cdkn2c	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4). (159 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDKN2A	TP53	ENSKMAP00000001588	ENSKMAP00000018969	Cyclin dependent kinase inhibitor 2A.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.847
CDKN2A	cdk4	ENSKMAP00000001588	ENSKMAP00000022679	Cyclin dependent kinase inhibitor 2A.	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.	0.815
CDKN2A	cdk6	ENSKMAP00000001588	ENSKMAP00000001458	Cyclin dependent kinase inhibitor 2A.	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.	0.764
CDKN2A	mdm4	ENSKMAP00000001588	ENSKMAP00000018825	Cyclin dependent kinase inhibitor 2A.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.836
Cdkn2c	cdk4	ENSKMAP00000030146	ENSKMAP00000022679	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4).	Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.	0.742
Cdkn2c	cdk6	ENSKMAP00000030146	ENSKMAP00000001458	Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4).	Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.	0.742
LOC108242980	LOC108249856	ENSKMAP00000012530	ENSKMAP00000012622	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Ets variant 2.	0.955
LOC108242980	TP53	ENSKMAP00000012530	ENSKMAP00000018969	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.577
LOC108242980	ets1	ENSKMAP00000012530	ENSKMAP00000002751	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	V-ets avian erythroblastosis virus E26 oncogene homolog 1.	0.955
LOC108242980	mapk1	ENSKMAP00000012530	ENSKMAP00000005892	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.901
LOC108244375	LOC108249856	ENSKMAP00000028937	ENSKMAP00000012622	Inhibitor of DNA binding 1, HLH protein.	Ets variant 2.	0.647
LOC108244375	ets1	ENSKMAP00000028937	ENSKMAP00000002751	Inhibitor of DNA binding 1, HLH protein.	V-ets avian erythroblastosis virus E26 oncogene homolog 1.	0.647
LOC108244375	id2	ENSKMAP00000028937	ENSKMAP00000010244	Inhibitor of DNA binding 1, HLH protein.	Inhibitor of DNA binding 2a.	0.915
LOC108249856	LOC108242980	ENSKMAP00000012622	ENSKMAP00000012530	Ets variant 2.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.955
LOC108249856	LOC108244375	ENSKMAP00000012622	ENSKMAP00000028937	Ets variant 2.	Inhibitor of DNA binding 1, HLH protein.	0.647
LOC108249856	TP53	ENSKMAP00000012622	ENSKMAP00000018969	Ets variant 2.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.503
LOC108249856	ets1	ENSKMAP00000012622	ENSKMAP00000002751	Ets variant 2.	V-ets avian erythroblastosis virus E26 oncogene homolog 1.	0.941
LOC108249856	id2	ENSKMAP00000012622	ENSKMAP00000010244	Ets variant 2.	Inhibitor of DNA binding 2a.	0.529
LOC108249856	mapk1	ENSKMAP00000012622	ENSKMAP00000005892	Ets variant 2.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.955
TP53	CDKN2A	ENSKMAP00000018969	ENSKMAP00000001588	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Cyclin dependent kinase inhibitor 2A.	0.847