STRINGSTRING
pole3 pole3 pold4 pold4 LOC108248126 LOC108248126 apex2 apex2 ENSKMAP00000009313 ENSKMAP00000009313 rfc3 rfc3 rpa1 rpa1 fen1 fen1 rcbtb2 rcbtb2 polb polb LOC108244487 LOC108244487 pcna pcna pold2 pold2 RCBTB1 RCBTB1 rfc5 rfc5 RPA1 RPA1 rfc1 rfc1 pold3 pold3 apex1 apex1 lig1 lig1 pold1 pold1 pole2 pole2 pole4 pole4 atad5 atad5 LOC108244139 LOC108244139 rfc4 rfc4 rpa2 rpa2 rpa3 rpa3 Pole Pole ENSKMAP00000020750 ENSKMAP00000020750 rfc2 rfc2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pole3CBFD_NFYB_HMF domain-containing protein. (153 aa)
pold4Uncharacterized protein. (110 aa)
LOC108248126RPA_C domain-containing protein. (199 aa)
apex2DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (553 aa)
ENSKMAP00000009313Methionine sulfoxide reductase B1b. (467 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
polbDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (336 aa)
LOC108244487Zgc:110269. (346 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
rfc5Replication factor C (activator 1) 5. (339 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
rfc1Replication factor C subunit 1. (1180 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (440 aa)
apex1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (310 aa)
lig1DNA ligase. (1010 aa)
pold1DNA polymerase. (1105 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (130 aa)
atad5ATPase family AAA domain containing 5a. (1804 aa)
LOC108244139Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
rfc4Replication factor C (activator 1) 4. (388 aa)
rpa2RPA_C domain-containing protein. (274 aa)
rpa3Replication protein A 14kDa subunit. (122 aa)
PoleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (298 aa)
ENSKMAP00000020750DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (314 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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