STRINGSTRING
LOC108240579 LOC108240579 LOC108250222 LOC108250222 mknk1 mknk1 flrt2 flrt2 LOC108239982 LOC108239982 LOC108237634 LOC108237634 ENSKMAP00000003379 ENSKMAP00000003379 LOC108238827 LOC108238827 rps27a rps27a fgf5 fgf5 LOC108248584 LOC108248584 gab1 gab1 LOC108231882 LOC108231882 KRAS KRAS PIK3CA PIK3CA LOC108231354 LOC108231354 LOC108230595 LOC108230595 mapk1 mapk1 fndc3a fndc3a uba52 uba52 fgf10 fgf10 FGFRL1 FGFRL1 CSDE1 CSDE1 LOC108240607 LOC108240607 fndc3b fndc3b LOC108240034 LOC108240034 fgf2 fgf2 LOC108236626 LOC108236626 LOC108231196 LOC108231196 LOC108238424 LOC108238424 LOC108242389 LOC108242389 LOC108242980 LOC108242980 LOC108243526 LOC108243526 fgf1 fgf1 LOC108243005 LOC108243005 LOC108232617 LOC108232617 frs2 frs2 LOC108233283 LOC108233283 fgf23 fgf23 fgfrl1 fgfrl1 spred1 spred1 ppp2cb ppp2cb fgf17 fgf17 LOC108233785 LOC108233785 LOC108235488 LOC108235488 ubb ubb LOC108238369 LOC108238369 LOC108236256 LOC108236256 fgf4 fgf4 fgf3 fgf3 LOC108228343 LOC108228343 mknk2 mknk2 flrt3 flrt3 SRC SRC LOC108237956 LOC108237956 cbl cbl ENSKMAP00000020331 ENSKMAP00000020331 SPRED2 SPRED2 LOC108239148 LOC108239148 LOC108238085 LOC108238085 ANOS1 ANOS1 plcg1 plcg1 fgfr1 fgfr1 ppp2ca ppp2ca LOC108241470 LOC108241470 FGF6 FGF6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108240579Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (158 aa)
LOC108250222PH domain-containing protein. (704 aa)
mknk1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (463 aa)
flrt2Fibronectin leucine rich transmembrane protein 2. (657 aa)
LOC108239982HRas proto-oncogene, GTPase a. (189 aa)
LOC108237634Tyrosine-protein kinase. (549 aa)
ENSKMAP00000003379SHC (Src homology 2 domain containing) transforming protein 1. (340 aa)
LOC108238827Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (140 aa)
rps27aRibosomal protein S27a. (156 aa)
fgf5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (222 aa)
LOC108248584Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
gab1GRB2-associated binding protein 1. (786 aa)
LOC108231882Fibronectin leucine rich transmembrane protein 2. (660 aa)
KRASGTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. May play a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs). Belongs to the small GTPase superfamily. Ras family. (189 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC108231354Fibronectin leucine rich transmembrane protein 1b. (727 aa)
LOC108230595Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (223 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
fndc3aFibronectin type III domain containing 3A. (1238 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
fgf10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (251 aa)
FGFRL1Fibroblast growth factor receptor like 1. (506 aa)
CSDE1Cold shock domain containing E1, RNA-binding. (861 aa)
LOC108240607Serine/threonine-protein phosphatase. (309 aa)
fndc3bFibronectin type III domain containing 3Ba. (896 aa)
LOC108240034Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
fgf2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
LOC108236626Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
LOC108231196Fibroblast growth factor receptor substrate 3. (611 aa)
LOC108238424Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC108242389Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
LOC108242980Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (408 aa)
LOC108243526Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
fgf1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (168 aa)
LOC108243005Zgc:55558. (187 aa)
LOC108232617Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
frs2Fibroblast growth factor receptor substrate 2b. (532 aa)
LOC108233283Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
fgf23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (260 aa)
fgfrl1Fibroblast growth factor receptor like 1a. (506 aa)
spred1Sprouty related EVH1 domain containing 1. (445 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
fgf17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
LOC108233785Fibronectin type-III domain-containing protein. (682 aa)
LOC108235488Cbl proto-oncogene C, E3 ubiquitin protein ligase. (570 aa)
ubbUncharacterized protein. (270 aa)
LOC108238369Anosmin 1b. (699 aa)
LOC108236256Growth factor receptor-bound protein 2b. (224 aa)
fgf4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (221 aa)
fgf3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (242 aa)
LOC108228343Sprouty related EVH1 domain containing 2a. (427 aa)
mknk2MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (491 aa)
flrt3Fibronectin leucine rich transmembrane 3. (650 aa)
SRCTyrosine-protein kinase. (550 aa)
LOC108237956Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (212 aa)
cblCbl proto-oncogene, E3 ubiquitin protein ligase. (950 aa)
ENSKMAP00000020331Sprouty RTK signaling antagonist 2. (329 aa)
SPRED2Sprouty related EVH1 domain containing 2. (477 aa)
LOC108239148Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (237 aa)
LOC108238085Uncharacterized protein. (881 aa)
ANOS1Anosmin 1. (679 aa)
plcg11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1312 aa)
fgfr1Fibroblast growth factor receptor. (831 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
LOC108241470Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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