STRINGSTRING
ENSKMAP00000018069 ENSKMAP00000018069 exo1 exo1 rpa2 rpa2 rad51d rad51d lig3 lig3 ENSKMAP00000017454 ENSKMAP00000017454 rad51 rad51 LOC108240719 LOC108240719 ubb ubb ube2i ube2i polk polk LOC108232577 LOC108232577 rhno1 rhno1 parp1 parp1 LOC108245856 LOC108245856 rad9a rad9a rfc4 rfc4 nsd2 nsd2 LOC108244139 LOC108244139 rad52 rad52 ppp4c ppp4c rad51ap1 rad51ap1 pole2 pole2 Brcc3 Brcc3 hus1 hus1 LOC108232098 LOC108232098 pold1 pold1 ENSKMAP00000013203 ENSKMAP00000013203 LOC108229777 LOC108229777 ENSKMAP00000012922 ENSKMAP00000012922 rad50 rad50 recql4 recql4 mdc1 mdc1 palb2 palb2 pole3 pole3 mre11 mre11 kat5 kat5 ccna2 ccna2 gen1 gen1 ENSKMAP00000011592 ENSKMAP00000011592 rfc2 rfc2 ENSKMAP00000011321 ENSKMAP00000011321 LOC108247233 LOC108247233 brca2 brca2 pold4 pold4 LOC108248126 LOC108248126 Rad9b Rad9b ENSKMAP00000009514 ENSKMAP00000009514 LOC108240031 LOC108240031 LOC108240030 LOC108240030 tp53bp1 tp53bp1 sirt6 sirt6 ENSKMAP00000009313 ENSKMAP00000009313 ENSKMAP00000009231 ENSKMAP00000009231 polq polq rfc1 rfc1 ENSKMAP00000000178 ENSKMAP00000000178 RPA1 RPA1 ENSKMAP00000000423 ENSKMAP00000000423 ENSKMAP00000000467 ENSKMAP00000000467 Atm Atm ENSKMAP00000000943 ENSKMAP00000000943 ENSKMAP00000001053 ENSKMAP00000001053 ENSKMAP00000001130 ENSKMAP00000001130 LOC108242722 LOC108242722 ankrd11 ankrd11 rfc5 rfc5 xrcc3 xrcc3 CDCA7L CDCA7L RCBTB1 RCBTB1 LOC108246201 LOC108246201 mus81 mus81 ENSKMAP00000003442 ENSKMAP00000003442 ENSKMAP00000003646 ENSKMAP00000003646 pold2 pold2 pcna pcna LOC108244487 LOC108244487 rps27a rps27a pias4 pias4 nbn nbn ENSKMAP00000004573 ENSKMAP00000004573 LOC108229423 LOC108229423 babam2 babam2 slf1 slf1 ppp4r2 ppp4r2 ube2n ube2n LOC108241661 LOC108241661 rcbtb2 rcbtb2 fen1 fen1 ENSKMAP00000006347 ENSKMAP00000006347 uba52 uba52 ube2v2 ube2v2 SPIDR SPIDR ccna1 ccna1 rpa1 rpa1 LOC108242278 LOC108242278 rfc3 rfc3 kxd1 kxd1 ENSKMAP00000008060 ENSKMAP00000008060 ENSKMAP00000008309 ENSKMAP00000008309 ENSKMAP00000008781 ENSKMAP00000008781 ENSKMAP00000008333 ENSKMAP00000008333 pole4 pole4 chek1 chek1 ENSKMAP00000029997 ENSKMAP00000029997 tdrd3 tdrd3 ENSKMAP00000028753 ENSKMAP00000028753 rmi1 rmi1 sumo2 sumo2 ENSKMAP00000028001 ENSKMAP00000028001 parp3 parp3 DNA2 DNA2 ENSKMAP00000027458 ENSKMAP00000027458 atrip atrip ankrd12 ankrd12 xrcc1 xrcc1 slx4 slx4 rmi2 rmi2 sirt7 sirt7 polh polh rnf8 rnf8 ENSKMAP00000024731 ENSKMAP00000024731 ENSKMAP00000024676 ENSKMAP00000024676 brca1 brca1 parp2 parp2 Rbbp8 Rbbp8 ENSKMAP00000023736 ENSKMAP00000023736 abl1 abl1 ENSKMAP00000023289 ENSKMAP00000023289 rad17 rad17 topbp1 topbp1 exd2 exd2 ENSKMAP00000022564 ENSKMAP00000022564 pold3 pold3 blm blm timeless timeless cdk2 cdk2 abraxas1 abraxas1 LOC108236207 LOC108236207 xrcc2 xrcc2 ENSKMAP00000021569 ENSKMAP00000021569 ENSKMAP00000021513 ENSKMAP00000021513 ENSKMAP00000021337 ENSKMAP00000021337 cdca7 cdca7 top3a top3a ENSKMAP00000020750 ENSKMAP00000020750 Pole Pole ENSKMAP00000020635 ENSKMAP00000020635 ENSKMAP00000020407 ENSKMAP00000020407 ENSKMAP00000020216 ENSKMAP00000020216 ENSKMAP00000020023 ENSKMAP00000020023 rpa3 rpa3 rad51c rad51c ENSKMAP00000019606 ENSKMAP00000019606 ENSKMAP00000019521 ENSKMAP00000019521 babam1 babam1 rad1 rad1 tipin tipin LOC108235081 LOC108235081 EME2 EME2 uimc1 uimc1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSKMAP00000018069Histone H2B; Belongs to the histone H2B family. (151 aa)
exo1Exonuclease 1. (769 aa)
rpa2RPA_C domain-containing protein. (274 aa)
rad51dRAD51 paralog D. (333 aa)
lig3DNA ligase. (1011 aa)
ENSKMAP00000017454Reverse transcriptase domain-containing protein. (1273 aa)
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (334 aa)
LOC108240719Small ubiquitin-related modifier. (94 aa)
ubbUncharacterized protein. (270 aa)
ube2iUbiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
polkPolymerase (DNA directed) kappa. (401 aa)
LOC108232577Small ubiquitin-related modifier. (94 aa)
rhno1Si:ch73-352p4.5. (290 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
LOC108245856Histone H2B; Belongs to the histone H2B family. (124 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (387 aa)
rfc4Replication factor C (activator 1) 4. (388 aa)
nsd2Nuclear receptor binding SET domain protein 2. (1267 aa)
LOC108244139Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
rad52RAD52 homolog, DNA repair protein. (382 aa)
ppp4cSerine/threonine-protein phosphatase. (311 aa)
rad51ap1RAD51 associated protein 1. (314 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
Brcc3BRCA1/BRCA2-containing complex, subunit 3. (263 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (285 aa)
LOC108232098Uncharacterized protein. (411 aa)
pold1DNA polymerase. (1105 aa)
ENSKMAP00000013203Reverse transcriptase domain-containing protein. (1258 aa)
LOC108229777Histone H4. (103 aa)
ENSKMAP00000012922Histone H2B; Belongs to the histone H2B family. (155 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
recql4RecQ helicase-like 4. (1281 aa)
mdc1Uncharacterized protein. (1989 aa)
palb2PALB2_WD40 domain-containing protein. (1335 aa)
pole3CBFD_NFYB_HMF domain-containing protein. (153 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (696 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (574 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)
gen1Chromo_2 domain-containing protein. (574 aa)
ENSKMAP00000011592Uncharacterized protein. (216 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
ENSKMAP00000011321annotation not available (1265 aa)
LOC108247233Histone H4. (103 aa)
brca2BRCA2 DNA repair associated. (2641 aa)
pold4Uncharacterized protein. (110 aa)
LOC108248126RPA_C domain-containing protein. (199 aa)
Rad9bRAD9 checkpoint clamp component B. (194 aa)
ENSKMAP00000009514Reverse transcriptase domain-containing protein. (489 aa)
LOC108240031Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC108240030Histone H2B; Belongs to the histone H2B family. (124 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1702 aa)
sirt6Sirtuin 6. (350 aa)
ENSKMAP00000009313Methionine sulfoxide reductase B1b. (467 aa)
ENSKMAP00000009231Reverse transcriptase domain-containing protein. (987 aa)
polqPolymerase (DNA directed), theta. (2148 aa)
rfc1Replication factor C subunit 1. (1180 aa)
ENSKMAP00000000178Reverse transcriptase domain-containing protein. (1096 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
ENSKMAP00000000423Reverse transcriptase domain-containing protein. (1066 aa)
ENSKMAP00000000467TAN domain-containing protein. (123 aa)
AtmUncharacterized protein. (130 aa)
ENSKMAP00000000943Uncharacterized protein. (144 aa)
ENSKMAP00000001053Uncharacterized protein. (109 aa)
ENSKMAP00000001130Reverse transcriptase domain-containing protein. (1110 aa)
LOC108242722Small ubiquitin-related modifier. (96 aa)
ankrd11Ankyrin repeat domain 11. (2822 aa)
rfc5Replication factor C (activator 1) 5. (339 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (343 aa)
CDCA7Lzf-4CXXC_R1 domain-containing protein. (406 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
LOC108246201Essential meiotic structure-specific endonuclease 1. (533 aa)
mus81MUS81 structure-specific endonuclease subunit. (556 aa)
ENSKMAP00000003442Reverse transcriptase domain-containing protein. (1237 aa)
ENSKMAP00000003646Uncharacterized protein; Belongs to the histone H2B family. (148 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
LOC108244487Zgc:110269. (346 aa)
rps27aRibosomal protein S27a. (156 aa)
pias4Protein inhibitor of activated STAT, 4a. (507 aa)
nbnNibrin. (832 aa)
ENSKMAP00000004573Reverse transcriptase domain-containing protein. (1001 aa)
LOC108229423Histone H2B; Belongs to the histone H2B family. (124 aa)
babam2BRISC and BRCA1 A complex member 2. (386 aa)
slf1SMC5-SMC6 complex localization factor 1. (879 aa)
ppp4r2Protein phosphatase 4, regulatory subunit 2b. (433 aa)
ube2nUbiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
LOC108241661Histone H2B; Belongs to the histone H2B family. (116 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
ENSKMAP00000006347Uncharacterized protein. (270 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (145 aa)
SPIDRScaffold protein involved in DNA repair. (938 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (335 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa)
LOC108242278Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (261 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
kxd1KxDL motif containing 1. (185 aa)
ENSKMAP00000008060Reverse transcriptase domain-containing protein. (975 aa)
ENSKMAP00000008309Reverse transcriptase domain-containing protein. (1265 aa)
ENSKMAP00000008781Reverse transcriptase domain-containing protein. (1162 aa)
ENSKMAP00000008333annotation not available (990 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (130 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (455 aa)
ENSKMAP00000029997Reverse transcriptase domain-containing protein. (1252 aa)
tdrd3Tudor domain containing 3. (787 aa)
ENSKMAP00000028753Histone H2A; Belongs to the histone H2A family. (124 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (699 aa)
sumo2Small ubiquitin-related modifier. (95 aa)
ENSKMAP00000028001Reverse transcriptase domain-containing protein. (874 aa)
parp3Poly [ADP-ribose] polymerase. (530 aa)
DNA2DNA replication helicase/nuclease 2. (1388 aa)
ENSKMAP00000027458Reverse transcriptase domain-containing protein. (1256 aa)
atripUncharacterized protein. (776 aa)
ankrd12Ankyrin repeat domain 12. (1924 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (629 aa)
slx4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1695 aa)
rmi2RecQ mediated genome instability 2. (145 aa)
sirt7Sirtuin 7. (406 aa)
polhPolymerase (DNA directed), eta. (738 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (515 aa)
ENSKMAP00000024731Uncharacterized protein. (235 aa)
ENSKMAP00000024676Reverse transcriptase domain-containing protein. (1254 aa)
brca1Uncharacterized protein. (1354 aa)
parp2Poly [ADP-ribose] polymerase. (655 aa)
Rbbp8SAE2 domain-containing protein. (82 aa)
ENSKMAP00000023736Reverse transcriptase domain-containing protein. (885 aa)
abl1Tyrosine-protein kinase. (1121 aa)
ENSKMAP00000023289Uncharacterized protein. (164 aa)
rad17RAD17 checkpoint clamp loader component. (528 aa)
topbp1DNA topoisomerase II binding protein 1. (1510 aa)
exd2Exonuclease 3'-5' domain containing 2. (639 aa)
ENSKMAP00000022564Histone H2B; Belongs to the histone H2B family. (168 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (440 aa)
blmBLM RecQ like helicase. (1384 aa)
timelessTimeless circadian clock. (1247 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (349 aa)
LOC108236207UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
xrcc2RECA_2 domain-containing protein. (357 aa)
ENSKMAP00000021569Reverse transcriptase domain-containing protein. (1121 aa)
ENSKMAP00000021513Reverse transcriptase domain-containing protein. (1156 aa)
ENSKMAP00000021337Reverse transcriptase domain-containing protein. (876 aa)
cdca7Cell division cycle associated 7a. (404 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1023 aa)
ENSKMAP00000020750DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (314 aa)
PoleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (298 aa)
ENSKMAP00000020635Uncharacterized protein. (178 aa)
ENSKMAP00000020407Reverse transcriptase domain-containing protein. (1258 aa)
ENSKMAP00000020216Reverse transcriptase domain-containing protein. (796 aa)
ENSKMAP00000020023annotation not available (828 aa)
rpa3Replication protein A 14kDa subunit. (122 aa)
rad51cRAD51 paralog C. (342 aa)
ENSKMAP00000019606Reverse transcriptase domain-containing protein. (1217 aa)
ENSKMAP00000019521Reverse transcriptase domain-containing protein. (1258 aa)
babam1BRISC and BRCA1 A complex member 1. (381 aa)
rad1RAD1 homolog (S. pombe). (280 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (270 aa)
LOC108235081UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
EME2ERCC4 domain-containing protein. (416 aa)
uimc1Uncharacterized protein. (976 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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