40 items (Kryptolebias marmoratus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC108244154	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1102 aa)
	LOC108238036	Ubiquitin carboxyl-terminal hydrolase. (391 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (303 aa)
	LOC108246545	Ubiquitin carboxyl-terminal hydrolase. (600 aa)
	LOC108235102	Uncharacterized protein. (476 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (372 aa)
	mdm4	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (490 aa)
	mapkap1	MAPK associated protein 1. (530 aa)
	ubb	Uncharacterized protein. (270 aa)
	SGK1	Non-specific serine/threonine protein kinase. (612 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (560 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (309 aa)
	txndc11	Thioredoxin domain containing 11. (847 aa)
	LOC108243526	Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
	ccna2	Cyclin A2; Belongs to the cyclin family. (434 aa)
	ENSKMAP00000011254	Uncharacterized protein. (107 aa)
	LOC108232543	Ring finger protein 34b. (408 aa)
	mlst8	MTOR associated protein, LST8 homolog (S. cerevisiae). (326 aa)
	ccng1	Cyclin G1; Belongs to the cyclin family. (298 aa)
	kxd1	KxDL motif containing 1. (185 aa)
	LOC108248076	Checkpoint kinase 2. (534 aa)
	LOC108240607	Serine/threonine-protein phosphatase. (309 aa)
	rffl	Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase. (410 aa)
	ccna1	Cyclin A1; Belongs to the cyclin family. (335 aa)
	mtor	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2516 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	LOC108246299	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC108238174	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	rictor	RPTOR independent companion of MTOR, complex 2 a. (1617 aa)
	LOC108236517	Ring finger protein 34a. (474 aa)
	mdm2	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family. (448 aa)
	Atm	Uncharacterized protein. (130 aa)
	ENSKMAP00000000467	TAN domain-containing protein. (123 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	phf20	PHD finger protein 20, a. (1027 aa)
	daxx	Death-domain associated protein. (756 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atm	ENSKMAP00000000467	ENSKMAP00000000507	ENSKMAP00000000467	Uncharacterized protein.	TAN domain-containing protein.	0.926
Atm	LOC108248076	ENSKMAP00000000507	ENSKMAP00000007793	Uncharacterized protein.	Checkpoint kinase 2.	0.993
Atm	TP53	ENSKMAP00000000507	ENSKMAP00000018969	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.995
Atm	ccna1	ENSKMAP00000000507	ENSKMAP00000007281	Uncharacterized protein.	Cyclin A1; Belongs to the cyclin family.	0.612
Atm	ccna2	ENSKMAP00000000507	ENSKMAP00000011677	Uncharacterized protein.	Cyclin A2; Belongs to the cyclin family.	0.612
Atm	cdk1	ENSKMAP00000000507	ENSKMAP00000020171	Uncharacterized protein.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.560
Atm	cdk2	ENSKMAP00000000507	ENSKMAP00000022151	Uncharacterized protein.	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	0.544
Atm	daxx	ENSKMAP00000000507	ENSKMAP00000029065	Uncharacterized protein.	Death-domain associated protein.	0.411
Atm	mdm2	ENSKMAP00000000507	ENSKMAP00000001092	Uncharacterized protein.	MDM2 proto-oncogene; Belongs to the MDM2/MDM4 family.	0.840
Atm	mdm4	ENSKMAP00000000507	ENSKMAP00000018825	Uncharacterized protein.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.776
Atm	mtor	ENSKMAP00000000507	ENSKMAP00000007071	Uncharacterized protein.	Serine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family.	0.545
Atm	rps27a	ENSKMAP00000000507	ENSKMAP00000004139	Uncharacterized protein.	Ribosomal protein S27a.	0.591
Atm	ubb	ENSKMAP00000000507	ENSKMAP00000016559	Uncharacterized protein.	Uncharacterized protein.	0.627
ENSKMAP00000000467	Atm	ENSKMAP00000000467	ENSKMAP00000000507	TAN domain-containing protein.	Uncharacterized protein.	0.926
ENSKMAP00000000467	LOC108248076	ENSKMAP00000000467	ENSKMAP00000007793	TAN domain-containing protein.	Checkpoint kinase 2.	0.921
ENSKMAP00000000467	TP53	ENSKMAP00000000467	ENSKMAP00000018969	TAN domain-containing protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.949
ENSKMAP00000000467	ccna1	ENSKMAP00000000467	ENSKMAP00000007281	TAN domain-containing protein.	Cyclin A1; Belongs to the cyclin family.	0.612
ENSKMAP00000000467	ccna2	ENSKMAP00000000467	ENSKMAP00000011677	TAN domain-containing protein.	Cyclin A2; Belongs to the cyclin family.	0.612
ENSKMAP00000000467	cdk1	ENSKMAP00000000467	ENSKMAP00000020171	TAN domain-containing protein.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.540
ENSKMAP00000000467	cdk2	ENSKMAP00000000467	ENSKMAP00000022151	TAN domain-containing protein.	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	0.540