STRINGSTRING
cdc6 cdc6 cdc45 cdc45 cdc7 cdc7 RPA1 RPA1 dbf4 dbf4 mcm9 mcm9 orc4 orc4 mcm4 mcm4 mcm8 mcm8 rpa1 rpa1 orc1 orc1 gmnn gmnn ENSKMAP00000009313 ENSKMAP00000009313 LOC108248126 LOC108248126 orc3 orc3 mcm6 mcm6 pole3 pole3 mcm10 mcm10 pole2 pole2 orc5 orc5 prim1 prim1 mcm5 mcm5 rpa2 rpa2 mcm2 mcm2 cdt1 cdt1 rpa3 rpa3 pola1 pola1 Pole Pole ENSKMAP00000020750 ENSKMAP00000020750 cdk2 cdk2 pola2 pola2 prim2 prim2 mcm7 mcm7 orc2 orc2 mcm3 mcm3 pole4 pole4 LOC108230590 LOC108230590
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (575 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (572 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (547 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
dbf4DBF4 zinc finger. (606 aa)
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1140 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
mcm4DNA helicase; Belongs to the MCM family. (861 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (781 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (695 aa)
gmnnGeminin DNA replication inhibitor. (224 aa)
ENSKMAP00000009313Methionine sulfoxide reductase B1b. (467 aa)
LOC108248126RPA_C domain-containing protein. (199 aa)
orc3Origin recognition complex, subunit 3. (718 aa)
mcm6DNA helicase; Belongs to the MCM family. (823 aa)
pole3CBFD_NFYB_HMF domain-containing protein. (153 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (848 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
orc5Origin recognition complex, subunit 5. (445 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (427 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
rpa2RPA_C domain-containing protein. (274 aa)
mcm2DNA helicase; Belongs to the MCM family. (890 aa)
cdt1Chromatin licensing and DNA replication factor 1. (642 aa)
rpa3Replication protein A 14kDa subunit. (122 aa)
pola1DNA polymerase. (1476 aa)
PoleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (298 aa)
ENSKMAP00000020750DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (314 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (516 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
orc2Origin recognition complex, subunit 2. (585 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (130 aa)
LOC108230590SCY domain-containing protein. (122 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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