STRINGSTRING
LOC108239362 LOC108239362 psmd14 psmd14 psmd7 psmd7 psmc2 psmc2 prim1 prim1 ubb ubb psmd8 psmd8 mcm5 mcm5 ccnd1 ccnd1 cdk7 cdk7 rb1 rb1 rpa2 rpa2 ccne1 ccne1 LOC108247076 LOC108247076 mcm2 mcm2 cdt1 cdt1 psmd2 psmd2 ppp4r1 ppp4r1 ppp2cb ppp2cb CKS2 CKS2 rpa3 rpa3 pola1 pola1 Pole Pole psmb3 psmb3 ENSKMAP00000020750 ENSKMAP00000020750 wee1 wee1 akt1 akt1 relch relch LOC108242534 LOC108242534 cdk2 cdk2 LOC108246065 LOC108246065 psmd10 psmd10 cdk4 cdk4 LOC108246606 LOC108246606 rbbp8nl rbbp8nl psmd12 psmd12 psmd3 psmd3 LOC108231921 LOC108231921 cul1 cul1 pola2 pola2 prim2 prim2 psma3 psma3 psmb2 psmb2 psmf1 psmf1 psme1 psme1 mcm7 mcm7 orc2 orc2 psmd9 psmd9 mcm3 mcm3 ppp2ca ppp2ca skp1 skp1 ccne2 ccne2 psmb1 psmb1 psmc3 psmc3 LOC108238608 LOC108238608 LOC108247317 LOC108247317 psmc5 psmc5 LOC112450491 LOC112450491 LOC108242642 LOC108242642 LOC108242639 LOC108242639 LOC108242637 LOC108242637 LOC108242638 LOC108242638 psma2 psma2 LOC108237560 LOC108237560 psme2 psme2 psmb4 psmb4 pole4 pole4 LOC108230590 LOC108230590 psmd6 psmd6 LOC108246975 LOC108246975 pole2 pole2 psma1 psma1 psmd5 psmd5 LOC108239983 LOC108239983 RPA1 RPA1 LOC108241005 LOC108241005 LOC108240964 LOC108240964 LOC108230759 LOC108230759 fnbp4 fnbp4 skp2 skp2 ppp4r4 ppp4r4 psma4 psma4 cdc7 cdc7 ppp2r3a ppp2r3a orc5 orc5 LOC108244154 LOC108244154 ENSKMAP00000004056 ENSKMAP00000004056 rps27a rps27a LOC108241132 LOC108241132 cdc45 cdc45 cables1 cables1 cdc6 cdc6 LOC108238174 LOC108238174 psmc1 psmc1 dbf4 dbf4 LOC108231735 LOC108231735 psmc6 psmc6 mcm9 mcm9 orc4 orc4 PPP2R3B PPP2R3B LOC108246299 LOC108246299 uba52 uba52 LOC108231906 LOC108231906 ccnh ccnh mcm4 mcm4 LOC108246342 LOC108246342 ccna1 ccna1 mcm8 mcm8 rpa1 rpa1 LOC108240607 LOC108240607 kxd1 kxd1 psme3 psme3 mnat1 mnat1 psma5 psma5 orc1 orc1 gmnn gmnn ENSKMAP00000009313 ENSKMAP00000009313 LOC108229608 LOC108229608 psmb6 psmb6 LOC108248126 LOC108248126 psmc4 psmc4 psma6 psma6 ppp2r3c ppp2r3c orc3 orc3 mcm6 mcm6 ccna2 ccna2 psmd13 psmd13 pole3 pole3 psmd1 psmd1 LOC108243526 LOC108243526 mcm10 mcm10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108239362Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (78 aa)
psmd14Uncharacterized protein. (689 aa)
psmd7Proteasome 26S subunit, non-ATPase 7. (330 aa)
psmc2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (433 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (427 aa)
ubbUncharacterized protein. (270 aa)
psmd8Proteasome 26S subunit, non-ATPase 8. (265 aa)
mcm5DNA helicase; Belongs to the MCM family. (737 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
rb1Retinoblastoma 1. (915 aa)
rpa2RPA_C domain-containing protein. (274 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (436 aa)
LOC108247076PCI domain-containing protein. (422 aa)
mcm2DNA helicase; Belongs to the MCM family. (890 aa)
cdt1Chromatin licensing and DNA replication factor 1. (642 aa)
psmd226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (906 aa)
ppp4r1WRNPLPNID domain-containing protein. (860 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
rpa3Replication protein A 14kDa subunit. (122 aa)
pola1DNA polymerase. (1476 aa)
PoleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (298 aa)
psmb3Proteasome subunit beta. (205 aa)
ENSKMAP00000020750DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (314 aa)
wee1Wee1-like protein kinase. (624 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
relchRAB11 binding and LisH domain, coiled-coil and HEAT repeat containing. (1195 aa)
LOC108242534Proteasome subunit beta. (278 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
LOC108246065Cell division cycle 25B. (528 aa)
psmd10Proteasome 26S subunit, non-ATPase 10. (226 aa)
cdk4Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily. (317 aa)
LOC108246606Cyclin-dependent kinase inhibitor 1Bb. (204 aa)
rbbp8nlRetinoblastoma binding protein 8-like. (573 aa)
psmd12Proteasome 26S subunit, non-ATPase 12. (456 aa)
psmd3Proteasome 26S subunit, non-ATPase 3. (525 aa)
LOC108231921Cdk5 and Abl enzyme substrate 2b; Belongs to the cyclin family. (518 aa)
cul1Cullin 1b; Belongs to the cullin family. (776 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (516 aa)
psma3Proteasome subunit alpha type. (252 aa)
psmb2Proteasome subunit beta. (199 aa)
psmf1Proteasome inhibitor subunit 1. (276 aa)
psme1Proteasome activator subunit 1. (250 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa)
orc2Origin recognition complex, subunit 2. (585 aa)
psmd9Proteasome 26S subunit, non-ATPase 9. (251 aa)
mcm3DNA helicase; Belongs to the MCM family. (815 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (396 aa)
psmb1Proteasome subunit beta. (237 aa)
psmc3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (427 aa)
LOC108238608Proteasome subunit beta. (271 aa)
LOC108247317Proteasome subunit alpha type. (258 aa)
psmc5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (406 aa)
LOC112450491Cyclin-dependent kinase inhibitor 1A. (159 aa)
LOC108242642Proteasome subunit beta. (216 aa)
LOC108242639Proteasome subunit beta 12. (217 aa)
LOC108242637Proteasome subunit beta. (275 aa)
LOC108242638Proteasome subunit beta. (275 aa)
psma2Proteasome subunit alpha type. (234 aa)
LOC108237560Wee1-like protein kinase. (546 aa)
psme2Proteasome activator subunit 2. (245 aa)
psmb4Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (130 aa)
LOC108230590SCY domain-containing protein. (122 aa)
psmd6Proteasome 26S subunit, non-ATPase 6. (389 aa)
LOC108246975Cyclin-dependent kinase inhibitor 1Cb. (202 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
psma1Proteasome subunit alpha type. (263 aa)
psmd5Proteasome 26S subunit, non-ATPase 5. (504 aa)
LOC108239983Proteasome 26S subunit, non-ATPase 4a. (372 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
LOC108241005Cyclin-dependent kinase inhibitor 1D. (175 aa)
LOC108240964Uncharacterized protein. (240 aa)
LOC108230759Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (76 aa)
fnbp4Formin binding protein 4. (879 aa)
skp2S-phase kinase-associated protein 2, E3 ubiquitin protein ligase. (346 aa)
ppp4r4Protein phosphatase 4, regulatory subunit 4. (967 aa)
psma4Proteasome subunit alpha type. (261 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (547 aa)
ppp2r3aProtein phosphatase 2, regulatory subunit B'', alpha. (1398 aa)
orc5Origin recognition complex, subunit 5. (445 aa)
LOC108244154Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
ENSKMAP00000004056Uncharacterized protein. (156 aa)
rps27aRibosomal protein S27a. (156 aa)
LOC108241132Proteasome 26S subunit, non-ATPase 4b. (374 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (572 aa)
cables1Cdk5 and Abl enzyme substrate 1. (560 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (575 aa)
LOC108238174Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
psmc1Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
dbf4DBF4 zinc finger. (606 aa)
LOC108231735Proteasome subunit alpha type. (246 aa)
psmc6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
mcm9Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1140 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
PPP2R3BProtein phosphatase 2 regulatory subunit B''beta. (581 aa)
LOC108246299Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
LOC108231906Cdk5 and Abl enzyme substrate 2a; Belongs to the cyclin family. (504 aa)
ccnhCyclin H; Belongs to the cyclin family. (333 aa)
mcm4DNA helicase; Belongs to the MCM family. (861 aa)
LOC108246342Proteasome 26S subunit, non-ATPase 11b. (422 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (335 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (781 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa)
LOC108240607Serine/threonine-protein phosphatase. (309 aa)
kxd1KxDL motif containing 1. (185 aa)
psme3Proteasome activator subunit 3. (256 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
psma5Proteasome subunit alpha type. (241 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (695 aa)
gmnnGeminin DNA replication inhibitor. (224 aa)
ENSKMAP00000009313Methionine sulfoxide reductase B1b. (467 aa)
LOC108229608Proteasome subunit beta. (286 aa)
psmb6Proteasome subunit beta. (233 aa)
LOC108248126RPA_C domain-containing protein. (199 aa)
psmc4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (417 aa)
psma6Proteasome subunit alpha type. (246 aa)
ppp2r3cProtein phosphatase 2, regulatory subunit B'', gamma. (459 aa)
orc3Origin recognition complex, subunit 3. (718 aa)
mcm6DNA helicase; Belongs to the MCM family. (823 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)
psmd13Proteasome 26S subunit, non-ATPase 13. (377 aa)
pole3CBFD_NFYB_HMF domain-containing protein. (153 aa)
psmd126S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (961 aa)
LOC108243526Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (848 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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