STRINGSTRING
rfc1 rfc1 RPA1 RPA1 cenpi cenpi LOC108240440 LOC108240440 rfc5 rfc5 pif1 pif1 RCBTB1 RCBTB1 rtel1 rtel1 LOC108242801 LOC108242801 ENSKMAP00000003646 ENSKMAP00000003646 pold2 pold2 pcna pcna LOC108244487 LOC108244487 chtf8 chtf8 LOC108229423 LOC108229423 smarca5 smarca5 ankrd44 ankrd44 MIS18A MIS18A nop10 nop10 shq1 shq1 LOC108241661 LOC108241661 rcbtb2 rcbtb2 fen1 fen1 ctc1 ctc1 wrap53 wrap53 ccna1 ccna1 H2AZ1 H2AZ1 rpa1 rpa1 rfc3 rfc3 LOC108247429 LOC108247429 LOC108231373 LOC108231373 ENSKMAP00000008045 ENSKMAP00000008045 trub1 trub1 pot1 pot1 atrx atrx ENSKMAP00000009313 ENSKMAP00000009313 ENSKMAP00000009348 ENSKMAP00000009348 terf1 terf1 LOC108240030 LOC108240030 LOC108240031 LOC108240031 chtf18 chtf18 LOC108248126 LOC108248126 pold4 pold4 LOC108247233 LOC108247233 ENSKMAP00000010652 ENSKMAP00000010652 dkc1 dkc1 ENSKMAP00000010784 ENSKMAP00000010784 ENSKMAP00000010962 ENSKMAP00000010962 LOC108236678 LOC108236678 PPP6C PPP6C rfc2 rfc2 ccna2 ccna2 ENSKMAP00000011726 ENSKMAP00000011726 recql4 recql4 ENSKMAP00000012922 ENSKMAP00000012922 LOC108229777 LOC108229777 LOC108230323 LOC108230323 pold1 pold1 terf2ip terf2ip ENSKMAP00000013709 ENSKMAP00000013709 gar1 gar1 cenpn cenpn cenpx cenpx LOC108233791 LOC108233791 LOC108244139 LOC108244139 ten1 ten1 rfc4 rfc4 LOC108245856 LOC108245856 LOC108237907 LOC108237907 LOC108245905 LOC108245905 prim1 prim1 LOC108243608 LOC108243608 cenph cenph rpa2 rpa2 ENSKMAP00000018069 ENSKMAP00000018069 ENSKMAP00000019155 ENSKMAP00000019155 ruvbl2 ruvbl2 LOC108232401 LOC108232401 rpa3 rpa3 pola1 pola1 ankrd28 ankrd28 LOC108234439 LOC108234439 LOC108239041 LOC108239041 ENSKMAP00000021523 ENSKMAP00000021523 LOC108242541 LOC108242541 cdk2 cdk2 blm blm pold3 pold3 ENSKMAP00000022564 ENSKMAP00000022564 exd2 exd2 lig1 lig1 rsf1 rsf1 LOC108228507 LOC108228507 dscc1 dscc1 pola2 pola2 prim2 prim2 terf2 terf2 ruvbl1 ruvbl1 cenpm cenpm DNA2 DNA2 cenpk cenpk ENSKMAP00000028753 ENSKMAP00000028753 stn1 stn1 daxx daxx tert tert LOC108250396 LOC108250396 knl1 knl1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rfc1Replication factor C subunit 1. (1180 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
cenpiCentromere protein I. (728 aa)
LOC108240440ANK_REP_REGION domain-containing protein. (1101 aa)
rfc5Replication factor C (activator 1) 5. (339 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (626 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1179 aa)
LOC108242801Histone H2A; Belongs to the histone H2A family. (132 aa)
ENSKMAP00000003646Uncharacterized protein; Belongs to the histone H2B family. (148 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
LOC108244487Zgc:110269. (346 aa)
chtf8CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (136 aa)
LOC108229423Histone H2B; Belongs to the histone H2B family. (124 aa)
smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1035 aa)
ankrd44Ankyrin repeat domain 44. (981 aa)
MIS18AMIS18 kinetochore protein A. (202 aa)
nop10NOP10 ribonucleoprotein homolog (yeast). (64 aa)
shq1SHQ1, H/ACA ribonucleoprotein assembly factor. (587 aa)
LOC108241661Histone H2B; Belongs to the histone H2B family. (116 aa)
rcbtb2Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (527 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
ctc1Uncharacterized protein. (993 aa)
wrap53WD repeat containing, antisense to TP53. (547 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (335 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
LOC108247429Uncharacterized protein. (1905 aa)
LOC108231373Centromere protein S. (158 aa)
ENSKMAP00000008045Uncharacterized protein. (79 aa)
trub1TruB pseudouridine (psi) synthase family member 1. (278 aa)
pot1Protection of telomeres 1 homolog. (770 aa)
atrxATRX chromatin remodeler. (2228 aa)
ENSKMAP00000009313Methionine sulfoxide reductase B1b. (467 aa)
ENSKMAP00000009348Histone H2A; Belongs to the histone H2A family. (135 aa)
terf1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (366 aa)
LOC108240030Histone H2B; Belongs to the histone H2B family. (124 aa)
LOC108240031Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae). (775 aa)
LOC108248126RPA_C domain-containing protein. (199 aa)
pold4Uncharacterized protein. (110 aa)
LOC108247233Histone H4. (103 aa)
ENSKMAP00000010652Histone H2A; Belongs to the histone H2A family. (146 aa)
dkc1Dyskeratosis congenita 1, dyskerin. (497 aa)
ENSKMAP00000010784annotation not available (146 aa)
ENSKMAP00000010962Histone H2A; Belongs to the histone H2A family. (134 aa)
LOC108236678Nucleophosmin 1b. (294 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)
ENSKMAP00000011726Histone H2A; Belongs to the histone H2A family. (134 aa)
recql4RecQ helicase-like 4. (1281 aa)
ENSKMAP00000012922Histone H2B; Belongs to the histone H2B family. (155 aa)
LOC108229777Histone H4. (103 aa)
LOC108230323CENP-C_C domain-containing protein. (947 aa)
pold1DNA polymerase. (1105 aa)
terf2ipUncharacterized protein. (682 aa)
ENSKMAP00000013709Uncharacterized protein. (437 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (211 aa)
cenpnCentromere protein N. (345 aa)
cenpxCentromere protein X. (81 aa)
LOC108233791Nucleophosmin 1a. (291 aa)
LOC108244139Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
ten1TEN1 subunit of CST complex. (135 aa)
rfc4Replication factor C (activator 1) 4. (388 aa)
LOC108245856Histone H2B; Belongs to the histone H2B family. (124 aa)
LOC108237907Retinoblastoma binding protein 4, like. (440 aa)
LOC108245905TERF1 (TRF1)-interacting nuclear factor 2. (570 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (427 aa)
LOC108243608Remodeling and spacing factor 1b, tandem duplicate 1. (1628 aa)
cenphCENP-H domain-containing protein. (239 aa)
rpa2RPA_C domain-containing protein. (274 aa)
ENSKMAP00000018069Histone H2B; Belongs to the histone H2B family. (151 aa)
ENSKMAP00000019155Histone H2A; Belongs to the histone H2A family. (137 aa)
ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (459 aa)
LOC108232401Retinoblastoma binding protein 4. (424 aa)
rpa3Replication protein A 14kDa subunit. (122 aa)
pola1DNA polymerase. (1476 aa)
ankrd28Ankyrin repeat domain 28b. (1052 aa)
LOC108234439Mis18 domain-containing protein. (177 aa)
LOC108239041Ankyrin repeat domain 66. (158 aa)
ENSKMAP00000021523Centromere protein O. (293 aa)
LOC108242541Histone domain-containing protein. (136 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
blmBLM RecQ like helicase. (1384 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (440 aa)
ENSKMAP00000022564Histone H2B; Belongs to the histone H2B family. (168 aa)
exd2Exonuclease 3'-5' domain containing 2. (639 aa)
lig1DNA ligase. (1010 aa)
rsf1PHD-type domain-containing protein. (1429 aa)
LOC108228507ATP-dependent DNA helicase; Belongs to the helicase family. (1236 aa)
dscc1DNA replication and sister chromatid cohesion 1. (390 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (602 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (516 aa)
terf2HTH myb-type domain-containing protein. (603 aa)
ruvbl1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
cenpmProliferation associated nuclear element. (182 aa)
DNA2DNA replication helicase/nuclease 2. (1388 aa)
cenpkCentromere protein K. (268 aa)
ENSKMAP00000028753Histone H2A; Belongs to the histone H2A family. (124 aa)
stn1STN1 subunit of CST complex. (315 aa)
daxxDeath-domain associated protein. (756 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1104 aa)
LOC108250396Uncharacterized protein. (272 aa)
knl1Knl1_RWD_C domain-containing protein. (1926 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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