STRINGSTRING
pgm2 pgm2 gucy1b1 gucy1b1 gucy1a1 gucy1a1 adcy2 adcy2 ak2 ak2 LOC108230170 LOC108230170 gart gart adcy7 adcy7 adcy8 adcy8 NT5M NT5M PDE2A PDE2A LOC108238690 LOC108238690 papss1 papss1 LOC108250878 LOC108250878 PDE1C PDE1C allc allc impdh2 impdh2 PDE3A PDE3A adprm adprm LOC108245652 LOC108245652 RRM2 RRM2 RRM2-2 RRM2-2 pde9a pde9a pde6b pde6b LOC108238115 LOC108238115 itpa itpa entpd5 entpd5 LOC108246797 LOC108246797 ENSKMAP00000004758 ENSKMAP00000004758 pde3b pde3b LOC108248619 LOC108248619 LOC108235536 LOC108235536 guk1 guk1 LOC108243405 LOC108243405 ppat ppat pde8a pde8a pde4c pde4c LOC108250326 LOC108250326 ampd1 ampd1 adcy5 adcy5 LOC108238311 LOC108238311 LOC108238290 LOC108238290 LOC108244602 LOC108244602 entpd4 entpd4 gda gda LOC108246905 LOC108246905 gmpr gmpr LOC108248111 LOC108248111 LOC108240618 LOC108240618 pfas pfas LOC108241179 LOC108241179 LOC108249238 LOC108249238 LOC108233051 LOC108233051 pde7a pde7a GUCY1A2 GUCY1A2 urad urad LOC108249273 LOC108249273 pde6d pde6d nudt9 nudt9 nme3 nme3 LOC108241415 LOC108241415 LOC108243505 LOC108243505 LOC108232566 LOC108232566 LOC108249878 LOC108249878 LOC108242919 LOC108242919 ntpcr ntpcr LOC108232538 LOC108232538 ada2 ada2 cant1 cant1 LOC108234387 LOC108234387 Ak9 Ak9 LOC108233917 LOC108233917 pde1a pde1a pgm1 pgm1 LOC108241305 LOC108241305 pde1b pde1b atic atic ak4 ak4 adcy6 adcy6 ak3 ak3 LOC108229911 LOC108229911 PDE7B PDE7B LOC108245931 LOC108245931 LOC108250633 LOC108250633 pde4b pde4b entpd1 entpd1 LOC108229092 LOC108229092 enpp4 enpp4 LOC108236166 LOC108236166 LOC108230195 LOC108230195 LOC108248264 LOC108248264 nme6 nme6 ada ada ADCY9 ADCY9 aprt aprt hddc3 hddc3 LOC108239683 LOC108239683 gucy2c gucy2c pde4d pde4d LOC108241942 LOC108241942 entpd6 entpd6 entpd2 entpd2 LOC108244232 LOC108244232 nme7 nme7 adss1 adss1 ak1 ak1 pde10a pde10a pde11a pde11a LOC108244848 LOC108244848 pde5a pde5a adsl adsl ADK ADK LOC108248330 LOC108248330 LOC108228471 LOC108228471 ak6 ak6 LOC108228472 LOC108228472 ampd2 ampd2 LOC108243727 LOC108243727 LOC108248366 LOC108248366 LOC108232889 LOC108232889 nt5c3a nt5c3a LOC108240265 LOC108240265 LOC108239163 LOC108239163 adcy3 adcy3 NT5C3B NT5C3B LOC108234509 LOC108234509 dck dck pde6c pde6c LOC108233522 LOC108233522 ak5 ak5 LOC108234107 LOC108234107 nudt2 nudt2 LOC108241462 LOC108241462 LOC108233346 LOC108233346 LOC108245595 LOC108245595 LOC108236422 LOC108236422 LOC108232311 LOC108232311 LOC108248449 LOC108248449 LOC108244904 LOC108244904 NT5C3B-2 NT5C3B-2 entpd3 entpd3 gmps gmps nt5e nt5e LOC108236371 LOC108236371 LOC108240955 LOC108240955 LOC108235706 LOC108235706 nudt5 nudt5 LOC108237445 LOC108237445 LOC108235883 LOC108235883 LOC108230666 LOC108230666
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
pgm2Phosphoglucomutase 2. (611 aa)
gucy1b1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (618 aa)
gucy1a1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (683 aa)
adcy2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1071 aa)
ak2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (243 aa)
LOC108230170Pyruvate kinase; Belongs to the pyruvate kinase family. (578 aa)
gartTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1017 aa)
adcy7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
adcy8Adenylate cyclase 8 (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1269 aa)
NT5M5',3'-nucleotidase, mitochondrial. (229 aa)
PDE2APhosphodiesterase. (959 aa)
LOC1082386905'-nucleotidase, cytosolic IAa. (385 aa)
papss13'-phosphoadenosine 5'-phosphosulfate synthase 1. (625 aa)
LOC108250878Zgc:110540. (262 aa)
PDE1CPhosphodiesterase. (748 aa)
allcAllantoicase. (420 aa)
impdh2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (538 aa)
PDE3APhosphodiesterase. (1043 aa)
adprmADP-ribose/CDP-alcohol diphosphatase, manganese-dependent. (329 aa)
LOC108245652Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (459 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (376 aa)
RRM2-2Ribonucleotide reductase regulatory subunit M2. (384 aa)
pde9aPhosphodiesterase 9A; Belongs to the cyclic nucleotide phosphodiesterase family. (387 aa)
pde6bPhosphodiesterase. (854 aa)
LOC108238115Guanylate cyclase. (1092 aa)
itpaInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (204 aa)
entpd5Ectonucleoside triphosphate diphosphohydrolase 5a; Belongs to the GDA1/CD39 NTPase family. (488 aa)
LOC108246797Pribosyltran_N domain-containing protein. (318 aa)
ENSKMAP00000004758MGS domain-containing protein. (95 aa)
pde3bPhosphodiesterase. (1099 aa)
LOC108248619Uncharacterized protein. (1285 aa)
LOC108235536Pyruvate kinase; Belongs to the pyruvate kinase family. (543 aa)
guk1Guanylate kinase 1a. (199 aa)
LOC108243405AIRC domain-containing protein. (1028 aa)
ppatAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (508 aa)
pde8aPhosphodiesterase. (718 aa)
pde4cPhosphodiesterase. (808 aa)
LOC108250326AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (793 aa)
ampd1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (733 aa)
adcy5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1202 aa)
LOC108238311Uncharacterized protein; Belongs to the phosphohexose mutase family. (564 aa)
LOC108238290Phosphodiesterase. (756 aa)
LOC108244602Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1182 aa)
entpd4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (618 aa)
gdaGuanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (454 aa)
LOC108246905Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (294 aa)
gmprGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa)
LOC1082481115-hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (119 aa)
LOC108240618Ribonucleotide reductase M2 b. (355 aa)
pfasPhosphoribosylformylglycinamidine synthase. (1316 aa)
LOC108241179Zgc:103559. (467 aa)
LOC108249238NDK domain-containing protein; Belongs to the NDK family. (149 aa)
LOC108233051Zgc:103759. (211 aa)
pde7aPhosphodiesterase. (513 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (806 aa)
uradUreidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase. (172 aa)
LOC108249273Guanylate cyclase. (1048 aa)
pde6dRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] (150 aa)
nudt9Nudix (nucleoside diphosphate linked moiety X)-type motif 9. (467 aa)
nme3Nucleoside diphosphate kinase. (168 aa)
LOC108241415Phosphodiesterase. (897 aa)
LOC108243505Phosphodiesterase 9A like; Belongs to the cyclic nucleotide phosphodiesterase family. (500 aa)
LOC1082325665'-nucleotidase, cytosolic II, like 1. (496 aa)
LOC108249878Uncharacterized protein. (261 aa)
LOC108242919Nucleoside diphosphate kinase. (201 aa)
ntpcrNucleoside-triphosphatase, cancer-related. (195 aa)
LOC108232538Phosphodiesterase. (854 aa)
ada2Adenosine deaminase 2b. (520 aa)
cant1Calcium activated nucleotidase 1a. (425 aa)
LOC108234387Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (299 aa)
Ak9Uncharacterized protein. (455 aa)
LOC108233917Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (473 aa)
pde1aPhosphodiesterase. (762 aa)
pgm1Phosphoglucomutase 1. (613 aa)
LOC108241305Phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog a. (90 aa)
pde1bPhosphodiesterase. (519 aa)
atic5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (377 aa)
ak4GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (226 aa)
adcy6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
ak3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (223 aa)
LOC108229911Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (215 aa)
PDE7BPhosphodiesterase. (521 aa)
LOC108245931GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (348 aa)
LOC108250633Guanylate cyclase. (1056 aa)
pde4bPhosphodiesterase. (743 aa)
entpd1Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (496 aa)
LOC108229092Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (814 aa)
enpp4Ectonucleotide pyrophosphatase/phosphodiesterase 4. (463 aa)
LOC108236166Uncharacterized protein. (86 aa)
LOC108230195Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (509 aa)
LOC108248264Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (794 aa)
nme6Nucleoside diphosphate kinase. (196 aa)
adaAdenosine deaminase. (363 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1435 aa)
aprtAdenine phosphoribosyltransferase. (181 aa)
hddc3HD domain containing 3. (179 aa)
LOC108239683Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1180 aa)
gucy2cGuanylate cyclase. (1081 aa)
pde4dPhosphodiesterase. (789 aa)
LOC108241942Phosphodiesterase. (900 aa)
entpd6Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (342 aa)
entpd2Ectonucleoside triphosphate diphosphohydrolase 2b; Belongs to the GDA1/CD39 NTPase family. (503 aa)
LOC108244232AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (775 aa)
nme7Nucleoside diphosphate kinase 7; Belongs to the NDK family. (379 aa)
adss1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
ak1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (193 aa)
pde10aPhosphodiesterase. (825 aa)
pde11aPhosphodiesterase. (933 aa)
LOC108244848Phosphodiesterase. (733 aa)
pde5aPhosphodiesterase. (882 aa)
adslAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (481 aa)
ADKAdenosine kinase. (357 aa)
LOC108248330Nucleoside diphosphate kinase. (159 aa)
LOC108228471Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (314 aa)
ak6Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (187 aa)
LOC108228472Guanylate cyclase. (803 aa)
ampd2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (825 aa)
LOC108243727Phosphodiesterase. (745 aa)
LOC108248366Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1125 aa)
LOC108232889Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (293 aa)
nt5c3a5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa)
LOC108240265Pyruvate kinase; Belongs to the pyruvate kinase family. (629 aa)
LOC1082391635'-nucleotidase, cytosolic IIa. (571 aa)
adcy3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
NT5C3B5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (298 aa)
LOC108234509dNK domain-containing protein. (299 aa)
dckDeoxycytidine kinase. (275 aa)
pde6cPhosphodiesterase. (864 aa)
LOC108233522Ectonucleotide pyrophosphatase/phosphodiesterase 1. (808 aa)
ak5Adenylate kinase 5; Belongs to the adenylate kinase family. (564 aa)
LOC108234107Adenosine kinase a. (431 aa)
nudt2Nudix (nucleoside diphosphate linked moiety X)-type motif 2. (147 aa)
LOC108241462Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1457 aa)
LOC1082333465'-nucleotidase, cytosolic IB b. (355 aa)
LOC1082455953'-phosphoadenosine 5'-phosphosulfate synthase 2a. (614 aa)
LOC108236422Calcium activated nucleotidase 1b. (471 aa)
LOC108232311Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1199 aa)
LOC108248449Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (293 aa)
LOC108244904Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (296 aa)
NT5C3B-25'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (289 aa)
entpd3Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (500 aa)
gmpsGuanine monophosphate synthase. (690 aa)
nt5e5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (574 aa)
LOC1082363715'-nucleotidase, cytosolic IIb. (562 aa)
LOC108240955Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (795 aa)
LOC108235706AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (986 aa)
nudt5Nudix (nucleoside diphosphate linked moiety X)-type motif 5; Belongs to the Nudix hydrolase family. (218 aa)
LOC108237445Adenosine deaminase 2a. (503 aa)
LOC108235883Guanylate cyclase. (1068 aa)
LOC108230666Guanylate kinase 1b. (238 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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