47 items (Kryptolebias marmoratus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (607 aa)
	ENSKMAP00000001053	Uncharacterized protein. (109 aa)
	rev1	REV1 DNA directed polymerase. (1363 aa)
	LOC108246201	Essential meiotic structure-specific endonuclease 1. (533 aa)
	LOC108248536	Uncharacterized protein. (245 aa)
	top3b	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa)
	brip1	BRCA1 interacting protein C-terminal helicase 1. (1177 aa)
	fanci	FA complementation group I. (1317 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa)
	LOC108242278	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (261 aa)
	LOC108231373	Centromere protein S. (158 aa)
	fance	FA complementation group E. (522 aa)
	LOC108248126	RPA_C domain-containing protein. (199 aa)
	poli	Polymerase (DNA directed) iota. (716 aa)
	pms2	PMS1 homolog 2, mismatch repair system component. (857 aa)
	mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (726 aa)
	FAAP100	FA core complex associated protein 100. (842 aa)
	palb2	PALB2_WD40 domain-containing protein. (1335 aa)
	hes1	Hairy-related 6. (301 aa)
	fancm	Helicase C-terminal domain-containing protein. (1616 aa)
	cenpx	Centromere protein X. (81 aa)
	usp1	Ubiquitin carboxyl-terminal hydrolase. (787 aa)
	polk	Polymerase (DNA directed) kappa. (401 aa)
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (334 aa)
	telo2	TEL2, telomere maintenance 2, homolog (S. cerevisiae). (835 aa)
	rpa2	RPA_C domain-containing protein. (274 aa)
	rad51c	RAD51 paralog C. (342 aa)
	faap24	FA core complex associated protein 24. (202 aa)
	rpa3	Replication protein A 14kDa subunit. (122 aa)
	top3a	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1023 aa)
	rev3l	REV3 like, DNA directed polymerase zeta catalytic subunit. (2448 aa)
	hes4	Hairy-related 9. (286 aa)
	blm	BLM RecQ like helicase. (1384 aa)
	fanca	Fanconi_A_N domain-containing protein. (1475 aa)
	brca1	Uncharacterized protein. (1354 aa)
	polh	Polymerase (DNA directed), eta. (738 aa)
	rmi2	RecQ mediated genome instability 2. (145 aa)
	wdr48	WD repeat domain 48b. (677 aa)
	slx4	SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1695 aa)
	ube2t	Ubiquitin-conjugating enzyme E2T (putative). (194 aa)
	ercc1	Excision repair cross-complementation group 1. (352 aa)
	atrip	Uncharacterized protein. (776 aa)
	fancd2	FA complementation group D2. (1361 aa)
	rmi1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (699 aa)
	fancf	FA complementation group F. (335 aa)
	fan1	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (969 aa)
	ercc4	Excision repair cross-complementation group 4. (899 aa)

Your Current Organism:

Kryptolebias marmoratus

NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSKMAP00000001053	LOC108231373	ENSKMAP00000001053	ENSKMAP00000007954	Uncharacterized protein.	Centromere protein S.	0.613
ENSKMAP00000001053	LOC108242278	ENSKMAP00000001053	ENSKMAP00000007581	Uncharacterized protein.	Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.	0.578
ENSKMAP00000001053	LOC108248126	ENSKMAP00000001053	ENSKMAP00000010056	Uncharacterized protein.	RPA_C domain-containing protein.	0.866
ENSKMAP00000001053	RPA1	ENSKMAP00000001053	ENSKMAP00000000242	Uncharacterized protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.953
ENSKMAP00000001053	atrip	ENSKMAP00000001053	ENSKMAP00000027428	Uncharacterized protein.	Uncharacterized protein.	0.999
ENSKMAP00000001053	blm	ENSKMAP00000001053	ENSKMAP00000022385	Uncharacterized protein.	BLM RecQ like helicase.	0.961
ENSKMAP00000001053	brca1	ENSKMAP00000001053	ENSKMAP00000024393	Uncharacterized protein.	Uncharacterized protein.	0.992
ENSKMAP00000001053	brip1	ENSKMAP00000001053	ENSKMAP00000003838	Uncharacterized protein.	BRCA1 interacting protein C-terminal helicase 1.	0.701
ENSKMAP00000001053	ercc1	ENSKMAP00000001053	ENSKMAP00000027419	Uncharacterized protein.	Excision repair cross-complementation group 1.	0.748
ENSKMAP00000001053	ercc4	ENSKMAP00000001053	ENSKMAP00000029520	Uncharacterized protein.	Excision repair cross-complementation group 4.	0.811
ENSKMAP00000001053	faap24	ENSKMAP00000001053	ENSKMAP00000019785	Uncharacterized protein.	FA core complex associated protein 24.	0.778
ENSKMAP00000001053	fanca	ENSKMAP00000001053	ENSKMAP00000022437	Uncharacterized protein.	Fanconi_A_N domain-containing protein.	0.965
ENSKMAP00000001053	fancd2	ENSKMAP00000001053	ENSKMAP00000027787	Uncharacterized protein.	FA complementation group D2.	0.875
ENSKMAP00000001053	fance	ENSKMAP00000001053	ENSKMAP00000009397	Uncharacterized protein.	FA complementation group E.	0.454
ENSKMAP00000001053	fancf	ENSKMAP00000001053	ENSKMAP00000028976	Uncharacterized protein.	FA complementation group F.	0.614
ENSKMAP00000001053	fanci	ENSKMAP00000001053	ENSKMAP00000004789	Uncharacterized protein.	FA complementation group I.	0.971
ENSKMAP00000001053	fancm	ENSKMAP00000001053	ENSKMAP00000012450	Uncharacterized protein.	Helicase C-terminal domain-containing protein.	0.998
ENSKMAP00000001053	mlh1	ENSKMAP00000001053	ENSKMAP00000011476	Uncharacterized protein.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.580
ENSKMAP00000001053	pms2	ENSKMAP00000001053	ENSKMAP00000011431	Uncharacterized protein.	PMS1 homolog 2, mismatch repair system component.	0.511
ENSKMAP00000001053	rad51	ENSKMAP00000001053	ENSKMAP00000017025	Uncharacterized protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.891