STRINGSTRING
LOC108251479 LOC108251479 LOC108250227 LOC108250227 ENSKMAP00000000736 ENSKMAP00000000736 nkd1 nkd1 LOC108245043 LOC108245043 cxxc4 cxxc4 FZD7 FZD7 dkk2 dkk2 lgr4 lgr4 lef1 lef1 znrf3 znrf3 nfatc2 nfatc2 LOC108241224 LOC108241224 fzd6 fzd6 ccn4 ccn4 fzd9 fzd9 LOC108233110 LOC108233110 Map3k7 Map3k7 daam2 daam2 rspo2 rspo2 LOC108234144 LOC108234144 fzd3 fzd3 LOC108238308 LOC108238308 WNT7A WNT7A wnt9a wnt9a wnt3a wnt3a nlk nlk tcf7l1 tcf7l1 LOC108240588 LOC108240588 invs invs VANGL1 VANGL1 LOC108240520 LOC108240520 LOC108249203 LOC108249203 LOC108244022 LOC108244022 wnt4 wnt4 sost sost LOC108235495 LOC108235495 PRICKLE1 PRICKLE1 prickle3 prickle3 LOC108245165 LOC108245165 sfrp2 sfrp2 porcn porcn ppard ppard LOC108230652 LOC108230652 csnk2a2 csnk2a2 LOC108242882 LOC108242882 dvl1 dvl1 LOC108250476 LOC108250476 fzd4 fzd4 LOC108237745 LOC108237745 LOC108248723 LOC108248723 ENSKMAP00000011188 ENSKMAP00000011188 LOC108229717 LOC108229717 dvl3 dvl3 LOC108237171 LOC108237171 RAC1 RAC1 RAC1-2 RAC1-2 LOC108237172 LOC108237172 rock2 rock2 LOC108249847 LOC108249847 lrp5 lrp5 prickle2 prickle2 LOC108241749 LOC108241749 dvl2 dvl2 LOC108245811 LOC108245811 LOC108245806 LOC108245806 LOC108247541 LOC108247541 LOC108241259 LOC108241259 prkacb prkacb wnt11 wnt11 LOC108248763 LOC108248763 LOC108246435 LOC108246435 LOC108248045 LOC108248045 ctbp1 ctbp1 LOC108233174 LOC108233174 cacybp cacybp RAC2 RAC2 ror1 ror1 LOC108250609 LOC108250609 daam1 daam1 LOC108237917 LOC108237917 ror2 ror2 LOC108235094 LOC108235094 LOC108248250 LOC108248250 ccnd1 ccnd1 serpinf1 serpinf1 rnf43 rnf43 csnk2b csnk2b LOC108241350 LOC108241350 CTBP2 CTBP2 LOC108249419 LOC108249419 LOC108231486 LOC108231486 LOC108251201 LOC108251201 TP53 TP53 nkd2 nkd2 LOC108247643 LOC108247643 RSPO4 RSPO4 LOC108228356 LOC108228356 LOC108248837 LOC108248837 LOC108237970 LOC108237970 csnk1e csnk1e wnt7a wnt7a LOC108238006 LOC108238006 LOC108231519 LOC108231519 bambi bambi PLCB2 PLCB2 rbx1 rbx1 ep300 ep300 LOC108239664 LOC108239664 LOC108230349 LOC108230349 ryk ryk LOC108249494 LOC108249494 LOC108232156 LOC108232156 LOC108244269 LOC108244269 Nfatc1 Nfatc1 ENSKMAP00000021756 ENSKMAP00000021756 Ctnnbip1 Ctnnbip1 camk2b camk2b LOC108242566 LOC108242566 LOC108237314 LOC108237314 wnt6 wnt6 LOC108242565 LOC108242565 LOC108246614 LOC108246614 tcf7l2 tcf7l2 ROCK2 ROCK2 PRKCA PRKCA LOC108241910 LOC108241910 LOC108242552 LOC108242552 VANGL2 VANGL2 cul1 cul1 LOC108231910 LOC108231910 PRKCB PRKCB LOC108239707 LOC108239707 apc2 apc2 nfatc3 nfatc3 LOC108246125 LOC108246125 LOC108239791 LOC108239791 prkaca prkaca Wnt16 Wnt16 rspo1 rspo1 LOC108244339 LOC108244339 RAC1-4 RAC1-4 notum notum LOC108239241 LOC108239241 axin1 axin1 LOC108239236 LOC108239236 FZD3 FZD3 LOC108243697 LOC108243697 LOC108235134 LOC108235134 Fzd2 Fzd2 LOC108251327 LOC108251327 LOC108241482 LOC108241482 smad3 smad3 skp1 skp1 tcf7 tcf7 ruvbl1 ruvbl1 LOC108235226 LOC108235226 LOC108230112 LOC108230112 chd8 chd8 LGR6 LGR6 AXIN2 AXIN2 Fzd10 Fzd10 LOC108234067 LOC108234067 LOC108244211 LOC108244211 LOC108235165 LOC108235165 LOC108235231 LOC108235231 LOC108232213 LOC108232213 ctnnb1 ctnnb1 csnk1a1 csnk1a1 sfrp5 sfrp5 Ccnd3 Ccnd3 LOC108236300 LOC108236300 wnt10b wnt10b wnt1 wnt1 ccnd2 ccnd2 LOC108235763 LOC108235763 gsk3b gsk3b LOC108235881 LOC108235881 cby1 cby1 LOC108236996 LOC108236996
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108251479BHLH domain-containing protein. (370 aa)
LOC108250227Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
ENSKMAP00000000736Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (340 aa)
nkd1NKD inhibitor of WNT signaling pathway 1. (447 aa)
LOC108245043Uncharacterized protein. (259 aa)
cxxc4CXXC finger 4. (289 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (561 aa)
dkk2Dickkopf WNT signaling pathway inhibitor 2. (242 aa)
lgr4Leucine-rich repeat containing G protein-coupled receptor 4. (975 aa)
lef1Lymphoid enhancer-binding factor 1. (379 aa)
znrf3Zinc and ring finger 3. (896 aa)
nfatc2Nuclear factor of activated T cells 2a. (888 aa)
LOC108241224Uncharacterized protein. (768 aa)
fzd6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (691 aa)
ccn4Cellular communication network factor 4a. (361 aa)
fzd9Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (584 aa)
LOC108233110Uncharacterized protein. (193 aa)
Map3k7Protein kinase domain-containing protein. (117 aa)
daam2Dishevelled associated activator of morphogenesis 2. (1075 aa)
rspo2R-spondin 2. (245 aa)
LOC108234144RHD domain-containing protein. (931 aa)
fzd3Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family. (696 aa)
LOC108238308Transducin (beta)-like 1 X-linked receptor 1b. (512 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (254 aa)
wnt9aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (372 aa)
wnt3aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
nlkNemo-like kinase, type 2. (325 aa)
tcf7l1Transcription factor 7 like 1b. (580 aa)
LOC108240588Mitogen-activated protein kinase. (420 aa)
invsInversin. (667 aa)
VANGL1Vang-like protein. (527 aa)
LOC108240520C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (448 aa)
LOC108249203Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LOC108244022Catenin (cadherin-associated protein), delta 2a. (1265 aa)
wnt4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
sostSclerostin. (217 aa)
LOC108235495Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (704 aa)
PRICKLE1Prickle homolog 1a. (846 aa)
prickle3Prickle homolog 3. (814 aa)
LOC108245165Rac family small GTPase 3b. (185 aa)
sfrp2Secreted frizzled-related protein 2. (308 aa)
porcnPorcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (448 aa)
ppardPeroxisome proliferator-activated receptor delta b. (509 aa)
LOC108230652Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
csnk2a2Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (350 aa)
LOC1082428821-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1180 aa)
dvl1Dishevelled segment polarity protein 1a. (727 aa)
LOC108250476G_PROTEIN_RECEP_F1_2 domain-containing protein. (859 aa)
fzd4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (545 aa)
LOC108237745Cyclin Dx; Belongs to the cyclin family. (298 aa)
LOC108248723Secreted frizzled-related protein 1a. (297 aa)
ENSKMAP00000011188Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (319 aa)
LOC108229717Uncharacterized protein. (431 aa)
dvl3Dishevelled segment polarity protein 3a. (684 aa)
LOC108237171Uncharacterized protein. (193 aa)
RAC1Rac family small GTPase 1. (190 aa)
RAC1-2Uncharacterized protein. (342 aa)
LOC108237172Uncharacterized protein. (192 aa)
rock2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1377 aa)
LOC108249847Casein kinase 2, alpha prime polypeptide a; Belongs to the protein kinase superfamily. (350 aa)
lrp5Low density lipoprotein receptor-related protein 5. (1645 aa)
prickle2Prickle homolog 2b. (924 aa)
LOC108241749Uncharacterized protein. (883 aa)
dvl2Dishevelled segment polarity protein 2. (717 aa)
LOC108245811Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
LOC108245806Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (342 aa)
LOC108247541Mothers against decapentaplegic homolog. (503 aa)
LOC108241259Notum, palmitoleoyl-protein carboxylesterase a. (504 aa)
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
wnt11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LOC108248763Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (579 aa)
LOC108246435Serine/threonine-protein phosphatase. (508 aa)
LOC108248045Protein kinase domain-containing protein. (616 aa)
ctbp1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (443 aa)
LOC108233174Cyclin D2, b; Belongs to the cyclin family. (294 aa)
cacybpCalcyclin binding protein. (227 aa)
RAC2Rac family small GTPase 2. (194 aa)
ror1Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (955 aa)
LOC108250609Glycogen synthase kinase binding protein. (125 aa)
daam1Uncharacterized protein. (648 aa)
LOC108237917Mothers against decapentaplegic homolog. (425 aa)
ror2Receptor tyrosine kinase-like orphan receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (937 aa)
LOC108235094Prickle homolog 1b. (939 aa)
LOC108248250RHD domain-containing protein. (837 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
serpinf1SERPIN domain-containing protein; Belongs to the serpin family. (412 aa)
rnf43RING-type domain-containing protein. (809 aa)
csnk2bCasein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (215 aa)
LOC108241350Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
CTBP2C-terminal binding protein 2. (877 aa)
LOC108249419Uncharacterized protein. (196 aa)
LOC108231486Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (374 aa)
LOC108251201Casein kinase 2, alpha 4 polypeptide; Belongs to the protein kinase superfamily. (393 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (372 aa)
nkd2NKD inhibitor of WNT signaling pathway 2a. (370 aa)
LOC108247643CREB binding protein b. (2428 aa)
RSPO4R-spondin 4. (246 aa)
LOC108228356Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (538 aa)
LOC108248837Vang-like protein. (526 aa)
LOC108237970Serine/threonine-protein phosphatase. (492 aa)
csnk1eProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (417 aa)
wnt7aProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
LOC108238006Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (555 aa)
LOC108231519RHD domain-containing protein. (880 aa)
bambiBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (255 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1219 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
ep300E1A binding protein p300 b. (2785 aa)
LOC108239664Uncharacterized protein; Belongs to the protein kinase superfamily. (349 aa)
LOC108230349SRY-box transcription factor 17. (395 aa)
rykReceptor like tyrosine kinase. (628 aa)
LOC108249494Myelocytomatosis oncogene homolog. (367 aa)
LOC108232156Prickle homolog 2a. (892 aa)
LOC108244269Calcium/calmodulin-dependent protein kinase (CaM kinase) II delta 1. (512 aa)
Nfatc1Nuclear factor of activated T cells 1. (562 aa)
ENSKMAP00000021756Frizzled class receptor 1. (233 aa)
Ctnnbip1Catenin, beta interacting protein 1. (76 aa)
camk2bCalcium/calmodulin-dependent protein kinase (CaM kinase) II beta 2. (539 aa)
LOC108242566HMG box domain-containing protein. (580 aa)
LOC108237314Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (482 aa)
wnt6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LOC108242565Serine/threonine-protein phosphatase. (505 aa)
LOC108246614Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
tcf7l2Transcription factor 7 like 2. (630 aa)
ROCK2Rho associated coiled-coil containing protein kinase 2; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1480 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (670 aa)
LOC108241910Zgc:86598; Belongs to the protein kinase superfamily. (392 aa)
LOC108242552Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
VANGL2Vang-like protein. (525 aa)
cul1Cullin 1b; Belongs to the cullin family. (776 aa)
LOC108231910Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (450 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (680 aa)
LOC108239707Transducin beta like 1 X-linked. (513 aa)
apc2APC regulator of WNT signaling pathway 2. (2533 aa)
nfatc3Nuclear factor of activated T cells 3a. (1116 aa)
LOC108246125Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
LOC108239791Vang-like protein. (539 aa)
prkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
Wnt16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (335 aa)
rspo1R-spondin 1. (281 aa)
LOC108244339DAN domain family, member 5. (255 aa)
RAC1-4Rac family small GTPase 1. (192 aa)
notumUncharacterized protein. (436 aa)
LOC108239241Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (681 aa)
axin1Axin 1. (848 aa)
LOC108239236Axin 2 (conductin, axil). (840 aa)
FZD3Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (734 aa)
LOC108243697Dickkopf WNT signaling pathway inhibitor 1a. (252 aa)
LOC108235134Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
Fzd2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (547 aa)
LOC108251327E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (286 aa)
LOC108241482CREB binding protein a. (2490 aa)
smad3Mothers against decapentaplegic homolog. (425 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
tcf7Transcription factor 7. (384 aa)
ruvbl1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
LOC108235226Uncharacterized protein. (191 aa)
LOC108230112TLE family member 3, transcriptional corepressor. (778 aa)
chd8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2616 aa)
LGR6Leucine rich repeat containing G protein-coupled receptor 6. (928 aa)
AXIN2Axin 2. (784 aa)
Fzd10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
LOC108234067Mitogen-activated protein kinase. (411 aa)
LOC108244211Uncharacterized protein. (1151 aa)
LOC108235165Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
LOC108235231Uncharacterized protein. (193 aa)
LOC108232213R-spondin 3. (325 aa)
ctnnb1Catenin (cadherin-associated protein), beta 1. (783 aa)
csnk1a1Casein kinase 1, alpha 1. (247 aa)
sfrp5Secreted frizzled-related protein 5. (307 aa)
Ccnd3Cyclin D3; Belongs to the cyclin family. (218 aa)
LOC108236300Notum pectinacetylesterase 2. (523 aa)
wnt10bProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (433 aa)
wnt1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ccnd2Cyclin D2, a; Belongs to the cyclin family. (340 aa)
LOC108235763Uncharacterized protein. (193 aa)
gsk3bGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
LOC108235881Casein kinase 1, epsilon; Belongs to the protein kinase superfamily. (440 aa)
cby1Chibby homolog 1 (Drosophila). (134 aa)
LOC108236996Serine/threonine-protein phosphatase. (522 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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