STRINGSTRING
LOC108238123 LOC108238123 ENSKMAP00000000323 ENSKMAP00000000323 ACVR1B ACVR1B LOC108251479 LOC108251479 id4 id4 GREM1 GREM1 tfdp1 tfdp1 LOC108239820 LOC108239820 bmpr2 bmpr2 grem2 grem2 LOC108236340 LOC108236340 bmp2 bmp2 rps6kb1 rps6kb1 tgfb3 tgfb3 LOC108233110 LOC108233110 amh amh gdf6 gdf6 INHBB INHBB rock1 rock1 LOC108230822 LOC108230822 LOC108231423 LOC108231423 smad1 smad1 acvr2a acvr2a mapk1 mapk1 LOC108231812 LOC108231812 LOC108244027 LOC108244027 bmpr1a bmpr1a fst fst smad9 smad9 LOC108240607 LOC108240607 LOC108241192 LOC108241192 LOC108250437 LOC108250437 Nog Nog id2 id2 LOC108235010 LOC108235010 LOC108228916 LOC108228916 dcn dcn LOC108242980 LOC108242980 LOC108243526 LOC108243526 LOC108247541 LOC108247541 LOC108247544 LOC108247544 pitx2 pitx2 LOC108249887 LOC108249887 ppp2cb ppp2cb bmp4 bmp4 LOC108237917 LOC108237917 LOC108237920 LOC108237920 inhba inhba sp1 sp1 LOC108230274 LOC108230274 INHBC INHBC TGFBR2 TGFBR2 LOC108235705 LOC108235705 LOC108236134 LOC108236134 LOC108248259 LOC108248259 rgmb rgmb ACVR1C ACVR1C acvr1 acvr1 bmp7 bmp7 LOC108249419 LOC108249419 LOC108237136 LOC108237136 LOC108242427 LOC108242427 LOC108232637 LOC108232637 LOC108247643 LOC108247643 chrd chrd LOC108235626 LOC108235626 LOC108235612 LOC108235612 LOC108247721 LOC108247721 bambi bambi rbx1 rbx1 ep300 ep300 LOC108249494 LOC108249494 LOC108230019 LOC108230019 LOC108245382 LOC108245382 LOC108236247 LOC108236247 LOC108250775 LOC108250775 LOC108231974 LOC108231974 SMURF2 SMURF2 LOC108247742 LOC108247742 cul1 cul1 LOC108234526 LOC108234526 rbl1 rbl1 zfyve9 zfyve9 LOC108228553 LOC108228553 LOC108241482 LOC108241482 hamp hamp bmp5 bmp5 smad6 smad6 smad3 smad3 ppp2ca ppp2ca skp1 skp1 LOC108247801 LOC108247801 LOC108235226 LOC108235226 LOC108246724 LOC108246724 bmpr1b bmpr1b LOC108232890 LOC108232890 thbs1 thbs1 LOC108235231 LOC108235231 LOC108232862 LOC108232862 LOC108244375 LOC108244375 e2f4 e2f4 NBL1 NBL1 LOC108235763 LOC108235763 LOC108233514 LOC108233514
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC108238123Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (496 aa)
ENSKMAP00000000323E2F_TDP domain-containing protein. (85 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
LOC108251479BHLH domain-containing protein. (370 aa)
id4Inhibitor of DNA binding 4. (153 aa)
GREM1Gremlin; Belongs to the DAN family. (172 aa)
tfdp1Transcription factor. (412 aa)
LOC108239820Homeobox domain-containing protein. (590 aa)
bmpr2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1061 aa)
grem2Gremlin 2, DAN family BMP antagonist a. (192 aa)
LOC108236340Thrombospondin 1a. (1172 aa)
bmp2Bone morphogenetic protein 2b. (418 aa)
rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (509 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (405 aa)
LOC108233110Uncharacterized protein. (193 aa)
amhTGF_BETA_2 domain-containing protein. (519 aa)
gdf6Growth differentiation factor 6a. (408 aa)
INHBBInhibin subunit beta B. (392 aa)
rock1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1364 aa)
LOC108230822RGM domain family, member D. (467 aa)
LOC108231423Transforming growth factor beta; Belongs to the TGF-beta family. (419 aa)
smad1Mothers against decapentaplegic homolog. (467 aa)
acvr2aSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
LOC108231812Left-right determination factor. (359 aa)
LOC108244027Bone morphogenetic protein 6. (422 aa)
bmpr1aReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (525 aa)
fstFollistatin a. (348 aa)
smad9Mothers against decapentaplegic homolog. (468 aa)
LOC108240607Serine/threonine-protein phosphatase. (309 aa)
LOC108241192Bone morphogenetic protein 7a. (425 aa)
LOC108250437Mothers against decapentaplegic homolog. (472 aa)
NogNoggin; Belongs to the noggin family. (211 aa)
id2Inhibitor of DNA binding 2a. (139 aa)
LOC108235010Mothers against decapentaplegic homolog. (467 aa)
LOC108228916Transforming growth factor beta; Belongs to the TGF-beta family. (381 aa)
dcnDecorin; May affect the rate of fibrils formation. (362 aa)
LOC108242980Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (408 aa)
LOC108243526Protein phosphatase 2, regulatory subunit A, beta b. (589 aa)
LOC108247541Mothers against decapentaplegic homolog. (503 aa)
LOC108247544Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (539 aa)
pitx2Homeobox protein. (312 aa)
LOC108249887Bone morphogenetic protein 8a. (445 aa)
ppp2cbSerine/threonine-protein phosphatase. (309 aa)
bmp4Bone morphogenetic protein 4. (403 aa)
LOC108237917Mothers against decapentaplegic homolog. (425 aa)
LOC108237920Mothers against decapentaplegic homolog. (521 aa)
inhbaInhibin subunit beta Ab. (397 aa)
sp1Sp1 transcription factor. (702 aa)
LOC108230274TGFB-induced factor homeobox 1. (281 aa)
INHBCInhibin subunit beta C. (380 aa)
TGFBR2Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (555 aa)
LOC108235705Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
LOC108236134E3 ubiquitin-protein ligase. (770 aa)
LOC108248259Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
rgmbRepulsive guidance molecule BMP co-receptor b. (474 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
acvr1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (686 aa)
bmp7Bone morphogenetic protein 7b. (428 aa)
LOC108249419Uncharacterized protein. (196 aa)
LOC108237136Noggin; Belongs to the noggin family. (209 aa)
LOC108242427Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
LOC108232637Nodal-related 1. (368 aa)
LOC108247643CREB binding protein b. (2428 aa)
chrdChordin; Belongs to the chordin family. (977 aa)
LOC108235626Zgc:113307. (367 aa)
LOC108235612Fibromodulin a. (343 aa)
LOC108247721Nodal-related 2. (387 aa)
bambiBMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (255 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
ep300E1A binding protein p300 b. (2785 aa)
LOC108249494Myelocytomatosis oncogene homolog. (367 aa)
LOC108230019Repulsive guidance molecule BMP co-receptor a. (449 aa)
LOC108245382Zinc finger, FYVE domain containing 16. (1425 aa)
LOC108236247E3 ubiquitin-protein ligase. (735 aa)
LOC108250775TGF_BETA_2 domain-containing protein. (275 aa)
LOC108231974Fibromodulin b. (346 aa)
SMURF2E3 ubiquitin-protein ligase. (775 aa)
LOC108247742TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (586 aa)
cul1Cullin 1b; Belongs to the cullin family. (776 aa)
LOC108234526Southpaw. (422 aa)
rbl1Retinoblastoma-like 1 (p107). (1034 aa)
zfyve9Zinc finger, FYVE domain containing 9a. (1195 aa)
LOC108228553Inhibin subunit beta Aa. (134 aa)
LOC108241482CREB binding protein a. (2490 aa)
hampUncharacterized protein. (89 aa)
bmp5Bone morphogenetic protein 5. (457 aa)
smad6Mothers against decapentaplegic homolog. (484 aa)
smad3Mothers against decapentaplegic homolog. (425 aa)
ppp2caSerine/threonine-protein phosphatase. (309 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (163 aa)
LOC108247801TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (557 aa)
LOC108235226Uncharacterized protein. (191 aa)
LOC108246724Inhibin subunit beta B. (396 aa)
bmpr1bSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
LOC108232890Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (514 aa)
thbs1Thrombospondin 1b. (1169 aa)
LOC108235231Uncharacterized protein. (193 aa)
LOC108232862Anti-dorsalizing morphogenic protein. (374 aa)
LOC108244375Inhibitor of DNA binding 1, HLH protein. (129 aa)
e2f4E2F transcription factor 4. (388 aa)
NBL1NBL1, DAN family BMP antagonist. (194 aa)
LOC108235763Uncharacterized protein. (193 aa)
LOC108233514Gremlin 1a, DAN family BMP antagonist. (173 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.