STRINGSTRING
rps6 rps6 LOC108239333 LOC108239333 LOC108230762 LOC108230762 LOC108238123 LOC108238123 adcy2 adcy2 LOC108247901 LOC108247901 LOC108239581 LOC108239581 ENSKMAP00000001096 ENSKMAP00000001096 adcy7 adcy7 PIK3R6 PIK3R6 adcy8 adcy8 pik3r5 pik3r5 calml4 calml4 LOC108228616 LOC108228616 rps6kb1 rps6kb1 LOC108244519 LOC108244519 LOC108239982 LOC108239982 LOC108248548 LOC108248548 ENSKMAP00000003254 ENSKMAP00000003254 LOC108244154 LOC108244154 LOC108241627 LOC108241627 LOC108251551 LOC108251551 mylk mylk map2k2 map2k2 Itpr3 Itpr3 LOC108238174 LOC108238174 gnb1 gnb1 calm1 calm1 prkaa2 prkaa2 plat plat KRAS KRAS pde3b pde3b LOC108248619 LOC108248619 LOC108241640 LOC108241640 rras2 rras2 itpr2 itpr2 mapk1 mapk1 sphk2 sphk2 LOC108246299 LOC108246299 mef2c mef2c Mef2b Mef2b mtor mtor egr1 egr1 PRKAB2 PRKAB2 LOC108239985 LOC108239985 adcy5 adcy5 LOC108231344 LOC108231344 LOC108244602 LOC108244602 LOC108232370 LOC108232370 LOC108231398 LOC108231398 LOC108235459 LOC108235459 camk4 camk4 LOC108247907 LOC108247907 serpine1 serpine1 LOC108242886 LOC108242886 LOC108251695 LOC108251695 LOC108242882 LOC108242882 LOC108251705 LOC108251705 LOC108247551 LOC108247551 jag1 jag1 LOC108235010 LOC108235010 nos1 nos1 SPHK1 SPHK1 LOC108233022 LOC108233022 LOC108235428 LOC108235428 gna13 gna13 ENSKMAP00000012146 ENSKMAP00000012146 prkaa1 prkaa1 LOC108244668 LOC108244668 LOC108242980 LOC108242980 GABARAPL2 GABARAPL2 LOC108247541 LOC108247541 LOC108243005 LOC108243005 MEF2D MEF2D LOC108248180 LOC108248180 prkacb prkacb GNG5 GNG5 GNG4 GNG4 LOC108234916 LOC108234916 gng3 gng3 LOC108233300 LOC108233300 LOC108233888 LOC108233888 prkce prkce mylk4 mylk4 agtr1 agtr1 LOC108237917 LOC108237917 SPHK1-2 SPHK1-2 adcy6 adcy6 LOC108230976 LOC108230976 pik3c3 pik3c3 PIK3R5 PIK3R5 LOC108229092 LOC108229092 gng10 gng10 ccnd1 ccnd1 LOC108239646 LOC108239646 LOC108248259 LOC108248259 LOC108241350 LOC108241350 LOC108248823 LOC108248823 raf1 raf1 gng7 gng7 LOC108244116 LOC108244116 LOC108248275 LOC108248275 ADCY9 ADCY9 LOC108239683 LOC108239683 LOC108239577 LOC108239577 PLCB2 PLCB2 LOC108250739 LOC108250739 slc8a3 slc8a3 LOC108239664 LOC108239664 hdac5 hdac5 nrf1 nrf1 akt1 akt1 mef2a mef2a ENSKMAP00000021311 ENSKMAP00000021311 LOC108243718 LOC108243718 tfam tfam LOC108239039 LOC108239039 slc8a1 slc8a1 LOC108241379 LOC108241379 LOC108243234 LOC108243234 LOC108236783 LOC108236783 LOC108248366 LOC108248366 adcy3 adcy3 mras mras LOC108235741 LOC108235741 prkaca prkaca LOC108236284 LOC108236284 LOC108238551 LOC108238551 ccn2 ccn2 becn1 becn1 LOC108240374 LOC108240374 prkag1 prkag1 LOC108242690 LOC108242690 map2k1 map2k1 LOC108241462 LOC108241462 LOC108243749 LOC108243749 LOC108246706 LOC108246706 smad3 smad3 LOC108232311 LOC108232311 MYL2 MYL2 LOC108234608 LOC108234608 itpr1 itpr1 LOC108235740 LOC108235740 ENSKMAP00000027940 ENSKMAP00000027940 LOC108248470 LOC108248470 klf2 klf2 gnb5 gnb5 gnb4 gnb4 gabarap gabarap LOC108236972 LOC108236972 ryr3 ryr3 LOC108236875 LOC108236875
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rps640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
LOC108239333Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
LOC108230762Guanine nucleotide binding protein (G protein), alpha 11a (Gq class). (359 aa)
LOC108238123Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (496 aa)
adcy2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1071 aa)
LOC108247901Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (744 aa)
LOC108239581Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
ENSKMAP00000001096B30.2/SPRY domain-containing protein. (296 aa)
adcy7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1096 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (781 aa)
adcy8Adenylate cyclase 8 (brain); Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1269 aa)
pik3r5Phosphoinositide-3-kinase, regulatory subunit 5. (875 aa)
calml4Calmodulin-like 4a. (153 aa)
LOC108228616Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family. (155 aa)
rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (509 aa)
LOC108244519Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
LOC108239982HRas proto-oncogene, GTPase a. (189 aa)
LOC108248548Solute carrier family 8 member 2b; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (989 aa)
ENSKMAP00000003254Apelin receptor a; Belongs to the G-protein coupled receptor 1 family. (361 aa)
LOC108244154Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
LOC108241627Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC108251551Uncharacterized protein. (408 aa)
mylkMyosin, light chain kinase a. (891 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
Itpr3Uncharacterized protein. (663 aa)
LOC108238174Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
gnb1Guanine nucleotide binding protein (G protein), beta polypeptide 1a. (340 aa)
calm1Calmodulin 3a (phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
prkaa2Non-specific serine/threonine protein kinase. (557 aa)
platPlasminogen activator, tissue. (609 aa)
KRASGTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. May play a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs). Belongs to the small GTPase superfamily. Ras family. (189 aa)
pde3bPhosphodiesterase. (1099 aa)
LOC108248619Uncharacterized protein. (1285 aa)
LOC108241640Myosin, light chain 13. (188 aa)
rras2R-ras. (202 aa)
itpr2Inositol 1,4,5-trisphosphate receptor, type 2. (2649 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
sphk2Sphingosine kinase 2. (887 aa)
LOC108246299Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
mef2cMyocyte enhancer factor 2cb. (483 aa)
Mef2bMADS-box domain-containing protein. (90 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2516 aa)
egr1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (509 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (268 aa)
LOC108239985Uncharacterized protein. (354 aa)
adcy5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1202 aa)
LOC108231344Guanine nucleotide binding protein (G protein), beta polypeptide 1b. (340 aa)
LOC108244602Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1182 aa)
LOC108232370Protein kinase, AMP-activated, gamma 3b non-catalytic subunit. (354 aa)
LOC108231398Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b. (355 aa)
LOC108235459Zgc:92606. (117 aa)
camk4Si:ch73-60h1.1; Belongs to the protein kinase superfamily. (479 aa)
LOC108247907Guanine nucleotide binding protein (G protein), gamma 13a. (135 aa)
serpine1Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Belongs to the serpin family. (390 aa)
LOC108242886Solute carrier family 8 member 4b; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (958 aa)
LOC108251695Uncharacterized protein. (430 aa)
LOC1082428821-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1180 aa)
LOC108251705Solute carrier family 8 member 1a; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (931 aa)
LOC108247551Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
jag1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
LOC108235010Mothers against decapentaplegic homolog. (467 aa)
nos1Nitric oxide synthase; Produces nitric oxide (NO). (1417 aa)
SPHK1Sphingosine kinase 1. (560 aa)
LOC108233022Si:rp71-17i16.5; Belongs to the PI3/PI4-kinase family. (1135 aa)
LOC108235428Guanine nucleotide binding protein (G protein), beta polypeptide 3a. (340 aa)
gna13Guanine nucleotide binding protein (G protein), alpha 13b. (377 aa)
ENSKMAP00000012146Apelin receptor b; Belongs to the G-protein coupled receptor 1 family. (358 aa)
prkaa1Non-specific serine/threonine protein kinase. (573 aa)
LOC108244668Ryanodine receptor 1b (skeletal). (4685 aa)
LOC108242980Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (408 aa)
GABARAPL2GABA type A receptor associated protein like 2. (143 aa)
LOC108247541Mothers against decapentaplegic homolog. (503 aa)
LOC108243005Zgc:55558. (187 aa)
MEF2DMyocyte enhancer factor 2D. (579 aa)
LOC108248180Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC108234916Protein kinase, AMP-activated, beta 1 non-catalytic subunit, b. (265 aa)
gng3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
LOC108233300Uncharacterized protein. (354 aa)
LOC108233888Solute carrier family 8 member 4a; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (936 aa)
prkceProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (741 aa)
mylk4Myosin light chain kinase family, member 4b. (679 aa)
agtr1Angiotensin II receptor, type 1b; Belongs to the G-protein coupled receptor 1 family. (363 aa)
LOC108237917Mothers against decapentaplegic homolog. (425 aa)
SPHK1-2Sphingosine kinase 1. (488 aa)
adcy6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1209 aa)
LOC108230976G protein subunit alpha q. (359 aa)
pik3c3Phosphatidylinositol 3-kinase catalytic subunit type 3. (885 aa)
PIK3R5Phosphoinositide-3-kinase regulatory subunit 5. (867 aa)
LOC108229092Si:ch211-132f19.7; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (814 aa)
gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
LOC108239646Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b. (543 aa)
LOC108248259Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (504 aa)
LOC108241350Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
LOC108248823Apelin receptor 2; Belongs to the G-protein coupled receptor 1 family. (402 aa)
raf1Raf-1 proto-oncogene, serine/threonine kinase a. (677 aa)
gng7Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
LOC108244116Uncharacterized protein. (1212 aa)
LOC108248275Guanine nucleotide binding protein (G protein), beta polypeptide 2. (340 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1435 aa)
LOC108239683Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1180 aa)
LOC108239577Myosin light chain kinase family, member 4a. (765 aa)
PLCB21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1219 aa)
LOC108250739Actin alpha 2, smooth muscle. (377 aa)
slc8a3Solute carrier family 8 member 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (926 aa)
LOC108239664Uncharacterized protein; Belongs to the protein kinase superfamily. (349 aa)
hdac5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1141 aa)
nrf1Nuclear respiratory factor 1. (520 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
mef2aMyocyte enhancer factor 2aa. (515 aa)
ENSKMAP00000021311Uncharacterized protein. (195 aa)
LOC108243718Notch receptor 3. (2463 aa)
tfamTranscription factor A, mitochondrial. (283 aa)
LOC108239039Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
slc8a1Solute carrier family 8 member 1b; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (975 aa)
LOC108241379Protein kinase, AMP-activated, beta 1 non-catalytic subunit, a. (269 aa)
LOC108243234Myocyte enhancer factor 2d. (595 aa)
LOC108236783Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (354 aa)
LOC108248366Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1125 aa)
adcy3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
mrasUncharacterized protein. (208 aa)
LOC108235741Inositol 1,4,5-trisphosphate receptor, type 1a. (2655 aa)
prkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
LOC108236284Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
LOC108238551Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1093 aa)
ccn2Cellular communication network factor 2a. (346 aa)
becn1Beclin 1, autophagy related. (447 aa)
LOC108240374Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (802 aa)
prkag1Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (356 aa)
LOC108242690Guanine nucleotide binding protein (G protein), beta polypeptide 3b. (342 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (450 aa)
LOC108241462Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1457 aa)
LOC108243749Myosin, light chain kinase 5. (862 aa)
LOC108246706Protein kinase, AMP-activated, gamma 3a non-catalytic subunit. (337 aa)
smad3Mothers against decapentaplegic homolog. (425 aa)
LOC108232311Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1199 aa)
MYL2Myosin light chain 2. (169 aa)
LOC108234608Uncharacterized protein. (359 aa)
itpr1Inositol 1,4,5-trisphosphate receptor, type 1b. (2724 aa)
LOC108235740Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a. (355 aa)
ENSKMAP00000027940Uncharacterized protein; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (637 aa)
LOC108248470RAS related. (197 aa)
klf2Kruppel-like factor 2b. (384 aa)
gnb5Guanine nucleotide binding protein (G protein), beta 5a. (361 aa)
gnb4Guanine nucleotide binding protein (G protein), beta polypeptide 4b. (340 aa)
gabarapGABA(A) receptor-associated protein b. (122 aa)
LOC108236972Ryanodine receptor 1a (skeletal). (5040 aa)
ryr3Ryanodine receptor 3. (4925 aa)
LOC108236875Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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