STRINGSTRING
rps6 rps6 LOC108238123 LOC108238123 exoc7 exoc7 socs2 socs2 LOC108230757 LOC108230757 LOC108248502 LOC108248502 calml4 calml4 LOC108228616 LOC108228616 rps6kb1 rps6kb1 inppl1 inppl1 mknk1 mknk1 LOC108228633 LOC108228633 LOC108250884 LOC108250884 LOC108239982 LOC108239982 pik3cb pik3cb phkb phkb LOC108233118 LOC108233118 LOC108231420 LOC108231420 pygb pygb LOC108244154 LOC108244154 prkar2b prkar2b map2k2 map2k2 LOC108238174 LOC108238174 LOC108248584 LOC108248584 calm1 calm1 prkaa2 prkaa2 LOC108239401 LOC108239401 ikbkb ikbkb KRAS KRAS pde3b pde3b PIK3CA PIK3CA mapk1 mapk1 LOC108246299 LOC108246299 foxo1 foxo1 LOC108240588 LOC108240588 gck gck phka1 phka1 eif4e2 eif4e2 LOC108236576 LOC108236576 LOC108238336 LOC108238336 mtor mtor LOC108234365 LOC108234365 PRKAB2 PRKAB2 LOC108242298 LOC108242298 LOC108246067 LOC108246067 g6pc g6pc ENSKMAP00000008344 ENSKMAP00000008344 LOC108232370 LOC108232370 LOC108241730 LOC108241730 ENSKMAP00000009134 ENSKMAP00000009134 LOC108250426 LOC108250426 ppp1cc ppp1cc bad bad LOC108240655 LOC108240655 g6pc3 g6pc3 LOC108245231 LOC108245231 LOC108245221 LOC108245221 PPP1R3D PPP1R3D LOC108235004 LOC108235004 LOC108247515 LOC108247515 LOC108238424 LOC108238424 LOC108237801 LOC108237801 LOC108244088 LOC108244088 LOC108248149 LOC108248149 prkaa1 prkaa1 LOC108235422 LOC108235422 prkar1a prkar1a LOC108242980 LOC108242980 LOC108241811 LOC108241811 phka2 phka2 gys1 gys1 LOC108245889 LOC108245889 LOC108245833 LOC108245833 socs3 socs3 LOC108246981 LOC108246981 LOC108243005 LOC108243005 ENSKMAP00000013862 ENSKMAP00000013862 LOC108236682 LOC108236682 LOC108249882 LOC108249882 prkacb prkacb LOC108247561 LOC108247561 ENSKMAP00000014416 ENSKMAP00000014416 braf braf LOC108245882 LOC108245882 LOC108234916 LOC108234916 gys2 gys2 LOC108237541 LOC108237541 rptor rptor phkg2 phkg2 pdpk1 pdpk1 LOC108245317 LOC108245317 flot2 flot2 LOC108236256 LOC108236256 Rhoq Rhoq LOC108239646 LOC108239646 LOC108241350 LOC108241350 crkl crkl raf1 raf1 LOC108232646 LOC108232646 mknk2 mknk2 prkar1b prkar1b SHC3 SHC3 ENSKMAP00000019936 ENSKMAP00000019936 LOC108246548 LOC108246548 cbl cbl G6PC2 G6PC2 LOC108239664 LOC108239664 pck1 pck1 akt1 akt1 acacb acacb phkg1 phkg1 ENSKMAP00000021560 ENSKMAP00000021560 LOC108244850 LOC108244850 pik3cd pik3cd trip10 trip10 fasn fasn LOC108241388 LOC108241388 LOC108241379 LOC108241379 LOC108248932 LOC108248932 LOC108237967 LOC108237967 pygl pygl LOC108242589 LOC108242589 LOC108238085 LOC108238085 socs1 socs1 eif4ebp1 eif4ebp1 LOC108249567 LOC108249567 tsc2 tsc2 prkaca prkaca LOC108245442 LOC108245442 prkag1 prkag1 LOC108235728 LOC108235728 map2k1 map2k1 LOC108246706 LOC108246706 PPP1CB PPP1CB srebf1 srebf1 LOC108234067 LOC108234067 LOC108232948 LOC108232948 LOC108237405 LOC108237405 LOC108237421 LOC108237421 SH2B2 SH2B2 socs4 socs4 LOC108232870 LOC108232870 LOC108247904 LOC108247904 LOC108242616 LOC108242616 ppp1r3a ppp1r3a gsk3b gsk3b irs2 irs2 insr insr prkci prkci LOC108237018 LOC108237018
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
rps640S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (249 aa)
LOC108238123Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (496 aa)
exoc7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (700 aa)
socs2Suppressor of cytokine signaling 2. (199 aa)
LOC108230757SHC (Src homology 2 domain containing) transforming protein 2. (738 aa)
LOC108248502Insulin receptor substrate 2a. (1038 aa)
calml4Calmodulin-like 4a. (153 aa)
LOC108228616Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family. (155 aa)
rps6kb1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (509 aa)
inppl1Inositol polyphosphate phosphatase-like 1a. (1257 aa)
mknk1MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (463 aa)
LOC108228633Protein phosphatase 1 regulatory subunit. (295 aa)
LOC108250884Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (728 aa)
LOC108239982HRas proto-oncogene, GTPase a. (189 aa)
pik3cbPhosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
phkbPhosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1088 aa)
LOC108233118Protein kinase, cAMP-dependent, regulatory, type II, alpha A. (391 aa)
LOC108231420Inositol polyphosphate phosphatase-like 1b. (1224 aa)
pygbAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (847 aa)
LOC108244154Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
prkar2bProtein kinase cAMP-dependent type II regulatory subunit beta. (404 aa)
map2k2Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
LOC108238174Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
LOC108248584Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
calm1Calmodulin 3a (phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
prkaa2Non-specific serine/threonine protein kinase. (557 aa)
LOC108239401Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ikbkbInhibitor of nuclear factor kappa B kinase subunit beta. (743 aa)
KRASGTPase KRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation. May play a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs). Belongs to the small GTPase superfamily. Ras family. (189 aa)
pde3bPhosphodiesterase. (1099 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
mapk1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (369 aa)
LOC108246299Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
foxo1Forkhead box O1 a. (667 aa)
LOC108240588Mitogen-activated protein kinase. (420 aa)
gckPhosphotransferase. (478 aa)
phka1Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1242 aa)
eif4e2Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (233 aa)
LOC108236576Inositol polyphosphate-5-phosphatase L. (395 aa)
LOC108238336Uncharacterized protein. (470 aa)
mtorSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2516 aa)
LOC108234365Uncharacterized protein. (426 aa)
PRKAB2Protein kinase AMP-activated non-catalytic subunit beta 2. (268 aa)
LOC108242298Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
LOC108246067Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (352 aa)
g6pcGlucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
ENSKMAP00000008344Uncharacterized protein. (247 aa)
LOC108232370Protein kinase, AMP-activated, gamma 3b non-catalytic subunit. (354 aa)
LOC108241730Eukaryotic translation initiation factor 4eb; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
ENSKMAP00000009134CBM21 domain-containing protein. (328 aa)
LOC108250426Suppressor of cytokine signaling 1b. (247 aa)
ppp1ccSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (323 aa)
badBCL2 associated agonist of cell death b. (166 aa)
LOC108240655Sorbin and SH3 domain containing 1. (1023 aa)
g6pc3Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (339 aa)
LOC108245231Si:ch211-284e13.4. (1169 aa)
LOC108245221Fork-head domain-containing protein. (629 aa)
PPP1R3DProtein phosphatase 1 regulatory subunit 3D. (318 aa)
LOC108235004Hexokinase 2. (921 aa)
LOC108247515Protein tyrosine phosphatase receptor type Fa. (1804 aa)
LOC108238424Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
LOC108237801Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (332 aa)
LOC108244088Thyroid hormone receptor interactor 10b. (503 aa)
LOC108248149V-crk avian sarcoma virus CT10 oncogene homolog. (307 aa)
prkaa1Non-specific serine/threonine protein kinase. (573 aa)
LOC108235422Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
prkar1aProtein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b. (380 aa)
LOC108242980Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (408 aa)
LOC108241811Si:ch73-335l21.1. (1287 aa)
phka2Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. (1137 aa)
gys1Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (711 aa)
LOC108245889Fructose-1,6-bisphosphatase 1a; Belongs to the FBPase class 1 family. (339 aa)
LOC108245833Fructose-1,6-bisphosphatase 2; Belongs to the FBPase class 1 family. (337 aa)
socs3Suppressor of cytokine signaling 3. (228 aa)
LOC108246981CBM21 domain-containing protein. (1272 aa)
LOC108243005Zgc:55558. (187 aa)
ENSKMAP00000013862CBM21 domain-containing protein. (261 aa)
LOC108236682Eukaryotic translation initiation factor 4ea; Belongs to the eukaryotic initiation factor 4E family. (216 aa)
LOC108249882A-Raf proto-oncogene, serine/threonine kinase. (608 aa)
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
LOC108247561Uncharacterized protein. (456 aa)
ENSKMAP00000014416Suppressor of cytokine signaling 3a. (201 aa)
brafB-Raf proto-oncogene, serine/threonine kinase. (778 aa)
LOC108245882Uncharacterized protein. (717 aa)
LOC108234916Protein kinase, AMP-activated, beta 1 non-catalytic subunit, b. (265 aa)
gys2Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (705 aa)
LOC108237541Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
rptorRegulatory associated protein of MTOR, complex 1. (1332 aa)
phkg2Phosphorylase kinase, gamma 2 (testis); Belongs to the protein kinase superfamily. (390 aa)
pdpk13-phosphoinositide dependent protein kinase 1b. (560 aa)
LOC108245317Uncharacterized protein. (923 aa)
flot2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (444 aa)
LOC108236256Growth factor receptor-bound protein 2b. (224 aa)
RhoqUncharacterized protein. (149 aa)
LOC108239646Protein kinase, AMP-activated, gamma 2 non-catalytic subunit b. (543 aa)
LOC108241350Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
crklV-crk avian sarcoma virus CT10 oncogene homolog-like. (316 aa)
raf1Raf-1 proto-oncogene, serine/threonine kinase a. (677 aa)
LOC108232646Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
mknk2MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (491 aa)
prkar1bProtein kinase, cAMP-dependent, regulatory, type I, beta. (380 aa)
SHC3SHC adaptor protein 3. (671 aa)
ENSKMAP00000019936Protein phosphatase 1, regulatory subunit 3Da. (284 aa)
LOC108246548CRK proto-oncogene, adaptor protein. (310 aa)
cblCbl proto-oncogene, E3 ubiquitin protein ligase. (950 aa)
G6PC2Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (357 aa)
LOC108239664Uncharacterized protein; Belongs to the protein kinase superfamily. (349 aa)
pck1Phosphoenolpyruvate carboxykinase 1 (soluble). (636 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
acacbAcetyl-CoA carboxylase beta. (2420 aa)
phkg1Phosphorylase kinase, gamma 1a (muscle); Belongs to the protein kinase superfamily. (394 aa)
ENSKMAP00000021560Uncharacterized protein. (364 aa)
LOC108244850Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (723 aa)
pik3cdPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
trip10Thyroid hormone receptor interactor 10a. (592 aa)
fasnCoiled-coil domain containing 57. (2516 aa)
LOC108241388CBM21 domain-containing protein. (327 aa)
LOC108241379Protein kinase, AMP-activated, beta 1 non-catalytic subunit, a. (269 aa)
LOC108248932Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
LOC108237967Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (111 aa)
pyglAlpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (853 aa)
LOC108242589Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (337 aa)
LOC108238085Uncharacterized protein. (881 aa)
socs1Suppressor of cytokine signaling 1a. (215 aa)
eif4ebp1Uncharacterized protein. (119 aa)
LOC108249567Tyrosine-protein phosphatase non-receptor type. (435 aa)
tsc2TSC complex subunit 2. (1145 aa)
prkacaUncharacterized protein; Belongs to the protein kinase superfamily. (351 aa)
LOC108245442Phosphoenolpyruvate carboxykinase 2 (mitochondrial). (635 aa)
prkag1Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (356 aa)
LOC108235728Ras homolog, mTORC1 binding like 1. (184 aa)
map2k1Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (450 aa)
LOC108246706Protein kinase, AMP-activated, gamma 3a non-catalytic subunit. (337 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
srebf1Sterol regulatory element binding transcription factor 1. (1169 aa)
LOC108234067Mitogen-activated protein kinase. (411 aa)
LOC108232948Ras homolog, mTORC1 binding. (184 aa)
LOC108237405Hexokinase 1. (913 aa)
LOC108237421Hexokinase domain containing 1. (945 aa)
SH2B2SH2B adaptor protein 2. (692 aa)
socs4Suppressor of cytokine signaling 4. (392 aa)
LOC108232870Protein tyrosine phosphatase receptor type Fb. (1923 aa)
LOC108247904Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (325 aa)
LOC108242616Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (424 aa)
ppp1r3aCBM21 domain-containing protein. (1270 aa)
gsk3bGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
irs2Insulin receptor substrate 2b. (1136 aa)
insrTyrosine-protein kinase receptor. (1354 aa)
prkciProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (598 aa)
LOC108237018Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
Your Current Organism:
Kryptolebias marmoratus
NCBI taxonomy Id: 37003
Other names: K. marmoratus, Rivulus marmoratus, mangrove rivulus, matanzas rivulus
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