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ESFL3 ESFL3 BRI1 BRI1 EXPA8 EXPA8 CYP734A1 CYP734A1 CYP90B1 CYP90B1 DET2 DET2 ASK7 ASK7 ASK9 ASK9 CYP90A1 CYP90A1 PRE6 PRE6 BZR1 BZR1 BSK3 BSK3 BEE2 BEE2 CYP85A2 CYP85A2 BSK1 BSK1 BEH2 BEH2 CYP90D1 CYP90D1 PRE3 PRE3 BHLH49 BHLH49 BSK8 BSK8 RABA2D RABA2D BSK5 BSK5 PUB40 PUB40 PRE1 PRE1 CYP85A1 CYP85A1 BKI1 BKI1 BIM1 BIM1 PRE5 PRE5 BZR2 BZR2 BSU1 BSU1 CYP90C1 CYP90C1 SCPL24 SCPL24 BHLH150 BHLH150 BSL3 BSL3 PAR1 PAR1 IBH1 IBH1 HBI1 HBI1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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gene co-occurrence
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co-expression
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ESFL3EMBRYO SURROUNDING FACTOR 1-like protein 3. (88 aa)
BRI1Protein BRASSINOSTEROID INSENSITIVE 1; Receptor with a dual specificity kinase activity acting on both serine/threonine- and tyrosine-containing substrates. Regulates, in response to brassinosteroid binding, a signaling cascade involved in plant development, including expression of light- and stress-regulated genes, promotion of cell elongation, normal leaf and chloroplast senescence, and flowering. Binds brassinolide, and less effectively castasterone, but not 2,3,22,23-O-tetramethylbrassinolide or ecdysone. May be involved in a feedback regulation of brassinosteroid biosynthesis. Pho [...] (1196 aa)
EXPA8Expansin-A8; Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found (By similarity). Belongs to the expansin family. Expansin A subfamily. (253 aa)
CYP734A1Cytochrome P450 734A1; Cytochrome P450 involved in brassinosteroids (BRs) inactivation and regulation of BRs homeostasis. Inactivates the BRs castasterone and brassinolide through carbon 26 hydroxylation. Acts in association with CYP72C1 to inactivate BRs and modulate photomorphogenesis. (520 aa)
CYP90B1Cytochrome P450 90B1; Catalyzes the C22-alpha-hydroxylation step in brassinosteroids biosynthesis. Converts campestanol to 6- deoxocathasterone and 6-oxocampestanol to cathasterone. (513 aa)
DET2Steroid 5-alpha-reductase DET2; Involved in a reduction step in the biosynthesis of the plant steroid, brassinolide; acts at the second step in brassinolide biosynthesis in the 5alpha-reduction of (24R)- 24-methylcholest-4-en-3- one, which is further modified to form campestanol. Can use progesterone, testosterone, androstenedione and campestenone as substrate. (262 aa)
ASK7Shaggy-related protein kinase eta; Negative regulator in brassinosteroid signal transduction pathway important for plant growth. May be also involved in auxin signaling pathway. Phosphorylates and increases the degradation of BZR1 and BZR2/BES1 by the proteasome. Phosphorylates BHLH150, beet curly top virus C4 and tomato golden mosaic virus AC4 on threonine and serine residues. Upon brassinosteroid signaling, inhibits stomatal development by phosphorylating and inhibiting the MAPKK kinase YDA and the MAPK kinases MKK4 and MKK5. Phosphorylates BSK1, BSK3, BSK5, BSK6, BSK8 AND BSK11 in v [...] (380 aa)
ASK9Shaggy-related protein kinase iota; Phosphorylates BSK1, BSK3, BSK5, BSK6, BSK8 AND BSK11 in vitro. May mediate extracellular signals to regulate transcription in differentiating cells (By similarity). (407 aa)
CYP90A1Cytochrome P450 90A1. (472 aa)
PRE6Transcription factor PRE6; Atypical and probable non DNA-binding bHLH transcription factor that regulates light-mediated responses in day light conditions by binding and inhibiting the activity of the bHLH transcription factor HFR1, a critical regulator of light signaling and shade avoidance. Forms non-functional heterodimers with HFR1, causing liberation and activation of PIF4 from the transcriptionally inactive HFR1-PIF4 complex. (94 aa)
BZR1Protein BRASSINAZOLE-RESISTANT 1; Transcriptional repressor that binds to the brassinosteroid (BR) response element (BRRE) 5'-CGTG(T/C)G-3' in gene promoter. Regulates positively the brassinosteroid-signaling pathway. Mediates downstream growth responses and negative feedback regulation of brassinosteroid biosynthesis. Promotes growth. Modulates ovule initiation and development by monitoring the expression of genes related to ovule development (e.g. HLL, ANT, and AP2). (336 aa)
BSK3Serine/threonine-protein kinase BSK3; Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Mediates signal transduction from BRI1 by functioning as substrate of BRI1. Functions redundantly with BSK4, BSK6, BSK7 and BSK8. (489 aa)
BEE2Transcription factor BEE 2; Positive regulator of brassinosteroid signaling. (304 aa)
CYP85A2Cytochrome P450 85A2; Catalyzes the C6-oxidation step in brassinosteroids biosynthesis. Converts 6-deoxocastasterone to castasterone, and castasterone to brassinolide. May also convert 6-deoxoteasterone to teasterone, 3-dehydro-6-deoxoteasterone to 3-dehydroteasterone, and 6- deoxotyphasterol to typhasterol; Belongs to the cytochrome P450 family. (465 aa)
BSK1Serine/threonine-protein kinase BSK1; Serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Mediates signal transduction from BRI1 by functioning as substrate of BRI1. Functions as a positive regulator of plant immunity. May be involved in the regulation of pattern-triggered immunity (PTI) downstream of the flagellin receptor FLS2. Possesses kinase activity in vitro. Kinase activity is required for its function in innate immunity. (512 aa)
BEH2BES1/BZR1 homolog protein 2. (318 aa)
CYP90D13-epi-6-deoxocathasterone 23-monooxygenase CYP90D1; Involved in brassinosteroid (BR) biosynthesis. May convert teasterone to 3- dehydroteasterone, or 6-deoxoteasterone to 3-dehydro-6-deoxoteasterone. C-23 hydroxylase that converts directly (22S,24R)- 22-hydroxy-5-alpha-ergostan-3-one and 3-epi-6-deoxocathasterone to 3- dehydro-6-deoxoteasterone and 6-deoxotyphasterol, respectively. These C-23 hydroxylation shortcuts bypass campestanol, 6-deoxocathasterone, and 6-deoxoteasterone. (491 aa)
PRE3Transcription factor PRE3; Atypical and probable non DNA-binding bHLH transcription factor required for MONOPTEROS-dependent root initiation in embryo. Promotes the correct definition of the hypophysis cell division plane. Transcriptionally controlled by MONOPTEROS. Moves from its site of synthesis in pro-embryos cells into the hypophysis. Regulates brassinosteroid (BR) signaling by sequestering negative BR signaling components. May function as positive regulator of gibberellin signaling. May play a role in the regulation of light signaling and possibly auxin signaling. (93 aa)
BHLH49Transcription factor bHLH49; Transcriptional activator involved in cell elongation. Regulates the expression of a subset of genes involved in cell expansion by binding to the G-box motif. (486 aa)
BSK8Serine/threonine-protein kinase BSK8; Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Functions redundantly with BSK3, BSK4, BSK6 and BSK7. Involved in the regulation of sucrose-phosphate synthase 1 (SPS1) in the context of sucrose resuply after starvation. Activates BSL2, a phosphatase that may dephosphorylate SPS1, leading to the activation of SPS1 ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (487 aa)
RABA2DRas-related protein RABA2d; Intracellular vesicle trafficking and protein transport. (217 aa)
BSK5Serine/threonine-protein kinase BSK5; Probable serine/threonine kinase that acts as positive regulator of brassinosteroid (BR) signaling downstream of the receptor kinase BRI1. Involved in abiotic stress tolerance. Required for salt stress and abscisic acid-mediated drought stress tolerance. (489 aa)
PUB40U-box domain-containing protein 40; Functions as an E3 ubiquitin ligase. (550 aa)
PRE1Transcription factor PRE1; Atypical and probable non DNA-binding bHLH transcription factor that integrates multiple signaling pathways to regulate cell elongation and plant development. Binds IBH1, forming a pair of antagonistic bHLH transcription factors that function downstream of BZR1 to mediate brassinosteroid regulation of cell elongation. Regulates light responses by binding and inhibiting the activity of the bHLH transcription factor HFR1, a critical regulator of light signaling and shade avoidance. May have a regulatory role in various aspects of gibberellin-dependent growth an [...] (92 aa)
CYP85A1Cytochrome P450 85A1; Catalyzes the C6-oxidation step in brassinosteroids biosynthesis. Converts 6-deoxocastasterone to castasterone. May also convert 6-deoxoteasterone to teasterone, 3-dehydro-6-deoxoteasterone to 3-dehydroteasterone, and 6-deoxotyphasterol to typhasterol. (465 aa)
BKI1BRI1 kinase inhibitor 1; Negative regulator of brassinosteroid signaling. When associated to the membrane, limits the interaction of BRI1 with BAK1 by binding to the kinase-inactive form of BRI1. (337 aa)
BIM1Transcription factor BIM1; Positive brassinosteroid-signaling protein. Transcription factor that bind specifically to the DNA sequence 5'-CANNTG-3'(E box). Can bind individually to the promoter as a homodimer or synergistically as a heterodimer with BZR2/BES1. Does not itself activate transcription but enhances BZR2/BES1-mediated target gene activation. (529 aa)
PRE5Transcription factor PRE5; Atypical and probable non DNA-binding bHLH transcription factor that integrates multiple signaling pathways to regulate cell elongation and plant development. May have a regulatory role in various aspects of gibberellin-dependent growth and development. (92 aa)
BZR2Protein BRASSINAZOLE-RESISTANT 2; Positive regulator of brassinosteroid (BR) signaling. Transcription factor that activates target gene expression by binding specifically to the DNA sequence 5'-CANNTG-3'(E box) through its N- terminal domain. Can bind individually to the promoter as a homodimer or synergistically as a heterodimer with BIM1, BIM2 or BIM3. The C- terminal domain is probably involved in transcriptional activation. Recruits the transcription elongation factor IWS1 to control BR- regulated gene expression. Forms a trimeric complex with IWS1 and ASHH2/SDG8 to regulate BR-reg [...] (335 aa)
BSU1Serine/threonine-protein phosphatase BSU1; Phosphatase that acts as a positive regulator of brassinosteroid (BR) signaling. Dephosphorylates BES1, a transcription factor that regulates the expression of BR-response genes, thereby playing an important role in the regulation of response to BRs. Inactivates the negative regulator of BR signaling ASK7/BIN2 by dephosphorylation at 'Tyr-200'. (793 aa)
CYP90C13-epi-6-deoxocathasterone 23-monooxygenase CYP90C1; Involved in brassinosteroid (BR) biosynthesis. Converts typhasterol to castasterone and 6-deoxotyphasterol to 6-deoxocastasterone. C-23 hydroxylase that converts directly (22S,24R)- 22-hydroxy-5-alpha-ergostan-3-one and 3-epi-6-deoxocathasterone to 3- dehydro-6-deoxoteasterone and 6-deoxotyphasterol, respectively. These C-23 hydroxylation shortcuts bypass campestanol, 6-deoxocathasterone, and 6-deoxoteasterone. Required for the regulation of polar elongation of leaf cells. Required for the longitudinal elongation of floral organs. (524 aa)
SCPL24Serine carboxypeptidase 24 chain A; Active serine carboxypeptidase with broad substrate preference, including basic and hydrophilic groups. Processes a protein involved in an early event in the brassinosteroid signaling pathway. (465 aa)
BHLH150Transcription factor bHLH150; Atypical bHLH transcription factor probably unable to bind DNA. Negatively regulates brassinosteroid signaling. (211 aa)
BSL3Serine/threonine-protein phosphatase BSL3; Phosphatase involved in elongation process, probably by acting as a regulator of brassinolide signaling. (1006 aa)
PAR1Transcription factor PAR1; Atypical bHLH transcription factor that acts as negative regulator of a variety of shade avoidance syndrome (SAS) responses, including seedling elongation and photosynthetic pigment accumulation. Acts as direct transcriptional repressor of two auxin-responsive genes, SAUR15 and SAUR68. May function in integrating shade and hormone transcriptional networks in response to light and auxin changes. (118 aa)
IBH1Transcription factor IBH1; Atypical and probable non DNA-binding bHLH transcription factor that acts as transcriptional repressor that negatively regulates cell and organ elongation in response to gibberellin (GA) and brassinosteroid (BR) signaling. Is able to form heterodimer with BHLH49, thus inhibiting DNA binding of BHLH49, which is a transcriptional activator that regulates the expression of a subset of genes involved in cell expansion by binding to the G-box motif. Binds and inhibits HBI1, a positive regulator of cell elongation that directly binds to the promoters and activated [...] (156 aa)
HBI1Transcription factor HBI1; Atypical bHLH transcription factor that acts as positive regulator of cell elongation downstream of multiple external and endogenous signals by direct binding to the promoters and activation of the two expansin genes EXPA1 and EXPA8, encoding cell wall loosening enzymes. Transcriptional activity is inhibited when binding to the bHLH transcription factor IBH1. (337 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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