node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CMT2 | DDM1 | Q94F87 | Q9XFH4 | DNA (cytosine-5)-methyltransferase CMT2; May be involved in the CpXpG methylation and in gene silencing. | ATP-dependent DNA helicase DDM1; ATP-dependent DNA helicase that plays a role in formation, organization, stability and heritability of heterochromatin and thus regulates several physiological traits. Binds to the nucleosome and promotes chromatin remodeling in an ATP-dependent manner; induces nucleosome repositioning on a short DNA fragment, and, possibly, could be guided to target sites (including silent transposable elements) by small interfering RNAs (siRNAs). Can bind both free and nucleosomal DNA. Required for the heritable maintenance of genome integrity and transcriptional gene [...] | 0.982 |
CMT2 | DML2 | Q94F87 | Q9SR66 | DNA (cytosine-5)-methyltransferase CMT2; May be involved in the CpXpG methylation and in gene silencing. | DEMETER-like protein 2; Potential transcriptional activator that may act by nicking the target promoter. Catalyzes the release of 5-methylcytosine (5-meC) from DNA by a glycosylase/lyase mechanism (By similarity). | 0.899 |
CMT2 | DMT1 | Q94F87 | P34881 | DNA (cytosine-5)-methyltransferase CMT2; May be involved in the CpXpG methylation and in gene silencing. | DNA (cytosine-5)-methyltransferase 1; Maintains chromatin CpG methylation that plays a role in genomic imprinting, regulation of embryogenesis and seed viability. Required for proper patterns of CG DNA methylation in dividing cells. Required for MEA promoter methylation in seeds. | 0.547 |
CMT2 | DRM2 | Q94F87 | Q9M548 | DNA (cytosine-5)-methyltransferase CMT2; May be involved in the CpXpG methylation and in gene silencing. | DNA (cytosine-5)-methyltransferase DRM2; Involved in de novo DNA methylation. Controls asymmetric and CpNpG methylation. Required for FWA gene silencing but not for the maintenance of SUP gene silencing. Functionally redundant to CMT3 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation (RdDM). Acts as major DNA methyltransferase in the RdDM pathway, and is essential for RNA-directed de novo DNA methylation of cytosines in all sequence contexts. Associates with long non- coding RNA (lncRNA) produced by RNA polymerase V (Pol V). This association is dependent on AGO4 [...] | 0.933 |
CMT2 | HTR4 | Q94F87 | P59169 | DNA (cytosine-5)-methyltransferase CMT2; May be involved in the CpXpG methylation and in gene silencing. | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] | 0.835 |
CMT2 | MGH3 | Q94F87 | Q9FXI7 | DNA (cytosine-5)-methyltransferase CMT2; May be involved in the CpXpG methylation and in gene silencing. | Histone H3-like 2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). | 0.835 |
CMT2 | MOM1 | Q94F87 | Q9M658 | DNA (cytosine-5)-methyltransferase CMT2; May be involved in the CpXpG methylation and in gene silencing. | Helicase protein MOM1; Required for the heritable maintenance of transcriptional gene silencing (TGS) in heterochromatin, and particularly in the intermediate bivalent heterochromatin, characterized by an unsual methylation pattern consisting in hypermethylated DNA and histone H3 'Lys-4' methylation (H3K4me) together with depletion of histone H3 'Lys-9' methylation (H3K9me), in a chromatin methylation-independent manner, in a non-CG methylation context. May play a role in the RNA polymerase IV/V (Pol-IV/V)-mediated RNA-directed DNA methylation (RdDM) leading to TGS (also called siRNA-m [...] | 0.740 |
CMT2 | SUVH4 | Q94F87 | Q8GZB6 | DNA (cytosine-5)-methyltransferase CMT2; May be involved in the CpXpG methylation and in gene silencing. | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4; Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. The silencing mechanism via DNA CpNpG methylation requires the targeting of chromomethylase CMT3 to methylated histones, probably through an interaction with an HP1-like adapter. By its function, KYP is directly required for the maintenance of the DNA CpNpG and asymmetric methylation. Involved in the silencing of transposable elements. Belongs to the class V-like SAM-bindi [...] | 0.930 |
CMT2 | SUVH5 | Q94F87 | O82175 | DNA (cytosine-5)-methyltransferase CMT2; May be involved in the CpXpG methylation and in gene silencing. | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5; Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. | 0.919 |
CMT2 | SUVH6 | Q94F87 | Q8VZ17 | DNA (cytosine-5)-methyltransferase CMT2; May be involved in the CpXpG methylation and in gene silencing. | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6; Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Seems to act preferentially on dsMRNA. | 0.917 |
CMT3 | DDM1 | Q94F88 | Q9XFH4 | DNA (cytosine-5)-methyltransferase CMT3; Involved in the CpXpG methylation and in gene silencing. Methylates preferentially transposon-related sequences. Functionally redundant to DRM1/DRM2 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | ATP-dependent DNA helicase DDM1; ATP-dependent DNA helicase that plays a role in formation, organization, stability and heritability of heterochromatin and thus regulates several physiological traits. Binds to the nucleosome and promotes chromatin remodeling in an ATP-dependent manner; induces nucleosome repositioning on a short DNA fragment, and, possibly, could be guided to target sites (including silent transposable elements) by small interfering RNAs (siRNAs). Can bind both free and nucleosomal DNA. Required for the heritable maintenance of genome integrity and transcriptional gene [...] | 0.938 |
CMT3 | DML2 | Q94F88 | Q9SR66 | DNA (cytosine-5)-methyltransferase CMT3; Involved in the CpXpG methylation and in gene silencing. Methylates preferentially transposon-related sequences. Functionally redundant to DRM1/DRM2 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | DEMETER-like protein 2; Potential transcriptional activator that may act by nicking the target promoter. Catalyzes the release of 5-methylcytosine (5-meC) from DNA by a glycosylase/lyase mechanism (By similarity). | 0.927 |
CMT3 | DMT1 | Q94F88 | P34881 | DNA (cytosine-5)-methyltransferase CMT3; Involved in the CpXpG methylation and in gene silencing. Methylates preferentially transposon-related sequences. Functionally redundant to DRM1/DRM2 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | DNA (cytosine-5)-methyltransferase 1; Maintains chromatin CpG methylation that plays a role in genomic imprinting, regulation of embryogenesis and seed viability. Required for proper patterns of CG DNA methylation in dividing cells. Required for MEA promoter methylation in seeds. | 0.639 |
CMT3 | DRM2 | Q94F88 | Q9M548 | DNA (cytosine-5)-methyltransferase CMT3; Involved in the CpXpG methylation and in gene silencing. Methylates preferentially transposon-related sequences. Functionally redundant to DRM1/DRM2 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | DNA (cytosine-5)-methyltransferase DRM2; Involved in de novo DNA methylation. Controls asymmetric and CpNpG methylation. Required for FWA gene silencing but not for the maintenance of SUP gene silencing. Functionally redundant to CMT3 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation (RdDM). Acts as major DNA methyltransferase in the RdDM pathway, and is essential for RNA-directed de novo DNA methylation of cytosines in all sequence contexts. Associates with long non- coding RNA (lncRNA) produced by RNA polymerase V (Pol V). This association is dependent on AGO4 [...] | 0.963 |
CMT3 | HTR4 | Q94F88 | P59169 | DNA (cytosine-5)-methyltransferase CMT3; Involved in the CpXpG methylation and in gene silencing. Methylates preferentially transposon-related sequences. Functionally redundant to DRM1/DRM2 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Histone H3.3; Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in [...] | 0.977 |
CMT3 | MGH3 | Q94F88 | Q9FXI7 | DNA (cytosine-5)-methyltransferase CMT3; Involved in the CpXpG methylation and in gene silencing. Methylates preferentially transposon-related sequences. Functionally redundant to DRM1/DRM2 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Histone H3-like 2; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). | 0.980 |
CMT3 | MOM1 | Q94F88 | Q9M658 | DNA (cytosine-5)-methyltransferase CMT3; Involved in the CpXpG methylation and in gene silencing. Methylates preferentially transposon-related sequences. Functionally redundant to DRM1/DRM2 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Helicase protein MOM1; Required for the heritable maintenance of transcriptional gene silencing (TGS) in heterochromatin, and particularly in the intermediate bivalent heterochromatin, characterized by an unsual methylation pattern consisting in hypermethylated DNA and histone H3 'Lys-4' methylation (H3K4me) together with depletion of histone H3 'Lys-9' methylation (H3K9me), in a chromatin methylation-independent manner, in a non-CG methylation context. May play a role in the RNA polymerase IV/V (Pol-IV/V)-mediated RNA-directed DNA methylation (RdDM) leading to TGS (also called siRNA-m [...] | 0.822 |
CMT3 | SUVH4 | Q94F88 | Q8GZB6 | DNA (cytosine-5)-methyltransferase CMT3; Involved in the CpXpG methylation and in gene silencing. Methylates preferentially transposon-related sequences. Functionally redundant to DRM1/DRM2 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4; Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. The silencing mechanism via DNA CpNpG methylation requires the targeting of chromomethylase CMT3 to methylated histones, probably through an interaction with an HP1-like adapter. By its function, KYP is directly required for the maintenance of the DNA CpNpG and asymmetric methylation. Involved in the silencing of transposable elements. Belongs to the class V-like SAM-bindi [...] | 0.979 |
CMT3 | SUVH5 | Q94F88 | O82175 | DNA (cytosine-5)-methyltransferase CMT3; Involved in the CpXpG methylation and in gene silencing. Methylates preferentially transposon-related sequences. Functionally redundant to DRM1/DRM2 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH5; Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. | 0.929 |
CMT3 | SUVH6 | Q94F88 | Q8VZ17 | DNA (cytosine-5)-methyltransferase CMT3; Involved in the CpXpG methylation and in gene silencing. Methylates preferentially transposon-related sequences. Functionally redundant to DRM1/DRM2 to maintain non-CpG methylation. Involved in RNA-directed DNA methylation. Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH6; Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Seems to act preferentially on dsMRNA. | 0.955 |