STRINGSTRING
F25P22.24 F25P22.24 A0A1P8BFS0 A0A1P8BFS0 CPSF30 CPSF30 MQL5.29 MQL5.29 T22C5.3 T22C5.3 F1O11.23 F1O11.23 FIPS3 FIPS3 T28J14.110 T28J14.110 F4K773_ARATH F4K773_ARATH T20K14.120 T20K14.120 FIPS5 FIPS5 F4I18.32 F4I18.32 PAPS2 PAPS2 PCFS4 PCFS4 F16J13.60 F16J13.60 F7H19.40 F7H19.40 PAPS3 PAPS3 MMI9.7 MMI9.7 TEL3N.1 TEL3N.1 FY FY RNJ RNJ CSTF77 CSTF77 CFIS2 CFIS2 CSTF50 CSTF50 K1L20.2 K1L20.2 PAPS4 PAPS4 PABN1 PABN1 CFIS1 CFIS1 PCFS1 PCFS1 CPSF73-I CPSF73-I CPSF160 CPSF160 PCFS5 PCFS5 PABN2 PABN2 K9L2.2 K9L2.2 CLPS5 CLPS5 CPSF100 CPSF100 PAPS1 PAPS1 EMB1789 EMB1789 PABN3 PABN3 APRF1 APRF1 ESP4 ESP4 CSTF64 CSTF64 CLPS3 CLPS3 T24C20_60 T24C20_60
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F25P22.24Ssu72-like family protein. (209 aa)
A0A1P8BFS0Transmembrane protein. (189 aa)
CPSF3030-kDa cleavage and polyadenylation specificity factor 30; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation. May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Mediates poly(A) site selection. Binds RNA in a calcium- dependent manner. Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3' ends with hydroxyl groups, thus mediating processing of the pre-mRNA as a pre [...] (631 aa)
MQL5.29E3 ubiquitin ligase PQT3-like. (892 aa)
T22C5.3Symplekin. (1325 aa)
F1O11.23Pre-mRNA cleavage complex 2 Pcf11-like protein. (963 aa)
FIPS3FIP1[III]-like protein; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. (997 aa)
T28J14.110Cell cycle regulated microtubule associated protein. (363 aa)
F4K773_ARATHTPX2 (Targeting protein for Xklp2) protein family. (178 aa)
T20K14.120TPX2 (Targeting protein for Xklp2) protein family. (519 aa)
FIPS5FIP1[V]-like protein; Essential gene. Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U- rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex (By similarity). (1196 aa)
F4I18.32Sterile alpha motif (SAM) domain-containing protein. (723 aa)
PAPS2Nuclear poly(A) polymerase 2; Essential protein. Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus (By similarity). Mediates the polyadenylation of RNAs that are associated with polynucleotide phosphorylase (e.g. PNP1). (800 aa)
PCFS4Polyadenylation and cleavage factor homolog 4; Promotes flowering by suppressing FLC-mediated inhibition of flowering through the regulation of FCA pre-mRNA alternative processing. Regulates mRNA maturation including alternative polyadenylation, splicing or transcription initiation of stress- associated genes. (808 aa)
F16J13.60Cell cycle regulated microtubule associated protein. (501 aa)
F7H19.40Cell cycle regulated microtubule associated protein. (509 aa)
PAPS3Nuclear poly(A) polymerase 3; Essential protein. Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus (By similarity). (507 aa)
MMI9.7Cell cycle regulated microtubule associated protein. (377 aa)
TEL3N.1TPX2 (Targeting protein for Xklp2) protein family. (488 aa)
FYFlowering time control protein FY; Plays a role in the regulation of flowering time in the autonomous flowering pathway by decreasing FLOWERING LOCUS C mRNA levels. Required for the negative autoregulation of FCA expression. Acts probably as an RNA 3' end-processing factor. Required for growth and development in plants. (647 aa)
RNJRibonuclease J; Essential protein required during embryogenesis, especially in initiating and maintaining the organization of shoot apical meristems (SAMs), cotyledons, and hypocotyls. Involved in auxin-mediated pathways during embryogenesis. RNase that has both endonuclease and 5'-3' exonuclease activities. Involved in RNA surveillance to prevent overaccumulation of antisense RNA. Probably involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay (By similarity). Belongs to the metallo-beta-lactamase superfamily. RNA- metabolizing metallo-beta-lactamase-li [...] (911 aa)
CSTF77Cleavage stimulation factor subunit 77; One of the multiple factors required for polyadenylation and 3'-end cleavage of pre-mRNAs (By similarity). Required for the targeted 3' processing of antisense transcripts that triggers transcriptional silencing of the corresponding sense gene. (734 aa)
CFIS2Pre-mRNA cleavage factor Im 25 kDa subunit 2; Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export; Belongs to the Nudix hydrolase family. CPSF5 subfamily. (200 aa)
CSTF50Cleavage stimulation factor subunit 50; One of the multiple factors required for polyadenylation and 3'-end cleavage of pre-mRNAs. May be responsible for the interaction of CSTF with other factors to form a stable complex on the pre-mRNA. (429 aa)
K1L20.2Transducin/WD40 repeat-like superfamily protein. (331 aa)
PAPS4Nuclear poly(A) polymerase 4; Essential protein. Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus (By similarity). (741 aa)
PABN1Polyadenylate-binding protein 1; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. (227 aa)
CFIS1Pre-mRNA cleavage factor Im 25 kDa subunit 1; Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export; Belongs to the Nudix hydrolase family. CPSF5 subfamily. (222 aa)
PCFS1Polyadenylation and cleavage factor homolog 1. (416 aa)
CPSF73-ICleavage and polyadenylation specificity factor subunit 3-I; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. May function as mRNA 3'-end-processing endonuclease and also be involved in the histone 3'-end pre-mRNA processing. (693 aa)
CPSF160Cleavage and polyadenylation specificity factor subunit 1; CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction; Belongs to the CPSF1 family. (1442 aa)
PCFS5Polyadenylation and cleavage factor homolog 5. (410 aa)
PABN2Polyadenylate-binding protein 2; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. (220 aa)
K9L2.2TPX2 (Targeting protein for Xklp2) protein family. (309 aa)
CLPS5Protein CLP1 homolog 5; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation. (424 aa)
CPSF100Cleavage and polyadenylation specificity factor subunit 2; CPSF plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A)polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Required for antisense-RNA-mediated gene silencing. (739 aa)
PAPS1Nuclear poly(A) polymerase 1; Essential protein. Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus (By similarity). (713 aa)
EMB1789Zinc finger CCCH domain-containing protein 65; Possesses RNA-binding and ribonuclease activities in vitro. (675 aa)
PABN3Polyadenylate-binding protein 3; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. (217 aa)
APRF1Protein ANTHESIS POMOTING FACTOR 1; Component of a chromatin regulatory complex involved in regulating chromatin structure in the nucleus (By similarity). Promotes flowering under long days (LD) via the regulation of bolting. (330 aa)
ESP4HEAT repeat-containing protein. (1467 aa)
CSTF64Cleavage stimulating factor 64; One of the multiple factors required for polyadenylation and 3'-end cleavage of pre-mRNAs (By similarity). This subunit is directly involved in the binding to pre-mRNAs, especially on the 3' non-coding region. Required for the targeted 3' processing of antisense transcripts that triggers transcriptional silencing of the corresponding sense gene. (461 aa)
CLPS3Protein CLP1 homolog; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation (By similarity). Functions in gametophyte, embryo and postembryotic development. Belongs to the Clp1 family. Clp1 subfamily. (444 aa)
T24C20_60CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase. (77 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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