STRINGSTRING
ELM2 ELM2 C7A10.170 C7A10.170 TIC20-II TIC20-II FTSZ2-1 FTSZ2-1 TOM20-1 TOM20-1 FZL FZL FTSZ1 FTSZ1 ARC3 ARC3 ARC5 ARC5 MCD1 MCD1 YUP8H12.12 YUP8H12.12 DRP3B DRP3B MBL20.6 MBL20.6 Dl4805W Dl4805W MIRO1 MIRO1 DRP3A DRP3A CDP1 CDP1 ELM1 ELM1 MINE1 MINE1 F28P5.9 F28P5.9 CRL CRL ARC6 ARC6 PDV1 PDV1 T31P16.70 T31P16.70 FTSZ2-2 FTSZ2-2 PMD1 PMD1 FIS1A FIS1A MIRO3 MIRO3 MIND1 MIND1 PMD2 PMD2 GC1-3 GC1-3 PCR12 PCR12 PDV2 PDV2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
ELM2ELM2 domain-containing protein. (434 aa)
C7A10.170Plasma membrane, autoregulation-binding site, misato segment II, myosin-like, tubulin/FtsZ protein. (562 aa)
TIC20-IIProtein TIC 20-II, chloroplastic; May be involved in protein precursor import into chloroplasts. Not redundant with TIC20-I, TIC20-IV or TIC20-V; Belongs to the Tic20 family. (208 aa)
FTSZ2-1Cell division protein FtsZ homolog 2-1, chloroplastic; Exhibits GTPase activity. Component of the plastid division machinery that forms a contractile ring at the division site. Required for plastid division in a dose-dependent manner. Belongs to the FtsZ family. (478 aa)
TOM20-1Mitochondrial import receptor subunit TOM20-1; Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the translocation pore. Belongs to the Tom20 family. (188 aa)
FZLProbable transmembrane GTPase FZO-like, chloroplastic; Probable membrane-remodeling GTPase that plays a unique role in the in the determination of thylakoid and chloroplast morphology and regulates organization of the thylakoid network. Not involved in the determination of mitochondrial morphology or ultrastructure. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. Mitofusin subfamily. (912 aa)
FTSZ1Cell division protein FtsZ homolog 1, chloroplastic; Exhibits GTPase activity. Component of the plastid division machinery that forms a contractile ring at the division site. Required for plastid division in a dose-dependent manner. Involved in blue light-induced chloroplast movements. May regulate thylakoid development. Belongs to the FtsZ family. (433 aa)
ARC3Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 3; Z-ring accessory protein involved in the initiation of plastid division and division site placement (might functionally replace bacterial MinC). May control the rate of chloroplast expansion. Seems to influence stromule (stroma-filled tubular extensions of the plastid envelope membrane) length and frequency. (741 aa)
ARC5Dynamin-like protein ARC5; Probable GTPase component of both plastid and peroxisme division machinery. Required for the last steps of plastid division specifically in mesophyll-cell, when the narrow isthmus breaks, facilitating the separation of the daughter plastids. Necessary for peroxisome activities. Seems to influence stromule (stroma-filled tubular extensions of the plastid envelope membrane) length and frequency. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (777 aa)
MCD1Protein MULTIPLE CHLOROPLAST DIVISION SITE 1; Required for chloroplast division. Regulates FtsZ ring positioning in chloroplasts. Determines the site of chloroplast division in concert with MIND1. Not directly involved in ring formation, but probably required for MIND1 localization to regulate FtsZ ring formation. (349 aa)
YUP8H12.12TraB family protein. (371 aa)
DRP3BDynamin-related protein 3B; Involved in the control of mitochondrial and peroxisomal division and morphology. (780 aa)
MBL20.6Fission ELM1-like protein (DUF1022). (404 aa)
Dl4805WDynamin. (294 aa)
MIRO1Mitochondrial Rho GTPase 1; Mitochondrial GTPase required to maintain proper development, morphology and intracellular distribution of mitochondria, which in turn are essential for the progress of embryonic cell division, development of haploid male and female gametes, and pollen tube growth. (648 aa)
DRP3ADynamin-related protein 3A; Involved in the control of mitochondrial and peroxisomal division and morphology. In association with PEX11C, PEX11D, PEX11E and FIS1B, is involved in cell cycle-associated constitutive self- replication of preexisting peroxisomes. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (808 aa)
CDP1Plastid division protein CDP1, chloroplastic; Component of the plastid division machinery required for PDV1 localization to constriction sites. Involved in chloroplast division site placement. Seems to inhibit FtsZ assembly, functioning as an antagonistic regulator of FtsZ dynamics against ARC6. (819 aa)
ELM1Mitochondrial fission protein ELM1; Plant-specific factor involved in mitochondria fission. Is required for the correct localization of DRP3A from the cytosol to mitochondrial fission sites. Does not seem to be required for peroxisomal division. (427 aa)
MINE1Cell division topological specificity factor homolog, chloroplastic; Acts as a topological specificity factor during plastid division and specify plastid constriction sites. May contribute to gravitropism in stems and hypocotyls. Stimulates MIND1 ATPase activity. In cooperation with MIND1, prevents FtsZ ring formation anywhere outside of the mid-plastids. Belongs to the MinE family. (229 aa)
F28P5.9TonB-dependent heme receptor A. (97 aa)
CRLChromophore lyase CRL, chloroplastic; Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity). Required for plastid division, and involved in cell differentiation and regulation of the cell division plane. Maintenance of plastid homeostasis controls plant preconditioning to stress and stress acclimation. Belongs to the CpcT/CpeT biliprotein lyase family. (269 aa)
ARC6Protein ACCUMULATION AND REPLICATION OF CHLOROPLASTS 6, chloroplastic; Component of the plastid division machinery. Involved in the initiation of proplastid and plastid division (including chloroplasts, statoliths and leukoplasts). Promotes the assembly and/or stabilization of the plastid-dividing FtsZ ring, functioning as an antagonistic regulator of FtsZ dynamics against CDP1. Relays plastid division site position between stroma and outer surface via interactions with the stromal FtsZ ring and the outer membrane PDV2 that recruits cytoplasmic ARC5 ring. Required for plastid equatoria [...] (801 aa)
PDV1Plastid division protein PDV1; Component of the plastid division machinery. Required to mediate the recruitment of ARC5 at the midplastid constriction site in the cytoplasm. (272 aa)
T31P16.70Aspartic proteinase-like protein 1. (528 aa)
FTSZ2-2Cell division protein FtsZ homolog 2-2, chloroplastic; Exhibits GTPase activity (By similarity). Component of the plastid division machinery that forms a contractile ring at the division site. (473 aa)
PMD1Peroxisomal and mitochondrial division factor 1; Involved in morphogenesis and proliferation of peroxisomes and mitochondria, independently from the previously defined pathway controlled by the FIS1-DRP3 complex. (318 aa)
FIS1AMitochondrial fission 1 protein A; Component of the peroxisomal and mitochondrial division machineries. Plays a role in promoting the fission of mitochondria and peroxisomes; Belongs to the FIS1 family. (170 aa)
MIRO3Mitochondrial Rho GTPase 3; Mitochondrial GTPase that may be involved in mitochondrion development; Belongs to the mitochondrial Rho GTPase family. (648 aa)
MIND1Putative septum site-determining protein minD homolog, chloroplastic; Calcium-dependent ATPase required for the correct placement of the plastid division site. Inhibits FtsZ filament and ring formation in the plastid. Mediates inhibition of plastid division. In cooperation with MINE1, prevents FtsZ ring formation anywhere outside of the mid- plastids. Belongs to the ParA family. MinD subfamily. (326 aa)
PMD2Peroxisomal and mitochondrial division factor 2; Involved in morphogenesis and proliferation of mitochondria. Does not act redundantly with PMD1. Is not involved in peroxisomal proliferation. (323 aa)
GC1-3Epimerase family protein SDR39U1 homolog, chloroplastic; Putative NADP-dependent oxidoreductase that acts as positive regulator of chloroplast division. May play a role at an early stage of the division process. (347 aa)
PCR12Protein PLANT CADMIUM RESISTANCE 12; May be involved in heavy metals transport; Belongs to the cornifelin family. (161 aa)
PDV2Plastid division protein PDV2; Component of the plastid division machinery. Required to mediate the recruitment of ARC5 at the midplastid constriction site in the cytoplasm. Relays plastid division site position between stroma and outer surface via interactions with the cytoplasmic ARC5 and the inner membrane ARC6 that recruits stromal FtsZ ring. (307 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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