STRINGSTRING
FH2 FH2 FH3 FH3 ADF9 ADF9 VLN1 VLN1 PRF5 PRF5 ADF1 ADF1 PRF2 PRF2 PRF1 PRF1 ADF7 ADF7 ACT8 ACT8 PRF3 PRF3 FIM5 FIM5 VLN5 VLN5 ADF11 ADF11 ADF5 ADF5 ADF3 ADF3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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FH2Formin-like protein 2; Might be involved in the organization and polarity of the actin cytoskeleton; Belongs to the formin-like family. Class-I subfamily. (894 aa)
FH3Formin-like protein 3; Acts as actin nucleation factor that directs the formation of actin cables and polarized growth in pollen tubes. (785 aa)
ADF9Actin-depolymerizing factor 9; Does not display typical F-actin depolymerizing activity. Exhibits a high ability to stabilize and cross-link actin filaments. Functions as an actin bundling protein with the highest efficiency under acidic conditions. May play a role in the modulation of levels of histone H3 lysine 4 trimethylation and H3 lysine 9 and 14 acetylation at the FLC locus. Belongs to the actin-binding proteins ADF family. (141 aa)
VLN1Villin-1; Binds actin and actin filament bundles in a Ca(2+)/calmodulin-insensitive manner, but is unable to sever, cap, and nucleate actin filament formation in vitro. Does not protect individual filaments from severing by VLN3 (AC O81645). Belongs to the villin/gelsolin family. (909 aa)
PRF5Profilin-5; Binds to actin monomers and regulates the organization of the actin cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. At low concentrations, associates with the poly-proline motif of formins to enhance actin filament elongation rate. Acts redundantly with PRF4 to regulate apical actin polymerization at the tip of pollen tube and control polarized pollen tube growth. Functions probably by favoring formin-mediated actin polymerization at pollen tube tips. (134 aa)
ADF1Actin-depolymerizing factor 1; Actin-depolymerizing protein. Stimulates F-actin depolymerization. Involved in plant development, cell organ expansion and flowering by controlling breakdown of thick actin cables. Severs actin filaments or bundles and promotes actin cytoskeleton disassembly. Binds monomeric actin (G- actin) with a marked preference for the ADP-loaded form and inhibits the rate of nucleotide exchange on G-actin. (139 aa)
PRF2Profilin-2; Binds to actin monomers and regulates the organization of the actin cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. At low concentrations, associates with the poly-proline motif of formins to enhance actin filament elongation rate. Binds G- actin and poly-L-proline with low affinity in vitro. Binds ACT1, ACT7 and ACT11 and inhibits actin polymerization. May be involved in the cross-talk between vesicular trafficking and the actin cytoskeleton. At high concentrations, profilin prevents the pol [...] (131 aa)
PRF1Profilin-1; Binds to actin monomers and regulates the organization of the actin cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. At low concentrations, associates with the poly-proline motif of formins to enhance actin filament elongation rate. Binds ACT1, ACT7 and ACT11 and inhibits actin polymerization. Coordinates the stochastic dynamic properties of actin filaments by modulating formin- mediated actin nucleation and assembly during axial cell expansion. Binds G-actin and poly-L-proline in vitro. Inhib [...] (131 aa)
ADF7Actin-depolymerizing factor 7; Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers. Binds monomeric actin (G-actin) with a marked preference for the ADP-loaded form and inhibits the rate of nucleotide exchange on G-actin. Required for pollen tube growth. Promotes turnover of longitudinal actin cables by severing actin filaments in pollen tubes. (137 aa)
ACT8Actin-8; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Essential component of cell cytoskeleton; plays an important role in cytoplasmic streaming, cell shape determination, cell division, organelle movement and extension growth. This is considered as one of the vegetative actins. (377 aa)
PRF3Profilin-3; Binds to actin monomers and regulates the organization of the actin cytoskeleton. Can increase the critical concentration (Cc) of actin assembly in vitro. Acts as downstream effector of the hydrogen sulfide signaling to regulate the assembly and depolymerization of F-actin. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (Probable). Binding to the poly-proline motif of formin induces oligomerization of PRF3. PRF3 oligomers inhibit formin-mediated actin assembly to modulate plant immunity triggered by pathog [...] (168 aa)
FIM5Fimbrin-5; Cross-links actin filaments (F-actin) in a calcium independent manner. Induces the formation of actin bundles. Stabilizes and prevents F-actin depolymerization mediated by latrunculin B (LatB). (687 aa)
VLN5Villin-5; Major actin filament stabilizing factor and regulator of actin dynamics. Binds actin and actin filament bundles in a Ca(2+)- insensitive manner, but caps the barbed end of actin filaments and is able to sever them in a calcium-dependent manner. Required for the construction of actin collars in pollen tubes. Acts synergistically with VLN2 (AC O81644) to regulate polarized pollen tube growth. Belongs to the villin/gelsolin family. (962 aa)
ADF11Putative actin-depolymerizing factor 11; Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers; Belongs to the actin-binding proteins ADF family. (133 aa)
ADF5Actin-depolymerizing factor 5; Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers. (143 aa)
ADF3Actin-depolymerizing factor 3; Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers. (139 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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