STRINGSTRING
F22H5.11 F22H5.11 RIC3 RIC3 RIC1 RIC1 ROPGAP2 ROPGAP2 ARAC10 ARAC10 ERABP1 ERABP1 TMK1 TMK1 ARAC11 ARAC11 ROPGEF4 ROPGEF4 ARAC1 ARAC1 ARAC3 ARAC3 ARAC4 ARAC4 ARAC5 ARAC5 PRK2 PRK2 ROPGAP3 ROPGAP3 ICR1 ICR1 ABC1K1 ABC1K1 T22C5.14 T22C5.14 SPK1 SPK1 ICR5 ICR5 ROPGEF1 ROPGEF1 KIN13A KIN13A T8K14.16 T8K14.16 F10F5.2 F10F5.2 T15M6.8 T15M6.8 ROPGAP4 ROPGAP4 RIC4 RIC4 MJJ3.26 MJJ3.26 F15M7.14 F15M7.14 ROPGAP6 ROPGAP6 ROPGAP1 ROPGAP1 ROPGEF8 ROPGEF8 ROPGEF7 ROPGEF7 F1I16_130 F1I16_130 ROPGEF6 ROPGEF6 T16L24.240 T16L24.240 GDI1-2 GDI1-2
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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F22H5.11DUF620 family protein (DUF620). (395 aa)
RIC3CRIB domain-containing protein RIC3; Functions as downstream effector of Rho-related GTP binding proteins of the 'Rho of Plants' (ROPs) family. Participates in the propagation of ROP GTPase signals in specific cellular responses. Functions as downstream effector of ARAC11/ROP1 to activate calcium signaling that leads to F-actin disassembly associated with exocytosis in the tip of the growing pollen tube. Counteracts the ARAC11/ROP1-RIC4 pathway, which promotes apical F-actin assembly associated with vesicle accumulation, to control actin dynamics and pollen tube apical growth. (220 aa)
RIC1CRIB domain-containing protein RIC1; Functions as downstream effector of Rho-related GTP binding proteins of the 'Rho of Plants' (ROPs) family. Participates in the propagation of ROP GTPase signals in specific cellular responses. Required for cortical microtubule organization. Promotes microtubule bundling and formation of well-ordered microtubule arrays in the neck region of pavement cells. This restricts cell lateral expansion to generate the narrow neck morphology of pavement cells. Its function is inhibited when it interacts with activated ARAC4/ROP2. Represses ARAC4/ROP2 activatio [...] (224 aa)
ROPGAP2Rho GTPase-activating protein 2; Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. (430 aa)
ARAC10Rac-like GTP-binding protein ARAC10; Involved in local disassembly of cortical microtubules when associated with ICR5 and KIN13A; Belongs to the small GTPase superfamily. Rho family. (215 aa)
ERABP1Auxin-binding protein 1; Auxin receptor that controls cell elongation and cell division. Involved in embryonic morphogenesis. Acts on the cell cycle, endocycle, cell plate formation, and cell expansion and contributes to the control of auxin-related gene expression. Controls root meristem size and mediates auxin responsiveness. Involved in activation of ROP GTPases in response to auxin and regulation of clathrin-mediated endocytosis in roots. Acts as a positive factor in clathrin recruitment to the plasma membrane, thereby promoting endocytosis. Upon auxin binding, restricts the intern [...] (198 aa)
TMK1Receptor protein kinase TMK1; Transmembrane kinase receptor. Phosphorylates only serine and threonine residues. Involved in auxin signal transduction and cell expansion and proliferation regulation. Forms with ABP1 a cell surface auxin perception complex that activates ROP signaling pathways. Required for auxin promotion of pavement cell interdigitation. Auxin promotes the formation of the ABP1-TMK1 protein complex. (942 aa)
ARAC11Rac-like GTP-binding protein ARAC11; May be involved in cell polarity control during the actin- dependent tip growth of pollen tubes. May regulate callose synthase 1 (CALS1) activity through the interaction with UGT1. (197 aa)
ROPGEF4Rop guanine nucleotide exchange factor 4; Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP. In association with ROPGEF1, acts as specific regulator of ARAC10/ROP11 function in ABA-mediated stomatal closure. (463 aa)
ARAC1Rac-like GTP-binding protein ARAC1; Inactive GDP-bound Rho GTPases reside in the cytosol, are found in a complex with Rho GDP-dissociation inhibitors (Rho GDIs), and are released from the GDI protein in order to translocate to membranes upon activation. (197 aa)
ARAC3Rac-like GTP-binding protein ARAC3; Inactive GDP-bound Rho GTPases reside in the cytosol, are found in a complex with Rho GDP-dissociation inhibitors (Rho GDIs), and are released from the GDI protein in order to translocate to membranes upon activation. May be involved in cell polarity control during the actin-dependent tip growth of root hairs. SPK1- dependent activation is required for auxin-mediated inhibition of PIN2 internalization during gravitropic responses. (198 aa)
ARAC4Rac-like GTP-binding protein ARAC4; Inactive GDP-bound Rho GTPases reside in the cytosol, are found in a complex with Rho GDP-dissociation inhibitors (Rho GDIs), and are released from the GDI protein in order to translocate to membranes upon activation (By similarity). May be involved in cell polarity control during the actin-dependent tip growth of root hairs. May regulate a WAVE complex that activates the Arp2/3 complex. (195 aa)
ARAC5Rac-like GTP-binding protein ARAC5; May be involved in cell polarity control during the actin- dependent tip growth of root hairs; Belongs to the small GTPase superfamily. Rho family. (196 aa)
PRK2Pollen receptor-like kinase 2; Receptor-like kinase involved in the control of pollen germination and pollen tube polar growth. Phosphorylates ROPGEF1 in its C-terminal region, releasing its auto-inhibition, and thereby activating the ROP1 signaling pathway. May act as a scaffolding protein, recruiting ROPGEF12 to the plasma membrane by binding to its C-terminal domain. Phosphorylates ROPGEF12, releasing its auto- inhibition. (647 aa)
ROPGAP3Rho GTPase-activating protein 3; Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Involved in secondary wall pattern formation. In association with ROPGEF4, mediates local activation of ARAC10/ROP11 to initiate the distinct pattern of secondary cell walls in xylem cells. (455 aa)
ICR1Interactor of constitutive active ROPs 1; Acts as a scaffold, mediating interaction of ROPs with different proteins. Required for primary and adventitious root maintenance, but not for their formation. Promotes the stabilization of ARAC11 on the plasma membrane of the pollen tube initiation site but not the activation of ARAC11. Regulates directionality of polar auxin transport, and is required for the formation of a stable auxin maximum and tip localized auxin gradient during embryogenesis, organogenesis, and meristem activity. Involved in exocytosis and in the recycling of PIN protei [...] (344 aa)
ABC1K1Protein ACTIVITY OF BC1 COMPLEX KINASE 1, chloroplastic; Kinase that can phosphorylate the tocopherol cyclase VTE1, a key enzyme of tocopherol (vitamin E) metabolism and involved in the recycling of oxidated alpha-tocopherol quinone, possibly stabilizing it at plastoglobules. Regulates also plastoglobule protein composition. Prevents photodamage of chloroplasts under continuous red light, thus working in opposition to ABC1K3. Together with ABC1K1, contributes to plastoglobule (PG) function in prenyl-lipid metabolism, stress response, and thylakoid remodeling. Involved in chlorophyll de [...] (682 aa)
T22C5.14Lipase, putative (DUF620). (433 aa)
SPK1Guanine nucleotide exchange factor SPIKE 1; Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. Controls actin polymerization via the two heteromeric complexes WAVE and actin-related protein (ARP) 2/3. Involved in cytoskeletal reorganization required for cell shape (e.g. trichome and cotyledon) control and tissue development. Promotes polarized growth and cell-cell adhesion in the leaf epidermis probably by promoting the formation of endoplasmic reticulum (ER) exit site (ERES) and/or trafficking between the [...] (1830 aa)
ICR5Interactor of constitutive active ROPs 5; ROP effector binding specifically activated ROPs and linking them to the microtubule cytoskeleton. Involved in ROP-regulated polar growth. Involved in local disassembly of cortical microtubules when associated with ARAC10 and KIN13A and conversely mediates also the elimination of ARAC10 from the plasma membrane by the cortical microtubules. Accumulates at the plus end of shrinking microtubules. Targets KIN13A to microtubules. (396 aa)
ROPGEF1Rop guanine nucleotide exchange factor 1; Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP. Acts downstream of PRK2 in the control of polarized pollen tube growth by activating ARAC11/ROP1. In association with ROPGEF4, acts as specific regulator of ARAC10/ROP11 function in ABA-mediated stomatal closure. May play a role in the Rac/Rop-signaling pathway that controls ROS-mediated root hair development. (548 aa)
KIN13AKinesin-like protein KIN-13A; Internal motor kinesin involved in trichome morphogenesis. Participates in regulating the formation of Golgi- associated vesicles. Plays a central role in microtubule disassembly via the active ARAC10-ICR5 cascade, which establishes the secondary cell wall pattern in metaxylem vessel cells. Acts redundantly with KIN13B to modulate cell wall synthesis and cell expansion via the THE1 pathway. (794 aa)
T8K14.16C-type mannose receptor (DUF620). (417 aa)
F10F5.2Glutamyl-tRNA (Gln) amidotransferase subunit A (DUF620). (494 aa)
T15M6.8WEB family protein. (284 aa)
ROPGAP4Rho GTPase-activating protein 4; Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Acts as negative feedback regulator in tolerance to oxygen deprivation which requires ARAC4/ROP2. (435 aa)
RIC4CRIB domain-containing protein RIC4; Functions as downstream effector of Rho-related GTP binding proteins of the 'Rho of Plants' (ROPs) family. Participates in the propagation of ROP GTPase signals in specific cellular responses. Required for actin cortical microfilament assembly. Activated by ARAC4/ROP2 to promote the assembly of cortical actin microfilaments required for lobe formation and lateral expansion of pavement cells. Interaction with, and activation by ARAC4/ROP2 is inhibited by RIC1. Functions as downstream effector of ARAC11/ROP1 to promote the assembly of apical F-actin a [...] (153 aa)
MJJ3.26Replication factor C subunit, putative (DUF620). (439 aa)
F15M7.14Lipase (DUF620). (368 aa)
ROPGAP6Rho GTPase-activating protein 6; Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. (827 aa)
ROPGAP1Rho GTPase-activating protein 1; Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. (466 aa)
ROPGEF8Rho guanine nucleotide exchange factor 8; Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP. Active as homodimer. (523 aa)
ROPGEF7Rop guanine nucleotide exchange factor 7; Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP. In postembryonic roots, modulates root stem cell maintenance by regulating the expression of PLT1 and PLT2, which are key transcription factors that mediate the patterning of the root stem cell niche. May connect RopGEF-regulated Rac/Rop signaling and auxin- dependent PLT-regulated root pattern formation. (546 aa)
F1I16_130Replication factor C subunit, putative (DUF620). (438 aa)
ROPGEF6Rop guanine nucleotide exchange factor 6; Guanine-nucleotide exchange factor (GEF) that acts as an activator of Rop (Rho of plants) GTPases by promoting the exchange of GDP for GTP. (579 aa)
T16L24.240IQ-domain 13. (517 aa)
GDI1-2Rho GDP-dissociation inhibitor 1; Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. (240 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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