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ATG1C ATG1C ATG13B ATG13B ATG1B ATG1B ATG101 ATG101 ATG2 ATG2 TSPO TSPO ATI1 ATI1 VPS34 VPS34 ATG3 ATG3 ATG16 ATG16 ATG8A ATG8A ATG9 ATG9 ATG12A ATG12A ATG8H ATG8H ATG8E ATG8E ATG8C ATG8C ATG4A ATG4A ATG8F ATG8F ATG10 ATG10 ATG18A ATG18A ATG1A ATG1A ATG7 ATG7 ATG5 ATG5 ATG8I ATG8I ATG12B ATG12B VPS15 VPS15 ATG4B ATG4B ATG6 ATG6 NBR1 NBR1 ATG13A ATG13A ATG11 ATG11
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
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ATG1CSerine/threonine-protein kinase ATG1c; Serine/threonine protein kinase involved in autophagy. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery. (733 aa)
ATG13BAutophagy-related protein 13b; Involved in autophagy in a nutritional condition dependent manner. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery. Becomes a target of autophagy under nutrient starvation (By similarity). Connects autophagy to plant nutritional status. (625 aa)
ATG1BSerine/threonine-protein kinase ATG1b; Serine/threonine protein kinase involved in autophagy. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery. (711 aa)
ATG101Autophagy-related protein 101; Accessory protein involved in autophagy. Acts as scaffold protein of the ATG1-ATG13 complex for faithful delivery of autophagic vesicles to the vacuole. Required for selective mitophagy. Belongs to the ATG101 family. (215 aa)
ATG2Autophagy-related protein 2; Required for autophagy that plays an essential role in plant nutrient recycling. Involved in the early steps of autophagosome biogenesis. Involved in the negative regulation of plant defense responses to biotrophic pathogens. Involved in a negative feedback loop that modulates NPR1-dependent salicylic acid (SA) signaling and limits senescence and immunity-related programmed cell death (PCD) in plants. Involved in the degradation of damaged peroxisomes ; Belongs to the ATG2 family. (1892 aa)
TSPOTranslocator protein homolog; Stress-induced membrane protein that can bind heme and may play a role in the transport of tetrapyrrole intermediates during salt stress and contribute to the detoxification of highly reactive porphyrins in the cytoplasm. Belongs to the TspO/BZRP family. (196 aa)
ATI1ATG8-interacting protein 1; Involved in a special stress-induced plastid-to-vacuole protein trafficking pathway. Interacts with ATG8F in plastid bodies to subsequently enable their delivery to the vacuole by an autophagic pathway. Interacts with the plastid proteins APE1 and PSBS/NPQ4 and may recruit them as cargo into plastid bodies that may be recognized by the autophagy machinery for degradation in the vacuole. Involved in the alleviation of damage caused by salt stress during plant development, probably through its involvement in plastid-to-vacuole and ER-to- vacuole trafficking. P [...] (256 aa)
VPS34Phosphatidylinositol 3-kinase VPS34; Belongs to the PI3/PI4-kinase family. (814 aa)
ATG3Autophagy-related protein 3; E2 conjugating enzyme responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt); Belongs to the ATG3 family. (313 aa)
ATG16Autophagy-related protein 16; May play a role in autophagy. (509 aa)
ATG8AAutophagy-related protein 8a; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (122 aa)
ATG9Autophagy-related protein 9; Required for autophagy that plays an essential role in plant nutrient recycling. Contributes to efficient autophagic flux, especially in early autophagic process prior to the fusion of the autophagosome with the vacuole. Belongs to the ATG9 family. (866 aa)
ATG12AUbiquitin-like protein ATG12A; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt) and autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. ATG12/ATG5 conjugate has an essential role in plant nutrient recycling; Belongs to the ATG12 family. (96 aa)
ATG8HAutophagy-related protein 8h; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton; Belongs to the ATG8 family. (119 aa)
ATG8EAutophagy-related protein 8e; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (122 aa)
ATG8CAutophagy-related protein 8c; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton; Belongs to the ATG8 family. (119 aa)
ATG4ACysteine protease ATG4a; Cysteine protease required for autophagy, which is able to cleave the C-terminal part of ATG8 that may be subsequently converted to a smaller form, with a revealed C-terminal glycine. ATG8 is then activated by ATG7 and is subsequently attached to ATG3, another E2-like enzyme, after which the C-terminal glycine of ATG8 is conjugated to phosphatidylethanolamine by an amide bond. This conjugated form has the capacity for the binding to autophagosomes; Belongs to the peptidase C54 family. (467 aa)
ATG8FAutophagy-related protein 8f; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (121 aa)
ATG10Ubiquitin-like-conjugating enzyme ATG10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. The ATG12-ATG5 conjugates is required for the formation of autophagic vesicles and for the timely progression of senescence and programmed cell death (PCD). Likely serves as an ATG5-recognition molecule. Confers some resistance to nitrogen and carbon starvation. Is also involved in the formation of anthocyanic vacuolar inclusions (AVI). Promotes an autophagic process that constitutes a pro-survival mechanism by controlling the contain [...] (225 aa)
ATG18AAutophagy-related protein 18a; The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Required for autophagy by autophagosome formation during nutrient deprivation, senescence and under abiotic stresses, including oxidative, high salt and osmotic stress conditions. Cooperates with jasmonate- and WRKY33-mediated signaling pathways in the regulation of plant defense responses to necrotrophic pathogens. (425 aa)
ATG1ASerine/threonine-protein kinase ATG1a; Serine/threonine protein kinase involved in autophagy in a nutritional condition-dependent manner. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery. Becomes a target of autophagy under nutrient starvation. Connects autophagy to plant nutritional status. (626 aa)
ATG7Ubiquitin-like modifier-activating enzyme atg7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes. Involved in the senescence process. Involved in the degradation of damaged peroxisomes. Involved in the non-selective degradation of chlorophylls and photosynthetic proteins during stress-induced leaf yellowing. (697 aa)
ATG5Autophagy protein 5; Required for autophagy. Conjugation to ATG12 is essential for plant nutrient recycling. Involved in a negative feedback loop that modulates NPR1-dependent salicylic acid (SA) signaling and limits senescence and immunity-related programmed cell death (PCD) in plants. Involved in complete proteolysis of chloroplast stroma proteins in senescent leaves. Involved in the degradation of damaged peroxisomes. Belongs to the ATG5 family. (337 aa)
ATG8IAutophagy-related protein 8i; Ubiquitin-like modifier involved in autophagosomes formation. May mediate the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. (115 aa)
ATG12BUbiquitin-like protein ATG12B; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt) and autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. ATG12/ATG5 conjugate has an essential role in plant nutrient recycling; Belongs to the ATG12 family. (94 aa)
VPS15Serine/threonine-protein kinase VPS15; Serine/threonine-protein kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy- specific VPS34 PI3-kinase complex I (By similarity). Required for pollen development and germination, probably via the modulation of phosphatidylinositol 3-phosphate (PI3P) formation and vacuolar organization. (1494 aa)
ATG4BCysteine protease ATG4b; Cysteine protease required for autophagy, which is able to cleave the C-terminal part of ATG8 that may be subsequently converted to a smaller form, with a revealed C-terminal glycine. ATG8 is then activated by ATG7 and is subsequently attached to ATG3, another E2-like enzyme, after which the C-terminal glycine of ATG8 is conjugated to phosphatidylethanolamine by an amide bond. This conjugated form has the capacity for the binding to autophagosomes. (477 aa)
ATG6Beclin-1-like protein; Required for normal plant development. Required for pollen germination. Required for autophagic activity. Required to limit the pathogen-associated cell death response. May be involved in vacuolar protein sorting. Binds to microtubules. May facilitate efficient recruitment of other ATG proteins to assemble scaffolds for autophagosome biogenesis. Belongs to the beclin family. (517 aa)
NBR1Protein NBR1 homolog; Autophagic substrate degraded in the vacuole by non-selective autophagy. Requires ATG8 protein expression to be recognized as an autophagic substrate. Acts probably as a receptor for autophagosomal degradation of ubiquitinated proteins. Targets ubiquitinated protein aggregates derived from denatured or damaged non- native proteins generated under stress conditions. Functions additively with the E3 ubiquitin-protein ligase CHIP for autophagosomal degradation of proteotoxic aggregates formed under stress conditions. (704 aa)
ATG13AAutophagy-related protein 13a; Involved in autophagy in a nutritional condition dependent manner. The ATG1-ATG13 protein kinase complex regulates downstream events required for autophagosome enclosure and/or vacuolar delivery. Becomes a target of autophagy under nutrient starvation. Connects autophagy to plant nutritional status. (603 aa)
ATG11Autophagy-related protein 11; Accessory protein involved in autophagy. Acts as scaffold protein of the ATG1-ATG13 complex for faithful delivery of autophagic vesicles to the vacuole. Involved in the stress-induced phosphorylation of ATG1A for turnover of ATG1-ATG13 complex and proper ATG1-ATG13 complex assembly or activity. Required for selective mitophagy. Required for senescence-induced breakdown of mitochondria-resident proteins and mitochondrial vesicles. Seems not essential for ATG8- mediated autophagy; Belongs to the ATG11 family. (1148 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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