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SPX2 SPX2 IPS1 IPS1 RNS1 RNS1 PHL1 PHL1 SPX1 SPX1 PHO1 PHO1 UBC24 UBC24 PHT1-1 PHT1-1 PHR1 PHR1 PHT1-9 PHT1-9 PHT1-8 PHT1-8
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gene co-occurrence
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SPX2SPX domain-containing protein 2; May inhibit PHR1 DNA-binding activity in a Pi-dependent manner. (287 aa)
IPS1Inositol-3-phosphate synthase isozyme 1; Catalyzes the majority of myo-inositol synthesis required for plant growth and development. Acts as a repressor of programmed cell death and protects plant cells against cell death under high light intensity or long days. Controls its own transcription by inhibiting ATXR6 activity. Reduces the deposition of inhibitory histone marks on its own promoter; Belongs to the myo-inositol 1-phosphate synthase family. (511 aa)
RNS1Ribonuclease 1; May remobilize phosphate, particularly when cells senesce or when phosphate becomes limiting. (230 aa)
PHL1Protein PHR1-LIKE 1; Transcription factor acting as central integrator of phosphate starvation responses. Regulates FER1 expression upon phosphate starvation, linking iron and phosphate homeostasis ; Belongs to the MYB-CC family. (413 aa)
SPX1SPX domain-containing protein 1; Plays a positive role in plant adaptation to phosphate starvation. Inhibits PHR1 DNA-binding activity in a Pi-dependent manner. (256 aa)
PHO1Phosphate transporter PHO1; Inositol polyphosphate sensor that associates with transcription factors to regulate inorganic phosphate (Pi) starvation responses. Probably acts by binding inositol polyphosphate via its SPX domain. Acts as a Pi exporter, mediating efflux of Pi out of cells. Transfers Pi from the epidermal and cortical cells to the root xylem vessels. Involved in the transfer of Pi from roots to shoots. Involved in abscisic acid (ABA) induction of stomatal closure and ABA repression of stomatal opening. Belongs to the SYG1 (TC 2.A.94) family. (782 aa)
UBC24Probable ubiquitin-conjugating enzyme E2 24; Accepts the ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (By similarity). Mediates PHO1 degradation through multivesicular body-mediated vacuolar proteolysis in response to inorganic phosphate (Pi) availability. Negatively regulates the protein abundance of PHF1 and PHT1s under Pi- sufficient conditions by facilitating the degradation of PHT1 proteins at the endomembrane. (907 aa)
PHT1-1Inorganic phosphate transporter 1-1; High-affinity transporter for external inorganic phosphate. Acts as a H(+):phosphate symporter in both low- and high-Pi conditions. Confers sensitivity to arsenate. (524 aa)
PHR1Protein PHOSPHATE STARVATION RESPONSE 1; Transcription factor involved in phosphate starvation signaling. Binds as a dimer to P1BS, an imperfect palindromic sequence 5'-GNATATNC-3', to promote the expression of inorganic phosphate (Pi) starvation- responsive genes. SPX1 is a competitive inhibitor of this DNA-binding. PHR1 binding to its targets is low Pi-dependent. Regulates the expression of miR399. Regulates the expression of IPS1 (At3g09922), a non-coding RNA that mimics the target of miR399 to block the cleavage of PHO2 under Pi-deficient conditions. Regulates lipid remodeling and [...] (409 aa)
PHT1-9Probable inorganic phosphate transporter 1-9; High-affinity transporter for external inorganic phosphate. Belongs to the major facilitator superfamily. phosphate:H(+) symporter (TC 2.A.1.9) family. (532 aa)
PHT1-8Probable inorganic phosphate transporter 1-8; High-affinity transporter for external inorganic phosphate. (534 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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