STRINGSTRING
A0A1P8B502 A0A1P8B502 MDA7.8 MDA7.8 CLE26 CLE26 CDF4 CDF4 CLE2 CLE2 CLV2 CLV2 PLL1 PLL1 CLE8 CLE8 CLE22 CLE22 CLE1 CLE1 CLE18 CLE18 CLE14 CLE14 CLE11 CLE11 CLE3 CLE3 CLE20 CLE20 CLE10 CLE10 CLE45 CLE45 CLE42 CLE42 CLE13 CLE13 WOX5 WOX5 CLE17 CLE17 CLE46 CLE46 CLE25 CLE25 CLE16 CLE16 CLE19 CLE19 CLE44 CLE44 CLE9 CLE9 CLE27 CLE27 CLE21 CLE21 ACR4-2 ACR4-2 CLE40 CLE40 CRN CRN RPK2 RPK2 WUS WUS HSL1 HSL1 CLV1 CLV1 CLV3 CLV3 FEZ FEZ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A1P8B502LRR receptor-like protein. (141 aa)
MDA7.8Leucine-rich receptor-like protein kinase family protein; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1090 aa)
CLE26CLAVATA3/ESR (CLE)-related protein 26; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (118 aa)
CDF4Cyclic dof factor 4; Transcription factor that binds specifically to a 5'-AA[AG]G- 3' consensus core sequence (By similarity). Transcriptional repressor of 'CONSTANS' expression (By similarity). Regulates a photoperiodic flowering response. (170 aa)
CLE2CLAVATA3/ESR (CLE)-related protein 2; Extracellular signal peptide that regulates cell fate. May act with CLV1 as a ligand-receptor pair in a signal transduction pathway, coordinating growth between adjacent meristematic regions. (75 aa)
CLV2Receptor-like protein CLAVATA2; Involved in the perception of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristems maintenance. Involved in controlling the stem cell population size in shoot and root apical meristems, and during organ development. Promotes the formation of CLV1 multimers. In complex with CRN, perceives secreted CLV3-like effector proteins from plant-parasitic cyst nematodes as ligand mimics of the plant CLE signaling pathway. This recognition is required for proper feeding structure (syncytium) development and ultimately successful [...] (720 aa)
PLL1Protein phosphatase 2C 29; Involved in the regulation of pedicel length and of CLAVATA pathways controlling stem cell identity at shoot and flower meristems. Belongs to the PP2C family. (783 aa)
CLE8CLAVATA3/ESR (CLE)-related protein 8; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Positively regulates the expression of the transcription factor WOX8 and thus, regulates early embryo development. (86 aa)
CLE22CLAVATA3/ESR (CLE)-related protein 22; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (103 aa)
CLE1CLAVATA3/ESR (CLE)-related protein 1; Extracellular signal peptide that regulates cell fate. Belongs to the CLV3/ESR signal peptide family. (74 aa)
CLE18CLAVATA3/ESR (CLE)-related protein 18; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (101 aa)
CLE14CLAVATA3/ESR (CLE)-related protein 14; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Acts as an elicitor of the root meristem differentiation through the CLV2/CRN complex signaling pathway. Inhibits irreversibly root growth by reducing cell division rates in the root apical meristem. (80 aa)
CLE11CLAVATA3/ESR (CLE)-related protein 11; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (99 aa)
CLE3CLAVATA3/ESR (CLE)-related protein 3; Extracellular signal peptide that regulates cell fate. Belongs to the CLV3/ESR signal peptide family. (83 aa)
CLE20CLAVATA3/ESR (CLE)-related protein 20; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Inhibits irreversibly root growth by reducing cell division rates in the root apical meristem ; Belongs to the CLV3/ESR signal peptide family. (83 aa)
CLE10CLAVATA3/ESR (CLE)-related protein 10; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (107 aa)
CLE45CLAVATA3/ESR (CLE)-related protein 45; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Prevents, in a dose-dependent manner, auxin response in the root meristem thus leading in the repression of protophloem differentiation and periclinal sieve element precursor cell division. (124 aa)
CLE42CLAVATA3/ESR (CLE)-related protein 42; Extracellular signal peptide that regulates cell fate. Represses tracheary element differentiation but promotes the formation of procambial cells; Belongs to the CLV3/ESR signal peptide family. (88 aa)
CLE13CLAVATA3/ESR (CLE)-related protein 13; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (107 aa)
WOX5WUSCHEL-related homeobox 5; Transcription factor, which may be involved in the specification and maintenance of the stem cells (QC cells) in the root apical meristem (RAM). (182 aa)
CLE17CLAVATA3/ESR (CLE)-related protein 17; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (99 aa)
CLE46CLAVATA3/ESR (CLE)-related protein 46; Extracellular signal peptide that regulates cell fate. (76 aa)
CLE25CLAVATA3/ESR (CLE)-related protein 25; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (81 aa)
CLE16CLAVATA3/ESR (CLE)-related protein 16; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (103 aa)
CLE19CLAVATA3/ESR (CLE)-related protein 19; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (74 aa)
CLE44CLAVATA3/ESR (CLE)-related protein 44; Extracellular signal peptide that regulates cell fate. May act with TDR as a ligand-receptor pair in a signal transduction pathway that represses tracheary element differentiation but promotes the formation of procambial cells adjacent to phloem cells in the veins. (112 aa)
CLE9CLAVATA3/ESR (CLE)-related protein 9; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (120 aa)
CLE27CLAVATA3/ESR (CLE)-related protein 27; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (91 aa)
CLE21CLAVATA3/ESR (CLE)-related protein 21; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (106 aa)
ACR4-2Serine/threonine-protein kinase-like protein ACR4; Controls formative cell division in meristems, including root tips and lateral root initiation zones of the pericycle, in response to CLE40 signal. Acts with CLE40p peptide as a ligand-receptor pair in a signal transduction pathway, coordinating movement of the root tip and organization of cell divisions in the root meristem. Required during embryogenesis and development, probably for the differentiation of protoderm and epidermal cells. Involved in the regulation of cellular organization during the development of sepal margins and ovu [...] (895 aa)
CLE40CLAVATA3/ESR (CLE)-related protein 40; Extracellular signal peptide secreted by differentiated root cells that regulates root cell fate. Acts with ACR4 as a ligand- receptor pair in a signal transduction pathway, coordinating movement of the root tip and organization of cell divisions in the root meristem. Promotes cell differentiation in the distal root meristem in a dose-dependent manner, especially the transition from columella stem cells (CSC) daughters into columella cells (CCs). Induces ACR4 expression in root quiescent center (QC). Involved in WUX5 QC-specific expression pattern [...] (80 aa)
CRNInactive leucine-rich repeat receptor-like protein kinase CORYNE; Involved in the perception of CLV3 and CLV3-like (CLE) peptides, that acts as a extracellular signals regulating meristems maintenance. Modulates root, shoot and flower apical meristems maintenance and floral organ development regulation, probably via CLAVATA (CLV)-like pathways involving at least CLV3 and CLE19. In complex with CLV2, perceives secreted CLV3-like effector proteins from plant-parasitic cyst nematodes as ligand mimics of the plant CLE signaling pathway. This recognition is required for proper feeding struc [...] (401 aa)
RPK2LRR receptor-like serine/threonine-protein kinase RPK2; Key regulator of anther development (e.g. lignification pattern), including tapetum degradation during pollen maturation (e.g. germination capacity). Together with RPK1, required for pattern formation along the radial axis (e.g. the apical embryonic domain cell types that generate cotyledon primordia), and the apical-basal axis (e.g. differentiation of the basal pole during early embryogenesis). (1151 aa)
WUSProtein WUSCHEL; Transcription factor that plays a central role during early embryogenesis, oogenesis and flowering, probably by regulating expression of specific genes. Required to specify stem cell identity in meristems, such as shoot apical meristem (SAM). May induce shoot stem cells activity in order to maintain the stem cell identity. Involved in the developmental root meristem. In shoot apices, it is sufficient to induce the expression of CLV3, a putative ligand of the CLV signaling pathway. Also required to sustain organogenesis in the floral meristem by contributing to the expr [...] (292 aa)
HSL1Receptor-like protein kinase HSL1; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (996 aa)
CLV1Receptor protein kinase CLAVATA1; Involved in the detection of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristem maintenance. Acts with CLV3p as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (980 aa)
CLV3Protein CLAVATA 3; Extracellular signal that regulates meristem maintenance. Acts with CLV1 as a ligand-receptor pair in a signal transduction pathway coordinating growth between adjacent meristematic regions and controlling the balance between meristem cell proliferation and differentiation; Belongs to the CLV3/ESR signal peptide family. (96 aa)
FEZProtein FEZ; Promotes periclinal root capforming cell divisions. Activates expression of its negative regulator SMB in a feedback loop for controlled switches in cell division plane. (418 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (28%) [HD]