(49 nodes) Phenylalanine, tyrosine and tryptophan biosynthesis network (Arabidopsis thaliana)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1I9LMN9	ADC synthase superfamily protein. (591 aa)
	F24J13.14	Anthranilate phosphoribosyltransferase. (632 aa)
	F20O9.90	Tyrosine transaminase family protein. (447 aa)
	F4K727_ARATH	Tryptophan synthase. (465 aa)
	MUL3.12	Tautomerase/MIF superfamily protein. (116 aa)
	ADT4	Arogenate dehydratase 4, chloroplastic; Converts the prephenate produced from the shikimate- chorismate pathway into phenylalanine. (424 aa)
	TRPA1	Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate (By similarity). Contributes to the tryptophan-independent indole biosynthesis, and possibly to auxin production; Belongs to the TrpA family. (275 aa)
	F4L23.19	3-phosphoshikimate 1-carboxyvinyltransferase, chloroplastic; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (520 aa)
	TSB1	Tryptophan synthase beta chain 1, chloroplastic; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine; Belongs to the TrpB family. (470 aa)
	TSB2	Tryptophan synthase beta chain 2, chloroplastic; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine; Belongs to the TrpB family. (475 aa)
	DHS1	Phospho-2-dehydro-3-deoxyheptonate aldolase 1, chloroplastic; Belongs to the class-II DAHP synthase family. (525 aa)
	ASA1	Anthranilate synthase alpha subunit 1, chloroplastic; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS to produce anthranilate. Plays an important regulatory role in auxin production via the tryptophan-dependent biosynthet [...] (595 aa)
	ASA2	Anthranilate synthase alpha subunit 2, chloroplastic; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS to produce anthranilate (By similarity). (621 aa)
	CM1	Chorismate mutase 1, chloroplastic; May play a role in chloroplast biogenesis. (340 aa)
	IGPS	Indole-3-glycerol phosphate synthase, chloroplastic; Indole-3-glycerol phosphate synthase required for tryptophan biosynthesis. (402 aa)
	EMB1144	Chorismate synthase, chloroplastic; Catalyzes the last common step of the biosynthesis of aromatic amino acids, produced via the shikimic acid pathway. (436 aa)
	DHS2	Phospho-2-dehydro-3-deoxyheptonate aldolase 2, chloroplastic; Belongs to the class-II DAHP synthase family. (507 aa)
	PAT1	Anthranilate phosphoribosyltransferase, chloroplastic. (444 aa)
	PAI1	N-(5'-phosphoribosyl)anthranilate isomerase 1, chloroplastic. (275 aa)
	PAI2	N-(5'-phosphoribosyl)anthranilate isomerase 2, chloroplastic; Belongs to the TrpF family. (275 aa)
	TSA1-2	Tryptophan synthase alpha chain, chloroplastic; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Required for tryptophan biosynthesis. Contributes to the tryptophan- independent indole biosynthesis, and possibly to auxin production. Belongs to the TrpA family. (312 aa)
	ASB1	Anthranilate synthase beta subunit 1, chloroplastic; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS to produce anthranilate. Plays an important regulatory role in auxin production via the tryptophan-dependent biosyntheti [...] (276 aa)
	F20O9.100	Probable aminotransferase TAT1; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (449 aa)
	SK2	Shikimate kinase 2, chloroplastic; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. Belongs to the shikimate kinase family. (300 aa)
	PAI3	N-(5'-phosphoribosyl)anthranilate isomerase 3, chloroplastic; Belongs to the TrpF family. (244 aa)
	F9D16.60	Probable aminotransferase TAT4. (424 aa)
	DHQS	3-dehydroquinate synthase, chloroplastic; Catalyzes the second step in the shikimate pathway. Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (442 aa)
	TYRAAT1	Arogenate dehydrogenase 1, chloroplastic; Involved in the biosynthesis of tyrosine. Has no prephenate dehydrogenase activity; Belongs to the prephenate/arogenate dehydrogenase family. (640 aa)
	CM3	Chorismate mutase 3, chloroplastic; May play a role in chloroplast biogenesis. (316 aa)
	F4F7.41	Glutamine amidotransferase type 1 family protein. (222 aa)
	TSBtype2	Tryptophan synthase beta type 2. (506 aa)
	ASB2	Anthranilate synthase beta subunit 2, chloroplastic; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS to produce anthranilate (By similarity). (273 aa)
	ADT5	Arogenate dehydratase 5, chloroplastic; Converts the prephenate produced from the shikimate- chorismate pathway into phenylalanine. (425 aa)
	F27K7.11	3-phosphoshikimate 1-carboxyvinyltransferase; Belongs to the EPSP synthase family. (521 aa)
	F5A9.17	Glutamine amidotransferase type 1 family protein. (235 aa)
	TYRAAT2	Arogenate dehydrogenase 2, chloroplastic; Involved in the biosynthesis of tyrosine. Has a weak prephenate dehydrogenase activity; Belongs to the prephenate/arogenate dehydrogenase family. (358 aa)
	MIF21.11	Aldolase-type TIM barrel family protein. (379 aa)
	TAT	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using L-glutamate in vitro. Can convert phenylalanine to phenylpyruvate and catalyze the reverse reaction in vitro. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (420 aa)
	ICS2	Isochorismate synthase 2, chloroplastic; Involved in the synthesis of salicylic acid (SA) required for both local and systemic acquired resistance (LAR and SAR) while SA synthesized through the phenylalanine ammonium lyase (PAL) pathway seems to potentiate plant cell death. Also involved in phylloquinone (vitamin K1) synthesis. Has no isochorismate pyruvate lyase (IPL) activity. (562 aa)
	CM2	Chorismate mutase 2. (265 aa)
	ADT1	Arogenate dehydratase/prephenate dehydratase 1, chloroplastic; Converts the prephenate produced from the shikimate- chorismate pathway into phenylalanine. (392 aa)
	ADT6	Arogenate dehydratase/prephenate dehydratase 6, chloroplastic; Converts the prephenate produced from the shikimate- chorismate pathway into phenylalanine. (413 aa)
	PAT	Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase; Prokaryotic-type aspartate aminotransferase. Has also a prenate transaminase activity. Involved in the aromatic amino acids biosynthesis pathway via the arogenate route. Required for the transamination of prephenate into arogenate. Required for early development of the embryo. (475 aa)
	SK1	Shikimate kinase 1, chloroplastic; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate. (303 aa)
	TAT3	Probable aminotransferase TAT3; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (445 aa)
	F12K8.24	Phospho-2-dehydro-3-deoxyheptonate aldolase. (527 aa)
	EMB3004	Bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase, chloroplastic; In the C-terminal section; belongs to the shikimate dehydrogenase family. (603 aa)
	ADT2	Arogenate dehydratase/prephenate dehydratase 2, chloroplastic; Converts the prephenate produced from the shikimate- chorismate pathway into phenylalanine. (381 aa)
	ADT3	Arogenate dehydratase 3, chloroplastic; Converts the prephenate produced from the shikimate- chorismate pathway into phenylalanine. Together with GCR1 and GPA1, required for blue light-mediated synthesis of phenylpyruvate and subsequently of phenylalanine (Phe), in etiolated seedlings. (424 aa)

Your Current Organism:

Arabidopsis thaliana

NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A1I9LMN9	ASA1	A0A1I9LMN9	P32068	ADC synthase superfamily protein.	Anthranilate synthase alpha subunit 1, chloroplastic; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS to produce anthranilate. Plays an important regulatory role in auxin production via the tryptophan-dependent biosynthet [...]	0.901
A0A1I9LMN9	ASA2	A0A1I9LMN9	P32069	ADC synthase superfamily protein.	Anthranilate synthase alpha subunit 2, chloroplastic; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS to produce anthranilate (By similarity).	0.901
A0A1I9LMN9	ASB1	A0A1I9LMN9	Q42565	ADC synthase superfamily protein.	Anthranilate synthase beta subunit 1, chloroplastic; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS to produce anthranilate. Plays an important regulatory role in auxin production via the tryptophan-dependent biosyntheti [...]	0.997
A0A1I9LMN9	ASB2	A0A1I9LMN9	Q9FJM5	ADC synthase superfamily protein.	Anthranilate synthase beta subunit 2, chloroplastic; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS to produce anthranilate (By similarity).	0.996
A0A1I9LMN9	CM1	A0A1I9LMN9	P42738	ADC synthase superfamily protein.	Chorismate mutase 1, chloroplastic; May play a role in chloroplast biogenesis.	0.813
A0A1I9LMN9	CM2	A0A1I9LMN9	Q9S7H4	ADC synthase superfamily protein.	Chorismate mutase 2.	0.813
A0A1I9LMN9	CM3	A0A1I9LMN9	Q9C544	ADC synthase superfamily protein.	Chorismate mutase 3, chloroplastic; May play a role in chloroplast biogenesis.	0.819
A0A1I9LMN9	EMB1144	A0A1I9LMN9	P57720	ADC synthase superfamily protein.	Chorismate synthase, chloroplastic; Catalyzes the last common step of the biosynthesis of aromatic amino acids, produced via the shikimic acid pathway.	0.976
A0A1I9LMN9	F20O9.100	A0A1I9LMN9	Q67Y55	ADC synthase superfamily protein.	Probable aminotransferase TAT1; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	0.629
A0A1I9LMN9	F20O9.90	A0A1I9LMN9	F4JL94	ADC synthase superfamily protein.	Tyrosine transaminase family protein.	0.629
A0A1I9LMN9	F24J13.14	A0A1I9LMN9	F4I5H7	ADC synthase superfamily protein.	Anthranilate phosphoribosyltransferase.	0.946
A0A1I9LMN9	F4F7.41	A0A1I9LMN9	Q9FE37	ADC synthase superfamily protein.	Glutamine amidotransferase type 1 family protein.	0.996
A0A1I9LMN9	F4K727_ARATH	A0A1I9LMN9	F4K727	ADC synthase superfamily protein.	Tryptophan synthase.	0.660
A0A1I9LMN9	F5A9.17	A0A1I9LMN9	Q9FXK1	ADC synthase superfamily protein.	Glutamine amidotransferase type 1 family protein.	0.995
A0A1I9LMN9	F9D16.60	A0A1I9LMN9	Q8VYP2	ADC synthase superfamily protein.	Probable aminotransferase TAT4.	0.629
A0A1I9LMN9	ICS2	A0A1I9LMN9	Q9M9V6	ADC synthase superfamily protein.	Isochorismate synthase 2, chloroplastic; Involved in the synthesis of salicylic acid (SA) required for both local and systemic acquired resistance (LAR and SAR) while SA synthesized through the phenylalanine ammonium lyase (PAL) pathway seems to potentiate plant cell death. Also involved in phylloquinone (vitamin K1) synthesis. Has no isochorismate pyruvate lyase (IPL) activity.	0.667
A0A1I9LMN9	IGPS	A0A1I9LMN9	P49572	ADC synthase superfamily protein.	Indole-3-glycerol phosphate synthase, chloroplastic; Indole-3-glycerol phosphate synthase required for tryptophan biosynthesis.	0.976
A0A1I9LMN9	MIF21.11	A0A1I9LMN9	Q9LUB2	ADC synthase superfamily protein.	Aldolase-type TIM barrel family protein.	0.976
A0A1I9LMN9	PAI1	A0A1I9LMN9	Q42440	ADC synthase superfamily protein.	N-(5'-phosphoribosyl)anthranilate isomerase 1, chloroplastic.	0.868
A0A1I9LMN9	PAI2	A0A1I9LMN9	Q42527	ADC synthase superfamily protein.	N-(5'-phosphoribosyl)anthranilate isomerase 2, chloroplastic; Belongs to the TrpF family.	0.868