STRINGSTRING
GRXS10 GRXS10 SWC4 SWC4 Q8S8S8_ARATH Q8S8S8_ARATH HDA5 HDA5 HDA18 HDA18 GRXC8 GRXC8 F3I6.14 F3I6.14 GRXS2 GRXS2 HDA15 HDA15 F21M11.33 F21M11.33 GRXS13 GRXS13 SLK1 SLK1 ELF3 ELF3 GRXC12 GRXC12 F3I6.18 F3I6.18 F3I6.15 F3I6.15 SNL3 SNL3 GRXS5 GRXS5 F17L21.3 F17L21.3 SNL4 SNL4 ELF4 ELF4 F2G14.150 F2G14.150 SLK3 SLK3 F4JKT1_ARATH F4JKT1_ARATH F4J6V1_ARATH F4J6V1_ARATH F4J0F5_ARATH F4J0F5_ARATH F17L21.6 F17L21.6 F17L21.32 F17L21.32 F3I6.16 F3I6.16 A0A1P8BFD5 A0A1P8BFD5 Q9LK19_ARATH Q9LK19_ARATH FIE FIE KUA1 KUA1 GRXC11 GRXC11 GRXS6 GRXS6 GRXC9 GRXC9 LUX LUX SNL1 SNL1 SNL5 SNL5 SNL6 SNL6 F5O8.36 F5O8.36 SEU SEU HDA14 HDA14 SLK2 SLK2 GRXC7 GRXC7 SRT1 SRT1 CDF1 CDF1 WRKY75 WRKY75 F17L21.5 F17L21.5 SNL2 SNL2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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GRXS10Monothiol glutaredoxin-S10; May only reduce GSH-thiol disulfides, but not protein disulfides; Belongs to the glutaredoxin family. CC-type subfamily. (102 aa)
SWC4SWR1-complex protein 4; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. (441 aa)
Q8S8S8_ARATHZinc ion binding protein. (275 aa)
HDA5Histone deacetylase 5; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (660 aa)
HDA18Histone deacetylase 18; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Required for appropriate cellular patterning in the root epidermis. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (682 aa)
GRXC8Glutaredoxin-C8; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity). Involved in flower development; Belongs to the glutaredoxin family. CC-type subfamily. (140 aa)
F3I6.14Paired amphipathic helix (PAH2) superfamily protein. (155 aa)
GRXS2Monothiol glutaredoxin-S2; May only reduce GSH-thiol disulfides, but not protein disulfides; Belongs to the glutaredoxin family. CC-type subfamily. (102 aa)
HDA15Histone deacetylase 15; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (552 aa)
F21M11.33Prefoldin chaperone subunit family protein. (391 aa)
GRXS13Monothiol glutaredoxin-S13; May only reduce GSH-thiol disulfides, but not protein disulfides. (150 aa)
SLK1Probable transcriptional regulator SLK1; Probable transcription regulator that functions in the development of the carpel margin meristem similarly to SEUSS (SEU). In association with SEU, supports organ development from meristematic regions by facilitating auxin response and thus organ initiation, and by sustaining meristematic potential through the maintenance of PHABULOSA expression. DNA-binding adapter subunit of the SEU-SLK1 transcriptional corepressor of abiotic stress (e.g. salt and osmotic stress) response genes. (748 aa)
ELF3Protein EARLY FLOWERING 3; May be a transcription factor part of a circadian clock input pathway. Acts within a 'zeitnehmer' feedback loop and is involved in its own circadian regulation. Has no role in regulating circadian clock function in the dark. Part of a corepressor complex consisting of ELF4, ELF3, and LUX involved in the transcriptional regulation of APRR9. The activity of the protein may be decreased in long day conditions due to its interaction with phytochrome B (phyB). Can regulate the initiation of flowering independently of phyB. Also involved in responses to nematode pa [...] (695 aa)
GRXC12Putative glutaredoxin-C12; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity); Belongs to the glutaredoxin family. CC-type subfamily. (103 aa)
F3I6.18Paired amphipathic helix (PAH2) superfamily protein. (252 aa)
F3I6.15Paired amphipathic helix repeat-containing protein. (744 aa)
SNL3Paired amphipathic helix protein Sin3-like 3; Acts as a transcriptional repressor. Interacts with ERF7 to repress genes in abscisic acid and drought stress responses. The heterodimer represses transcription by tethering SNL3 to DNA. (1330 aa)
GRXS5Monothiol glutaredoxin-S5; May only reduce GSH-thiol disulfides, but not protein disulfides; Belongs to the glutaredoxin family. CC-type subfamily. (102 aa)
F17L21.3Paired amphipathic helix (PAH2) superfamily protein. (186 aa)
SNL4Paired amphipathic helix protein Sin3-like 4; Acts as a transcriptional repressor. Plays roles in regulating gene expression and genome stability (By similarity). (1326 aa)
ELF4Protein EARLY FLOWERING 4; Component of the central CCA1/LHY-TOC1 feedback loop in the circadian clock that promotes clock accuracy and is required for sustained rhythms in the absence of daily light/dark cycles. Part of a corepressor complex consisting of ELF4, ELF3, and LUX involved in the transcriptional regulation of APRR9. Increases ELF3 nuclear distribution and localization in nuclear bodies. Required for responsiveness to continuous red, by regulating phytochrome B (phyB) signaling (including during seedling de-etiolation) and gene expression. Mediates both entrainment to an env [...] (111 aa)
F2G14.150Paired amphipathic helix Sin3-like protein. (139 aa)
SLK3Probable transcriptional regulator SLK3; Probable transcription regulator that functions in the development of the carpel margin meristem similarly to SEUSS (SEU). In association with SEU, supports organ development from meristematic regions by facilitating auxin response and thus organ initiation, and by sustaining meristematic potential through the maintenance of PHABULOSA expression (By similarity). (685 aa)
F4JKT1_ARATHHistone deacetylase. (70 aa)
F4J6V1_ARATHDuplicated homeodomain-like superfamily protein. (1656 aa)
F4J0F5_ARATHPaired amphipathic helix SIN3-like protein. (355 aa)
F17L21.6Paired amphipathic helix (PAH2) superfamily protein. (225 aa)
F17L21.32Paired amphipathic helix (PAH2) superfamily protein. (222 aa)
F3I6.16Paired amphipathic helix (PAH2) superfamily protein. (245 aa)
A0A1P8BFD5Paired amphipathic helix Sin3-like protein. (122 aa)
Q9LK19_ARATHPaired amphipathic helix Sin3-like protein. (374 aa)
FIEPolycomb group protein FERTILIZATION-INDEPENDENT ENDOSPERM; Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via the methylation of histones, rendering chromatin heritably changed in its expressibility. Required to prevent the proliferation of the central cell by repressing unknown target genes before fertilization. Pr [...] (369 aa)
KUA1Transcription factor KUA1; Transcriptional repressor. Direct regulator of the transcription of peroxidase (Prxs) and reactive oxygen species (ROS)-related genes via the recognition of 5'-ATCACA-3' motif. Binds to 5'-TATCCA-3' motif (TA box) and represses the activity of corresponding promoters (e.g. sugar response genes). Regulates hypocotyl elongation in response to darkness by enhancing auxin accumulation in a phytochrome-interacting factor (PIF) proteins-dependent manner. Promotes lateral roots formation. Promotes cell expansion during leaves development via the modulation of cell w [...] (365 aa)
GRXC11Glutaredoxin-C11; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity); Belongs to the glutaredoxin family. CC-type subfamily. (103 aa)
GRXS6Monothiol glutaredoxin-S6; May only reduce GSH-thiol disulfides, but not protein disulfides; Belongs to the glutaredoxin family. CC-type subfamily. (102 aa)
GRXC9Glutaredoxin-C9; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity). (137 aa)
LUXTranscription factor LUX; Transcription factor that is essential for the generation of the circadian clock oscillation. Is necessary for activation of CCA1 and LHY expression. Is coregulated with TOC1 and seems to be repressed by CCA1 and LHY by direct binding of these proteins to the evening element in the LUX promoter. Directly regulates the expression of PRR9, a major component of the morning transcriptional feedback circuit, by binding specific sites on PRR9 promoter. Binds to its own promoter, inducing a negative auto-regulatory feedback loop within the core clock. Binds to ELF3 a [...] (323 aa)
SNL1Paired amphipathic helix protein Sin3-like 1; Acts as a transcriptional repressor. An histone deacetylase (HDAC) activity is required for transcription repression. May play a role in telomere stability. (1372 aa)
SNL5Paired amphipathic helix protein Sin3-like 5; Acts as a transcriptional repressor. Plays roles in regulating gene expression and genome stability (By similarity). (1162 aa)
SNL6Paired amphipathic helix protein Sin3-like 6; Acts as a transcriptional repressor. Plays roles in regulating gene expression and genome stability (By similarity). (1173 aa)
F5O8.36Paired amphipathic helix (PAH2) superfamily protein. (241 aa)
SEUTranscriptional corepressor SEUSS; DNA-binding adapter subunit of the SEU-LUG transcriptional corepressor of the C class floral homeotic gene AGAMOUS during the early stages of floral meristem development. Is part of the A class cadastral complex that define the boundaries between the A and C class homeotic genes expression and function. Interacts together with APETALA2 and LEUNIG to repress AGAMOUS expression. In association with LUG, regulates petal shape through AGAMOUS-independent mechanisms. Controls cell division during petal development and enable the proper patterning of petal [...] (877 aa)
HDA14Histone deacetylase 14; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (423 aa)
SLK2Probable transcriptional regulator SLK2; Probable transcription regulator that functions in the development of the carpel margin meristem similarly to SEUSS (SEU). In association with SEU, supports organ development from meristematic regions by facilitating auxin response and thus organ initiation, and by sustaining meristematic potential through the maintenance of PHABULOSA expression. DNA-binding adapter subunit of the SEU-SLK2 transcriptional corepressor of abiotic stress (e.g. salt and osmotic stress) response genes. (816 aa)
GRXC7Glutaredoxin-C7; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity). Involved in flower development as a regulator of petal primorida initiation and further petal morphogenesis. May mediate post-translational modifications of target proteins required for normal petal organ initiation and morphogenesis. ROXY1/TGA protein interactions can occur in vivo and support their biological relevance in petal development. May be involved in the regulation of the floral regulato [...] (136 aa)
SRT1NAD-dependent protein deacetylase SRT1; NAD-dependent protein deacetylase. Has deacetylase activity towards H3K9Ac. May have a function in the safeguard against genome instabiliy and DNA damage to ensure plant cell growth (By similarity). Belongs to the sirtuin family. Class IV subfamily. (473 aa)
CDF1Cyclic dof factor 1; Transcription factor that binds specifically to a 5'-AA[AG]G- 3' consensus core sequence. A flanking TGT sequence contributes to the specificity of binding. Regulates a photoperiodic flowering response. Transcriptional repressor of 'CONSTANS' expression. The DNA-binding ability is not modulated by 'GIGANTEA' but the stability of CDF1 is controlled by the proteasome-dependent pathway. Ubiquitinated by the SCF(ADO3) E3 ubiquitin ligase complex. Binds to the FT promoter in the morning. (298 aa)
WRKY75Probable WRKY transcription factor 75; Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis- acting element (By similarity); Belongs to the WRKY group II-c family. (145 aa)
F17L21.5Paired amphipathic helix (PAH2) superfamily protein. (241 aa)
SNL2Paired amphipathic helix protein Sin3-like 2; Acts as a transcriptional repressor. Plays roles in regulating gene expression and genome stability (By similarity). (1367 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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