STRINGSTRING
LECRK72 LECRK72 RLP23 RLP23 LECRKS2 LECRKS2 LECRK53 LECRK53 LECRK54 LECRK54 LECRK51 LECRK51 LECRK52 LECRK52 CBP60G CBP60G IBS1 IBS1 CLT2 CLT2 GEBP GEBP LECRK55 LECRK55 CLT3 CLT3 OCP3 OCP3 PGL3-2 PGL3-2 LSU2 LSU2 LECRK21 LECRK21 LECRK22 LECRK22 LECRKS6 LECRKS6 LECRKS7 LECRKS7 LECRKS5 LECRKS5 SARD1 SARD1 LECRK111 LECRK111 IOS1 IOS1 LECRK32 LECRK32 LECRK31 LECRK31 DLO1 DLO1 DLO2 DLO2 LECRK57 LECRK57 ABCG36 ABCG36 LECRK59 LECRK59 LECRKS3 LECRKS3 LECRK61 LECRK61 LECRK71 LECRK71 ABCG40 ABCG40 LECRKS1 LECRKS1 LECRK11 LECRK11 LECRK13 LECRK13 LECRK14 LECRK14 LECRK42 LECRK42 LECRKS4 LECRKS4 LECRK58 LECRK58 LECRK15 LECRK15 LECRK16 LECRK16 LECRK62 LECRK62 LECRK63 LECRK63 LECRK82 LECRK82 CRN CRN WRKY70 WRKY70 LECRK91 LECRK91 DTX18 DTX18 LECRK17 LECRK17 LECRK18 LECRK18 LECRK19 LECRK19 LECRK92 LECRK92 MKK7 MKK7 F22G5.19 F22G5.19 LECRK81 LECRK81 LECRK56 LECRK56 EDR1 EDR1 EXA1 EXA1 DMR6 DMR6 MKK6 MKK6 ADR2 ADR2 LECRK12 LECRK12 LECRK64 LECRK64 CYP79B3 CYP79B3 LECRK110 LECRK110 CYP79B2 CYP79B2 LECRK43 LECRK43 LECRK44 LECRK44 LECRK41 LECRK41
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LECRK72Probable L-type lectin-domain containing receptor kinase VII.2; In the N-terminal section; belongs to the leguminous lectin family. (681 aa)
RLP23Receptor like protein 23; Involved in the perception of necrosis and ethylene-inducing peptide 1-like proteins (NLPs), that act as extracellular signals mediating immune activation. Component of the RLP23-SOBIR1-BAK1 complex that mediates NLP-triggered immunity. (890 aa)
LECRKS2Receptor like protein kinase S.2. (851 aa)
LECRK53Probable L-type lectin-domain containing receptor kinase V.3; In the N-terminal section; belongs to the leguminous lectin family. (664 aa)
LECRK54L-type lectin-domain containing receptor kinase V.4; Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici and to the pathogenic bacteria Pseudomonas syringae; In the N-terminal section; belongs to the leguminous lectin family. (658 aa)
LECRK51Putative L-type lectin-domain containing receptor kinase V.1; In the N-terminal section; belongs to the leguminous lectin family. (666 aa)
LECRK52Putative L-type lectin-domain containing receptor kinase V.2; In the N-terminal section; belongs to the leguminous lectin family. (656 aa)
CBP60GCalmodulin-binding protein 60 G; Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes. Recruited to the promoter of ICS1 and other defense-related genes (e.g. PR1, PR2 and EDS5) in response to both biotic (e.g. Pseudomonas syringae pv. maculicola ES4326, P. syringae pv. tomato DC3000, and microbe- associated molecular patterns (MAMPs) such as flg22) and abiotic stresses (e.g. UV-B, drought and abscisic acid), thus triggering rapid defense responses by stimulating salicylic acid (SA) biosynthesis. Involved in b [...] (563 aa)
IBS1Protein IMPAIRED IN BABA-INDUCED STERILITY 1; Required for beta-aminobutyric acid (BABA)-induced resistance (BABA-IR) against bacteria (e.g. P.syringae) and oomycetes (e.g. H.parasitica) via priming for salicylate (SA)-dependent defense responses such as pathogenesis-related PR-1 gene expression and trailing necrosis. Involved in BABA-mediated sterility. Necessary for the inheritance of BABA-priming to next generation, especially for the primed to be primed phenotype which consists in an enhanced second BABA-priming in transgenerationally primed plants. (709 aa)
CLT2Protein CLT2, chloroplastic; Involved in thiol transport from the plastid to the cytosol. Transports probably both glutathione (GSH) and its precursor, gamma- glutamylcysteine (gamma-EC); Belongs to the CRT-like transporter family. (431 aa)
GEBPGLABROUS1 enhancer-binding protein; DNA-binding protein, which specifically recognizes the GL1 enhancer sequence. May be involved in leaf initiation. May play redundant roles with GPL1 and GPL2 in cytokinin responses by regulating the transcript levels of type-A ARR response genes. Involved in stress responses. Plays a repressive role in cell expansion by counteracting the positive role of CPR5 in this process, but does not regulate cell proliferation or endoreduplication. May play a role in plant defense. Belongs to the GeBP family. (302 aa)
LECRK55L-type lectin-domain containing receptor kinase V.5; Confers resistance to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici, but confers susceptibility to the pathogenic bacteria Pseudomonas syringae. In the N-terminal section; belongs to the leguminous lectin family. (661 aa)
CLT3Protein CLT3, chloroplastic; Involved in thiol transport from the plastid to the cytosol. Transports probably both glutathione (GSH) and its precursor, gamma- glutamylcysteine (gamma-EC). Exhibits some functional redundancy with CLT1 in maintaining the root GSH pool. (452 aa)
OCP3Protein OVEREXPRESSOR OF CATIONIC PEROXIDASE 3; May modulate chromatin structure by regulation of nucleosome assembly/disassembly (By similarity). Homeodomain transcription factor that mediates jasmonic acid (JA)-mediated COI1-dependent and abscisic acid (ABA)-mediated PMR4-dependent resistance to infection by necrotrophic fungal pathogens (e.g. B.cinerea and P.cucumerina) and bacterial pathogens (e.g. P.syringae DC3000); this resistance involves at least callose deposition. Required for the P.fluorescens WCS417r-triggered JA- dependent induced systemic resistance (ISR) against both P. [...] (354 aa)
PGL3-26-phosphogluconolactonase 3, chloroplastic; Catalyzes the hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate. Involved in the regulation of cellular redox state; enzymatic activity is required for this function. Required for sugar-dependent expression of nitrate assimilation genes in the nucleus of root cells. Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. (325 aa)
LSU2Protein RESPONSE TO LOW SULFUR 2; May be involved in defense responses monitoring. Probably implicated into osmotic stress signaling. (94 aa)
LECRK21Probable L-type lectin-domain containing receptor kinase II.1; In the N-terminal section; belongs to the leguminous lectin family. (674 aa)
LECRK22Putative L-type lectin-domain containing receptor kinase II.2; In the N-terminal section; belongs to the leguminous lectin family. (694 aa)
LECRKS6L-type lectin-domain containing receptor kinase S.6; Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici and to the pathogenic bacteria Pseudomonas syringae; In the N-terminal section; belongs to the leguminous lectin family. (691 aa)
LECRKS7Probable L-type lectin-domain containing receptor kinase S.7; Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici. In the N-terminal section; belongs to the leguminous lectin family. (681 aa)
LECRKS5Probable L-type lectin-domain containing receptor kinase S.5; In the N-terminal section; belongs to the leguminous lectin family. (652 aa)
SARD1Protein SAR DEFICIENT 1; Transcription activator that binds DNA in a sequence-specific manner, 5'-GAAATTTTGG-3', to promote the expression of target genes. Recruited to the promoter of ICS1 and other defense-related genes (e.g. PR1 and SID2) in response to both biotic (e.g. Pseudomonas syringae pv. maculicola ES4326) and abiotic stresses (e.g. UV-B), thus triggering slow defense responses by stimulating salicylic acid (SA) biosynthesis. Required for basal and systemic acquired resistance to P. syringae pv. maculicola and Hyaloperonospora arabidopsidis. Belongs to the plant ACBP60 prote [...] (451 aa)
LECRK111Putative L-type lectin-domain containing receptor kinase I.11; In the N-terminal section; belongs to the leguminous lectin family. (675 aa)
IOS1LRR receptor-like serine/threonine-protein kinase IOS1; Regulates negatively the abscisic acid (ABA) signaling pathway. Required for full susceptibility to filamentous (hemi)biotrophic oomycetes (e.g. H.arabidopsidis and P.parasitica) and fungal (e.g. E.cruciferarum) pathogens, probably by triggering the repression of ABA-sensitive COLD REGULATED and RESISTANCE TO DESICCATION genes during infection, but independently of immune responses. Involved in BAK1- dependent and BAK1-independent microbe-associated molecular patterns (MAMPs)-triggered immunity (PTI) leading to defense responses, [...] (894 aa)
LECRK32Putative inactive L-type lectin-domain containing receptor kinase III.2; Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici. In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (623 aa)
LECRK31Probable inactive L-type lectin-domain containing receptor kinase III.1; In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (627 aa)
DLO1Protein DMR6-LIKE OXYGENASE 1; Converts salicylic acid (SA) to both 2,3-dihydroxybenzoic acid (2,3-DHBA) and 2,5-DHBA in vitro but only 2,3-DHBA in vivo. Component of a negative feedback regulation system of SA levels during senescence. Regulates both onset and progression of leaf senescence. Negative regulator of defense against Hyaloperonospora arabidopsidis. Belongs to the iron/ascorbate-dependent oxidoreductase family. (349 aa)
DLO2Protein DMR6-LIKE OXYGENASE 2; Converts salicylic acid (SA) to 2,3-dihydroxybenzoic acid (2,3-DHBA) (By similarity). Negative regulator of defense against Hyaloperonospora arabidopsidis. Belongs to the iron/ascorbate-dependent oxidoreductase family. (348 aa)
LECRK57L-type lectin-domain containing receptor kinase V.7; Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici and to the pathogenic bacteria Pseudomonas syringae; In the N-terminal section; belongs to the leguminous lectin family. (659 aa)
ABCG36ABC transporter G family member 36; Key factor that controls the extent of cell death in the defense response. Necessary for both callose deposition and glucosinolate activation in response to pathogens. Required for limiting invasion by nonadapted powdery mildews. Confers resistance to cadmium (Cd) and lead (Pb), probably as an efflux pump of Cd2+ or Cd conjugates, and possibly, of chemicals that mediate pathogen resistance. (1469 aa)
LECRK59L-type lectin-domain containing receptor kinase V.9; In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (669 aa)
LECRKS3Receptor like protein kinase S.3; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (337 aa)
LECRK61Probable L-type lectin-domain containing receptor kinase VI.1; In the N-terminal section; belongs to the leguminous lectin family. (693 aa)
LECRK71L-type lectin-domain containing receptor kinase VII.1; In the N-terminal section; belongs to the leguminous lectin family. (686 aa)
ABCG40ABC transporter G family member 40; May be a general defense protein (By similarity). Functions as a pump to exclude Pb(2+) ions and/or Pb(2+)-containing toxic compounds from the cytoplasm. Contributes to Pb(2+) ions resistance. Confers some resistance to the terpene sclareol. (1423 aa)
LECRKS1L-type lectin-domain containing receptor kinase S.1; Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici and to the pathogenic bacteria Pseudomonas syringae; In the N-terminal section; belongs to the leguminous lectin family. (656 aa)
LECRK11Putative L-type lectin-domain containing receptor kinase I.1; Involved in resistance response to the pathogenic fungus Alternaria brassicicola; In the N-terminal section; belongs to the leguminous lectin family. (682 aa)
LECRK13L-type lectin-domain containing receptor kinase I.3; Involved in resistance response to the pathogenic fungus Alternaria brassicicola; In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (664 aa)
LECRK14Putative L-type lectin-domain containing receptor kinase I.4; In the N-terminal section; belongs to the leguminous lectin family. (667 aa)
LECRK42L-type lectin-domain containing receptor kinase IV.2; Required during pollen development. In the N-terminal section; belongs to the leguminous lectin family. (677 aa)
LECRKS4L-type lectin-domain containing receptor kinase S.4; Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici and to the pathogenic bacteria Pseudomonas syringae; In the N-terminal section; belongs to the leguminous lectin family. (684 aa)
LECRK58Putative L-type lectin-domain containing receptor kinase V.8; In the N-terminal section; belongs to the leguminous lectin family. (626 aa)
LECRK15Probable L-type lectin-domain containing receptor kinase I.5; In the N-terminal section; belongs to the leguminous lectin family. (674 aa)
LECRK16Probable L-type lectin-domain containing receptor kinase I.6; In the N-terminal section; belongs to the leguminous lectin family. (669 aa)
LECRK62L-type lectin-domain containing receptor kinase VI.2; Involved in negative regulation of abscisic acid response in seed germination; In the N-terminal section; belongs to the leguminous lectin family. (682 aa)
LECRK63Lectin-domain containing receptor kinase VI.3; Involved in negative regulation of abscisic acid response in seed germination; In the N-terminal section; belongs to the leguminous lectin family. (688 aa)
LECRK82L-type lectin-domain containing receptor kinase VIII.2; Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici. In the N-terminal section; belongs to the leguminous lectin family. (711 aa)
CRNInactive leucine-rich repeat receptor-like protein kinase CORYNE; Involved in the perception of CLV3 and CLV3-like (CLE) peptides, that acts as a extracellular signals regulating meristems maintenance. Modulates root, shoot and flower apical meristems maintenance and floral organ development regulation, probably via CLAVATA (CLV)-like pathways involving at least CLV3 and CLE19. In complex with CLV2, perceives secreted CLV3-like effector proteins from plant-parasitic cyst nematodes as ligand mimics of the plant CLE signaling pathway. This recognition is required for proper feeding struc [...] (401 aa)
WRKY70Probable WRKY transcription factor 70; Transcription factor involved in senescence, biotic and abiotic stress responses by modulating various phytohormones signaling pathways. Interacts specifically with the W box (5'- (T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Binds to the 5'-[CT]GACTTTT-3' motif in promoters of target genes to induce their expression. Plays an important but not indispensable role in jasmonate and salicylic acid signaling. Regulates positively the salicylic acid (SA)-mediated signal pathway, but negatively the jasmo [...] (294 aa)
LECRK91L-type lectin-domain containing receptor kinase IX.1; Promotes hydrogen peroxide H(2)O(2) production and cell death; In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (651 aa)
DTX18Protein DETOXIFICATION 18. (469 aa)
LECRK17L-type lectin-domain containing receptor kinase I.7; Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici. In the N-terminal section; belongs to the leguminous lectin family. (668 aa)
LECRK18L-type lectin-domain containing receptor kinase I.8; Involved in resistance response to the pathogenic fungus Alternaria brassicicola; In the N-terminal section; belongs to the leguminous lectin family. (657 aa)
LECRK19L-type lectin-domain containing receptor kinase I.9; Essential receptor for extracellular ATP. Binds ATP with high affinity through its extracellular legume-lectin like region. Is required for ATP-induced intracellular calcium response, mitogen-activated protein kinase 3 (MPK3) and MPK6 activation and ATP-induced gene expression. May play a variety of roles in stress resistance. May be involved in protein-protein interactions with RGD motif-containing proteins as potential ligands. Plays probably a structural and signaling role at the plant cell surfaces. (766 aa)
LECRK92L-type lectin-domain containing receptor kinase IX.2; Promotes hydrogen peroxide H(2)O(2) production and cell death; In the N-terminal section; belongs to the leguminous lectin family. (675 aa)
MKK7Mitogen-activated protein kinase kinase 7; May function as a negative regulator of polar auxin transport. Positively regulates plant basal and systemic acquired resistance (SAR). Activates MPK3 and MPK6 in vitro. (307 aa)
F22G5.19Concanavalin A-like lectin family protein; Belongs to the leguminous lectin family. (322 aa)
LECRK81L-type lectin-domain containing receptor kinase VIII.1; In the N-terminal section; belongs to the leguminous lectin family. (715 aa)
LECRK56Putative L-type lectin-domain containing receptor kinase V.6; In the N-terminal section; belongs to the leguminous lectin family. (523 aa)
EDR1Serine/threonine-protein kinase EDR1; MAPKKK serine/threonine-protein kinase involved in the regulation of a MAP kinase cascade (probably including MPK3 and MPK6) that negatively regulates salicylic acid- (SA-) dependent defense responses, abscisic acid (ABA) signaling, and ethylene-induced senescence. Modulates also stress response (e.g. drought) signaling and cell death, in an ORE9-dependent manner. Functions at a point of cross talk between ethylene, ABA and SA signaling that impinges on senescence and cell death. On the other hand, it confers sensitivity to various pathogens such a [...] (933 aa)
EXA1Protein ESSENTIAL FOR POTEXVIRUS ACCUMULATION 1; Translational repressor involved in the negative regulation of immune receptor accumulation via the inhibition of nucleotide- binding leucine-rich repeat (NLR) receptor mediated defense. Represses NLR protein accumulation (e.g. SNC1, RPS4, RPM1 and RPS2). Together with SMG7, helps to restrict effector-triggered immunity (ETI) cell death induction during pathogen infection in a salicylic acid- (SA) and reactive oxygen species- (ROS) independent manner. Required for pathogen-associated molecular pattern (PAMP)-induced suppression of necrot [...] (1714 aa)
DMR6Protein DOWNY MILDEW RESISTANCE 6; Converts salicylic acid (SA) to 2,3-dihydroxybenzoic acid (2,3-DHBA) (By similarity). Suppressor of immunity. Regulates negatively defense associated genes expression (e.g. PR-1, PR-2, and PR-5). Negative regulator of defense against Hyaloperonospora arabidopsidis. (Microbial infection) Required for susceptibility to Pseudomonas syringae pv. tomato DC3000; Belongs to the iron/ascorbate-dependent oxidoreductase family. (341 aa)
MKK6Mitogen-activated protein kinase kinase 6; The ANPs-MKK6-MPK4 module is involved in the regulation of plant cytokinesis during meiosis and mitosis. MKK6-MPK13 module positively regulates lateral root formation. Phosphorylates and activates MPK4. Activates MPK5 and MPK13 in vitro. (356 aa)
ADR2Disease resistance protein ADR2; TIR-NB-LRR receptor-like protein that confers broad-spectrum resistance and full immunity to several races of the pathogen Albugo candida (white rust disease). Confers resistance to the biotrophic pathogens Pseudomonas syringae pv. tomato DC3000 and Hyaloperonospora arabidopsis isolate Noco2. May play a role in the response to UV stress. (1007 aa)
LECRK12Probable L-type lectin-domain containing receptor kinase I.2; Involved in resistance response to the pathogenic fungus Alternaria brassicicola; In the N-terminal section; belongs to the leguminous lectin family. (669 aa)
LECRK64Lectin-domain containing receptor kinase VI.4; Involved in negative regulation of abscisic acid response in seed germination; In the N-terminal section; belongs to the leguminous lectin family. (691 aa)
CYP79B3Tryptophan N-monooxygenase 2; Converts tryptophan to indole-3-acetaldoxime, a precursor for tryptophan derived glucosinolates and indole-3-acetic acid (IAA). Belongs to the cytochrome P450 family. (543 aa)
LECRK110Putative L-type lectin-domain containing receptor kinase I.10; In the N-terminal section; belongs to the leguminous lectin family. (616 aa)
CYP79B2Tryptophan N-monooxygenase 1; Converts tryptophan to indole-3-acetaldoxime, a precursor for tryptophan-derived glucosinolates and indole-3-acetic acid (IAA). Involved in the biosynthetic pathway to 4-hydroxyindole-3-carbonyl nitrile (4-OH-ICN), a cyanogenic metabolite required for inducible pathogen defense. Belongs to the cytochrome P450 family. (541 aa)
LECRK43L-type lectin-domain containing receptor kinase IV.3; In the N-terminal section; belongs to the leguminous lectin family. (674 aa)
LECRK44L-type lectin-domain containing receptor kinase IV.4; Involved in resistance response to the pathogenic oomycetes Phytophthora infestans and Phytophthora capsici and to the pathogenic bacteria Pseudomonas syringae; In the N-terminal section; belongs to the leguminous lectin family. (669 aa)
LECRK41L-type lectin-domain containing receptor kinase IV.1; In the N-terminal section; belongs to the leguminous lectin family. (675 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.