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KTI4 KTI4 SAG21 SAG21 MYB76 MYB76 MYB28 MYB28 CRPK1 CRPK1 BGLU18 BGLU18 PAD4 PAD4 WRKY70 WRKY70 CYP71B15 CYP71B15 IRM1 IRM1 KTI5 KTI5 ESM1 ESM1 MYB29 MYB29 CYP79F1 CYP79F1 CAMRLK CAMRLK PDF1.2A PDF1.2A MAM1 MAM1 KTI2 KTI2 MYB122 MYB122 TPS03 TPS03 COI1 COI1 MYB51 MYB51 AtXYP10 AtXYP10 CYP83B1 CYP83B1 CYP79B2 CYP79B2 PP2A1 PP2A1 VSP2 VSP2 TGG1 TGG1 CYP83A1 CYP83A1 ETR1 ETR1 NPR1 NPR1 CYP79B3 CYP79B3 DOF1.1 DOF1.1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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from curated databases
experimentally determined
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KTI4Kunitz trypsin inhibitor 4; Exhibits Kunitz trypsin protease inhibitor activity. Involved in modulating programmed cell death (PCD) in plant-pathogen interactions. Can inhibit both serine proteases and cysteine proteases. May be involved in the modulation of the proteases that participate in the hydrolysis of dietary proteins in the gut of spider mites ; Belongs to the protease inhibitor I3 (leguminous Kunitz- type inhibitor) family. (215 aa)
SAG21Protein SENESCENCE-ASSOCIATED GENE 21, mitochondrial; Mediates tolerance to oxidative stresses (e.g. hydrogen peroxide H(2)O(2), diamide, menadione and tert-butyl hydroperoxide) by minimizing the negative effects of oxidation and monitoring photosynthesis during stress. Promotes root development. Prevents premature aging (e.g. senescence and flowering). Involved in resistance against compatible pathogens such as Botrytis cinerea and Pseudomonas syringae pv. tomato. (97 aa)
MYB76Transcription factor MYB76; Plays a role in determining the spatial distribution of aliphatic glucosinolates (AGLSs) within the leaf, mostly short chained. Together with MYB28/HAG1 and MYB29/HAG3, promotes aliphatic glucosinolate biosynthesis and represses indolic glucosinolate biosynthesis, but could not activate AGSL biosynthesis on its own. (338 aa)
MYB28Transcription factor MYB28; Major regulator of short-chained aliphatic glucosinolates (GLSs) biosynthesis. Together with MYB29/HAG3 and MYB76/HAG2, promotes aliphatic glucosinolate biosynthesis but represses indolic glucosinolate biosynthesis. Prevents insect performance (e.g. lepidopteran insect Mamestra brassicae and Spodoptera exigua) by promoting glucosinolates. (366 aa)
CRPK1Cold-responsive protein kinase 1; Negative regulator of freezing tolerance that phosphorylates 14-3-3 proteins (e.g. GRF6) thus triggering their translocation from the cytosol to the nucleus in response to cold stress. (390 aa)
BGLU18Beta-D-glucopyranosyl abscisate beta-glucosidase; Hydrolyzes abscisic acid glucose ester (ABA-GE) which represents the predominant form of conjugated ABA (biologically inactive). No activity with beta-D-glucopyranosyl zeatin. The hydrolysis of ABA-GE in the endoplasmic reticulum (ER) forms free ABA and contributes to increase its cellular levels under dehydration conditions. ABA-GE hydrolyzing activity is enhanced by dehydration stress-induced polymerization into higher molecular weight forms. The ABA produced by BGLU18 contributes to the initiation of intracellular signaling as well a [...] (528 aa)
PAD4Lipase-like PAD4; Probable lipase required downstream of MPK4 for accumulation of the plant defense-potentiating molecule, salicylic acid, thus contributing to the plant innate immunity against invasive biotrophic pathogens and to defense mechanisms upon recognition of microbe- associated molecular patterns (MAMPs). Participates in the regulation of various molecular and physiological processes that influence fitness. Together with SG101, required for programmed cell death (PCD) triggered by NBS-LRR resistance proteins (e.g. RPS4, RPW8.1 and RPW8.2) in response to the fungal toxin fumo [...] (541 aa)
WRKY70Probable WRKY transcription factor 70; Transcription factor involved in senescence, biotic and abiotic stress responses by modulating various phytohormones signaling pathways. Interacts specifically with the W box (5'- (T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element (By similarity). Binds to the 5'-[CT]GACTTTT-3' motif in promoters of target genes to induce their expression. Plays an important but not indispensable role in jasmonate and salicylic acid signaling. Regulates positively the salicylic acid (SA)-mediated signal pathway, but negatively the jasmo [...] (294 aa)
CYP71B15Bifunctional dihydrocamalexate synthase/camalexin synthase; Multifunctional enzyme involved in the biosynthesis of the indole-derived phytoalexin camalexin. Catalyzes two reactions, the formation of dihydrocamalexate from indole-3-acetonitrile-cysteine conjugate and the oxidative decarboxylation of dihydrocamalexate which is the final step in camalexin biosynthesis. Required for the resistance to the fungal pathogens A.brassicicola, B.cinerea, B.elliptica, B.tulipae, L.maculans and Colletotrichum higginsianum. Seems not to be required for resistance to P.syringae, P.porri, and not invo [...] (490 aa)
IRM1Protein INCREASED RESISTANCE TO MYZUS PERSICAE 1; May act as an adapter to facilitate the interaction of SnRK1 complex with effector proteins, conferring tissue- and stimulus-type specific differences in the SnRK1 regulation pathway. Belongs to the FLZ family. (113 aa)
KTI5Kunitz trypsin inhibitor 5; Can inhibit both serine proteases and cysteine proteases. May be involved in the modulation of the proteases that participate in the hydrolysis of dietary proteins in the gut of spider mites. (196 aa)
ESM1GDSL esterase/lipase ESM1; Represses or inhibits nitriles production from methionine- derived and from indol-3-ylmethyl glucosinolates. Favors isothiocyanate production; Belongs to the 'GDSL' lipolytic enzyme family. (392 aa)
MYB29Transcription factor MYB29; Plays a minor rheostat role in aliphatic glucosinolates (GLSs) biosynthesis, mostly short chained. Together with MYB28/HAG1 and MYB76/HAG2, promotes aliphatic glucosinolate biosynthesis but represses indolic glucosinolate biosynthesis. Prevents insect performance (e.g. lepidopteran insect Mamestra brassicae) by promoting glucosinolates. (336 aa)
CYP79F1Dihomomethionine N-hydroxylase; Catalyzes the conversion of the short chain elongated methionines di-, tri-, and tetrahomomethionine to their respective aldoximes 5-methylthiopentanaldoxime, 6-methylthiohexanaldoxime, and 7- methylheptanaldoxime. (538 aa)
CAMRLKCalmodulin-binding receptor kinase CaMRLK; Can phosphorylate the myelin basic protein in vitro. Required for endosperm development in embryos. Maybe involved in auxin and osmotic stress responses ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (666 aa)
PDF1.2ADefensin-like protein 16; Confers broad-spectrum resistance to pathogens. Has antifungal activity in vitro; Belongs to the DEFL family. (80 aa)
MAM1Methylthioalkylmalate synthase 1, chloroplastic; Determines the side chain length of aliphatic glucosinolate structures. Catalyzes exclusively the condensation reactions of both the first and second methionine carbon chain elongation. Belongs to the alpha-IPM synthase/homocitrate synthase family. (506 aa)
KTI2Kunitz trypsin inhibitor 2; Water-soluble and chlorophyll-binding protein that probably does not function as a chloroplast chlorophyll carrier and is not involved in photosynthesis. Involved in the control of cell death in the transmitting tract and septum epidermis during flower development. Binds and inhibits the activity of the cysteine protease RD21A as a pro-death protein. May play a role in herbivore resistance activation during seedling greening ; Belongs to the protease inhibitor I3 (leguminous Kunitz- type inhibitor) family. (215 aa)
MYB122Transcription factor MYB122; Transcription factor involved in glucosinolates biosynthesis. (333 aa)
TPS03Tricyclene synthase, chloroplastic; Predominantly involved in sesquiterpenes (C15) biosynthesis. Using FPP as substrate, the major product is (E,E)-alpha-farnesene with minor amounts of (Z,E)-alpha-farnesene and (E,E)-beta-farnesene. Using GPP as substrate, could also be able in vitro to synthesize monoterpene (C10) with (E)-beta-ocimene as the major product and with (Z)-beta- ocimene and myrcene as minor products; Belongs to the terpene synthase family. Tpsb subfamily. (565 aa)
COI1Coronatine-insensitive protein 1; Required for jasmonate-regulated plant fertility and defense processes, and for coronatine and/or other elicitors perceptions/responses. Seems to not be required for meiosis. Required for the regulation of some genes induced by wounding, but not for all. Component of SCF(COI1) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (probably including the ribulose bisphosphate carboxylase small chain 1B RBCS-1B and the histone deacetylase HDA6). These SCF complexes play crucial roles [...] (592 aa)
MYB51Transcription factor MYB51; Transcription factor positively regulating indolic glucosinolate biosynthetic pathway genes. (352 aa)
AtXYP10Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein; Belongs to the plant LTP family. (204 aa)
CYP83B1Cytochrome P450 83B1; Involved in the metabolism of aromatic oximes. Catalyzes the oxime metabolizing step in indole glucosinolate biosynthesis by converting indole-3-acetaldoxime into indole-3-S-alkyl-thiohydroximate. Probably required for glucosinolate activation in response to pathogens. Functions in auxin homeostasis because indole-3-acetaldoxime also serves as a precursor for auxin biosynthesis. Specifically metabolizes (E)-p-hydroxyphenylacetaldoxime into an S-alkyl- thiohydroximate. (499 aa)
CYP79B2Tryptophan N-monooxygenase 1; Converts tryptophan to indole-3-acetaldoxime, a precursor for tryptophan-derived glucosinolates and indole-3-acetic acid (IAA). Involved in the biosynthetic pathway to 4-hydroxyindole-3-carbonyl nitrile (4-OH-ICN), a cyanogenic metabolite required for inducible pathogen defense. Belongs to the cytochrome P450 family. (541 aa)
PP2A1Protein PHLOEM PROTEIN 2-LIKE A1. (246 aa)
VSP2Vegetative storage protein 2; May function as somatic storage protein during early seedling development; Belongs to the APS1/VSP family. (265 aa)
TGG1Myrosinase 1; Degradation of glucosinolates (glucose residue linked by a thioglucoside bound to an amino acid derivative) to glucose, sulfate and any of the products: thiocyanates, isothiocyanates, nitriles, epithionitriles or oxazolidine-2-thiones. These toxic degradation products can deter insect herbivores. Seems to function in abscisic acid (ABA) and methyl jasmonate (MeJA) signaling in guard cells. Functionally redundant with TGG2. Hydrolyzes sinigrin and, with lower efficiency, p-nitrophenyl beta-D-glucoside. (541 aa)
CYP83A1Cytochrome P450 83A1; Involved in the metabolism of aliphatic and aromatic oximes. Involved in the biosynthesis of both short-chain and long-chain aliphatic glucosinolates. Belongs to the cytochrome P450 family. (502 aa)
ETR1Ethylene receptor 1; Ethylene receptor related to bacterial two-component regulators. Acts as a redundant negative regulator of ethylene signaling. In the presence of ethylene, the auto-kinase activity of ETR1 is inhibited and the non- phosphorylated kinase domain binds tightly to the corresponding domain of EIN2. (738 aa)
NPR1Regulatory protein NPR1; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Key positive regulator of the SA-dependent signaling pathway that negatively regulates JA-dependent signaling pathway. Mediates the binding of TGA factors to the as-1 motif found in the pathogenesis-related PR-1 gene, leading to the transcriptional regulation of the gene defense. Controls the onset of systemic acquired resistance (SAR). Upon SAR induction, [...] (593 aa)
CYP79B3Tryptophan N-monooxygenase 2; Converts tryptophan to indole-3-acetaldoxime, a precursor for tryptophan derived glucosinolates and indole-3-acetic acid (IAA). Belongs to the cytochrome P450 family. (543 aa)
DOF1.1Dof zinc finger protein DOF1.1; Transcription factor that binds specifically to a 5'-AA[AG]G- 3' consensus core sequence. Enhances the DNA binding of OBF transcription factors to OCS elements (By similarity). Involved in the regulation of root development. The PEAR proteins (e.g. DOF2.4, DOF5.1, DOF3.2, DOF1.1, DOF5.6 and DOF5.3) activate gene expression that promotes radial growth of protophloem sieve elements. Element of a regulatory network controlling indole glucosinolates (IGS) biosynthesis, probably by inducing the expression of accurate genes (e.g. CYP83B1). Promotes apical dominance. (331 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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