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SHW1 SHW1 GLV9 GLV9 HY5 HY5 PID PID NPY4 NPY4 NPY2 NPY2 NPY5 NPY5 ARAC3 ARAC3 NGR1 NGR1 LA1 LA1 PIP5K2 PIP5K2 SPK1 SPK1 RGF6 RGF6 TAR2 TAR2 AUX1 AUX1 ROSY1 ROSY1 SNX1 SNX1 RGF9 RGF9 CYP705A5 CYP705A5 EB1B EB1B HSFA4C HSFA4C NPY3 NPY3 T27I15_140 T27I15_140 RGF4 RGF4 ABCB19 ABCB19 CYP705A22 CYP705A22 PIN2 PIN2 TAA1 TAA1 PIN3 PIN3 SAUR41 SAUR41 PKS1 PKS1 ABCB1 ABCB1 ATJ15 ATJ15
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second shell of interactors
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proteins of unknown 3D structure
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SHW1Protein SHORT HYPOCOTYL IN WHITE LIGHT 1; Negative regulator of photomorphogenesis modulating both light and abscisic acid (ABA) signaling pathways. Regulates negatively the light- mediated inhibition of hypocotyl elongation, probably in a PHYB- mediated signaling pathway, but promotes flowering time (especially in long days) and lateral root formation. Enhances light-regulated gene expression. Promotes COP1-mediated degradation of HY5 during seedling development (e.g. hypocotyl growth) through enhanced ubiquitination in the darkness. Also involved in root gravitropism. (192 aa)
GLV9Transmembrane protein. (95 aa)
HY5Transcription factor HY5; Transcription factor that promotes photomorphogenesis in light. Acts downstream of the light receptor network and directly affects transcription of light-induced genes. Specifically involved in the blue light specific pathway, suggesting that it participates in transmission of cryptochromes (CRY1 and CRY2) signals to downstream responses. In darkness, its degradation prevents the activation of light-induced genes (Probable). Acts coordinately with SPL7 to regulate the microRNA miR408 and its target genes in response to changes in light and copper conditions. R [...] (168 aa)
PIDProtein kinase PINOID; Serine/threonine-protein kinase involved in the regulation of auxin signaling. Acts as a positive regulator of cellular auxin efflux and regulates organ development by enhancing polar auxin transport. Phosphorylates conserved serine residues in the PIN auxin efflux carriers. Phosphorylation of PIN proteins is required and sufficient for apical-basal PIN polarity that enables directional intercellular auxin fluxes, which mediate differential growth, tissue patterning and organogenesis. Acts in association with PIN1 to control the establishment of bilateral symmetr [...] (438 aa)
NPY4BTB/POZ domain-containing protein NPY4; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May play an essential role in auxin-mediated organogenesis and in root gravitropic responses; Belongs to the NPH3 family. (481 aa)
NPY2BTB/POZ domain-containing protein NPY2; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May play an essential role in auxin-mediated organogenesis and in root gravitropic responses; Belongs to the NPH3 family. (634 aa)
NPY5BTB/POZ domain-containing protein NPY5; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May play an essential role in auxin-mediated organogenesis and in root gravitropic responses; Belongs to the NPH3 family. (580 aa)
ARAC3Rac-like GTP-binding protein ARAC3; Inactive GDP-bound Rho GTPases reside in the cytosol, are found in a complex with Rho GDP-dissociation inhibitors (Rho GDIs), and are released from the GDI protein in order to translocate to membranes upon activation. May be involved in cell polarity control during the actin-dependent tip growth of root hairs. SPK1- dependent activation is required for auxin-mediated inhibition of PIN2 internalization during gravitropic responses. (198 aa)
NGR1NGR1. (295 aa)
LA1Protein LAZY 1; Involved in the regulation of shoot gravitropism. Involved in the regulation of inflorescence branch angle. Belongs to the LAZY family. (358 aa)
PIP5K2Phosphatidylinositol 4-phosphate 5-kinase 2; Possesses phosphatidylinositol kinase activity in vitro. (754 aa)
SPK1Guanine nucleotide exchange factor SPIKE 1; Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP. Controls actin polymerization via the two heteromeric complexes WAVE and actin-related protein (ARP) 2/3. Involved in cytoskeletal reorganization required for cell shape (e.g. trichome and cotyledon) control and tissue development. Promotes polarized growth and cell-cell adhesion in the leaf epidermis probably by promoting the formation of endoplasmic reticulum (ER) exit site (ERES) and/or trafficking between the [...] (1830 aa)
RGF6Root meristem growth factor 6; Maintains the postembryonic root stem cell niche. Belongs to the RGF family. (86 aa)
TAR2Tryptophan aminotransferase-related protein 2; Involved in auxin production. Both TAA1 and TAR2 are required for maintaining proper auxin levels in roots, while TAA1, TAR1 and TAR2 are required for proper embryo patterning. Involved in the maintenance of the root stem cell niches. (440 aa)
AUX1Auxin transporter protein 1; Carrier protein involved in proton-driven auxin influx. Mediates the formation of auxin gradient from developing leaves (site of auxin biosynthesis) to tips by contributing to the loading of auxin in vascular tissues and facilitating acropetal (base to tip) auxin transport within inner tissues of the root apex, and basipetal (tip to base) auxin transport within outer tissues of the root apex. Unloads auxin from the mature phloem to deliver the hormone to the root meristem via the protophloem cell files. Coordinated subcellular localization of AUX1 is regula [...] (485 aa)
ROSY1MD-2-related lipid-recognition protein ROSY1; Involved in the regulation of gravitropic response and basipetal auxin transport in roots. Involved in salt stress tolerance. May facilitate membrane trafficking and asymmetric cell elongation via SYT1. Binds stigmasterol and dipalmitoyl phosphoethanolamine (DPPE) in vitro. (160 aa)
SNX1Sorting nexin 1; Plays a role in vesicular protein sorting. Acts at the crossroads between the secretory and endocytic pathways. Is involved in the endosome to vacuole protein transport via its interaction with the BLOS1/2 proteins and, as component of the membrane-associated retromer complex, is also involved in endosome-to-Golgi retrograde transport. Required for the auxin-carrier protein PIN2 sorting to the lytic vacuolar pathway and the trafficking of several plasma membrane proteins. Also involved in the efficient sorting of seed storage protein globulin 12S. (402 aa)
RGF9Root meristem growth factor 9; Maintains the postembryonic root stem cell niche. Belongs to the RGF family. (79 aa)
CYP705A5Cytochrome P450 705A5; Converts thalian-diol to a desaturated thalian-diol. Belongs to the cytochrome P450 family. (511 aa)
EB1BMicrotubule-associated protein RP/EB family member 1B; Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. May be involved in anchoring microtubules to their nucleation sites and/or functioning as a reservoir for distribution to the growing end. In plants, microtubule minus ends are not necessarily severed from the nucleation site and transported to the plus end of a microtubule as part of the recycling process. May play a role in endomembrane organization during polarized growth of plant cells. (293 aa)
HSFA4CHeat stress transcription factor A-4c; Transcriptional activator that specifically binds DNA sequence 5'-AGAAnnTTCT-3' known as heat shock promoter elements (HSE). May be involved in general response to auxin. (345 aa)
NPY3BTB/POZ domain-containing protein NPY3; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). May play an essential role in auxin-mediated organogenesis and in root gravitropic responses. (579 aa)
T27I15_140Calcium-dependent lipid-binding (CaLB domain) family protein. (510 aa)
RGF4Root meristem growth factor 4; Maintains the postembryonic root stem cell niche. (163 aa)
ABCB19ABC transporter B family member 19; Auxin efflux transporter that acts as a negative regulator of light signaling to promote hypocotyl elongation. Mediates the accumulation of chlorophyll and anthocyanin, as well as the expression of genes in response to light. Participates in auxin efflux and thus regulates the polar auxin basipetal transport (from auxin-producing leaves to auxin-sensitive tissues, and from root tips to root elongating zone). Involved in diverse auxin-mediated responses including gravitropism, phototropism and lateral root formation. (1252 aa)
CYP705A22Cytochrome P450 705A22; Plays a role in the gravitropic response of the inflorescence stems and roots. May affect the synthesis of flavonols that have a role in regulating auxin transport; Belongs to the cytochrome P450 family. (515 aa)
PIN2Auxin efflux carrier component 2; Acts as a component of the auxin efflux carrier. Seems to be involved in the root-specific auxin transport, and mediates the root gravitropism. Its particular localization suggest a role in the translocation of auxin towards the elongation zone. (647 aa)
TAA1L-tryptophan--pyruvate aminotransferase 1; L-tryptophan aminotransferase involved in auxin (IAA) biosynthesis. Can convert L-tryptophan and pyruvate to indole-3-pyruvic acid (IPA) and alanine. Catalyzes the first step in IPA branch of the auxin biosynthetic pathway. Required for auxin production to initiate multiple change in growth in response to environmental and developmental cues. It is also active with phenylalanine, tyrosine, leucine, alanine, methionine and glutamine. Both TAA1 and TAR2 are required for maintaining proper auxin levels in roots, while TAA1, TAR1 and TAR2 are requ [...] (391 aa)
PIN3Auxin efflux carrier component 3; Acts as a component of the auxin efflux carrier. Seems to be involved in the lateral auxin transport system and mediates tropic growth. Coordinated polar localization of PIN3 is directly regulated by the vesicle trafficking process. (640 aa)
SAUR41Auxin-responsive protein SAUR41; Plays a role in the regulation of cell expansion, root meristem patterning and auxin transport; Belongs to the ARG7 family. (147 aa)
PKS1Protein PHYTOCHROME KINASE SUBSTRATE 1; May be responsible for light-regulated cytoplasmic sequestration of phytochromes or may be a negative regulator of phytochrome B signaling. Component of the network that modulates the very low-fluence response (VLFR) branch of phyA signaling. Acts positively in PHOT1 signaling. Regulates phytochrome-mediated photomorphogenesis and hypocotyl phototropism. Involved in the control of leaf flattening and leaf positioning. Promotes negative root phototropism and negatively regulates root gravitropism. May act by controlling auxin homeostasis. Belongs [...] (439 aa)
ABCB1ABC transporter B family member 1; Auxin efflux transporter that acts as a negative regulator of light signaling to promote hypocotyl elongation. Mediates the accumulation of chlorophyll and anthocyanin, as well as the expression of genes in response to light. Participates directly in auxin efflux and thus regulates the polar (presumably basipetal) auxin transport (from root tips to root elongating zone). Transports also some auxin metabolites such as oxindoleacetic acid and indoleacetaldehyde. Involved in diverse auxin-mediated responses including gravitropism, phototropism and latera [...] (1286 aa)
ATJ15Chaperone protein dnaJ 15; Plays a continuous role in plant development probably in the structural organization of compartments (By similarity). Seems to be involved in early gravitropic signal transduction within the gravity- perceiving cells (statocytes), where it influences pH changes and auxin distribution. Probably affects the localization and/or activity of auxin efflux carrier components (PIN proteins) or other proteins involved in lateral auxin transport; Belongs to the DnaJ family. B/II subfamily. (410 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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