STRINGSTRING
RGF7 RGF7 JMJ14 JMJ14 MMS21 MMS21 MKK5 MKK5 CLE19 CLE19 CYP71 CYP71 RGF6 RGF6 ARR1 ARR1 ARP5 ARP5 RFC3-2 RFC3-2 F10D13.7 F10D13.7 RGF9 RGF9 ARR11 ARR11 RCH2 RCH2 MCM2 MCM2 AMP1 AMP1 RGF8 RGF8 MAIL1 MAIL1 ARR2 ARR2 GLV8 GLV8 F11C1_150 F11C1_150 RGF5 RGF5 F12G12.7 F12G12.7 RGI3 RGI3 RCH1 RCH1 MDA7.8 MDA7.8 VICTR VICTR ARR10 ARR10 ARR12 ARR12 AGL14 AGL14 MPK6 MPK6 RGF1 RGF1 CLE18 CLE18 TPST TPST RGF2 RGF2 rgf3 rgf3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
RGF7Root meristem growth factor 7; Maintains the postembryonic root stem cell niche. Belongs to the RGF family. (102 aa)
JMJ14Probable lysine-specific demethylase JMJ14; Transcriptional repressor. Histone demethylase that demethylates 'Lys-4' (H3K4me) of histone H3 with a higher activity for H3K4me3 and H3K4me2 than H3K4me1. No activity on H3K9me3/2, H3K36me3/2 and H3K27me3/2. Represses FT and TSF expression to inhibit the floral transition. Binds around the transcription start site of the FT locus. Involved in the DRM2-mediated maintenance of DNA methylation, but not required for the de novo DNA methylation. Required for demethylating histone H3K4me3 at the target of RNA silencing. Together with NAC051/NAC05 [...] (954 aa)
MMS21E3 SUMO-protein ligase MMS21; E3 SUMO-protein ligase that modulates cell cycle progression and functions as a repressor of endocycle onset in meristems. May function downstream of the meristem patterning transcription factors PLETHORA 1 and 2 (PLT1 and PLT2) in root meristem development. Modulates the expression of the mitotic cyclins CYCB1-1 and CYCB1-2 and cyclin-dependent kinases CDKB1-1 and CDKB2-1 in root meristem. Involved in cytokinin signaling in root development. Belongs to the NSE2 family. (249 aa)
MKK5Mitogen-activated protein kinase kinase 5; Involved in the second phase of hydrogen peroxide generation during hypersensitive response-like cell death. Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. Activates by phosphorylation the downstream MPK3 and MPK6. YDA-MKK4/MKK5-MPK3/MPK6 module regulates stomatal cell fate before the guard mother cell (GMC) is specified. This MAPK cascade also functions downstream of the ER receptor in regulating coordinated local cell proliferation, which shapes the [...] (348 aa)
CLE19CLAVATA3/ESR (CLE)-related protein 19; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (74 aa)
CYP71Peptidyl-prolyl cis-trans isomerase CYP71; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Histone remodeling factor involved in chromatin-based gene silencing. Reinforces H3K27 methylation. Involved in fundamental processes of chromatin assembly and histone modification by mediating the targeting of FAS1 and LHP1 on the chromatin. Required for the formation and development of leaves, for normal phyllotaxy and for the formation, maintenance and activity of root and shoot apical meristems. (631 aa)
RGF6Root meristem growth factor 6; Maintains the postembryonic root stem cell niche. Belongs to the RGF family. (86 aa)
ARR1Two-component response regulator ARR1; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. Regulates SHY2 by binding to its promoter. Involved in the root-meristem size determination through the regulation of cell differentiation. Belon [...] (690 aa)
ARP5Actin-related protein 5; Probable subunit of a chromatin-remodeling complex. Involved in DNA repair. Required for multicellular development of all organs. (724 aa)
RFC3-2Translation elongation factor EF1B/ribosomal protein S6 family protein. (314 aa)
F10D13.7Sporulation protein (DUF155). (373 aa)
RGF9Root meristem growth factor 9; Maintains the postembryonic root stem cell niche. Belongs to the RGF family. (79 aa)
ARR11Two-component response regulator ARR11; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins (By similarity); Belongs to the ARR family. Type-B subfamily. (521 aa)
RCH2Receptor-like protein kinase 2; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1141 aa)
MCM2DNA replication licensing factor MCM2; Probable component of the MCM2-7 complex (MCM complex) that may function as a DNA helicase and which is essential to undergo a single round of replication initiation and elongation per cell cycle in eukaryotic cells. May play a crucial role in the control of de- differentiation and cell proliferation processes required for lateral root formation. Is essential for embryo development. Is involved in the geminivirus mungbean yellow mosaic virus (MYMV) DNA replication, presumably in conjunction with other host factors. (936 aa)
AMP1Probable glutamate carboxypeptidase AMP1; May modulate the level of one or more small signaling molecules that have a role in regulating meristem function. May play a role in balancing and restricting the meristem-promoting activity of auxin signaling. Involved in ethylene and giberellin (GA) signaling pathways or in a parallel pathway controlling cell and hypocotyl elongation and cellular organization. Involved in abscisic acid (ABA) signaling pathway. Plays a negative role in ABA-mediated seed germination and seedling development. Acts in association with LAMP1 to suppress ectopic st [...] (705 aa)
RGF8Probable root meristem growth factor 8; May be involved in maintaining the postembryonic root stem cell niche; Belongs to the RGF family. (123 aa)
MAIL1Protein MAIN-LIKE 1; Acts as an important factor for cell fate determination and maintenance throughout plant development. Required for the organization of the root apical meristem (RAM) and the shoot apical meristem (SAM). Required to maintain genome stability and cell division activity in meristematic cells. (509 aa)
ARR2Two-component response regulator ARR2; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. Involved in the expression of nuclear genes for components of mitochondrial complex I. Promotes cytokinin-mediated leaf longevity. Involved in th [...] (664 aa)
GLV8Protein GOLVEN 8; Promotes root hairs formation and growth. Belongs to the RGF family. (111 aa)
F11C1_150Mitogen-activated protein kinase kinase kinase 20. (342 aa)
RGF5Root meristem growth factor 5; Maintains the postembryonic root stem cell niche. Belongs to the RGF family. (88 aa)
F12G12.7Probable LRR receptor-like serine/threonine-protein kinase At1g34110; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1072 aa)
RGI3LRR receptor-like serine/threonine-protein kinase; Acts as receptor of RGF1, a peptide hormone that maintains the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT). Links RGF1 signal with its downstream components. (1091 aa)
RCH1LRR receptor-like serine/threonine-protein kinase RCH1. (1135 aa)
MDA7.8Leucine-rich receptor-like protein kinase family protein; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1090 aa)
VICTRProtein VARIATION IN COMPOUND TRIGGERED ROOT growth response; Disease resistance protein of the TIR-NB-LRR-type. Part of the RPS6 locus that contains a cluster of several paralogous disease resistance (R) genes. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth (By similarity). Required for [5-(3,4- dichlorophenyl)furan-2-yl]-piperidine-1-ylmethanethione-(DFPM-) induced root [...] (1168 aa)
ARR10Two-component response regulator ARR10; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. (552 aa)
ARR12Two-component response regulator ARR12; Transcriptional activator that binds specifically to the DNA sequence 5'-[AG]GATT-3'. Functions as a response regulator involved in His-to-Asp phosphorelay signal transduction system. Phosphorylation of the Asp residue in the receiver domain activates the ability of the protein to promote the transcription of target genes. Could directly activate some type-A response regulators in response to cytokinins. Involved in the root-meristem size determination through the regulation of cell differentiation. Involved in activating SHY2 during meristem gro [...] (596 aa)
AGL14Agamous-like MADS-box protein AGL14; Transcriptional activator that regulates root development by controlling meristem size and patterning of the root apical meristem. Regulates auxin transport and gradients in the root meristematic cells via direct regulation of the auxin efflux carrier PIN1 and PIN4 gene expression. Binds specifically to the CArG-box DNA sequences in the promoter regions of PIN1 and PIN4 genes. Involved in the regulation of shoot apical meristem (SAM) cell identities and transitions. Promotes flowering transition and participates in flower meristem maintenance and de [...] (221 aa)
MPK6Mitogen-activated protein kinase 6; Involved in oxidative stress-mediated signaling cascade (such as ozone). Involved in the innate immune MAP kinase signaling cascade (MEKK1, MKK4/MKK5 and MPK3/MPK6) downstream of bacterial flagellin receptor FLS2. May be involved in hypersensitive response (HR)-mediated signaling cascade by modulating LIP5 phosphorylation and subsequent multivesicular bodies (MVBs) trafficking. May phosphorylate regulators of WRKY transcription factors. Phosphorylates 1-aminocyclopropane-1- carboxylic acid synthases (ACS2 and ACS6) and may be involved in the regulati [...] (395 aa)
RGF1Root meristem growth factor 1; Maintains the postembryonic root stem cell niche by regulating the expression levels and patterns of the transcription factor PLETHORA (PLT), mainly at the post-transcriptional level. Belongs to the RGF family. (116 aa)
CLE18CLAVATA3/ESR (CLE)-related protein 18; Extracellular signal peptide that regulates cell fate. Represses root apical meristem maintenance. Belongs to the CLV3/ESR signal peptide family. (101 aa)
TPSTProtein-tyrosine sulfotransferase; Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides. (500 aa)
RGF2Root meristem growth factor 2; Maintains the postembryonic root stem cell niche. Belongs to the RGF family. (109 aa)
rgf3Root meristem growth factor 3; Maintains the postembryonic root stem cell niche. Belongs to the RGF family. (110 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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