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GRXS5 GRXS5 GRXS4 GRXS4 GRXS8 GRXS8 PGM PGM CIPK8 CIPK8 AFB3 AFB3 NPF7.3 NPF7.3 GRXS6 GRXS6 GRXC11 GRXC11 NRT2.6 NRT2.6 NPF6.4 NPF6.4 NRT2.2 NRT2.2 NRT2.5 NRT2.5 CTL1 CTL1 GRXS1 GRXS1 NRT3.2 NRT3.2 NLP5 NLP5 ANR1 ANR1 BAH1 BAH1 NPF6.3 NPF6.3 CLC-A CLC-A NRT2.1 NRT2.1 GRXS3 GRXS3 NRT2.7 NRT2.7 GATA22 GATA22 Q1G385_ARATH Q1G385_ARATH NIR1 NIR1 NLP7 NLP7 NPF7.2 NPF7.2 NRG2 NRG2 BT2 BT2 NRT3.1 NRT3.1 NRT2.3 NRT2.3 NRT2.4 NRT2.4 NLP4 NLP4
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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GRXS5Monothiol glutaredoxin-S5; May only reduce GSH-thiol disulfides, but not protein disulfides; Belongs to the glutaredoxin family. CC-type subfamily. (102 aa)
GRXS4Monothiol glutaredoxin-S4; May only reduce GSH-thiol disulfides, but not protein disulfides; Belongs to the glutaredoxin family. CC-type subfamily. (102 aa)
GRXS8Monothiol glutaredoxin-S8; May only reduce GSH-thiol disulfides, but not protein disulfides; Belongs to the glutaredoxin family. CC-type subfamily. (102 aa)
PGMPhosphoglycerate/bisphosphoglycerate mutase. (332 aa)
CIPK8CBL-interacting serine/threonine-protein kinase 8; CIPK serine-threonine protein kinases interact with CBL proteins. Binding of a CBL protein to the regulatory NAF domain of CIPK protein lead to the activation of the kinase in a calcium-dependent manner (By similarity); Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. (445 aa)
AFB3Protein AUXIN SIGNALING F-BOX 3; Confers sensitivity to the virulent bacterial pathogen P.syringae (By similarity). Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Auxin receptor that mediates Aux/IAA proteins proteasomal degradation and auxin- regulated transcription. Involved in embryogenesis regulation by auxin. (577 aa)
NPF7.3Protein NRT1/ PTR FAMILY 7.3; Low-affinity proton-dependent bidirectional nitrate transporter. Involved in nitrate loading into xylem and not in nitrate uptake. Not involved in histidine or dipeptides transport. Belongs to the PTR2/POT transporter (TC 2.A.17) family. (614 aa)
GRXS6Monothiol glutaredoxin-S6; May only reduce GSH-thiol disulfides, but not protein disulfides; Belongs to the glutaredoxin family. CC-type subfamily. (102 aa)
GRXC11Glutaredoxin-C11; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity); Belongs to the glutaredoxin family. CC-type subfamily. (103 aa)
NRT2.6High affinity nitrate transporter 2.6; Involved in high-affinity nitrate transport. Required for the nitrate uptake-independent plant growth promotion and lateral root response to the rhizospheric Phyllobacterium. (542 aa)
NPF6.4Protein NRT1/ PTR FAMILY 6.4; Low-affinity nitrate transporter; Belongs to the PTR2/POT transporter (TC 2.A.17) family. (590 aa)
NRT2.2High-affinity nitrate transporter 2.2; Involved in high-affinity nitrate transport. (522 aa)
NRT2.5High affinity nitrate transporter 2.5; Nitrate transporter involved in the constitutive high- affinity transport system (cHATS) under long-term N starvation conditions. Predominantly expressed in roots of nitrate-deprived plants as a 150 kDa molecular complex with NRT3.1 representing the major contributor to cHATS influx. The principal role of this cHATS is to enable roots previously deprived of nitrate to absorb this ion and initiate induction of nitrate-inducible genes. Not involved in transfer of nitrate from roots to shoots. Contributes to phloem loading of nitrate in shoots during [...] (502 aa)
CTL1Chitinase-like protein 1; No chitinase activity. Essential for normal plant growth and development. Regulates cell expansion extent and differentiation at least in roots and hypocotyls. Prevents lignin accumulation in the pith. May modulate ethylene-mediated regulation during development. Probably required to establish thermotolerance acclimation. Plays a role for controlled anisotropic cell expansion in the regulation of waving during root gravitropism and thigmotropism. Involved in the root system architecture adaptation to multiple environmental conditions such as nitrate. Contribut [...] (321 aa)
GRXS1Monothiol glutaredoxin-S1; May only reduce GSH-thiol disulfides, but not protein disulfides; Belongs to the glutaredoxin family. CC-type subfamily. (102 aa)
NRT3.2High-affinity nitrate transporter 3.2; Acts as a dual component transporter with NTR2.1. Required for high-affinity nitrate transport (By similarity); Belongs to the NAR2 family. (209 aa)
NLP5Protein NLP5; Probable transcription factor. (808 aa)
ANR1MADS-box transcription factor ANR1; Probable transcription factor. Required for root plasticity in response to nitrate, NO(3)(-). Promotes lateral root growth in a NRT1.1-dependent manner. (234 aa)
BAH1E3 ubiquitin-protein ligase BAH1; Mediates E2-dependent protein ubiquitination. Plays a role in salicylic acid-mediated negative feedback regulation of salicylic acid (SA) accumulation. May be involved in the overall regulation of SA, benzoic acid and phenylpropanoid biosynthesis. Controls the adaptability to nitrogen limitation by channeling the phenylpropanoid metabolic flux to the induced anthocyanin synthesis. (335 aa)
NPF6.3Protein NRT1/ PTR FAMILY 6.3; Dual affinity nitrate transporter. Involved in proton- dependent nitrate uptake and in the regulation of the nitrate transporter NRT2.1. Acts also as a nitrate sensor that trigger a specific signaling pathway stimulating lateral root growth and seed germination. The uptake activity is not required for sensor function. Displays an auxin transport facilitation inhibited by high nitrate concentration. Required to prevent auxin accumulation in preemerged lateral root primordia and young lateral roots when external nitrate concentration is low or null. May be i [...] (590 aa)
CLC-AChloride channel protein CLC-a; Voltage-gated chloride channel that could play a role in the regulation of nitrate content. (775 aa)
NRT2.1High-affinity nitrate transporter 2.1; Involved in nitrate transport, but does not seem to be able to mediate transport by its own. Acts as a dual component transporter with NTR3.1. Acts as a repressor of lateral root initiation under high sucrose/low nitrate conditions. (530 aa)
GRXS3Monothiol glutaredoxin-S3; May only reduce GSH-thiol disulfides, but not protein disulfides; Belongs to the glutaredoxin family. CC-type subfamily. (102 aa)
NRT2.7High affinity nitrate transporter 2.7; Involved in high-affinity nitrate transport. Controls nitrate content in seeds; Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family. (493 aa)
GATA22Putative GATA transcription factor 22; Transcriptional regulator that specifically binds 5'-GATA-3' or 5'-GAT-3' motifs within gene promoters. Involved in the modulation of chloroplast development, growth and division in a cytokinin-dependent manner. Repressor of the gibberellic acid (GA) signaling pathway that regulates flowering and modulates greening, in a SOC1-dependent manner. Prevents the accumulation of SOC1 during flowering. Promotes chlorophyll biosynthesis throughout the plant, by regulating chlorophyll biosynthetic genes (e.g. HEMA1 and GUN4) and chloroplast localized glutam [...] (352 aa)
Q1G385_ARATHHigh affinity nitrate transporter. (87 aa)
NIR1Ferredoxin--nitrite reductase, chloroplastic; Catalyzes the six-electron reduction of nitrite to ammonium. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (586 aa)
NLP7Protein NLP7; Transcription factor involved in regulation of nitrate assimilation and in transduction of the nitrate signal. (959 aa)
NPF7.2Protein NRT1/ PTR FAMILY 7.2; Low-affinity nitrate transporter. Involved in nitrate removal from xylem sap. Not involved in oligopeptides transport. (589 aa)
NRG2Nitrate regulatory gene2 protein; Required for nitrate signaling. Regulates expression of the nitrate-responsive genes NIA1, NIR1, NRT2.1 and NPF6.3/NRT1.1. (796 aa)
BT2BTB/POZ and TAZ domain-containing protein 2; May act as a substrate-specific adapter of an E3 ubiquitin- protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Plays a key role as a component of the TAC1-mediated telomerase activation pathway certainly by targeting a telomerase repressor to degradation. Seems to occupy an integral position in a complex signaling network that perceives, integrates, and responds to multiple, and sometimes competing, signals. Enhances responses to auxin in postgermination and veg [...] (364 aa)
NRT3.1High-affinity nitrate transporter 3.1; Acts as a dual component transporter with NTR2.1. Required for high-affinity nitrate transport. Acts as a repressor of lateral root initiation. May be involved in targeting NRT2 proteins to the plasma membrane. Belongs to the NAR2 family. (210 aa)
NRT2.3High affinity nitrate transporter 2.3; Involved in high-affinity nitrate transport. Acts as a dual component transporter with NTR3.1 (By similarity). (539 aa)
NRT2.4High affinity nitrate transporter 2.4; Involved in high-affinity nitrate transport. Might be involved in the transfer of nitrate from stored pools to cytoplasm. Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family. (527 aa)
NLP4Protein NLP4; Probable transcription factor. (844 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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