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NDR1 NDR1 RPP1 RPP1 F3N23.9 F3N23.9 F3N23.4 F3N23.4 LECRK92 LECRK92 CPSF30 CPSF30 E2FC E2FC GRI GRI OXI1 OXI1 RBA1 RBA1 NAC101 NAC101 ATL55 ATL55 LECRK91 LECRK91 GH3.12 GH3.12 PAD4 PAD4 SOBIR1 SOBIR1 F3N23.14 F3N23.14 EDS1 EDS1 MYB65 MYB65 NAC92 NAC92 Q94K36_ARATH Q94K36_ARATH LOL1 LOL1 RIN3 RIN3 MYB33 MYB33 RIN2 RIN2 NAC074 NAC074 MORC1 MORC1 AMC1 AMC1 F5O11.3 F5O11.3 UGP1 UGP1 BAG6 BAG6 MYB101 MYB101 AMC5 AMC5 AMC4 AMC4
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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NDR1Protein NDR1; Involved in disease resistance. Required for resistance conferred by multiple R genes recognizing different bacterial and oomycete pathogen isolates like avirulent P.syringae or H.parasitica (downy mildew). Required for the establishment of hypersensitive response (HR) and systemic acquired resistance (SAR) after infection with the bacterial pathogen P.syringae DC3000 carrying avrRpt2. Required for resistance to the soilborne fungus V.longisporum. Interaction with RIN4 is required for the activation of the R gene RPS2 and RPS2-mediated resistance. (219 aa)
RPP1Probable disease resistance protein RPP1; TIR-NB-LRR receptor-like protein that confers resistance to the pathogen Hyaloperonospora arabidopsis (By similarity). Probably acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death. (1194 aa)
F3N23.9Disease resistance protein (TIR-NBS class). (487 aa)
F3N23.4Disease resistance protein (TIR-NBS-LRR class). (1183 aa)
LECRK92L-type lectin-domain containing receptor kinase IX.2; Promotes hydrogen peroxide H(2)O(2) production and cell death; In the N-terminal section; belongs to the leguminous lectin family. (675 aa)
CPSF3030-kDa cleavage and polyadenylation specificity factor 30; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation. May interact with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition (By similarity). Mediates poly(A) site selection. Binds RNA in a calcium- dependent manner. Exhibits endonuclease activity with an ability to nick and degrade linear as well as circular single-stranded RNA that leaves RNA 3' ends with hydroxyl groups, thus mediating processing of the pre-mRNA as a pre [...] (631 aa)
E2FCTranscription factor E2FC; Involved in transcriptional repression. May act by repressing E2F-regulated genes in mature differentiated cells, but is not an antagonist of E2FA. Restricts cell division and is involved in the coordination between cell proliferation and endoreduplication during development. May play a role during the transition from skotomorphogenesis to photomorphogenesis. Regulated by phosphorylation- dependent proteolysis via the protein-ubiquitin ligase SCF(SKP2A) complex. Belongs to the E2F/DP family. (396 aa)
GRIProtein GRIM REAPER; Involved in the regulation of cell death induced by extracellular reactive oxygen species. Only the processed peptide, and not the full length GRI can bind in vivo to the extracellular domain of the receptor PRK5. The GRIp-induced cell death is superoxide and salicylic acid dependent. Belongs to the STIG1 family. (168 aa)
OXI1Serine/threonine-protein kinase OXI1; Involved in oxidative burst-mediated signaling. Required for basal resistance to P.parasitica infection and root hair growth. Partly required for the activation of MPK3 and MPK6 by hydrogen peroxide and cellulase elicitor. (421 aa)
RBA1Disease resistance protein RBA1; Disease resistance (R) protein that specifically recognizes the HopBA1 type III effector protein from P.syringae, and triggers cell death. Acts as a NAD(+) hydrolase (NADase): in response to pathogen-recognition, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death. In addition to ADPR, also generates a cyclization variant of cyclic ADPR (cADPR), termed v-cADPR, for which the cyclizing bond is unknown. Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules. (363 aa)
NAC101NAC domain-containing protein 101; Transcription activator that binds to the secondary wall NAC binding element (SNBE), 5'- (T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', and to the tracheary elements (TE) specific regulating cis-element (TERE), 5'- CTTNAAAGCNA-3', in the promoter of target genes (e.g. genes involved in secondary wall biosynthesis, cell wall modification such as xylan accumulation, and programmed cell death). Involved in xylem formation in roots and shoots, especially regulating metaxylem vessel differentiation by promoting immature xylem vessel-specific genes exp [...] (348 aa)
ATL55E3 ubiquitin-protein ligase RING1; E3 ubiquitin-protein ligase that may be involved in positive regulation of programmed cell death (PCD) by facilitating degradation of negative regulators of PCD. May be involved in the early steps of the plant defense signaling pathway. Undergoes auto-ubiquitination. Belongs to the RING-type zinc finger family. ATL subfamily. (301 aa)
LECRK91L-type lectin-domain containing receptor kinase IX.1; Promotes hydrogen peroxide H(2)O(2) production and cell death; In the C-terminal section; belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (651 aa)
GH3.124-substituted benzoates-glutamate ligase GH3.12; Catalyzes the conjugation of specific amino acids (e.g. Glu and possibly His, Lys, and Met) to their preferred acyl substrates (e.g. 4-substituted benzoates), in a magnesium ion- and ATP-dependent manner. Can use 4-substituted benzoates such as 4-aminobenzoate (pABA), 4-fluorobenzoate and 4-hydroxybenzoate (4-HBA), and, to a lesser extent, benzoate, vanillate and trans-cinnamate, but not 2-substituted benzoates and salicylic acid (SA), as conjugating acyl substrates. Involved in both basal and induced resistance in a SA-dependent manner. [...] (575 aa)
PAD4Lipase-like PAD4; Probable lipase required downstream of MPK4 for accumulation of the plant defense-potentiating molecule, salicylic acid, thus contributing to the plant innate immunity against invasive biotrophic pathogens and to defense mechanisms upon recognition of microbe- associated molecular patterns (MAMPs). Participates in the regulation of various molecular and physiological processes that influence fitness. Together with SG101, required for programmed cell death (PCD) triggered by NBS-LRR resistance proteins (e.g. RPS4, RPW8.1 and RPW8.2) in response to the fungal toxin fumo [...] (541 aa)
SOBIR1Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1; Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Acting as a counterplayer of BIR1, promotes the activation of plant defense and cell death. Component of the RLP23-SOBIR1-BAK1 complex that mediates NLP-triggered immunity. Functions as an inhibitor/regulator of abscission, probably by regulating membrane trafficking during abscission. (641 aa)
F3N23.14Toll-Interleukin-Resistance (TIR) domain-containing protein. (371 aa)
EDS1Protein EDS1; Positive regulator of basal resistance and of effector- triggered immunity specifically mediated by TIR-NB-LRR (TNL) resistance proteins. Disruption by bacterial effector of EDS1-TIR-NB-LRR resistance protein interactions constitutes the first step in resistance activation. Acts redundantly with salicylic acid to regulate resistance gene-mediated signaling. Triggers early plant defenses and hypersensitive response independently of PAD4, and then recruits PAD4 to potentiate plant defenses through the accumulation of salicylic acid. Nuclear localization is essential for bas [...] (623 aa)
MYB65Transcription factor MYB65; Transcriptional activator of alpha-amylase expression that binds to 5'-CAACTGTC-3' motif in target gene promoter. In vegetative tissues, inhibits growth by reducing cell proliferation. Promotes the expression of aleurone-related genes (e.g. CP1, CP, GASA1, BXL1 and BXL2) in seeds. Together with MYB33 and MYB101, promotes the programmed cell death (PCD) the vacuolation of protein storage vacuoles (PSVs) in the aleurone layers during seed germination. Together with MYB33, facilitates anther and tapetum development. (553 aa)
NAC92NAC domain-containing protein 92; Transcription activator that binds to DNA in promoters of target genes on a specific bipartite motif 5'-[ACG][CA]GT[AG](5- 6n)[CT]AC[AG]-3'. Promotes lateral root development. Triggers the expression of senescence-associated genes during age-, salt- and dark-induced senescence through a regulatory network that may involve cross-talk with salt- and H(2)O(2)- dependent signaling pathways. Regulates also genes during seed germination. Regulates positively aging-induced cell death. Involved in age-related resistance (ARR) against Pseudomonas syringae pv. t [...] (285 aa)
Q94K36_ARATHUncharacterized protein family SERF. (69 aa)
LOL1Protein LOL1; Positive regulator of reactive oxygen-induced cell death. May be involved in the repression of the copper/zinc superoxide dismutase CSD1 and CSD2 that detoxify accumulating superoxide before the reactive oxygen species (ROS) can trigger a cell death cascade. LSD1 and LOL1 have antagonistic effects on CSD1 and CSD2 accumulation to regulate oxidative stress-induced cell death. (154 aa)
RIN3E3 ubiquitin protein ligase RIN3; E3 ubiquitin protein ligase that acts as positive regulator of RPM1- and RPS2-dependent hypersensitive response (HR), in association with RIN2. Probably not required for RPM1 degradation during HR. (577 aa)
MYB33Transcription factor MYB33; Transcriptional activator of alpha-amylase expression that binds to 5'-CAACTGTC-3' motif in target gene promoter. Positive regulator of abscisic acid (ABA) responses leading to growth arrest during seed germination. In vegetative tissues, inhibits growth by reducing cell proliferation. Promotes the expression of aleurone-related genes (e.g. CP1, CP, GASA1, BXL1 and BXL2) in seeds. Together with MYB65 and MYB101, promotes the programmed cell death (PCD) the vacuolation of protein storage vacuoles (PSVs) in the aleurone layers during seed germination. Binds to [...] (520 aa)
RIN2E3 ubiquitin protein ligase RIN2; E3 ubiquitin protein ligase that acts as positive regulator of RPM1- and RPS2-dependent hypersensitive response (HR), in association with RIN3. Probably not required for RPM1 degradation during HR. (578 aa)
NAC074NAC domain containing protein 74. (352 aa)
MORC1Protein MICRORCHIDIA 1; Mediator of defense signaling triggered by distinct classes of R proteins. Required during hypersensitive response (HR) that confers disease resistance to turnip crinkle virus (TCV). Exhibits ATPase activity. Contributes to resistance against Pseudomonas syringae and Hyaloperonospora arabidopsidis, at early stages prior to cytosolic calcium ions Ca(2+) accumulation. Required for pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI), basal resistance, non-host resistance and systemic acquired resistance (SAR). Binds DNA/RNA in a non-specific manne [...] (635 aa)
AMC1Metacaspase-1; Cysteine protease that cleaves specifically after arginine or lysine residues. Does not cleave caspase-specific substrates. Acts as a positive regulator of cell death. Required for both oxidative stress cell death response and hypersensitive cell death response mediated by immune response. (367 aa)
F5O11.3Probable disease resistance protein At1g12290; Probable disease resistance protein. (884 aa)
UGP1UTP--glucose-1-phosphate uridylyltransferase 1; Converts glucose 1-phosphate to UDP-glucose, which is the major glycosyl donor for polysaccharides. Acts redundantly with UGP2 and is essential for the synthesis of sucrose, starch and cell wall, and callose deposition. Involved in the regulation of the programmed cell death (PCD) induced by the fungal toxin fumonisin B1 (FB1). (470 aa)
BAG6BAG family molecular chaperone regulator 6; Co-chaperone that regulates diverse cellular pathways, such as programmed cell death and stress responses. Involved in plant basal resistance. Involved in basal heat response through the regulation of the heat induced small HSP (sHSP) transcriptional cascade. (1043 aa)
MYB101Transcription factor MYB101; Transcription activator. Binds to 5'-CAACTGTC-3' and/or 5'-TAACAAA-3' motif in target gene promoter (e.g. alpha-amylase) to promote their expression. Positive regulator of abscisic acid (ABA) responses leading to growth arrest during seed germination. Promotes the expression of aleurone-related genes (e.g. CP1, CP, GASA1, BXL1 and BXL2) in seeds. Together with MYB33 and MYB65, promotes the programmed cell death (PCD) leading to vacuolation of protein storage vacuoles (PSVs) in the aleurone layers during seed germination. Maybe involved in the regulation of [...] (490 aa)
AMC5Metacaspase-5; Cysteine protease that cleaves specifically after arginine or lysine residues. Does not cleave caspase-specific substrates. May be involved in the modulation of programmed cell death activated by oxidative stress. (410 aa)
AMC4Metacaspase-4 subunit p10; Cysteine protease that cleaves specifically after arginine or lysine residues. Does not cleave caspase-specific substrates. Plays a positive regulatory role in biotic and abiotic stress-induced programmed cell death. (418 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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