STRINGSTRING
F13I12.170 F13I12.170 U2AF35A U2AF35A LAF1 LAF1 SMU1 SMU1 RCF3 RCF3 ML1 ML1 PABN1 PABN1 HUA1 HUA1 EIF4A3 EIF4A3 MTB MTB RRC1 RRC1 F23C21.4 F23C21.4 CDKG1 CDKG1 SWC6 SWC6 VIN3 VIN3 PABN2 PABN2 SC35 SC35 U2AF35B U2AF35B RS2Z32 RS2Z32 F1I16_140 F1I16_140 HAKAI HAKAI VIL1 VIL1 FIP37 FIP37 RS2Z33 RS2Z33 SNRNP35 SNRNP35 ML5 ML5 SPL7 SPL7 T27G7.27 T27G7.27 U2AF65B U2AF65B SCL30 SCL30 TGH TGH MLE2.7 MLE2.7 PAPP5 PAPP5 SR45A SR45A SIZ1 SIZ1 F18F4.130 F18F4.130 CPL1 CPL1 BHLH72 BHLH72 RNU1 RNU1 ULP1D ULP1D SCL28 SCL28 RS41 RS41 RS40 RS40 RS31 RS31 PHYB PHYB PHYA PHYA MTA MTA RSZ21 RSZ21 RSZ22 RSZ22 SKIP SKIP SMU2 SMU2 MAGO MAGO U2AF65A U2AF65A RZ1B RZ1B SR34 SR34 LIS LIS DRB1 DRB1 MYB25 MYB25 HEN4 HEN4 MJJ3.13 MJJ3.13 GFL GFL F24J7.162 F24J7.162 SR34B SR34B VIR VIR F4IZU8_ARATH F4IZU8_ARATH F4IVU7_ARATH F4IVU7_ARATH THO2 THO2 Y14 Y14 CTN CTN NSRB NSRB CSU2 CSU2 FHL FHL SR34A SR34A NSRA NSRA HEN2 HEN2 KIN17 KIN17 SE SE CYP63 CYP63 PABN3 PABN3 OXS3 OXS3 CLO CLO SCL30A SCL30A ML3-2 ML3-2 SMD1B SMD1B CSU1 CSU1 SPA1 SPA1 SR30 SR30 RS31A RS31A SMD1A SMD1A BAH1 BAH1 ML2 ML2 RSZ22A RSZ22A SCL33-2 SCL33-2 SR45 SR45
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F13I12.170Zinc finger CCCH domain-containing protein 42. (352 aa)
U2AF35ASplicing factor U2af small subunit A; Necessary for the splicing of pre-mRNA (By similarity). Probably active at the 3' splice sites; Belongs to the splicing factor SR family. (296 aa)
LAF1Transcription factor LAF1; Transcription factor that promotes photomorphogenesis in the light by participating in the transmission of phytochrome A (phyA) signals to downstream responses. Probably acts by activating expression of light-induced genes. In darkness, its degradation prevents the activation of light-induced genes. (283 aa)
SMU1Suppressor of mec-8 and unc-52 protein homolog 1; Auxiliary spliceosomal protein involved in splicing of specific pre-mRNAs that affect multiple aspects of development. Required for proper accumulation of SMU2. (511 aa)
RCF3RNA-binding KH domain-containing protein RCF3; Acts as negative regulator of osmotic stress-induced gene expression. Involved in the regulation of thermotolerance responses under heat stress. Functions as an upstream regulator of heat stress transcription factor (HSF) genes. Negatively regulates HSFA1A, HSFA1B AND HSFA1D, but positively controls the expression of HSFA1E, HSFA3, HSFA9, HSFB3, and DREB2C. Forms a complex with CPL1 that modulates co- transcriptional processes such as mRNA capping and polyadenylation, and functions to repress stress-inducible gene expression. Regulates pre [...] (652 aa)
ML1Protein MEI2-like 1; Probable RNA-binding transcriptional activator that plays a role in meiosis and vegetative growth. May be a downstream effector of TOR signaling pathway and recruited by RAPTOR1 for TOR substrate. (915 aa)
PABN1Polyadenylate-binding protein 1; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. (227 aa)
HUA1Zinc finger CCCH domain-containing protein 37; Involved in flower development. Functions in floral reproductive organ identity by binding AGAMOUS (AG) pre-mRNA and promoting its processing. Functions in association with HUA2 and HEN4. (524 aa)
EIF4A3Eukaryotic initiation factor 4A-III homolog; ATP-dependent RNA helicase. Core component of the splicing- dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs through [...] (408 aa)
MTBN6-adenosine-methyltransferase non-catalytic subunit MTB; Probable non-catalytic subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, FIP37, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. (775 aa)
RRC1Protein RRC1; SR-like splicing factor required for phytochrome B (phyB) signal transduction and involved in phyB-dependent alternative splicing. (946 aa)
F23C21.4U2 snRNP auxiliary factor, large subunit, putative; 15147-15692. (111 aa)
CDKG1Cyclin-dependent kinase G1; Cyclin-dependent kinase involved in pre-mRNA splicing. Required for the correct splicing of the sixth intron of CALS5 pre- mRNA. May stabilize the binding of U1 snRNP to this rare type of intron with a GC 5'SS. Involved in chromosome pairing and is required for the completion of synapsis in male meiocytes at high ambient temperatures. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (612 aa)
SWC6SWR1 complex subunit 6; Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant H2A.F/Z leading to transcriptional regulation of selected genes (e.g. FLC) by chromatin remodeling. Coodinates SWR1-C, FRI-C (FLC transcription activator complex), histone methyltransferase and general transcription factors. Represses flowering by positively regulating FLC and MAF4. Binds to the promoter region of FLC chromatin. (171 aa)
VIN3Protein VERNALIZATION INSENSITIVE 3; Plays a central role in vernalization by mediating the initial transcriptional repression of the homeotic gene FLC, a floral repressor, after a cold treatment. However, due to its transient expression, it cannot maintain repression of FLC, which is then maintained by Polycomb Group complexes containing VRN2 throughout development. Required to deacetylate histones on the FLC promoter. Together with VIL1, required during vernalization for the modifications of FLC and FLM chromatin that are associated with an epigenetically silenced state (e.g. chromat [...] (620 aa)
PABN2Polyadenylate-binding protein 2; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. (220 aa)
SC35Serine/arginine-rich splicing factor SC35; Probably involved in intron recognition and spliceosome assembly, but not involved in alternative splicing regulation of the SCL33 intron. (303 aa)
U2AF35BSplicing factor U2af small subunit B; Necessary for the splicing of pre-mRNA (By similarity). Probably active at the 3' splice sites; Belongs to the splicing factor SR family. (283 aa)
RS2Z32Serine/arginine-rich splicing factor RS2Z32; Probably involved in intron recognition and spliceosome assembly; Belongs to the splicing factor SR family. RS2Z subfamily. (284 aa)
F1I16_140MYB transcription factor-like protein. (399 aa)
HAKAIE3 ubiquitin-protein ligase HAKAI homolog; Probable E3 ubiquitin-protein ligase which is a subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, FIP37 and VIR to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6- methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. (360 aa)
VIL1VIN3-like protein 1; Involved in both the vernalization and photoperiod pathways by regulating expression of the related floral repressors FLOWERING LOCUS C (FLC) and FLOWERING LOCUS M (FLM). Together with VIN3, required during vernalization for the modifications of FLC and FLM chromatin that are associated with an epigenetically silenced state (e.g. chromatin modifications, histone deacetylation, and trimethylated H3 'Lys-4' H3K4me3 and 'Lys-27' H3K27me3) and with acquisition of competence to flower. Promotes flowering in short days (SD=8 hours light/16 hours dark). Associates dynamic [...] (602 aa)
FIP37FKBP12-interacting protein of 37 kDa; Probable regulatory subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6- methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. Essential protein required during endosperm development and embryogenesis. Involved in endoreduplication, especia [...] (330 aa)
RS2Z33Serine/arginine-rich splicing factor RS2Z33; Splicing factor involved in constitutive and/or alternative splicing. Regulates the splicing of its own pre-mRNA and the alternative splicing of RS30, RS31 and RS34. Associates the cyclin- dependent kinase G1 (CDKG1) with the spliceosome and recruits it to U1 snRNP to facilitate splicing. (290 aa)
SNRNP35U11/U12 small nuclear ribonucleoprotein 35 kDa protein; May facilitate 5' splice site recognition in the minor spliceosome. May be involved in interactions with components of the major spliceosome bound to the pyrimidine tract of an upstream U2-type intron. (333 aa)
ML5Protein MEI2-like 5; Probable RNA-binding protein that plays a role in meiosis and vegetative growth. (800 aa)
SPL7Squamosa promoter-binding-like protein 7; Transcription factor that participates in reprogramming global gene expression during copper deficiency in order to improve the metal uptake and prioritize its distribution to copper proteins of major importance (Probable). Binds directly to 5'-GTAC-3' motifs in the microRNA (miRNA) promoter of the stress-responsive miRNAs miR398b and miR398c to activate their transcription. During copper deficiency, activates the copper transporters COPT1 and COPT2, and the copper chaperone CCH, directly or indirectly via miRNAs. Required for the expression of [...] (801 aa)
T27G7.27RecQ-mediated instability-like protein. (137 aa)
U2AF65BSplicing factor U2af large subunit B; Necessary for the splicing of pre-mRNA; Belongs to the splicing factor SR family. (589 aa)
SCL30Serine/arginine-rich SC35-like splicing factor SCL30; Involved in intron recognition and spliceosome assembly (Probable). Probably active at the 5' splice sites. (262 aa)
TGHG patch domain-containing protein TGH; Functions as component of microRNA (miRNA) and small interfering RNA (siRNA) biogenesis. May assist DCL1 and DCL4 to efficiently process and/or recruit the precursors of miRNAs and siRNAs. In the miRNA biogenesis pathway, associates with the DCL1 complex that processes primary miRNAs (pri-miRNAs) into miRNAs. Binds pri-miRNAs and precursor miRNAs (pre-miRNAs). Is required for the interaction between pri-miRNAs and DRB1. Required for general proper plant growth and, in particular, initiation of vascular development. Interacts genetically with AMP1, [...] (930 aa)
MLE2.7UPF0235 protein At5g63440; May play a role during early embryonic development. Probably involved in pre-mRNA splicing (By similarity); Belongs to the UPF0235 family. (232 aa)
PAPP5Serine/threonine-protein phosphatase 5; Isoform 2 dephosphorylates phosphorylated phytochromes, with a preference toward Pfr forms, and enhances phytochrome-mediated photoresponses, probably by enhancing their stability and their binding affinity for light signal transducers such as NDPK2. Can use para- nitrophenylphosphate (pNPP) as substrate. (538 aa)
SR45ASerine/arginine-rich splicing factor SR45a; Probable splicing factor involved in constitutive and/or alternative splicing events. May bridge the 5' and 3' components of the spliceosome; Belongs to the splicing factor SR family. SR45 subfamily. (382 aa)
SIZ1E3 SUMO-protein ligase SIZ1; E3 SUMO protein ligase involved in regulation processes. Mediates SUMO/ attachment to PHR1, a MYB transcriptional activator controlling the phosphate deficiency responses. Functions as an upstream negative regulator of salicylic acid (SA) accumulation and subsequent SA-mediated systemic acquired resistance (SAR) signaling. Probably not involved in jasmonic acid (JA)-mediated defense response. Participates in abiotic stress-induced sumoylation. Controls heat shock-induced SUMO1 and SUMO2 conjugation and facilitates basal thermotolerance. Involved in freezing [...] (884 aa)
F18F4.130RNA-binding (RRM/RBD/RNP motifs) family protein. (152 aa)
CPL1RNA polymerase II C-terminal domain phosphatase-like 1; Processively dephosphorylates 'Ser-5' but not 'Ser-2' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II. Together with CPL2, required for male gametes fertility. Multifunctional regulator that modulates plant growth, stress, and phytohormones responses. Negative regulator of stress gene transcription involved in abscisic acid (ABA) mediated and jasmonic acid (JA) mediated signaling pathways, NaCl, osmotic stress, wounding, and col [...] (967 aa)
BHLH72Transcription factor PIF7; Transcription factor acting negatively in the phytochrome B signaling pathway under prolonged red light. Regulates PHYB abundance at the post-transcriptional level, possibly via the ubiquitin- proteasome pathway. May regulate the expression of a subset of genes by binding to the G-box motif. (366 aa)
RNU1U1 small nuclear ribonucleoprotein 70 kDa; Mediates the splicing of pre-mRNA by binding to the loop I region of U1-snRNA. (427 aa)
ULP1DUbiquitin-like-specific protease 1D; Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMOs to their mature forms and deconjugation of SUMO from targeted proteins. Cleaves precursors of SUM1 and SUM2, but not of SUM3 or SUM5. Able to release SUM1 and SUM2 from conjugates, but unable to cleave SUM3. Protease activity mainly directed at deconjugating SUM1 and SUM2 from their target proteins. Regulates salt stress responses and flowering time. Redundant with ULP1C. (584 aa)
SCL28Serine/arginine-rich SC35-like splicing factor SCL28; Involved in intron recognition and spliceosome assembly (Probable). Probably active at the 5' splice sites; Belongs to the splicing factor SR family. SCL subfamily. (236 aa)
RS41Serine/arginine-rich splicing factor RS41; Required for constitutive and alternative pre-mRNA splicing (Probable). Involved in primary miRNA processing and pri-miRNA biogenesis. Binds both intronless and intron-containing pri-miRNAs. (356 aa)
RS40Serine/arginine-rich splicing factor RS40; Required for constitutive and alternative pre-mRNA splicing (Probable). Involved in primary miRNA processing and pri-miRNA biogenesis. Binds both intronless and intron-containing pri-miRNAs. (350 aa)
RS31Serine/arginine-rich splicing factor RS31; Required for constitutive and alternative pre-mRNA splicing; Belongs to the splicing factor SR family. RS subfamily. (264 aa)
PHYBPhytochrome B; Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region. Photoconversion of Pr to Pfr induces an array of morphogenetic responses, whereas reconversion of Pfr to Pr cancels the induction of those responses. Pfr controls the expression of a number of nuclear genes including those encoding the small subunit of ribulose-bisphosphate carboxylase, chlorophyll A/B binding protein, protochlorophyllide reduct [...] (1172 aa)
PHYAPhytochrome A; Regulatory photoreceptor which exists in two forms that are reversibly interconvertible by light: the Pr form that absorbs maximally in the red region of the spectrum and the Pfr form that absorbs maximally in the far-red region. Photoconversion of Pr to Pfr induces an array of morphogenetic responses, whereas reconversion of Pfr to Pr cancels the induction of those responses. Pfr controls the expression of a number of nuclear genes including those encoding the small subunit of ribulose-bisphosphate carboxylase, chlorophyll A/B binding protein, protochlorophyllide reduct [...] (1122 aa)
MTAN6-adenosine-methyltransferase MT-A70-like; Catalytic subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'-[AG]GAC-3' consensus sites of some mRNAs. Associates with MTB, FIP37, VIR and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. Belongs to the MT-A70-like family. (685 aa)
RSZ21Serine/arginine-rich splicing factor RSZ21; Probably involved in intron recognition and spliceosome assembly. (187 aa)
RSZ22Serine/arginine-rich splicing factor RSZ22; Sequence-specific RNA-binding protein probably involved in pre-mRNA splicing. In vitro, can complement efficiently splicing- deficient mammalian SRSF7-depleted HeLa cell extract. Belongs to the splicing factor SR family. RSZ subfamily. (200 aa)
SKIPSNW/SKI-interacting protein; Splicing factor involved in post-transcriptional regulation of circadian clock and flowering time genes. Associates with the pre- mRNA of PRR7, PRR9, ELF3 and GI, and is necessary for the regulation of their alternative splicing and mRNA maturation. Probably involved in splice site recognition; Belongs to the SNW family. (613 aa)
SMU2Suppressor of mec-8 and unc-52 protein homolog 2; Auxiliary spliceosomal protein involved in splicing of specific pre-mRNAs that affect multiple aspects of development. (585 aa)
MAGOProtein mago nashi homolog; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby infl [...] (150 aa)
U2AF65ASplicing factor U2af large subunit A; Necessary for the splicing of pre-mRNA; Belongs to the splicing factor SR family. (573 aa)
RZ1BGlycine-rich RNA-binding protein RZ1B; Binds RNA and DNA sequences non-specifically. May be involved in tolerance to cold stress. (292 aa)
SR34Serine/arginine-rich-splicing factor SR34; General splicing factor. Can promote splice site selection in vitro presumably by antagonizing the effects of the A1 heterogeneous nuclear ribonucleoprotein. May have an essential function during early plant development; Belongs to the splicing factor SR family. SR subfamily. (303 aa)
LISU4/U6 small nuclear ribonucleoprotein PRP4-like protein; Participates in pre-mRNA splicing. Part of the U4/U5/U6 tri- snRNP complex, one of the building blocks of the spliceosome (By similarity). Essential for reproduction. In female gametophyte, is necessary for the egg cell and central cell fate determination and hence reproductive success. Involved in a mechanism that prevents accessory cells from adopting gametic cell fate. Modulates egg cell signaling center that regulates the development of all female gametophytic cells. (554 aa)
DRB1Double-stranded RNA-binding protein 1; Double-stranded RNA-binding protein involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis by assisting DICER-LIKE 1 (DCL1) in the accurate processing from primary miRNAs (pri-miRNAs) to miRNAs in the nucleus. Forms a complex with SERRATE (SE) and DCL1 to promote accurate processing of pri-miRNAs by DCL1. Binds and assist DCL1 for accurate processing of precursor miRNAs (pre-miRNA). Indirectly involved in the production of trans-acting small interfering RNAs (ta-siRNAs) derived from the [...] (419 aa)
MYB25Transcription factor MYB25; Required for male gametophyte (pollen) development. (367 aa)
HEN4KH domain-containing protein HEN4; Functions in floral reproductive organ identity in the third whorl and floral determinacy specification by specifically promoting the processing of AGAMOUS (AG) pre-mRNA. Functions in association with HUA1 and HUA2. (857 aa)
MJJ3.13RNA-binding (RRM/RBD/RNP motifs) family protein. (451 aa)
GFL109 kDa U5 small nuclear ribonucleoprotein component GFL; Splicing factor involved in pre-mRNA splicing and component of the spliceosome. (973 aa)
F24J7.162Nucleotide/nucleic acid binding protein. (816 aa)
SR34BSerine/arginine-rich splicing factor SR34B; Probably involved in intron recognition and spliceosome assembly. (278 aa)
VIRProtein virilizer homolog; Subunit of the N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine (m6A) methylation at the 5'- [AG]GAC-3' consensus sites of some mRNAs. Associates with MTA, MTB, FIP37 and HAKAI to form the m6A writer complex which is essential for adenosine methylation at specific mRNA sequences. N6-methyladenosine (m6A) plays a role in mRNA stability, processing, translation efficiency and editing. (2138 aa)
F4IZU8_ARATHRNA-binding (RRM/RBD/RNP motifs) family protein. (132 aa)
F4IVU7_ARATHRNA-binding (RRM/RBD/RNP motifs) family protein. (1325 aa)
THO2THO complex subunit 2; Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export. (1823 aa)
Y14RNA-binding protein Y14; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influen [...] (202 aa)
CTNCactin; Required for embryogenesis. May be involved with the spliceosome; Belongs to the CACTIN family. (716 aa)
NSRBNuclear speckle RNA-binding protein B; Alternative splicing (AS) regulator that binds to specific mRNAs and modulates auxin effects on the transcriptome. Displaced from its targets upon binding to AS competitor long non-coding RNA (ASCO- RNA). (421 aa)
CSU2Protein COP1 SUPPRESSOR 2; Inhibits E3 ubiquitin-protein ligase activity of COP1, a central repressor of seedling photomorphogenesis. Represses COP1- mediated turnover of HY5 in the dark. Required for primary root development under normal light growth conditions. (279 aa)
FHLProtein FAR-RED-ELONGATED HYPOCOTYL 1-LIKE; Can activate transcription (By similarity). Essential for light-regulated PHYA nuclear accumulation and subsequent PHYA phototropic signaling processes. PHYA-specific signal transducer in response to continuous FR lights. Mediates the association of PHYA with HFR1 and LAF1 in the nucleus in response to FR conditions. Contributes to inhibition of hypocotyl elongation in continuous blue light (B). Belongs to the FHY1 protein family. (201 aa)
SR34ASerine/arginine-rich splicing factor SR34A; Probably involved in intron recognition and spliceosome assembly. (300 aa)
NSRANuclear speckle RNA-binding protein A; Alternative splicing (AS) regulator that binds to specific mRNAs and modulates auxin effects on the transcriptome. Displaced from its targets upon binding to AS competitor long non-coding RNA (ASCO- RNA). (233 aa)
HEN2DExH-box ATP-dependent RNA helicase DExH10; ATP-dependent RNA helicase that associates with the RNA exosome complex, with the cap binding complex (CBC) and with the NEXT- like complex. Involved in the degradation of a large number of non- coding nuclear exosome substrates such as snoRNA and miRNA precursors, incompletely spliced mRNAs, and spurious transcripts produced from pseudogenes and intergenic regions. Involved in the maintenance of homeotic B and C gene expression in the reproductive whorls. Regulates floral organ spacing and identity, probably through the regulation of protein [...] (995 aa)
KIN17KIN17-like protein; Promotes the copper deficiency response by direct interaction with SPL7. Acts with SPL7 in a common pathway to promote copper- responsive genes and alleviate oxidative stress during copper-limiting periods. May promote SPL7 function when copper is limiting. Participates in the control of general plant growth and development, and in the response to counteract the negative effects of UV radiation. (411 aa)
SESerrate RNA effector molecule; Acts as a mediator between the cap-binding complex (CBC) and both the pre-mRNA splicing and primary microRNAs (miRNAs) processing machinery. Required for proper processing of primary miRNAs to miRNAs, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Does not participate in sense post-transcriptional gene silencing. Acts as a regulator of meristem activity and adaxial leaf fate via the miRNA gene-silencing pathway by regulating the expression of PHB and by limiting the competence of shoot tissue to respond to KNOX expression. Its fun [...] (720 aa)
CYP63Peptidyl-prolyl cis-trans isomerase CYP63; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. Probably involved in early steps of spliceosomal assembly. (570 aa)
PABN3Polyadenylate-binding protein 3; Involved in the 3'-end formation of mRNA precursors (pre- mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation. (217 aa)
OXS3Oxidative stress 3. (172 aa)
CLO110 kDa U5 small nuclear ribonucleoprotein component CLO; Splicing factor involved in pre-mRNA splicing and component of the spliceosome. Essential for reproduction. In female gametophyte, is necessary for the egg cell and central cell fate determination and hence reproductive success. Involved in a mechanism that prevents accessory cells from adopting gametic cell fate. Is necessary to restrict LIS expression to interfere with egg-cell specification. Probable component of U5 small nuclear ribonucleoprotein (snRNP) that is required for pre-mRNA splicing. Plays an essential role in fema [...] (987 aa)
SCL30ASerine/arginine-rich SC35-like splicing factor SCL30A; Involved in intron recognition and spliceosome assembly. Binds probably to multiple 5'-GAAG-3' repeats found in its third intron, suggesting autoregulation of alternative splicing. May be necessary for accurate splicing of the 3' region of introns. (262 aa)
ML3-2Protein MEI2-like 3; Probable RNA-binding protein that plays a role in meiosis and vegetative growth. (759 aa)
SMD1BSmall nuclear ribonucleoprotein SmD1b; Involved in splicing regulation. Facilitates post- transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs. (116 aa)
CSU1E3 ubiquitin-protein ligase CSU1; RING-finger E3 ubiquitin-protein ligase that plays an major role in maintaining COP1 homeostasis in darkness. Negatively regulates COP1 protein accumulation by targeting COP1 for ubiquitination and subsequent proteasomal degradation in dark-grown seedlings. Negatively regulates the accumulation of SPA1 protein in the dark. Belongs to the NOSIP family. (310 aa)
SPA1Protein SUPPRESSOR OF PHYA-105 1; Controls normal photoperiodic flowering and regulates circadian rhythms. Required for suppression of photomorphogenesis in dark-grown seedlings and for normal elongation growth of adult plants. Integral component of the COP1/SPA E3 ubiquitin-protein ligase complex. Involved in HY5, HFR1, LAF1 and CO degradation. (1029 aa)
SR30Serine/arginine-rich splicing factor SR30; Regulatory splicing factor that modulates alternative splicing and gene expression in specific cell types. Autoregulates its own expression. Probably involved in intron recognition and spliceosome assembly; Belongs to the splicing factor SR family. SR subfamily. (268 aa)
RS31ASerine/arginine-rich splicing factor RS31A; Probably involved in intron recognition and spliceosome assembly. (250 aa)
SMD1ASmall nuclear ribonucleoprotein SmD1a; Involved in splicing regulation. Facilitates post- transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs. (114 aa)
BAH1E3 ubiquitin-protein ligase BAH1; Mediates E2-dependent protein ubiquitination. Plays a role in salicylic acid-mediated negative feedback regulation of salicylic acid (SA) accumulation. May be involved in the overall regulation of SA, benzoic acid and phenylpropanoid biosynthesis. Controls the adaptability to nitrogen limitation by channeling the phenylpropanoid metabolic flux to the induced anthocyanin synthesis. (335 aa)
ML2Protein MEI2-like 2; Probable RNA-binding protein that plays a role in meiosis and vegetative growth. (843 aa)
RSZ22ASerine/arginine-rich splicing factor RSZ22A; Probably involved in intron recognition and spliceosome assembly; Belongs to the splicing factor SR family. RSZ subfamily. (196 aa)
SCL33-2Serine/arginine-rich SC35-like splicing factor SCL33; Involved in intron recognition and spliceosome assembly. Binds to multiple 5'-GAAG-3' repeats found in its third intron, suggesting autoregulation of alternative splicing. May be necessary for accurate splicing of the 3' region of introns. Belongs to the splicing factor SR family. SCL subfamily. (287 aa)
SR45Serine/arginine-rich splicing factor SR45; Involved in 5' and 3' splicing site selection of introns, and may bridge the 5' and 3' components of the spliceosome. Isoform 1 is required during flower petal development and isoform 2 is involved in root growth. Regulates negatively glucose and abscisic acid (ABA) signaling during early seedling development. Involved in the RNA- directed DNA methylation pathway. Modulates KIN10 stability in response to sugars, probably through the splicing regulation of 5PTASE13, a protein implicated in the proteasomal degradation of KIN10. Belongs to the sp [...] (414 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.