(8 nodes) HOPS complex network (Arabidopsis thaliana)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	VPS18	Vacuolar sorting protein 18; Essential protein required during embryogenesis. Believed to act as a core component of the putative HOPS endosomal tethering complex and of the class C core vacuole/endosome tethering (CORVET) complex. CORVET is required for vacuolar transport of SYP22. HOPS is required for the central vacuole formation. Involved in root development. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (By similarity); Belongs to the VPS18 family. (988 aa)
	SETH5	Transducin family protein / WD-40 repeat family protein. (1913 aa)
	VPS41	Vacuolar protein sorting-associated protein 41 homolog; Required for vacuolar assembly and vacuolar traffic. Belongs to the VPS41 family. (980 aa)
	VPS39	Vacuolar sorting protein 39; Essential protein required during embryogenesis. Believed to act in part as a component of the putative HOPS endosomal tethering complex. HOPS is required for the central vacuole formation. May play a role in clustering and fusion of late endosomes and lysosomes. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Required for fusion of endosomes and autophagosomes with lysosomes (By similarity). (1000 aa)
	VCL1	Protein VACUOLELESS1; Required for vacuole biogenesis and vacuole enlargment in dividing and expanding cells. Involved in the docking or fusion of prevacuolar vesicles. Important for the function of both male and female gametophytes, but is not essential for the germination and development of pollen. (858 aa)
	VPS33	Vacuolar protein-sorting-associated protein 33 homolog; Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment. (592 aa)
	VAMP713	Vesicle-associated membrane protein 713; Involved in the targeting and/or fusion of transport vesicles to their target membrane. (221 aa)
	VPS11	Vacuolar protein-sorting-associated protein 11 homolog; Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment; Belongs to the VPS11 family. (932 aa)

Your Current Organism:

Arabidopsis thaliana

NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SETH5	VAMP713	F4JHM9	Q9LFP1	Transducin family protein / WD-40 repeat family protein.	Vesicle-associated membrane protein 713; Involved in the targeting and/or fusion of transport vesicles to their target membrane.	0.626
SETH5	VCL1	F4JHM9	Q93VQ0	Transducin family protein / WD-40 repeat family protein.	Protein VACUOLELESS1; Required for vacuole biogenesis and vacuole enlargment in dividing and expanding cells. Involved in the docking or fusion of prevacuolar vesicles. Important for the function of both male and female gametophytes, but is not essential for the germination and development of pollen.	0.997
SETH5	VPS11	F4JHM9	Q9SJ40	Transducin family protein / WD-40 repeat family protein.	Vacuolar protein-sorting-associated protein 11 homolog; Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment; Belongs to the VPS11 family.	0.997
SETH5	VPS18	F4JHM9	F4IDS7	Transducin family protein / WD-40 repeat family protein.	Vacuolar sorting protein 18; Essential protein required during embryogenesis. Believed to act as a core component of the putative HOPS endosomal tethering complex and of the class C core vacuole/endosome tethering (CORVET) complex. CORVET is required for vacuolar transport of SYP22. HOPS is required for the central vacuole formation. Involved in root development. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (By similarity); Belongs to the VPS18 family.	0.997
SETH5	VPS33	F4JHM9	Q94KJ7	Transducin family protein / WD-40 repeat family protein.	Vacuolar protein-sorting-associated protein 33 homolog; Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment.	0.997
SETH5	VPS39	F4JHM9	Q8L5Y0	Transducin family protein / WD-40 repeat family protein.	Vacuolar sorting protein 39; Essential protein required during embryogenesis. Believed to act in part as a component of the putative HOPS endosomal tethering complex. HOPS is required for the central vacuole formation. May play a role in clustering and fusion of late endosomes and lysosomes. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Required for fusion of endosomes and autophagosomes with lysosomes (By similarity).	0.977
SETH5	VPS41	F4JHM9	P93043	Transducin family protein / WD-40 repeat family protein.	Vacuolar protein sorting-associated protein 41 homolog; Required for vacuolar assembly and vacuolar traffic. Belongs to the VPS41 family.	0.813
VAMP713	SETH5	Q9LFP1	F4JHM9	Vesicle-associated membrane protein 713; Involved in the targeting and/or fusion of transport vesicles to their target membrane.	Transducin family protein / WD-40 repeat family protein.	0.626
VAMP713	VCL1	Q9LFP1	Q93VQ0	Vesicle-associated membrane protein 713; Involved in the targeting and/or fusion of transport vesicles to their target membrane.	Protein VACUOLELESS1; Required for vacuole biogenesis and vacuole enlargment in dividing and expanding cells. Involved in the docking or fusion of prevacuolar vesicles. Important for the function of both male and female gametophytes, but is not essential for the germination and development of pollen.	0.964
VAMP713	VPS11	Q9LFP1	Q9SJ40	Vesicle-associated membrane protein 713; Involved in the targeting and/or fusion of transport vesicles to their target membrane.	Vacuolar protein-sorting-associated protein 11 homolog; Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment; Belongs to the VPS11 family.	0.950
VAMP713	VPS18	Q9LFP1	F4IDS7	Vesicle-associated membrane protein 713; Involved in the targeting and/or fusion of transport vesicles to their target membrane.	Vacuolar sorting protein 18; Essential protein required during embryogenesis. Believed to act as a core component of the putative HOPS endosomal tethering complex and of the class C core vacuole/endosome tethering (CORVET) complex. CORVET is required for vacuolar transport of SYP22. HOPS is required for the central vacuole formation. Involved in root development. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (By similarity); Belongs to the VPS18 family.	0.954
VAMP713	VPS33	Q9LFP1	Q94KJ7	Vesicle-associated membrane protein 713; Involved in the targeting and/or fusion of transport vesicles to their target membrane.	Vacuolar protein-sorting-associated protein 33 homolog; Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment.	0.992
VAMP713	VPS39	Q9LFP1	Q8L5Y0	Vesicle-associated membrane protein 713; Involved in the targeting and/or fusion of transport vesicles to their target membrane.	Vacuolar sorting protein 39; Essential protein required during embryogenesis. Believed to act in part as a component of the putative HOPS endosomal tethering complex. HOPS is required for the central vacuole formation. May play a role in clustering and fusion of late endosomes and lysosomes. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Required for fusion of endosomes and autophagosomes with lysosomes (By similarity).	0.947
VAMP713	VPS41	Q9LFP1	P93043	Vesicle-associated membrane protein 713; Involved in the targeting and/or fusion of transport vesicles to their target membrane.	Vacuolar protein sorting-associated protein 41 homolog; Required for vacuolar assembly and vacuolar traffic. Belongs to the VPS41 family.	0.938
VCL1	SETH5	Q93VQ0	F4JHM9	Protein VACUOLELESS1; Required for vacuole biogenesis and vacuole enlargment in dividing and expanding cells. Involved in the docking or fusion of prevacuolar vesicles. Important for the function of both male and female gametophytes, but is not essential for the germination and development of pollen.	Transducin family protein / WD-40 repeat family protein.	0.997
VCL1	VAMP713	Q93VQ0	Q9LFP1	Protein VACUOLELESS1; Required for vacuole biogenesis and vacuole enlargment in dividing and expanding cells. Involved in the docking or fusion of prevacuolar vesicles. Important for the function of both male and female gametophytes, but is not essential for the germination and development of pollen.	Vesicle-associated membrane protein 713; Involved in the targeting and/or fusion of transport vesicles to their target membrane.	0.964
VCL1	VPS11	Q93VQ0	Q9SJ40	Protein VACUOLELESS1; Required for vacuole biogenesis and vacuole enlargment in dividing and expanding cells. Involved in the docking or fusion of prevacuolar vesicles. Important for the function of both male and female gametophytes, but is not essential for the germination and development of pollen.	Vacuolar protein-sorting-associated protein 11 homolog; Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment; Belongs to the VPS11 family.	0.999
VCL1	VPS18	Q93VQ0	F4IDS7	Protein VACUOLELESS1; Required for vacuole biogenesis and vacuole enlargment in dividing and expanding cells. Involved in the docking or fusion of prevacuolar vesicles. Important for the function of both male and female gametophytes, but is not essential for the germination and development of pollen.	Vacuolar sorting protein 18; Essential protein required during embryogenesis. Believed to act as a core component of the putative HOPS endosomal tethering complex and of the class C core vacuole/endosome tethering (CORVET) complex. CORVET is required for vacuolar transport of SYP22. HOPS is required for the central vacuole formation. Involved in root development. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways (By similarity); Belongs to the VPS18 family.	0.999
VCL1	VPS33	Q93VQ0	Q94KJ7	Protein VACUOLELESS1; Required for vacuole biogenesis and vacuole enlargment in dividing and expanding cells. Involved in the docking or fusion of prevacuolar vesicles. Important for the function of both male and female gametophytes, but is not essential for the germination and development of pollen.	Vacuolar protein-sorting-associated protein 33 homolog; Involved in regulating membrane fusion at the tonoplast and the prevacuolar compartment.	0.999
VCL1	VPS39	Q93VQ0	Q8L5Y0	Protein VACUOLELESS1; Required for vacuole biogenesis and vacuole enlargment in dividing and expanding cells. Involved in the docking or fusion of prevacuolar vesicles. Important for the function of both male and female gametophytes, but is not essential for the germination and development of pollen.	Vacuolar sorting protein 39; Essential protein required during embryogenesis. Believed to act in part as a component of the putative HOPS endosomal tethering complex. HOPS is required for the central vacuole formation. May play a role in clustering and fusion of late endosomes and lysosomes. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Required for fusion of endosomes and autophagosomes with lysosomes (By similarity).	0.999