STRINGSTRING
IRE3 IRE3 SPI SPI IREH1 IREH1 SFH1 SFH1 XI-K XI-K CNGC6 CNGC6 KIP KIP CNGC5 CNGC5 SAC7 SAC7 F2J7.20 F2J7.20 F26A9.21 F26A9.21 AGD1 AGD1 PI4KB1 PI4KB1 ALMT3 ALMT3 PAT04 PAT04 MTPC3 MTPC3 RABA4B RABA4B DTX42 DTX42 ANN1 ANN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IRE3Probable serine/threonine protein kinase IRE3; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1235 aa)
SPIProtein SPIRRIG; Involved in cell morphogenesis. May have a function in membrane fusion or membrane composition. Required for salt stress tolerance. Regulates the salt stress-dependent post-transcriptional stabilization, cytoplasmic agglomeration, and localization to P-bodies of a subset of salt stress- regulated mRNAs. (3601 aa)
IREH1Probable serine/threonine protein kinase IREH1; May be involved in root hair elongation. (1296 aa)
SFH1Phosphatidylinositol/phosphatidylcholine transfer protein SFH1; Required for transport of secretory proteins from the Golgi complex (By similarity). Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro. Plays a role in root hair tip elongation as a key regulator of polarized membrane trafficking. May promote the PtdIns(4,5)P2 synthesis and organization in root hair membrane. Belongs to the SFH family. (554 aa)
XI-KMyosin-17; Myosin heavy chain that is required for the cell cycle- regulated transport of various organelles and proteins for their segregation. Functions by binding with its tail domain to receptor proteins on organelles and exerting force with its N-terminal motor domain against actin filaments, thereby transporting its cargo along polarized actin cables. Involved in the tip growth of root hair cells and in the elongation of trichome stalk and branches. Plays a major role in trafficking of Golgi stacks, mitochondria and peroxisomes during root hair development. Acts as the primary co [...] (1531 aa)
CNGC6Probable cyclic nucleotide-gated ion channel 6; Probable cyclic nucleotide-gated ion channel; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. (747 aa)
KIPProtein KINKY POLLEN; May be involved in membrane trafficking (By similarity). Required for tip growth in pollen tubes and root hairs. Belongs to the SABRE family. (2587 aa)
CNGC5Probable cyclic nucleotide-gated ion channel 5; Probable cyclic nucleotide-gated ion channel; Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. (717 aa)
SAC7Phosphoinositide phosphatase SAC7; Phosphoinositide phosphatase that preferentially hydrolyzes PtdIns(4)P. Regulates the accumulation of PtdIns(4)P on membrane compartments at the tips of growing root hairs leading to proper root hair development. (597 aa)
F2J7.20GDT1-like protein 4. (230 aa)
F26A9.21ARM repeat superfamily protein. (909 aa)
AGD1ADP-ribosylation factor GTPase-activating protein AGD1; Probable GTPase-activating protein (By similarity). Regulator of membrane trafficking. Required for maintaining a straight growth of root hairs. (828 aa)
PI4KB1Phosphatidylinositol 4-kinase beta 1; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5- trisphosphate. Necessary for proper organization of the trans-Golgi network (TGN) and post-Golgi secretion in root hairs. Together with PI4KB2, required during polarized root hair expansion and pollen tube elongation. Functions redundantly with PI4KB2 upstream of the cold response phosphoinositide-dependent phospholipase C (PI-PLC) pathway. (1121 aa)
ALMT3Putative aluminum-activated malate transporter 3; Malate transporter; Belongs to the aromatic acid exporter (TC 2.A.85) family. (581 aa)
PAT04Probable protein S-acyltransferase 4; Palmitoyl acyltransferase. (477 aa)
MTPC3Putative metal tolerance protein C3; Involved in sequestration of excess metal in the cytoplasm into vacuoles to maintain metal homeostasis; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. (411 aa)
RABA4BRas-related protein RABA4b; Regulator of membrane trafficking. May be required for secretion of cell wall components in cells; Belongs to the small GTPase superfamily. Rab family. (224 aa)
DTX42Protein DETOXIFICATION 42; Citrate transporter critical for aluminum tolerance. Responsible for citrate exudation into the rhizosphere to protect roots from aluminum toxicity; Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. (515 aa)
ANN1Annexin D1; Has a peroxidase activity. May act in counteracting oxidative stress. May also mediate regulated, targeted secretion of Golgi-derived vesicles during seedling development. (317 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.