STRINGSTRING
MSH2 MSH2 RTEL1 RTEL1 F20D21.5 F20D21.5 T1G11.9 T1G11.9 FIGL1 FIGL1 MJP23.7 MJP23.7 F4H5.15 F4H5.15 T06B20.3 T06B20.3 His1-3 His1-3 F20D21.6 F20D21.6 SKP1A SKP1A HMGA HMGA HON5 HON5 Q6AWW7_ARATH Q6AWW7_ARATH T27G7.27 T27G7.27 HON4 HON4 F16G16.7 F16G16.7 OSB1 OSB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MSH2DNA mismatch repair protein MSH2; Component of the post-replicative DNA mismatch repair system (MMR). Forms three different heterodimers: MutS alpha (MSH2-MSH6 heterodimer), MutS beta (MSH2-MSH3 heterodimer) and MutS gamma (MSH2- MSH7 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS alpha and MutS beta recognize single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA. MutS gamma recognizes specifically the T/G single base mismatch. Plays a role in DNA homologous recombination repair and has a broad range of anti- recombination ef [...] (937 aa)
RTEL1Regulator of telomere elongation helicase 1 homolog; ATP-dependent DNA helicase implicated in DNA replication, DNA repair and the maintenance of genomic stability. Acts as an anti- recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Plays also a role in preserving the stability of 45S rDNA repeats. (1040 aa)
F20D21.5Winged helix-turn-helix transcription repressor DNA-binding protein. (232 aa)
T1G11.9Holliday junction resolvase. (997 aa)
FIGL1ATPase family AAA domain-containing protein FIGL1; Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Limits class II meiotic crossover (CO) formation by regulating the invasion step of meiotic HR. May counteract DMC1 and RAD51-mediated inter-homolog strand invasion to limit CO formation. Functions independently of FANCM. Belongs to the AAA ATPase family. (680 aa)
MJP23.7DNA mismatch repair protein MutS, type 2. (796 aa)
F4H5.15Histone H1.1; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (274 aa)
T06B20.3Histone H1.2; Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. (273 aa)
His1-3Putative histone H1 protein. (167 aa)
F20D21.6Winged-helix DNA-binding transcription factor family protein. (229 aa)
SKP1ASKP1-like protein 1A; Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1. SCF(UFO) is required for vegetative and floral organ development as well as for male gametogenesis. SCF(TIR1) is involved in auxin signaling pathway. SCF(COI1) regulates responses to jasmonates. SCF(EID1) and SCF(AFR) are implicate [...] (160 aa)
HMGAHMG-Y-related protein A; Binds A/T-rich DNA with a highly dynamic distribution into the nucleus. (204 aa)
HON5High mobility group A5. (479 aa)
Q6AWW7_ARATHWinged-helix DNA-binding transcription factor family protein. (457 aa)
T27G7.27RecQ-mediated instability-like protein. (137 aa)
HON4Winged-helix DNA-binding transcription factor family protein. (480 aa)
F16G16.7DNA mismatch repair protein MutS, type 2. (876 aa)
OSB1Protein OSB1, mitochondrial; Regulates mitochondrial DNA recombination. Represses homologous recombination, preventing mitochondrial genome instability and unbalanced transmission of alternative mtDNA configurations. Binds preferentially single-stranded DNA. Does not bind to RNA. (261 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.