STRINGSTRING
RPK2 RPK2 AGO10 AGO10 RPK1 RPK1 TPR1 TPR1 TPR4 TPR4 ACC1 ACC1 ATHB-8 ATHB-8 WOX4 WOX4 CLE41 CLE41 DCP2 DCP2 CDC27B CDC27B ALE2 ALE2 SUB SUB CLE44 CLE44 RFC3-2 RFC3-2 TPL TPL CHER1 CHER1 TDR TDR DOF5.6 DOF5.6 PXL1 PXL1 ATHB-14 ATHB-14 NAC098 NAC098 NAC054 NAC054 WOX14 WOX14 IP5P6 IP5P6 TPR2-2 TPR2-2 VCS VCS ATHB-9 ATHB-9 OBE2 OBE2 MIK1 MIK1 OBE1 OBE1
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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RPK2LRR receptor-like serine/threonine-protein kinase RPK2; Key regulator of anther development (e.g. lignification pattern), including tapetum degradation during pollen maturation (e.g. germination capacity). Together with RPK1, required for pattern formation along the radial axis (e.g. the apical embryonic domain cell types that generate cotyledon primordia), and the apical-basal axis (e.g. differentiation of the basal pole during early embryogenesis). (1151 aa)
AGO10Protein argonaute 10; Involved in RNA-mediated post-transcriptional gene silencing (PTGS). Main component of the RNA-induced silencing complex (RISC) that binds to a short guide RNA such as a microRNA (miRNA) or small interfering RNA (siRNA). RISC uses the mature miRNA or siRNA as a guide for slicer-directed cleavage of homologous mRNAs to repress gene expression. Required for reliable formation of primary and axillary shoot apical meristems. Specifies leaf adaxial identity by repressing the miR165 and miR166 microRNAs in the embryonic shoot apex, in the shoot apical meristem (SAM) and [...] (988 aa)
RPK1Probable LRR receptor-like serine/threonine-protein kinase RPK1; Involved in the main abscisic acid-mediated (ABA) signaling pathway and in early ABA perception. Together with RPK2, required for pattern formation along the radial axis (e.g. the apical embryonic domain cell types that generate cotyledon primordia), and the apical- basal axis (e.g. differentiation of the basal pole during early embryogenesis). (540 aa)
TPR1Topless-related protein 1; Transcriptional corepressor. Activates TIR-NB-LRR R protein- mediated immune responses through repression of negative regulators such as CNGC2/DND1. Negative regulator of jasmonate responses (By similarity). (1120 aa)
TPR4Topless-related protein 4; Transcription corepressor of Zinc finger transcription factors GAF1/IDD2 and ENY/IDD1 in regulation of gibberellin homeostasis and signaling. (1135 aa)
ACC1Acetyl-CoA carboxylase 1; Multifunctional enzyme that catalyzes the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation. Required for very long chain fatty acids elongation. Necessary for embryo and plant development. Plays a central function in embryo morphogenesis, especially in apical meristem development. Involved in cell proliferation and tissue patterning. May act as a repressor of cytokinin response. (2254 aa)
ATHB-8Homeobox-leucine zipper protein ATHB-8; Probable transcription factor involved in the regulation of vascular development. May promote differentiation of precambial and cambial cells. (833 aa)
WOX4WUSCHEL-related homeobox 4; Transcription factor which may be involved in developmental processes. (251 aa)
CLE41CLAVATA3/ESR (CLE)-related protein 41; Extracellular signal peptide that regulates cell fate. May act with TDR as a ligand-receptor pair in a signal transduction pathway that represses tracheary element differentiation but promotes the formation of procambial cells adjacent to phloem cells in the veins in an auxin-dependent manner. (99 aa)
DCP2mRNA-decapping enzyme subunit 2; Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense- mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Essential for postembryonic development, especially during the formation of the shoot apical meristem (SAM). Belongs to the Nudix hydrolase family. DCP2 subfamily. (373 aa)
CDC27BCell division cycle protein 27 homolog B; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex controls several key steps in the cell cycle by mediating ubiquitination and subsequent degradation of target proteins such as cyclins. The APC/C complex is required for the female gametophyte development and is involved in several aspect of development by controlling cell division and cell elongation. Involved in the control of e [...] (744 aa)
ALE2Receptor-like serine/threonine-protein kinase ALE2; Required during the differentiation of the protoderm into shoots epidermis and cuticle; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (744 aa)
SUBProtein STRUBBELIG; Regulates the expression of transcription factors that define the cell fates. Acts in a non-cell-autonomous fashion, functions in a radial inside-out signaling process, and mediates cell morphogenesis and cell fate across clonally distinct cell layers in floral primordia, developing ovules, and root meristems. Seems to be required for the regulation of cell shape and the orientation of the mitotic division plane. Involved in root hair specification, in the formation of the outer integument and the shape of organs such as carpels and petals and is necessary for the s [...] (768 aa)
CLE44CLAVATA3/ESR (CLE)-related protein 44; Extracellular signal peptide that regulates cell fate. May act with TDR as a ligand-receptor pair in a signal transduction pathway that represses tracheary element differentiation but promotes the formation of procambial cells adjacent to phloem cells in the veins. (112 aa)
RFC3-2Translation elongation factor EF1B/ribosomal protein S6 family protein. (314 aa)
TPLProtein TOPLESS; Transcriptional corepressor. May repress the expression of root-promoting genes in the top half of the embryo to allow proper differentiation of the shoot pole during the transition stage of embryogenesis. Regulates the expression of PLT1 and PLT2. Negative regulator of jasmonate responses. Negative regulator of auxin responses. Negative regulator of multiple floral organ identity genes. Required for ovule development. (1131 aa)
CHER1Choline transporter protein 1; Regulator of vesicle trafficking, including endocytosis. Necessary for secondary plasmodesmata (PD) formation and development via the secretory trafficking regulation of proteins required for PD development, thus influencing intercellular communication. Modulates ion homeostasis, especially in roots, by monitoring the transport and subsequent subcellular localization of some ion transporters. Choline transporter involved in the regulation of choline metabolite homeostasis during root and phloem development. Modulates phloem morphogenesis and conductivity. [...] (700 aa)
TDRLeucine-rich repeat receptor-like protein kinase TDR; Acts with CLE41p and CLE44p peptides as a ligand-receptor pair in a signal transduction pathway involved in the regulation of procambium maintenance and polarity during vascular-tissue development. Mediates repression of tracheary element differentiation and the promotion of procambial cells formation and polar division adjacent to phloem cells in the veins; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. (1041 aa)
DOF5.6Dof zinc finger protein DOF5.6; Transcription factor that binds specifically to a 5'-AA[AG]G- 3' consensus core sequence (By similarity). Promotes expression. The PEAR proteins (e.g. DOF2.4, DOF5.1, DOF3.2, DOF1.1, DOF5.6 and DOF5.3) activate gene expression that promotes radial growth of protophloem sieve elements. Involved in the regulation of interfascicular cambium formation and vascular tissue development, particularly at a very early stage during inflorescence stem development; promotes both cambium activity and phloem specification, but prevents xylem specification. (372 aa)
PXL1Leucine-rich repeat receptor-like protein kinase PXL1; Involved in the regulation of procambium maintenance and polarity during vascular-tissue development. Phosphorylates HIRD11 and LHCA1 in vitro. (1029 aa)
ATHB-14Homeobox-leucine zipper protein ATHB-14; Probable transcription factor involved in the determination of adaxial-abaxial polarity in ovule primordium. Specifies adaxial leaf fates; Belongs to the HD-ZIP homeobox family. Class III subfamily. (852 aa)
NAC098Protein CUP-SHAPED COTYLEDON 2; Transcription activator of STM and KNAT6. Involved in molecular mechanisms regulating shoot apical meristem (SAM) formation during embryogenesis and organ separation. Required for the fusion of septa of gynoecia along the length of the ovaries. Activates the shoot formation in callus in a STM-dependent manner. Controls leaf margin development and required for leaf serration. Involved in axillary meristem initiation and separation of the meristem from the main stem. Regulates the phyllotaxy throughout the plant development. Seems to act as an inhibitor of [...] (375 aa)
NAC054Protein CUP-SHAPED COTYLEDON 1; Transcription activator of STM and KNAT6. Involved in molecular mechanisms regulating shoot apical meristem (SAM) formation during embryogenesis and organ separation. Required for the fusion of septa of gynoecia along the length of the ovaries. Activates the shoot formation in callus in a STM-dependent manner. Seems to act as an inhibitor of cell division. (310 aa)
WOX14WUSCHEL-related homeobox 14; Transcription factor which may be involved in developmental processes. (211 aa)
IP5P6Type IV inositol polyphosphate 5-phosphatase 6; Has phosphatase activity toward PtdIns(4,5)P2 and PtdIns(3,4,5)P3. Required for the patterning of procambium and during the differentiation of vascular tissues. Acts before the acquisition of preprocambial identity. Seems to be also involved in the abscisic acid (ABA) signaling pathway. Acts redundantly with CVL1 for maintaining vascular continuity. Regulates phosphoinositide-dependent VAN3 localization. Belongs to the inositol polyphosphate 5-phosphatase family. (617 aa)
TPR2-2Topless-related protein 2; Transcriptional corepressor. Negative regulator of jasmonate responses (By similarity). (1131 aa)
VCSEnhancer of mRNA-decapping protein 4; As a component of the decapping complex, involved in the degradation of mRNAs. Essential for postembryonic development, especially during the formation of the shoot (SAM) and root apical meristems. Required for normal patterning of internal tissues of leaves; Belongs to the WD repeat EDC4 family. (1344 aa)
ATHB-9Homeobox-leucine zipper protein ATHB-9; Probable transcription factor involved in the determination of adaxial-abaxial polarity in ovule primordium. Specifies adaxial leaf fates. Binds to the DNA sequence 5'-GTAAT[GC]ATTAC-3'. (841 aa)
OBE2Protein OBERON 2; Probable transcription factor that acts together with OBE1 for the maintenance and/or establishment of both the shoot and root meristems, probably by controlling the expression of the meristem genes such as WUS, PLT1 and PLT2 and of genes required for auxin responses. Promotes cell meristematic activity via the WUSCHEL-CLAVATA pathway. Involved in the development of the basal pole and in auxin-mediated root and vascular development in the embryo. Confers sensitivity to turnip mosaic virus (TuMV) probably by promoting viral movement and multiplication via interaction w [...] (574 aa)
MIK1MDIS1-interacting receptor like kinase 1; Involved in the regulation of procambium maintenance and polarity during vascular-tissue development. Involved in the pollen tube perception of the female signal. Phosphorylates MDSI1. (1013 aa)
OBE1Protein OBERON 1; Probable transcription factor that acts together with OBE2 for the maintenance and/or establishment of both the shoot and root meristems, probably by controlling the expression of the meristem genes such as WUS, PLT1 and PLT2 and of genes required for auxin responses. Promotes cell meristematic activity via the WUSCHEL-CLAVATA pathway. Involved in the development of the basal pole and in auxin-mediated root and vascular development in the embryo. Confers sensitivity to turnip mosaic virus (TuMV) probably by promoting viral movement and multiplication via interaction w [...] (566 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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