STRINGSTRING
S2P S2P NAC59 NAC59 NAC92 NAC92 LHY LHY VQ4 VQ4 ZPR3 ZPR3 VQ9 VQ9 SIB1 SIB1 MYC2 MYC2 SUMO1 SUMO1 SIB2 SIB2 TCP21 TCP21
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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experimentally determined
Predicted Interactions
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gene fusions
gene co-occurrence
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textmining
co-expression
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S2PMembrane-bound transcription factor site-2 protease homolog; Metalloprotease that catalyzes the second step (site-2 cleavage) in the proteolytic activation of various factors, after site- 1 cleavage. Part of a regulated intramembrane proteolysis (RIP) cascade. After ER stress, cleaves BZIP17 and BZIP28 proteins which functions as stress sensors and transducers in ER stress signaling pathway. The N-terminal bZIP component is translocated to the nucleus, where it activates the expression and production of ER chaperones, as well as proteins involved in brassinosteroid (BR) signaling, whic [...] (513 aa)
NAC59NAC domain-containing protein 59; Transcription activator that binds to DNA in promoters of target genes on a specific bipartite motif 5'-[AG]CGT[AG](4- 5n)[AG][CT]ACGCAA-3'. Triggers the expression of senescence-associated genes during age-, salt- and dark- induced senescence through a regulatory network that may involve cross- talk with salt- and H(2)O(2)-dependent signaling pathways. (318 aa)
NAC92NAC domain-containing protein 92; Transcription activator that binds to DNA in promoters of target genes on a specific bipartite motif 5'-[ACG][CA]GT[AG](5- 6n)[CT]AC[AG]-3'. Promotes lateral root development. Triggers the expression of senescence-associated genes during age-, salt- and dark-induced senescence through a regulatory network that may involve cross-talk with salt- and H(2)O(2)- dependent signaling pathways. Regulates also genes during seed germination. Regulates positively aging-induced cell death. Involved in age-related resistance (ARR) against Pseudomonas syringae pv. t [...] (285 aa)
LHYProtein LHY; Transcription factor involved in the circadian clock. Binds to the promoter region of APRR1/TOC1 and TCP21/CHE to repress their transcription. Represses both CCA1 and itself. (645 aa)
VQ4VQ motif-containing protein 4; Acts as negative regulator of WRKY33 transcription factor activity in the promotion of defense gene expression. Acts as a negative regulator of pathogen-associated molecular pattern (PAMP)- induced responses to modulate resistance to pathogens. (247 aa)
ZPR3Protein LITTLE ZIPPER 3; Competitive inhibitor of the HD-ZIPIII transcription factors in shoot apical meristem (SAM) development. Acts by forming non- functional heterodimers. Part of a negative feedback loop. Involved in SAM development and lateral organ patterning. Essential for proper functioning of stem cells in the SAM. (67 aa)
VQ9VQ motif-containing protein 9; Functions as a negative regulator of salt stress response. Functions as repressor of WRKY8 transcription factor by decreasing the DNA-binding activity of WRKY8 and acts antagonistically with WRKY8 to regulate sodium and potassium homeostasis under salt stress. (311 aa)
SIB1Sigma factor binding protein 1, chloroplastic; Contributes to plant defense. May regulate chloroplast metabolism upon infection with pathogens such as Pseudomonas syringae. Functions as activator of WRKY33 in plant defense against necrotrophic pathogens by stimulating the DNA-binding activity of WRKY33. (151 aa)
MYC2Transcription factor MYC2; Transcriptional activator. Common transcription factor of light, abscisic acid (ABA), and jasmonic acid (JA) signaling pathways. With MYC3 and MYC4, controls additively subsets of JA-dependent responses. In cooperation with MYB2 is involved in the regulation of ABA-inducible genes under drought stress conditions. Can form complexes with all known glucosinolate-related MYBs to regulate glucosinolate biosynthesis. Binds to the MYC recognition site (5'-CACATG-3'), and to the G-box (5'-CACNTG-3') and Z-box (5'-ATACGTGT-3') of promoters. Binds directly to the prom [...] (623 aa)
SUMO1Small ubiquitin-related modifier 1; Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Required for the massive protein sumoylation in the nucleus induced by heat shock and controlled by SIZ1. Involved in the regulation of the heat stress transcription factor HSFA2 in acquired thermotolerance. (100 aa)
SIB2Sigma factor binding protein 2, chloroplastic; Functions as activator of WRKY33 in plant defense against necrotrophic pathogens by stimulating the DNA-binding activity of WRKY33. (141 aa)
TCP21Transcription factor TCP21; Transcription factor involved in the regulation of the circadian clock. Acts as a repressor of CCA1 by binding to its promoter. No binding to the LHY promoter. (239 aa)
Your Current Organism:
Arabidopsis thaliana
NCBI taxonomy Id: 3702
Other names: A. thaliana, Arabidopsis thaliana (L.) Heynh., mouse-ear cress, thale cress, thale-cress
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